ライフサイエンスコーパス: FOXO

1 FOXO (forkhead box O) transcription factors are tumor su

2 FOXO activation inversely correlated with JNK/c-JUN sign

3 FOXO deficiency further affected internalization of Haem

4 FOXO inhibition resulted in myeloid maturation and subse

5 FOXO protein expressed in baculovirus system binds to FO

6 FOXO transcription factors can repress Cyclin D1 transcr

7 FOXOs are crucial regulators of cellular homeostasis tha

8 FOXOs in turn attenuate Wnt/beta-catenin signaling by di

9 8) with expression levels of Sema 3A, NRP-1, FOXO 3a and MelCAM were studied by Kaplan-Meier analysis

10 receptor or by over-expression of the DAF-16 FOXO transcription factor.

11 compounds do not appear to activate DAF-16 (FOXO orthologue) or mimic dietary restriction (DR) effec

12 Our data indicate that DAF-16/FOXO activity in certain somatic gonad cells is required

13 ed branching, and this delay required DAF-16/FOXO activity.

14 ect is partially dependent on gonadal DAF-16/FOXO activity.

15 m-3 are dependent on the functions of daf-16/FOXO and daf-18/PTEN.

16 ural integrity into old age, and both DAF-16/FOXO and heat shock factor transcription factor HSF-1 ex

17 he PI3K signaling pathway to activate DAF-16/FOXO and promote developmental neurite outgrowth.

18 lifespan extension was independent of DAF-16/FOXO and SKN-1/Nrf2 signaling, but tryptophan and severa

19 on resulting in the activation of the DAF-16/FOXO and SKN-1/Nrf2 stress response pathways.

20 n a manner dependent on inhibition of DAF-16/FOXO by insulin/IGF-1 signalling (IIS).

21 cold sensation in C. elegans, whereby DAF-16/FOXO gets activated via complementary kinase signaling.

22 also demonstrate that the capacity of DAF-16/FOXO in regulating neuron morphology is conserved in mam

23 role is separable from the effect of DAF-16/FOXO on organismal aging.

24 roprotective effect also requires the DAF-16/FOXO partner bar-1/beta-catenin and putative DAF-16-regu

25 gely be explained by perturbations in DAF-16/FOXO target gene expression.

26 also allows the transcription factor DAF-16/FOXO to induce development into dauer, a diapause that w

27 r translocation of the cytoprotective DAF-16/FOXO transcription factor and protected from paraquat-in

28 stimuli required the function of the DAF-16/FOXO transcription factor in neurons, but not that of NP

29 ensitive membrane TRP channel and the DAF-16/FOXO transcription factor, but in more complex organisms

30 via the action of AKT kinases and the DAF-16/FOXO transcription factor.

31 G16L exert their function through the DAF-16/FOXO transcription factor.

32 ing transcriptional regulation by the DAF-16/FOXO transcription factor.

33 y signals to the transcription factor DAF-16/FOXO, a key regulator of lifespan.

34 Here, we report a role for DAF-16/FOXO, a transcription factor that is active under condit

35 ch regulates stress induction through DAF-16/FOXO, does not contribute to ESRE gene expression or bin

36 s, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ribosomal S6 kinase), gcn-2, and

37 uction in insulin signaling activates DAF-16/FOXO, which represses the transcription of germline and

38 programs by controlling noise in the DAF-16/FOXO-regulated gene network.

39 lling, requiring DAF-18/PTEN, but not DAF-16/FOXO.

40 of the forkhead transcription factor DAF-16/FOXO.

41 itivity by regulating AKT kinases and DAF-16/FOXO.

42 imuli did not require the function of DAF-16/FOXO.

43 t signals to the transcription factor DAF-16/FOXO.

44 on the conserved transcription factor DAF-16/FOXO.

45 quires the longevity-promoting factor daf-16/FOXO.

46 he canonical PI3K pathway, inhibiting DAF-16/FOXO.

47 activity of the transcription factor DAF-16/FOXO.

48 tive feedback loop between miR-34 and DAF-16/FOXO.

49 ead box O subfamily transcription factor-3a (FOXO-3a)-dependent F-box-only protein (FBXO) expression.

50 d that in CD34(+) CML cells FOXO1, 3a and 4 (FOXOs) were phosphorylated, predominantly cytoplasmic an

51 y mutants, XBP-1 collaborates with DAF-16, a FOXO-transcription factor that is activated in these mut

52 he uPA inhibitor UK122, dexamethasone, and a FOXO inhibitor.

53 TLR3 activates innate immune responses in a FOXO-dependent manner.

54 The life span extension required a FOXO transcriptional factor DAF-16 but not HSF-1.

55 w that bacterial pathogens potently activate FOXO transcription factors in cultured human respiratory

56 of reactive oxygen species (ROS), activates FOXOs through JNK-mediated phosphorylation.

57 Active FOXO was also detectable in human bronchial tissue obtai

58 JNK1) kinase activity, which in turn affects FOXO localization through a compensatory dephosphorylati

59 ing IRS1/2-phosphatidylinositol 3-kinase-Akt-FOXO-1 signaling and insulin-induced maturation of SREBP

60 These data reveal a molecular role for AKT/FOXO and JNK/c-JUN in maintaining a differentiation bloc

61 through suppression of cytokine-mediated Akt/FOXO inhibition, and blunting of cathepsin-L-mediated ly

62 defense and mitochondrial uncoupling to Akt/FOXO signaling, these results have implications in obesi

63 We show a converse role for AKT/FOXOs in acute myeloid leukemia (AML).

64 Although FOXOs were localized in the nucleus and showed increased

65 eficial predominance of the adiponectin-AMPK-FOXO-signaling axis over the sustained JNK-elevation and

66 d "cargo" proteins including p53, c-Abl, and FOXO-3A.

67 ated lower levels of proteasome activity and FOXO expressions than their WT counterparts.

68 hibits regeneration independently of age and FOXO signaling via the TOR pathway.

69 Phosphorylated Akt and FOXO proteins were both increased in lung tumors, correl

70 s and molecules, including TGFbeta, AKT, and FOXO transcription factors (TFs).

71 efore, NFIL3 alters cancer cell behavior and FOXO function by acting on chromatin to restrict the men

72 Sirtuin deacetylases and FOXO (Forkhead box, class O) transcription factors have

73 ched for the FOXO transcription factors, and FOXO acetylation was elevated in Hdac3 knockout (KO) and

74 l progenitor cells had deficits in HDAC3 and FOXO recruitment and gene expression.

75 IIS and FOXO also regulate important neuronal and adult behaviou

76 signaling, via phosphoinositide 3-kinase and FOXO, intrinsically controls the competence of cap cells

77 onal programs associated with metabolism and FOXO and Hippo signaling were affected, analogous to wha

78 ated with activation of the AMPK pathway and FOXO transcription factors, inhibition of the mTORC1 and

79 Diapause is a complex phenotype, and FOXO emerges as a prime candidate for activating many of

80 ema 3A modulates phosphorylation of PTEN and FOXO 3a and expression of MelCAM, leading to suppression

81 Overexpression of PTEN and FOXO 3a enhances Sema 3A-induced attenuation of breast c

82 -mediated MelCAM expression through PTEN and FOXO 3a.

83 of phosphatase and tensin homolog (PTEN) and FOXO 3a.

84 -3beta and mammalian target of rapamycin and FOXO proteins FOXO1, FOXO3A, and FOXO4 and decreased per

85 ylinositol 3' OH kinase (PI3K) signaling and FOXO transcription factors play opposing roles at severa

86 tions for the role of insulin signalling and FOXO activation in diabetic wound healing.

87 hat integration of beta-catenin, sirtuin and FOXO signaling protects from the early phases of mutant

88 Down-regulating RUNX1 and FOXOs simultaneously causes widespread oxidative stress,

89 As FOXOs and PGC-1alpha are essential for memory and long-t

90 eased catabolic (TNF-alpha, TWEAK/Fn14 axis; FOXO-1, Atrogin-1 and MuRF1; Myostatin) and increased an

91 Both FOXO and 4E-BP delay muscle functional decay and extend

92 cellular survival programs that involve both FOXO-regulated transcription and cap-independent transla

93 orticoid receptor signaling or forkhead box (FOXO) 1/3 inhibition abolished the rapamycin-induced uPA

94 The forkhead boxO1A (FOXO) transcription factor DAF-16, the major transcripti

95 These 10 genes activated by FOXO are highly up-regulated during diapause and are thu

96 et containing genes potentially regulated by FOXO.

97 proposed mechanism in which the beta-catenin FOXO and SIRT1 proteins may together regulate gene expre

98 anner, NFIL3 repressed expression of certain FOXO targets--e.g., FAS, GADD45alpha (growth arrest and

99 Depending on the circumstance, FOXO (Forkhead O) (FOXO1, FOXO3, and FOXO4) transcriptio

100 orkhead transcription factor of the O class (FOXO)3A, known Akt targets that are related to cell surv

101 In conclusion, FOXO transcription factors are involved in the cellular

102 Under stress conditions FOXO transcription factors activate 4E-BP expression amp

103 ort that excessive activity of the conserved FOXO transcription factor DAF-16 enhances susceptibility

104 SIRT1 and SIRT2 deacetylate FOXO factors to regulate FOXO function.

105 Rather than decreased FOXO activity, we observed that FOXOs are active in appr

106 hway that mediates ROS-induced JNK-dependent FOXO regulation.

107 ma 3A controls NRP-1-mediated PTEN-dependent FOXO 3a activation.

108 For example, distinct FOXO-regulated transcriptional programs stimulate cell d

109 identified an interaction between Drosophila FOXO (dFOXO) and the zinc finger transcription factor Kr

110 ition of the transcription factor Drosophila FOXO (dFOXO) and the serine/threonine protein kinase sha

111 Here, we show that Drosophila FOXO (dFOXO) regulates the expression of core small RNA

112 Here we show that Drosophila FOXO binds the PDCD4 promoter and stimulates the transcr

113 Collectively, our results identify E2F1/FOXO cooperation as a regulatory mechanism that places E

114 re identified as specific activators of E2F1/FOXO transcription, acting to enhance E2F1-induced apopt

115 pes and by the association of a reduced E2F1/FOXO transcriptional program with poor prognosis.

116 The E2F1/FOXO axis is frequently blocked in cancer, as evidenced

117 Here, we report that knockdown of endogenous FOXO proteins in hippocampal and cerebellar granule neur

118 d Akt and ERK phosphorylations, and enhanced FOXO-1 and p27(kip1) levels in Caco-2 cells.

119 nostat with a PI3K inhibitor led to enhanced FOXO-dependent apoptosis.

120 ection against oxidative stress by enhancing FOXO-driven Sod2 transcription.

121 ression by deacetylating the forkhead factor FOXO in response to stress and nutrient deprivation.

122 e activity of the longevity-promoting factor FOXO through a noncanonical mechanism that implicates th

123 The transcription factor FOXO and its target 4E-BP remove damaged proteins at lea

124 c network, the forkhead transcription factor FOXO has been shown to interact with diverse transcripti

125 suppressor PTEN, or the transcription factor FOXO in the subperineurial glia.

126 d redistribution of the transcription factor FOXO.

127 e deduced the forkhead transcription factor (FOXO) family to be a downstream mechanism through which

128 on the forkhead box O transcription factor (FOXO), which is negatively regulated by the insulin-sign

129 tion of forkhead box O transcription factor (FOXO)-3a and enhanced atrogin-1 expression, which in tur

130 regulation of forkhead transcription factor (FOXO).

131 The forkhead O transcription factors (FOXO) integrate a range of extracellular signals, includ

132 Forkhead transcription factors (FOXOs) alter a diverse array of cellular processes inclu

133 Forkhead O transcription factors (FOXOs) have been implicated in glucose and lipid homeost

134 e, DJ-1 and forkhead box, subgroup O family (FOXOs).

135 regions of the Hsp70 promoter essential for FOXO-dependent transcription using in vitro methods and

136 diated, although the ubiquitin E3 ligase for FOXO factors remains to be defined.

137 ion experiments revealed a critical role for FOXO transcription factors in mediating these proliferat

138 ro methods and find a physiological role for FOXO-dependent expression of heat shock proteins in vivo

139 t al. identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells.

140 The members of the class O forkhead (FOXO) transcription factor family, including FOXO3a, act

141 Importantly, in mammals, four FOXO genes have overlapping and different functions, and

142 to generate isogenic controls rescued HDAC3-FOXO-mediated impairments in gene expression.

143 ear factor interleukin 3-regulated) hindered FOXO transcription factor access to chromatin at the TRA

144 To gain insight into how FOXOs select specific genes for regulation, we performed

145 Here, we identify FOXO transcription factors as E2F1 target genes that act

146 IIS/FOXO neuron-specific targets are distinct from canonical

147 ng, we identified both the wild-type and IIS/FOXO mutant adult neuronal transcriptomes for the first

148 ific targets are distinct from canonical IIS/FOXO-regulated longevity and metabolism targets, and are

149 Together, neuron-specific and canonical IIS/FOXO-regulated targets enable the coordinated extension

150 and C. elegans, but the neuron-specific IIS/FOXO targets that regulate these functions are still unk

151 s reveal that the Ryk-ICD pathway may impair FOXO protective activity in mutant polyglutamine neurons

152 ial respiration not previously implicated in FOXO localization.

153 that selectively phosphorylates/inactivates FOXO transcription factors and downregulates the ROS-sca

154 The integration of individual FOXO and sirtuin family members into various aspects of

155 Lapatinib-induced FOXO transcription factors, normally tumor-suppressing,

156 insulin-like peptides (ILPs) and influenced FOXO subcellular localization, resulting in the down-reg

157 cies, where AKT acts, in part, by inhibiting FOXO tumor suppressors.

158 trometry to show that the C. elegans insulin/FOXO pathway regulates the metabolism of locally acting

159 Recently, insulin/FOXO signaling has been implicated in the regulation of

160 of JAK2V617F mutation, suggesting that JAK2-FOXO signaling has a different effect on progenitors com

161 an and stress, distinct from the insulin/JNK/FOXO pathway.

162 Mammalian FOXO degradation is proteasome-mediated, although the ub

163 53, to regulate the degradation of mammalian FOXO factors.

164 we performed a screen for genes that modify FOXO activation of TRAIL, a death receptor ligand capabl

165 Moreover, FOXO/4E-BP signaling in muscles decreases feeding behavi

166 aging and longevity pathways including mTOR, FOXO and MAPK, most of which also demonstrated associati

167 morphogenesis, both of which require normal FOXO function.

168 Nuclear FOXO proteins act as tumor suppressors by transcriptiona

169 be partially reversed by maintaining nuclear FOXO but not by increasing PGC-1alpha.

170 The resulting nuclear FOXO increases expression of target genes, including mit

171 wnstream signaling molecules forkhead box O (FOXO) and p70 S6 kinase in a tissue and blood meal-speci

172 Evasion of forkhead box O (FOXO) family of longevity-related transcription factors-

173 The forkhead box O (FOXO) family of transcription factors is a conserved fam

174 DAF-16 transcription factor (forkhead box O (FOXO) homologue), whose global targets were identified i

175 habditis elegans, the single forkhead box O (FOXO) homologue, DAF-16, functions as the major target o

176 Here we report that the forkhead box O (FOXO) transcription factor FOXO1 is an essential regulat

177 Forkhead box O (FOXO) transcription factors control diverse cellular fun

178 ession program downstream of Forkhead box O (FOXO) transcription factors during 3D breast epithelial

179 Forkhead box O (FOXO) transcription factors favor both T cell quiescence

180 the activation of mammalian forkhead box O (FOXO) transcription factors.

181 ifferentiation by modulating Forkhead box O (FOXO), target of rapamycin, and Hippo signaling pathways

182 ivated protein kinase (AMPK)-forkhead box O (FOXO)-signaling axis stemming from at the least three sy

183 knock-down of CREB and Forkhead box class O (FOXO) 3a led to a reduction in TPA-induced MnSOD gene ex

184 ted AKT, GSK3beta, and forkhead box class O (FOXO)1 in CON and IUGR fetal livers.

185 d transcription factor Forkhead box class O (FOXO)3a and VEGF expression.

186 Forkhead box transcription factor family O (FOXO) transcription factors are key regulators of cellul

187 omolog (Pten), the forkhead box, subgroup O (FOXO) transcription factors, and TSC1, have demonstrated

188 ertebrate model organisms, Forkhead box "O" (FOXO) transcription factors and sirtuin deacetylases are

189 inhibition reduces forkhead box, class 'O' (FOXO)3a protein expression and its downstream anti-oxida

190 se genes via deacetylation and activation of FOXO family transcription factors.

191 loroacetate (DCA), would blunt activation of FOXO gene targets and reduce statin myopathy.

192 rial pathogens resulted in the activation of FOXO transcription factors in alveolar and bronchial epi

193 nous expression of Pak1 in the background of FOXO knockdown in both primary neurons and postnatal rat

194 eflects direct and indirect contributions of FOXO, EcR, Rbf and additional transcription factors thro

195 of endogenous Pak1 phenocopies the effect of FOXO knockdown on neuronal polarity.

196 Finally, we explore the effects of FOXO knockouts in three different mouse tissues.

197 tein in cells and enhances the expression of FOXO target genes.

198 ed proteasome activity and the expression of FOXO transcription factors in three wild-type (WT) and t

199 FOXO1 inhibition decreased the expression of FOXO/BRD4 target genes.

200 Inactivation of FOXO proteins and elevation of intracellular ROS are cha

201 ACs in murine liver results in inhibition of FOXO target genes and lowers blood glucose, resulting in

202 occurred at least in part via inhibition of FOXO-mediated transcription of genes regulating muscle C

203 creen and discovered selective inhibitors of FOXO-dependent glucose production devoid of lipogenic ac

204 nriched regions predicted the involvement of FOXO transcription factors.

205 Small interfering RNA-mediated knockdown of FOXO in bronchial epithelial cells resulted in reduced e

206 ae that lacked the CA had elevated levels of FOXO activity, whereas a loss-of-function mutation of FO

207 uiescent CML stem cells showed low levels of FOXO phosphorylation and predominant nuclear localisatio

208 ivity, no change in the expression levels of FOXO target genes were observed.

209 Examination of subcellular localization of FOXO protein via CRISPR-assisted, single-stranded oligod

210 acting on chromatin to restrict the menu of FOXO target genes.

211 vity, whereas a loss-of-function mutation of FOXO rescued the effects of CA ablation on final body si

212 iation to the specific signaling pathways of FOXO, mTOR, and Wnt/beta-catenin.

213 Furthermore, regulation of FOXO by RALA and JIP1 is conserved in C. elegans, where

214 Importantly, JNK regulation of FOXO is evolutionarily conserved.

215 tudy, our aim was to investigate the role of FOXO transcription factors in innate immune functions of

216 n response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal a

217 phorylation and cytoplasmic sequestration of FOXO away from its target genes and serves as an endpoin

218 RNAi-mediated silencing of FOXO impaired E2F1 binding to the promoters of cooperati

219 epithelial cells, we found that a subset of FOXO target genes was jointly regulated by the transcrip

220 hIP sequencing to identify direct targets of FOXO.

221 Upregulation of FOXO gene targets known to regulate proteasomal and lyso

222 enitor cells is mediated by re-activation of FOXOs, whilst quiescence of CML stem cells is regulated

223 es how oncogenic RAS-mediated degradation of FOXOs, via post-translational mechanisms, blocks these i

224 The elucidation of a restraining effect of FOXOs on Wnt signaling in bipotential progenitors sugges

225 TKIs decreased phosphorylation of FOXOs, leading to their re-localisation from cytoplasm (

226 and lipid homeostasis; however, the role of FOXOs in the development of nonalcoholic fatty liver dis

227 phorylation and cytoplasmic sequestration of FOXOs.

228 soform), as well as nuclear stabilization of FOXOs, well-known CHIP-ubiquitination targets.

229 gradation, a process apparently dependent on FOXO phosphorylation at AKT sites and the E3 ligase acti

230 Injection of bovine insulin or FOXO double-stranded RNA into the previtellogenic, starv

231 erine 207, a site that is conserved in other FOXO family members.

232 accumulated tumor-suppressor proteins (p27, FOXO, p73, and prostate apoptosis response-4 [PAR-4]) an

233 ER2(+) breast cancer by inhibiting HER2-PI3K-FOXO-survivin signaling.

234 by acting upstream of the lifespan-promoting FOXO transcription factor DAF-16 and likely upstream of

235 ration of Akt activation in part by reducing FOXO-mediated transcriptional activation of mitochondrio

236 t flies are starvation sensitive, reflecting FOXO-dependent increases in lipolysis that deplete trigl

237 echanisms by which hormonal signals regulate FOXO deacetylation remain unclear, however.

238 d SIRT2 deacetylate FOXO factors to regulate FOXO function.

239 axis, unraveling an epigenetically regulated FOXO/c-Myc axis as a potential target to improve therapy

240 class IIa deacetylase HDAC4, which regulates FOXO activity in Drosophila.

241 erentiation, at least in part, by regulating FOXO factor function on enhancers to activate TP63 and G

242 cating a potential role of AKT in regulating FOXO levels.

243 r this mode of regulation extends to related FOXO family members is unknown.

244 ction in expanded-polyQ nematodes, repressed FOXO transcriptional activity, and abolished beta-cateni

245 regulation of microRNA bantam that represses FOXO-mediated transcription of pro-apoptotic Smac/DIABLO

246 erent functions, and in C. elegans, a single FOXO/DAF-16 uses distinct isoforms to fine-tune the IIS-

247 are characterized by activation of the SIRT/FOXO/SOD2 axis of the mitochondrial unfolded protein res

248 ne but not reporter genes dependent on SMAD, FOXO, C/EBP, NF-kappaB, or AP-1.

249 Although implicated as tumor suppressors, FOXO genetic inactivation has not been observed in human

250 of CML stem cells is regulated by sustained FOXO activity.

251 etic mobility shift assay data revealed that FOXO 3a regulates MelCAM at the transcriptional level.

252 Thus, our data suggest that FOXO transcription factors play a salutary role in the p

253 ing in bipotential progenitors suggests that FOXO activation by accumulation of age-associated cellul

254 an decreased FOXO activity, we observed that FOXOs are active in approximately 40% of AML patient sam

255 These data suggest that FOXOs modulate proteasome activity, and thus represents

256 The FOXO family of transcription factors elicits cell cycle

257 The FOXO transcription factors control proliferation and apo

258 The FOXO transcription factors, including the brain-enriched

259 n, and RAS/ERK1/2 signaling pathways and the FOXO/FOXL2 transcription factors.

260 -2-signaling pathway and is regulated by the FOXO transcription factor DAF-16, which contributes to t

261 n-6, a subunit of the 19S proteasome, by the FOXO transcription factor DAF-16.

262 In cancer, the FOXO family of transcription factors functions as tumor

263 These findings define the FOXO proteins and Pak1 as components of a cell-intrinsic

264 inhibited Akt signaling and facilitated the FOXO-3a/FBXO-dependent BK-beta(1) degradation in diabeti

265 d that ROS signaling cascade facilitates the FOXO-3a/FBXO-mediated BK-beta(1) degradation and leads t

266 y, thus identifying a novel function for the FOXO transcription factors in a unique aspect of neural

267 ortex in vivo, reveals a requirement for the FOXO transcription factors in the establishment of neuro

268 3-associated promoters were enriched for the FOXO transcription factors, and FOXO acetylation was ele

269 ance by phosphorylating and inactivating the FOXO transcription factors.

270 ivity of downstream effectors, including the FOXO family of transcription factors.

271 The PI3K/Akt pathway inhibits the FOXO-mediated transcription of the muscle-specific E3 li

272 naling in pituitary gonadotrope cells is the FOXO subfamily of forkhead transcription factors.

273 is primarily attributable to activity of the FOXO (forkhead box O) transcription factor DAF-16 in neu

274 Members of the FOXO (forkhead O) class of transcription factors are tum

275 or production, which activate members of the FOXO family of transcription factors.

276 ons and transcriptional dysregulation of the FOXO genes are infrequent in human cancers, it remains u

277 t shock-induced nuclear translocation of the FOXO orthologue DAF16.

278 of FOXO4 and increase the expression of the FOXO target genes MnSOD and catalase.

279 ignaling is dependent on the activity of the FOXO transcription factor DAF-16 and the nuclear hormone

280 ription factor pha-4, and independent of the FOXO transcription factor daf-16.

281 ity, as a critical direct target gene of the FOXO transcription factors.

282 Suppression of the FOXO-3a/FBXO pathway prevented vascular BK-beta(1) degra

283 denced by the specific downregulation of the FOXO-dependent E2F1 transcriptional program in multiple

284 cer growth in vivo, partly by repressing the FOXO/c-Myc axis, unraveling an epigenetically regulated

285 the Ryk-ICD fragment and its binding to the FOXO co-factor beta-catenin.

286 This effect of insulin utilizes the FOXO-dependent regulation of the thor gene, which encode

287 ses do not require insulin signaling via the FOXO homolog DAF-16 or the insulin/IGF-1-receptor homolo

288 hosphorylate conserved AKT motifs within the FOXO family and that PP2A is entwined in a dynamic inter

289 l cell morphology during development through FOXO.

290 regulates a subset of neuronal genes through FOXO deacetylation, and disruption of HDAC3 contributes

291 and AKT2 appeared to regulate growth through FOXO proteins, but not through either GSK3beta or mTOR.

292 on and nuclear translocation of HDAC4 and to FOXO deacetylation.

293 ein expressed in baculovirus system binds to FOXO response element present in the Vg gene promoter.

294 Binding of MDM2 to FOXO occurs through the region of MDM2 that directs its

295 y defective signalling downstream of pAKT to FOXO and GSK3 in fs188 and fswt cells, which also correl

296 N signaling, and leukemic cells resistant to FOXO inhibition responded to JNK inhibition.

297 aling by diverting beta-catenin from TCF- to FOXO-mediated transcription.

298 antagonize the primary effects on ageing via FOXO in mouse and via SKN-1 in worm.

299 ucose culture conditions was associated with FOXO-3a/FBXO-dependent increase in BK-beta(1) degradatio

300 tly necessary for normal wound healing, with FOXO and S6K as their respective effectors.