ライフサイエンスコーパス: FP receptor

1 is mediated through the PGF2alpha receptor (FP receptor).

2 2alpha in cats is mediated by EP1 but not by FP receptor.

3 yocytes through the activation of endogenous FP receptors.

4 osomal PGE synthase-1 and EP1, EP2, EP3, and FP receptors.

5 melanocyte dendricity through EP1, EP3, and FP receptors.

6 odies to the EP(1), EP(2), EP(3), EP(4), and FP receptors.

7 ctural requirements for substrate binding to FP receptors.

8 ted sizes corresponding to the EP2, EP4, and FP receptors.

9 lls that was consistent with the presence of FP receptors.

10 WT mice via activation of the F prostanoid (FP) receptor.

11 These data provide evidence that FP receptor activation leads to an increase in the secre

12 gonist 17-phenyl trinor PGE2 and the partial FP receptor agonist AL-8810, were uniformly abolished by

13 Stimulation of HLE-B3 cells by the FP receptor agonist fluprostenol increased [Ca2+]i in a

14 o 0.1 microM PGF(2alpha) was mimicked by the FP receptor agonist fluprostenol, whilst the effect of 1

15 Thus, prostaglandin F2alpha (PGF2alpha) (FP receptor agonist), Butaprost (EP2 receptor agonist),

16 ly with prostaglandin F2alpha, fluprostenol (FP receptor agonist), or 17-phenyl trinor PGE2 (EP1 rece

17 as approximately equipotent to the selective FP receptor agonists fluprostenol and 17-phenyl PGF(2alp

18 iverse PGF(2alpha) structural analogs to the FP receptor and compared these with binding by the PG tr

19 PGF(2alpha) may compete for binding between FP receptors and PGT, these findings have implications f

20 1 expression after PGF(2alpha) activation of FP receptors and suggests that this could be an early ev

21 The FP receptor antagonist AL8810 attenuated the PVAT-induce

22 ained iberiotoxin (IbTX)-sensitive, AL-8810 (FP receptor antagonist)-insensitive BK channel currents

23 c (FP-selective) PG agonist analogues and an FP receptor antagonist, AL-8810.

24 (PKC) inhibitor, chelerythrine chloride; the FP receptor antagonist, AL-8810; and the MEK inhibitor,

25 nhibition of FP receptor signalling with the FP receptor antagonist, chemical disruptors of the phosp

26 Digoxigenin-labeled human EP(1) and FP receptor antisense and sense riboprobes were used for

27 This study indicates that functional FP receptors are present in the human trabecular meshwor

28 staglandin F2alpha (PGF2alpha) F prostanoid (FP) receptors are both potent regulators of blood pressu

29 yl group produced only a modest reduction in FP receptor binding, but eliminated binding by PGT.

30 in the omega chain increased binding to the FP receptor but reduced affinity for PGT, and substituti

31 man melanocytes express EP1 and EP3, and the FP receptor, but not EP2 and EP4.

32 We hypothesized that activation of the human FP receptor by PGF(2alpha) could induce the expression o

33 As the FP receptor can increase levels of intracellular calcium

34 Previous studies suggested that FP receptors do not mediate the relaxation of the ciliar

35 Swiss white mice (n = 17), which have normal FP receptor expression, provided the control population.

36 teries from males, correlating with a higher FP receptor expression.

37 An intact FP receptor gene is critical to the IOP response to bima

38 Positive EP(1) and FP receptor immunoreactivity was observed in fibroblasts

39 The expression of FP receptors in HLE-B3 cells was explored by measuring i

40 e characterized the expression of the EP and FP receptors in human melanocytes and show that human me

41 lities for GPCRs and suggest novel roles for FP receptors in normal tissue development and malignant

42 Consistent with FP receptor induced formation of actin stress fibers and

43 The FP receptor is highly expressed in the distal convoluted

44 ken together, these results suggest that the FP receptor isoforms are coupled to at least two second

45 il now, functional differences between these FP receptor isoforms have not been identified.

46 Alternative mRNA splicing generates two FP receptor isoforms.

47 us studies have shown that the activation of FP receptors leads to phosphatidylinositol hydrolysis, i

48 In a prostaglandin FP receptor-linked second-messenger assay, racemic analo

49 This FP receptor-mediated induction of EGR-1 expression invol

50 The pharmacology of the h-TM cell FP-receptor-mediated PI turnover and [Ca(2+)](i) mobiliz

51 FP-receptor-mediated PI turnover and [Ca(2+)](i) mobiliz

52 showed conclusively the presence of EP4 and FP receptor messenger RNAs and proteins, respectively, i

53 Selective localization of FP receptor mRNA in the circular muscles and collagenous

54 In the ciliary muscle, FP receptor mRNA transcript was predominantly present in

55 he presence of high levels of both EP(1) and FP receptor mRNA transcripts in the blood vessels of iri

56 The wide distribution of EP(1) and FP receptor mRNAs in human ocular tissues appears to be

57 obtained from the cloned human ciliary body FP receptor (r = 0.92; P < 0.0001).

58 rabecular meshwork is mediated by prostanoid FP receptors (receptors for prostaglandin F2 alpha) in t

59 ponses to PGF2alpha, are mediated by EP1 and FP receptors, respectively.

60 The FP receptor-selective antagonist AL-8810 antagonized the

61 FP receptor signaling plays a crucial role in the early

62 etrapeptide arg-gly-asp-ser or inhibition of FP receptor signalling with the FP receptor antagonist,

63 Fluprostenol, a specific activator of the FP receptor, significantly increased mineralization of O

64 oup was essential for optimal binding to the FP receptor, since replacement by larger moieties with a

65 FP receptor stimulation by PGF(2alpha) induced the phosp

66 uite different signal transduction pathways, FP receptor stimulation up-regulates CTGF and Cyr61.

67 The EP(1), EP(2), and FP receptor subtypes are present in HSFs, suggesting tha

68 confirmed the presence of EP(1), EP(2), and FP receptor subtypes.

69 at low concentrations of PGF(2alpha) act via FP receptors to cause IP3-dependent Ca2+ release and sto

70 The hybridization signals corresponding to FP receptor transcript were similar to those of EP(1) re

71 work cells were examined for the presence of FP receptors using immunofluorescence microscopy with af

72 The mRNA levels for the prostaglandin FP receptor were downregulated in the ciliary muscle cel

73 nd neither did M1, except for activating the FP receptor with EC(50) = 557.9 +/- 55.2 nM (n = 4).