ライフサイエンスコーパス: FMRP

1 FMRP did not appear to regulate synapses individually, b

2 FMRP has been confirmed to bind voltage-gated potassium

3 FMRP is a master regulator of local translation but its

4 FMRP is a RNA-binding protein predominantly resident in

5 FMRP is a selective RNA binding protein owing to two cen

6 FMRP is an mRNA-binding protein regulating neuronal tran

7 FMRP is an RNA-binding protein involved in the control o

8 FMRP is an RNA-binding protein that is involved in the t

9 FMRP is both an RNA- and channel-binding regulator, with

10 FMRP is present predominantly in the cytoplasm, where it

11 FMRP uses an arginine-glycine-rich (RGG) motif for speci

12 FMRP was also shown to interact with the auxiliary beta4

13 FMRP was shown to directly interact with, and modulate,

14 FMRP-null PNs lose activity-dependent synaptic modulatio

15 FMRP-null PNs reduce synaptic branching and enlarge bout

16 e of fragile X mental retardation protein 1 (FMRP) leads to both pre- and postsynaptic defects, yet w

17 nucleotide repeat expansions in FMR1 abolish FMRP expression, leading to hyperactivation of ERK and m

18 In addition, FMRP expression levels varied in a subset of mice across

19 behavioral plasticity occurs normally after FMRP knockdown, but performance rapidly deteriorated in

20 anscripts, particularly those that were also FMRP targets.

21 Although FMRP levels were normal, mGlu5(R/R) mice mimicked multip

22 out of FMRP suppresses, and expression of an FMRP mutant protein that fails to interact with Cdh1 phe

23 tural modifications and learning triggers an FMRP-dependent increase of alphaCaMKII dendritic transla

24 TDP-43 and FMRP form a complex in flies and human cells.

25 These findings define Cdh1-APC and FMRP as components of a novel ubiquitin signaling pathwa

26 Visual conditioning and FMRP knockdown produce similar increases in FUNCAT in te

27 ranscripts overexpressed in the Mecp2 KO and FMRP mRNA targets.

28 led a novel mechanism by which Gp1 mGluR and FMRP mediate protein translation and neural network acti

29 this issue, we measured brain Fmr1 mRNA and FMRP levels as a function of CGG-repeat length in a cong

30 spectrum disorder (ASD) including RBFOX1 and FMRP.

31 t Mdm2 acts as a translation suppressor, and FMRP is required for its ubiquitination and down-regulat

32 However, as FMRP expression levels decrease with increasing CGG-repe

33 that PFC dysfunction may persist as long as FMRP is absent and therefore can be rescued after develo

34 ion of FXS synaptic phenotypes by astroglial FMRP.

35 idence that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS, l

36 s show that the selective loss of astroglial FMRP contributes to cortical synaptic deficits in FXS, p

37 ns; whether the selective loss of astroglial FMRP in vivo alters astrocyte functions and contributes

38 Although the selective loss of astroglial FMRP only modestly increases spine density and length in

39 The previous association between FMRP and G-quadruplexes prompted the analysis of the dis

40 triguing new mechanistic connections between FMRP, innate immunity, and abnormal development.

41 The interaction between FMRP and Ca(V)2.2 occurs between the carboxy-terminal do

42 advances focus on discovering links between FMRP roles to determine whether FMRP has a multitude of

43 Both FMRP and FXR2P regulate neurogenesis, a process affected

44 Analysis of the brain FMRP transcriptome has revealed hundreds of potential mR

45 Although connections between burgeoning FMRP functions remain unknown, recent advances have exte

46 es have attempted to identify mRNAs bound by FMRP through several methods, each generating a list of

47 ty to normalize multilevel defects caused by FMRP loss.

48 ty normalizes multi-level deficits caused by FMRP loss.

49 ise mechanism of translational inhibition by FMRP is unknown.

50 Regulation of this machinery by FMRP could support complex behaviours in humans througho

51 itic branching defects that are modulated by FMRP and Orb2.

52 coordinated regulation of PSD95/Dlg4 mRNA by FMRP and FXR2P that ultimately affects its fine-tuning d

53 st that specific binding of cellular RNAs by FMRP may involve hydrogen bonding with RNA duplexes and

54 BET protein and chromatin reader targeted by FMRP.

55 Regulation of axonal translation by FMRP may shape the structure and function of the axonal

56 tal retardation 1 protein (Fmr1, also called FMRP) acts independently of futsch/MAP-1B to abolish act

57 Canonically, FMRP functions as an mRNA-binding translation suppressor

58 To clarify FMRP's binding to its target mRNAs, we produced a shared

59 Remarkably, dendritic FMRP in NL/MSO neurons often accumulates at branch point

60 Despite FMRP importance for proper brain function, its overall e

61 immunoreactive neurons in 1 d differentiated FMRP-deficient neurospheres is normalized.

62 microarray analyses of endfeet, we discover FMRP-bound transcripts, which encode signaling and cytos

63 The R138Q mutation also disrupts FMRP's interaction with the large-conductance calcium-ac

64 ears ago, studies continue to reveal diverse FMRP functions.

65 We show that Drosophila FMRP (dFMR1) is required for long-term olfactory habitua

66 use conditional knock-out mice to eliminate FMRP only in the PFC alone of adult mice.

67 ous Cdh1-APC forms a complex with endogenous FMRP, and knockout of Cdh1 impairs mGluR-induced ubiquit

68 it remains unclear, however, to what extent FMRP-BK channel interactions contribute to synaptic and

69 identification of fragile X protein family (FMRP, Fxr1 and Fxr2) as binding partners.

70 e in mice mirrored the more limited data for FMRP expression in the human samples.

71 oportionately longer lengths, enrichment for FMRP binding and G-quartets, and their genes are under g

72 rate an independent presynaptic function for FMRP through the study of an ID patient with an FMR1 mis

73 ut direct demonstration of a requirement for FMRP control of local protein synthesis during behaviora

74 ing synaptoneurosomes demonstrate a role for FMRP and miR-125a in regulating the translation of PSD-9

75 This reveals a new role for FMRP-regulated dendritic local translation in learning-i

76 e uncovered a number of additional roles for FMRP besides RNA regulation.

77 n the Drosophila FXS disease model, we found FMRP binds shrub mRNA (human Chmp4) to repress Shrub exp

78 Consistently, we found FMRP loss and Shrub overexpression similarly elevate end

79 ntral brain learning/memory center, we found FMRP loss and Shrub overexpression similarly increase co

80 rome (FXS), caused by the loss of functional FMRP, is a leading cause of autism.

81 Among these presynaptic FMRP functions, FMRP interaction with large-conductance calcium-activate

82 RGG/RG domains from Fused in Sarcoma (FUS), FMRP and hnRNPU.

83 Analysis of RGG/RG domains from FUS, FMRP and hnRNPU against a spectrum of contrasting RNAs r

84 d from birth through adulthood, with greater FMRP reductions in the soma than in the neurite, despite

85 expansion (preCGG), cortical and hippocampal FMRP expression is moderately reduced from birth through

86 How FMRP impacts synaptic protein translation and which mRNA

87 Efforts aimed at elucidating how FMRP target mRNAs are selected have produced divergent s

88 Understanding how FMRP regulates iontophoresis should reveal new molecular

89 However, FMRP regulates the transcription of other proteins and p

90 l structure of the complex between the human FMRP RGG peptide bound to the in vitro selected G-rich R

91 ator and chicken are highly similar to human FMRP with identical mRNA-binding and phosphorylation sit

92 the FCBS dataset of reproducibly identified FMRP binding sites is a valuable tool for investigating

93 We identify FMRP as a chromatin-binding protein that functions in th

94 atment with the tPA-neutralizing antibody in FMRP-deficient cells during early neural progenitor diff

95 Cocaine reward deficits in FMRP-deficient mice stem from elevated mGluR5 (or GRM5)

96 We found GACR to be highly enriched in FMRP datasets, while ACUK was not.

97 we observed highly clustered WGGA motifs in FMRP targets compared with other genes, implicating both

98 ent behavioral plasticity occurs normally in FMRP knockdown animals, but plasticity degrades over 24

99 mily of RNA-binding proteins, which includes FMRP and FXR2P.

100 This study may provide a novel insight into FMRP involvement in the intracellular localization of FU

101 g sites is a valuable tool for investigating FMRP targets and function.

102 regulated by MNK1 and those encoded by known FMRP-binding mRNAs.

103 Neurons lacking FMRP show aberrant mRNA translation and intracellular si

104 circuit, we discovered that neurons lacking FMRP take up dramatically more current-injected small dy

105 physical property of central neurons lacking FMRP that could underlie aspects of FXS disruption of ne

106 ic increase in dye uptake in neurons lacking FMRP.

107 Here, we analyze four large FMRP target datasets to generate high-confidence consens

108 in the midbrain and hypothalamus exhibit low FMRP levels.

109 mediated transcription regulation and mGluR5/FMRP-mediated protein translation regulation through cor

110 17 FXTAS individuals revealed that the mild FMRP decrease in mice mirrored the more limited data for

111 a, and are enriched for chromatin modifiers, FMRP-associated genes and embryonically expressed genes.

112 Furthermore, mutant FMRP loses the ability to rescue presynaptic action pote

113 , neuronally driven expression of the mutant FMRP is unable to rescue structural defects at the neuro

114 osophila FXS model is key to discovering new FMRP roles, because of its genetic malleability and indi

115 These findings suggest that nuclear FMRP regulates genomic stability at the chromatin interf

116 rn neurons that are prevented by ablation of FMRP in adult-born neurons and rescued by an metabotropi

117 y bulb neurons and cell-specific ablation of FMRP, we investigated whether learning shapes adult-born

118 gulate BK channel activity in the absence of FMRP and determine its ability to normalize multilevel d

119 an be attributed to the continued absence of FMRP from the PFC, independent of FMRP status during dev

120 The absence of FMRP in neurons abolishes group 1 metabotropic glutamate

121 these deficits (1) are due to the absence of FMRP in the PFC alone and (2) are not the result of deve

122 dysfunction due to the continued absence of FMRP is necessary to understand the different roles of F

123 Absence of FMRP results in abnormal neuronal morphologies in a sele

124 In the absence of FMRP-mediated repression, a condition that occurs in a m

125 tatory hippocampal neurons in the absence of FMRP.

126 mance rapidly deteriorated in the absence of FMRP.

127 in the hippocampal circuit in the absence of FMRP.

128 gulate BK channel activity in the absence of FMRP.

129 nction is also due to the ongoing absence of FMRP.

130 f facilitating molecular characterization of FMRP signaling in future studies.

131 arget mRNAs, we produced a shared dataset of FMRP consensus binding sequences (FCBS), which were repr

132 uR-induced ubiquitination and degradation of FMRP in the hippocampus.

133 ce to systematically map the distribution of FMRP expression in the entire mouse brain.

134 ccurs between the carboxy-terminal domain of FMRP and domains of Ca(V)2.2 known to interact with the

135 Downregulation of FMRP was dependent on group I mGluR activation and was b

136 ly rescued by the selective re-expression of FMRP in astrocytes in i-astro-Fmr1-cON mice.

137 yramidal neurons, selective re-expression of FMRP in astrocytes significantly attenuates abnormal spi

138 Loss and abnormal expression of FMRP occur in fragile X syndrome (FXS) and some forms of

139 tic- and translation-independent function of FMRP that is linked to a specific subset of FXS phenotyp

140 ether the pre- and postsynaptic functions of FMRP are independent and have distinct roles in FXS neur

141 tudies identified important new functions of FMRP in regulating neural excitability and synaptic tran

142 We examined a group of FMRP targets that encode transcriptional regulators, par

143 but the molecular mechanism and identity of FMRP targets mediating this phenotype remain largely unk

144 absence of FMRP from the PFC, independent of FMRP status during development.

145 Furthermore, initiation of FMRP production in the PFC of adult FX animals rescues P

146 more, we confirmed the direct interaction of FMRP with one candidate, RhoC, by in vitro RNA binding a

147 endent mechanisms and direct interactions of FMRP with a number of ion channels in the axons and pres

148 (Cyfip2) was identified as an interactor of FMRP, and its mRNA is a highly ranked FMRP target in mou

149 Knockout of FMRP suppresses, and expression of an FMRP mutant protei

150 In the mouse, the lack of FMRP is associated with an excessive translation of hund

151 minent cell groups expressing high levels of FMRP at the subcortical levels, in particular sensory an

152 r brain areas contain high and low levels of FMRP cell groups adjacent to each other or between layer

153 Loss of FMRP in mice results in widespread changes in chromatin

154 ze task was also not affected by the loss of FMRP in rats.

155 We conclude that loss of FMRP results in significant epigenetic misregulation and

156 ampal phenotypes associated with the loss of FMRP.

157 stinct from the current RNA-binding model of FMRP, we show that FMRP occupies the GAR domain of TRF2-

158 ot previously recognized in the RGG motif of FMRP.

159 ure and sequence in the recognition motif of FMRP.

160 gether, these findings support the notion of FMRP differential neuronal regulation and strongly impli

161 ortant, we describe differential patterns of FMRP distribution in both cortical and subcortical brain

162 sive experience decreases phosphorylation of FMRP in the NAc, which is coupled to a long-term increas

163 However, there is a small portion of FMRP present in the nucleus, and its function there has

164 cits are rescued by initiating production of FMRP in adult conditional restoration mice, suggesting t

165 ing glutamate exposure caused proteolysis of FMRP.

166 Reduction of FMRP led to enhanced synaptic group I mGluR-mediated tra

167 ogether reveal an unexpected nuclear role of FMRP in DDR and uncover a feed-forward mechanism by whic

168 ovel information about the selective role of FMRP in hippocampus-dependent associative memory.

169 To explore the molecular role of FMRP in this nucleus, we performed proteomic analysis of

170 cessary to understand the different roles of FMRP and to treat patients effectively throughout life.

171 at it is possible to dissociate the roles of FMRP in neural function from developmental dysregulation

172 endrites and spines, as well as the roles of FMRP or miR-125a, have not been directly studied.

173 translational regulator FMRP and a subset of FMRP mRNA targets.

174 the well-characterized target transcripts of FMRP are synaptic proteins, yet targeting these proteins

175 uR impairs activity-dependent translation of FMRP, which may hinder synaptic plasticity in a clinical

176 P-bound motifs, and a clear understanding of FMRP's binding determinants has been lacking.

177 r synaptic integration and its dependence on FMRP.

178 f control appears to be different from other FMRP target mRNAs.

179 k show that elevated PN activity phenocopies FMRP-null defects, whereas PN silencing causes opposing

180 n 3, as well as the levels of phosphorylated FMRP.

181 Of these, 94 are potential FMRP targets, by comparative analysis with previously pr

182 in NL and in particular a list of potential FMRP targets, with the goal of facilitating molecular ch

183 This mutation, c.413G > A (R138Q), preserves FMRP's canonical functions in RNA binding and translatio

184 nels and mechanisms that mediate presynaptic FMRP actions, it remains unclear, however, to what exten

185 Among these presynaptic FMRP functions, FMRP interaction with large-conductance

186 omparative analysis with previously proposed FMRP targets in mammals.

187 eins, including the syndromic autism protein FMRP, move in basal processes at velocities consistent w

188 of the fragile X mental retardation protein FMRP.

189 also identify the fragile X syndrome protein FMRP as a substrate of Cdh1-APC.

190 ene silencing and insufficient FMR1 protein (FMRP), FXTAS is thought to be caused by 'toxicity' of ex

191 n of these progenitors lacking FMR1 protein (FMRP).

192 Fragile X mental retardation protein (FMRP) and Ataxin-2 (Atx2) are triplet expansion disease-

193 n with fragile X mental retardation protein (FMRP) and bind to one another's mRNA.

194 oss of fragile X mental retardation protein (FMRP) and haploinsufficiency of synaptic GTPase-activati

195 oss of fragile X mental retardation protein (FMRP) and that FMRP acts on BK channels by modulating th

196 luding Fragile X mental retardation protein (FMRP) and the related protein FXR2P.

197 oss of fragile X mental retardation protein (FMRP) cause fragile X syndrome (FXS), a genetic disorder

198 oss of fragile X mental retardation protein (FMRP) causes defects in episodic-like memory.

199 ion of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS) have largely focus

200 oss of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS), yet the mechanism

201 nce of Fragile X Mental Retardation Protein (FMRP) from birth results in developmental disabilities a

202 oss of fragile X mental retardation protein (FMRP) in different brain cell types, especially in non-n

203 of the Fragile X Mental Retardation Protein (FMRP) in neurons.

204 Fragile X mental retardation protein (FMRP) is a multifunctional RNA-binding protein with cruc

205 Fragile X Mental Retardation Protein (FMRP) is a regulatory RNA binding protein that plays a c

206 The fragile X mental retardation protein (FMRP) is an mRNA binding protein that regulates activity

207 Fragile X mental retardation protein (FMRP) is thought to regulate neuronal plasticity by limi

208 oss of fragile X mental retardation protein (FMRP) is thought to underlie cognitive deficits in FXS,

209 nce of fragile X mental retardation protein (FMRP) leads to defects in plasticity and learning defici

210 Fragile X mental retardation protein (FMRP) loss causes Fragile X syndrome (FXS), a major diso

211 oss of fragile X mental retardation protein (FMRP) on these pathways is brain region specific.

212 of the fragile X mental retardation protein (FMRP) pathway (10 observed vs. 4.4 expected, P = .0076).

213 gh the fragile X mental retardation protein (FMRP) pathway may underlie synaptic plasticity associate

214 The fragile X mental retardation protein (FMRP) plays an important role in normal brain developmen

215 AD) of fragile X mental retardation protein (FMRP) protein is considered to be a member of the methyl

216 s, the Fragile X Mental Retardation protein (FMRP) regulates expression of the scaffolding postsynapt

217 The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence

218 Fragile X mental retardation protein (FMRP) sculpts synaptic refinement in an activity sensor

219 ion of fragile X mental retardation protein (FMRP), a highly selective RNA-binding protein and transl

220 l with fragile X mental retardation protein (FMRP), a transport granule component.

221 of the fragile X mental retardation protein (FMRP), an RNA binding protein that regulates translation

222 le for fragile X mental retardation protein (FMRP), an RNA-binding protein and regulator of dendritic

223 ently, fragile X mental retardation protein (FMRP), an RNA-binding protein that regulates local prote

224 genous fragile X mental retardation protein (FMRP), and a reporter containing a patient 3'UTR caused

225 n with Fragile X mental retardation protein (FMRP), its upregulation in transformed lymphoblastoid ce

226 ent on fragile X mental retardation protein (FMRP), the protein that is deficient in the most common

227 Fragile X mental retardation protein (FMRP), the protein that is lacking in fragile X syndrome

228 ion of fragile X mental retardation protein (FMRP), which represses translation of target transcripts

229 uiring fragile-X mental retardation protein (FMRP).

230 oss of fragile X mental retardation protein (FMRP).

231 zed by fragile X mental retardation protein (FMRP).

232 ng the fragile X mental retardation protein (FMRP).

233 oduct, fragile X mental retardation protein (FMRP).

234 of the fragile X mental retardation protein (FMRP).

235 ion of Fragile X Mental Retardation Protein (FMRP).

236 oss of Fragile X mental retardation protein (FMRP).

237 ressor Fragile X Mental Retardation Protein (FMRP).

238 of the fragile X mental retardation protein (FMRP, product of FMR1) are enriched for case mutations.

239 As a selective RNA-binding protein, FMRP is localized predominately in cytoplasm, where it r

240 y and interacts with an RNA-binding protein, FMRP, to promote synapse formation; and Top3beta gene de

241 ore of the Fragile X related (FXR) proteins (FMRP, FXR2P, and FXR1P) along with mRNA and ribosomes.

242 ere reproducibly identified in two published FMRP CLIP sequencing datasets.

243 d divergent sets of target mRNA and putative FMRP-bound motifs, and a clear understanding of FMRP's b

244 tor of FMRP, and its mRNA is a highly ranked FMRP target in mouse brain.

245 More recently, FMRP was shown to directly interact with the voltage-gat

246 utamate exposure (10 mum for 30 min) reduced FMRP levels in wild-type mouse hippocampal slices.

247 ntain ribosomes, the translational regulator FMRP and a subset of FMRP mRNA targets.

248 within the target RNAs to validate reported FMRP binding motifs (GACR, ACUK and WGGA).

249 the loss of the mRNA translational repressor FMRP leads to exaggerated protein synthesis downstream o

250 cking, with synaptic requirements resembling FMRP.

251 Together, our findings reveal FMRP as a critical mediator of cocaine-induced behaviora

252 We show FMRP controls transport and localization of one target,

253 Overexpressing TRF2-S and silencing FMRP promotes mRNA entry to axons and enhances axonal ou

254 the mutant defect, demonstrating a specific FMRP requirement.

255 al motifs that have been proposed to specify FMRP binding, the short sequence motifs TGGA and GAC wer

256 X mental retardation protein (FMRP) and that FMRP acts on BK channels by modulating the channel's gat

257 We conclude that FMRP is absolutely required for experience-dependent cha

258 but no direct evidence has demonstrated that FMRP-regulated dendritic protein synthesis affects behav

259 stribution of the FCBS set demonstrates that FMRP preferentially binds to the coding region of its ta

260 ll, Chen et al. (2014) provide evidence that FMRP represses translation by binding the ribosome, sugg

261 We find that FMRP functions in the adult nucleus accumbens (NAc), a c

262 These results indicate that FMRP affects visual conditioning-induced local protein s

263 These differential patterns indicate that FMRP expression appears to be specific to individual neu

264 Our data indicate that FMRP is a potent regulator of presynaptic activity, and

265 These findings indicate that FMRP is an important regulator of protein synthesis foll

266 immunoprecipitation in cortical neurons that FMRP is mostly associated with one unique mRNA: diacylgl

267 Single-channel analyses revealed that FMRP loss reduced BK channel open probability, and this

268 Specifically, we show that FMRP binds chromatin through its tandem Tudor (Agenet) d

269 These studies show that FMRP negatively regulates local protein synthesis and is

270 We show that FMRP occupies meiotic chromosomes and regulates the dyna

271 rent RNA-binding model of FMRP, we show that FMRP occupies the GAR domain of TRF2-S protein to block

272 Experiments in Fmr1 null mice show that FMRP regulates axonal protein expression but is not requ

273 The results show that FMRP strongly limits the rate of dye entry via a cytosol

274 We showed that FMRP knockdown and visual conditioning dramatically incr

275 These findings suggest that FMRP inhibits translation by blocking the essential comp

276 Our results strongly suggest that FMRP mediates structural plasticity of olfactory bulb ad

277 g and phosphorylation sites, suggesting that FMRP functions similarly across vertebrates.

278 However, several properties of the FMRP amino terminus are unresolved.

279 Activation of the FMRP pathway by group I metabotropic glutamate receptors

280 in BLAST analyses first demonstrate that the FMRP amino acid sequences in the alligator and chicken a

281 However, it remains unclear how these FMRP activities relate to each other and how dysfunction

282 translation to investigate the role of this FMRP messenger RNA target in learning-dependent structur

283 f mRNA species that were reported to bind to FMRP.

284 Transgenic wild-type FMRP reintroduction rescues the mutant defect, demonstra

285 ino terminal crystal structures of wild-type FMRP, and a mutant (R138Q) that disrupts the amino termi

286 Furthermore, when FMRP was knocked-down, translocation of exogenously expr

287 s to FXS pathology and support a model where FMRP, by controlling the translation of Dgkkappa, indire

288 local protein synthesis in vivo and whether FMRP knockdown affects protein synthesis-dependent visua

289 inks between FMRP roles to determine whether FMRP has a multitude of unrelated functions or whether c

290 Here we tested whether FMRP knockdown in Xenopus optic tectum affects local pro

291 n effort to determine the mechanism by which FMRP mediates protein translation and neural network act

292 nes, leading to distinct hypotheses by which FMRP recognizes its targets; namely, by RNA structure or

293 ndividuals are defective in association with FMRP; whereas one of the mutants is also deficient in bi

294 on-related protein 2 (FXR2P) cooperates with FMRP in binding to the 3'-UTR of mouse PSD95/Dlg4 mRNA.

295 sensor mechanism based on sensory cues, with FMRP loss causing the most common heritable autism spect

296 All FXGs contain FXR2P, with FMRP and/or FXR1P present in circuit-selective subsets.

297 ion channel shown to directly interact with FMRP; this interaction alters the single-channel propert

298 researchers established the causal link with FMRP loss >;25 years ago, studies continue to reveal div

299 teins might form collaborative networks with FMRP and possibly other post-transcriptional regulators

300 ce, that these significantly overlapped with FMRP direct targets and/or SFARI human autism genes, and

301 redominantly express a single FXG type, with FMRP-containing FXGs the most prevalent in forebrain neu