ライフサイエンスコーパス: Fanconi anemia

1 sensitivity to DNA crosslinking agents, and Fanconi anemia.

2 and genetically heterogeneous BMF syndrome: Fanconi anemia.

3 y identified in hereditary breast cancer and Fanconi anemia.

4 associated with breast cancer and linked to Fanconi anemia.

5 ailure is a nearly universal complication of Fanconi anemia.

6 ed to uncover a novel pathway linking HPV to Fanconi anemia.

7 opoietic stem cell defects characteristic of Fanconi anemia.

8 e sequence-related FANCJ helicase mutated in Fanconi anemia.

9 reatment, unlike cells from individuals with Fanconi anemia.

10 ny key features of the human genetic illness Fanconi anemia.

11 strand crosslinks is the defining feature in Fanconi anemia.

12 alive but die of malignancy associated with Fanconi anemia.

13 for chemotherapy responses and prevention of Fanconi anemia.

14 SCC cell lines derived from patients without Fanconi anemia.

15 at least sixteen FANC genes (FANCA-Q) cause Fanconi anemia, a disorder characterized by sensitivity

16 response in cells derived from patients with Fanconi anemia, a hereditary disorder characterized by b

17 Human FANCM has been linked to Fanconi anemia, a syndrome characterized by cancer predi

18 Fanconi anemia and Bloom syndrome are genomic instabilit

19 FANCD2, a pivotal protein in the Fanconi anemia and BRCA pathway/network, is monoubiquity

20 Cancer Cell, Schlacher et al. show that the Fanconi anemia and BRCA2 tumor suppressor pathways coope

21 Q motif DEAH box DNA helicase implicated in Fanconi anemia and breast cancer.

22 Inactivation of known Fanconi anemia and chromatid cohesion genes does explain

23 As in Fanconi anemia and dyskeratosis congenita, DBA is both a

24 se therefore establishes a disease model for Fanconi anemia and genetically links a regulator of nucl

25 These triggered processing by the Fanconi anemia and homologous recombination DNA repair p

26 hich is accompanied by downregulation of the Fanconi anemia and homologous recombination pathways.

27 re coordinated by the combined action of the Fanconi anemia and homologous recombination pathways.

28 cle arrest and uncovered a critical role for Fanconi anemia and homologous recombination proteins in

29 minor groove adducts normally recognized by Fanconi anemia and nucleotide excision repair machinery,

30 ndividuals with typical clinical features of Fanconi anemia and show that the cellular defects in the

31 g the pathogenesis of bone marrow failure in Fanconi anemia and suggest possible therapeutic approach

32 tudy included 330 patients (235 acquired, 85 Fanconi anemia, and 10 Diamond-Blackfan anemia) and thei

33 rth defects and bone marrow failure occur in Fanconi anemia, and may have implications for fetal well

34 es the S-phase accumulation of the BRCA1 and Fanconi anemia-associated DNA helicase FANCJ to sites of

35 omplex consists of eight FA proteins and two Fanconi anemia-associated proteins (FAAP24 and FAAP100).

36 k repair pathway commonly referred to as the Fanconi anemia-BRCA pathway.

37 The Fanconi anemia/BRCA (FA/BRCA) pathway is a DNA repair pa

38 radiation or UVB, UVA does not activate the Fanconi anemia/BRCA DNA damage response pathway or the "

39 ream HSP90-dependent regulatory point in the Fanconi anemia/BRCA DSB/ICL repair pathway, illuminate t

40 ckdown suppresses the genomic instability of Fanconi Anemia/BRCA pathway-deficient cells.

41 a DNA helicase that is genetically linked to Fanconi anemia, breast cancer, and ovarian cancer.

42 Here, by complementing a null FA-P Fanconi anemia cell line with SLX4 mutants that specific

43 In Fanconi anemia complementation gene M (FANCM), nonsense

44 The Fanconi anemia complementation group A (FANCA) gene is o

45 Intriguingly, ICL repair protein, Fanconi anemia complementation group A protein (FANCA),

46 Fanconi anemia complementation group C (FANCC) protein i

47 rcomes inherent TNFalpha hypersensitivity of Fanconi anemia complementation group C deficient progeni

48 tivates the FA pathway by monoubiquitinating Fanconi anemia complementation group D2 (FANCD2) for the

49 /EBPdelta promotes monoubiquitination of the Fanconi anemia complementation group D2 protein (FANCD2)

50 we report that the purified wild-type FANCI (Fanconi anemia complementation group I) protein directly

51 itivity to replication-blocking lesions than Fanconi anemia complementation group L (FANCL)-null muta

52 We show that Fml1, the Fanconi anemia complementation group M (FANCM)-ortholog

53 which encodes the DNA translocase FANCM (for Fanconi anemia complementation group M), which is requir

54 l cells depleted of alphaIISp by siRNA or in Fanconi anemia, complementation group A (FA-A) cells, wh

55 ules using TLR agonist-stimulated FANCC- and Fanconi anemia, complementation group A (FANCA)-deficien

56 Fanconi anemia, complementation group C (FANCC)-deficien

57 his model leads to the discovery that Fancl (Fanconi anemia, complementation group L) is downregulate

58 AAP20 UBZ is required for recruitment of the Fanconi anemia complex to interstrand DNA crosslink site

59 ger module, toward ubiquitin recognition and Fanconi anemia complex-mediated DNA interstrand crosslin

60 Rev1-pol zeta recruitment requires the Fanconi anemia core complex but not FancI-FancD2.

61 FAAP20 is an integral component of the Fanconi anemia core complex that mediates the repair of

62 s essential for viability, yet patients with Fanconi anemia-D1 subtype are born alive with biallelic

63 tral to this pathway is the Fanconi anemia I-Fanconi anemia D2 (FANCI-FANCD2) (ID) complex, which is

64 Potential implication for treatment of Fanconi anemia-deficient tumors by their sensitization t

65 ulator of nuclease incision complexes to the Fanconi anemia DNA crosslink repair pathway.

66 terstrand cross-link (ICL) repair within the Fanconi anemia DNA damage response (DDR) pathway.

67 ive in both homologous recombination and the Fanconi anemia DNA damage response pathways.

68 plicate a functional interaction between the Fanconi anemia DNA repair and FOXO3a pathways in HSC mai

69 g enzyme that promotes the activation of the Fanconi anemia DNA repair pathway and facilitates replic

70 s the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpresse

71 t data have shown that HIV-1 Vpr targets the Fanconi anemia DNA repair pathway by interacting with an

72 The Fanconi anemia DNA repair pathway consists of an anchor

73 pport the development of embryos lacking the Fanconi anemia DNA repair pathway gene Fanca.

74 eins and that the ability to dysregulate the Fanconi anemia DNA repair pathway is an essential functi

75 at the ability to dysregulate members of the Fanconi anemia DNA repair pathway is essential for HIV/S

76 The Fanconi anemia DNA repair pathway is pivotal for the eff

77 link colorectal cancer predisposition to the Fanconi anemia DNA repair pathway, supporting the connec

78 1 exonuclease complex that forms part of the Fanconi anemia DNA repair pathway.

79 and in the unfractionated BM of healthy and Fanconi anemia donors, resulting in the correction of CD

80 The 4 most frequent syndromes are Fanconi anemia, dyskeratosis congenita, Diamond Blackfan

81 olved diagnosis after medical evaluation and Fanconi anemia exclusion.

82 Fanconi Anemia (FA) and Bloom Syndrome share overlapping

83 Fanconi Anemia (FA) and Bloom's Syndrome (BS) are geneti

84 Fanconi anemia (FA) and Bloom's syndrome (BS) are rare h

85 basis of the phenotypic similarities between Fanconi Anemia (FA) and Bloom's Syndrome, identifying FA

86 FANCJ mutations are linked to Fanconi anemia (FA) and increase breast cancer risk.

87 Bloom's syndrome (BS) and Fanconi anemia (FA) are autosomal recessive disorders ch

88 The hallmarks of the rare inherited disorder Fanconi anemia (FA) are progressive bone marrow failure

89 In response to DNA cross-linking damage, the Fanconi anemia (FA) core complex activates the FA pathwa

90 FANCM is a component of the Fanconi anemia (FA) core complex and one FA patient (EUF

91 so associates with FANCM, a component of the Fanconi anemia (FA) core complex that is important for r

92 n vertebrates, FANCM-MHF associates with the Fanconi anemia (FA) core complex, promotes FANCD2 monoub

93 tute a complex involved in the activation of Fanconi anemia (FA) DNA damage response mechanism, but n

94 The Fanconi Anemia (FA) DNA repair pathway is essential for

95 Herein, we identify a member of the Fanconi anemia (FA) DNA repair pathway, FANCI, as a key

96 F1 complex is required for regulation of the Fanconi anemia (FA) DNA repair pathway, less is known ab

97 We show that central components of the Fanconi anemia (FA) DNA repair pathway, the tumor suppre

98 Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequen

99 ietic stem cell function and are part of the Fanconi anemia (FA) double-strand break DNA repair pathw

100 oteins disabled in the cancer-prone disorder Fanconi anemia (FA) ensure the maintenance of chromosoma

101 Previous Fanconi anemia (FA) gene therapy studies have failed to

102 It has recently been designated as a Fanconi anemia (FA) gene, following the discovery of two

103 c stem and progenitor cells with inactivated Fanconi anemia (FA) genes, FANCA and FANCC, are hypersen

104 Similar to mutations in Fanconi anemia (FA) genes, unc-84 mutants and human cell

105 Here, we establish that the cellular Fanconi anemia (FA) genomic stability pathway is exploit

106 Patients with Fanconi anemia (FA) have a high risk of developing acute

107 Genes mutated in patients with Fanconi anemia (FA) interact with the DNA repair genes B

108 Fanconi anemia (FA) is a cancer predisposition syndrome

109 Fanconi anemia (FA) is a cancer susceptibility syndrome

110 Fanconi anemia (FA) is a chromosome instability syndrome

111 Fanconi anemia (FA) is a genetic disease characterized b

112 Fanconi anemia (FA) is a genetic disease characterized b

113 Fanconi anemia (FA) is a genetic disease of bone marrow

114 Fanconi anemia (FA) is a genetic disorder associated wit

115 Fanconi anemia (FA) is a genetic disorder characterized

116 Fanconi anemia (FA) is a genetically heterogeneous disor

117 Fanconi anemia (FA) is a genetically heterogeneous, auto

118 Fanconi anemia (FA) is a genome instability syndrome cha

119 Fanconi anemia (FA) is a genome instability syndrome cha

120 Fanconi anemia (FA) is a genome instability syndrome tha

121 Fanconi anemia (FA) is a genomic instability disorder ch

122 Fanconi anemia (FA) is a heterogenous genetic disease wi

123 Fanconi anemia (FA) is a human recessive genetic disease

124 Fanconi anemia (FA) is a rare bone marrow failure disord

125 Fanconi anemia (FA) is a rare chromosomal-instability di

126 Fanconi anemia (FA) is a rare disease characterized by c

127 Fanconi anemia (FA) is a rare familial genome instabilit

128 Fanconi anemia (FA) is a rare genetic disease characteri

129 Fanconi anemia (FA) is a rare genetic disorder associate

130 Fanconi anemia (FA) is a rare genetic disorder caused by

131 Fanconi anemia (FA) is a rare genetic disorder character

132 Fanconi anemia (FA) is a rare genetic disorder character

133 Fanconi anemia (FA) is a rare genetic disorder character

134 Fanconi anemia (FA) is a rare human genetic disease caus

135 Fanconi anemia (FA) is a rare inherited disorder clinica

136 Fanconi Anemia (FA) is a rare recessive disease characte

137 Fanconi anemia (FA) is a recessive genetic disease chara

138 Fanconi anemia (FA) is a recessive syndrome characterize

139 Fanconi anemia (FA) is a recessive X-linked and autosoma

140 Fanconi anemia (FA) is an autosomal recessive genetic di

141 Fanconi anemia (FA) is an inherited bone marrow failure

142 Fanconi anemia (FA) is an inherited bone marrow failure

143 Fanconi anemia (FA) is an inherited bone marrow failure

144 Fanconi anemia (FA) is an inherited cancer predispositio

145 Fanconi anemia (FA) is an inherited chromosomal instabil

146 Fanconi anemia (FA) is an inherited chromosomal instabil

147 Fanconi anemia (FA) is an inherited chromosomal instabil

148 Fanconi anemia (FA) is an inherited disorder in which mu

149 Fanconi anemia (FA) is an inherited DNA repair disorder

150 Fanconi anemia (FA) is an inherited genetic disorder ass

151 Fanconi Anemia (FA) is an inherited genomic instability

152 Fanconi anemia (FA) is characterized by a progressive bo

153 Fanconi anemia (FA) is the most frequent inherited cause

154 Fanconi anemia (FA) macrophages were hypersensitive to t

155 the bone marrow failure (BMF) mechanisms in Fanconi anemia (FA) may improve current therapeutic stra

156 Similar to the reported Fanconi anemia (FA) mouse model, chromosomal instability

157 The Fanconi anemia (FA) network is important for the repair

158 Fanconi anemia (FA) nuclear core complex is a multiprote

159 ICLs can be repaired by the Fanconi anemia (FA) pathway and through FA-independent p

160 Fanconi anemia (FA) pathway genes are important tumor su

161 viously reported intrinsic activation of the Fanconi anemia (FA) pathway in a tumor-prone mouse model

162 Despite a well-defined role for the Fanconi anemia (FA) pathway in mediating DNA repair, the

163 The Fanconi anemia (FA) pathway involved in DNA crosslink re

164 The Fanconi anemia (FA) pathway is essential for the repair

165 The Fanconi anemia (FA) pathway is essential for the repair

166 along with a second report, describe how the Fanconi anemia (FA) pathway is involved in preventing ab

167 The Fanconi anemia (FA) pathway is responsible for interstra

168 Fanconi anemia (FA) pathway members, FANCD2 and FANCI, c

169 The Fanconi anemia (FA) pathway participates in interstrand

170 The Fanconi anemia (FA) pathway plays a central role in the

171 Moreover, we have identified several new Fanconi anemia (FA) pathway SNPs that are likely to modu

172 the possibility that HELQ is involved in the Fanconi anemia (FA) pathway, a dominant mechanism for in

173 Several pathways, including the Fanconi anemia (FA) pathway, can faithfully repair ICLs

174 Several proteins in the BRCA-Fanconi anemia (FA) pathway, such as FANCJ, BRCA1, and F

175 The Fanconi anemia (FA) pathway, which promotes error-free r

176 tivates Trans-Lesion Synthesis (TLS) and the Fanconi Anemia (FA) pathway.

177 Cells from Fanconi anemia (FA) patients are extremely sensitive to

178 Fanconi anemia (FA) patients exhibit bone marrow failure

179 hematopoietic cell transplantation (HCT) for Fanconi anemia (FA) patients resulted in excessive morbi

180 The Fanconi anemia (FA) protein network is necessary for rep

181 Eight of the Fanconi anemia (FA) proteins form a core complex that ac

182 The molecular pathway by which Fanconi anemia (FA) proteins function in oxidative stres

183 There is evidence that Fanconi anemia (FA) proteins play an important role in t

184 The Fanconi Anemia (FA) proteins, encoded by genes that are

185 tes faithful DNA replication consists of the Fanconi anemia (FA) proteins.

186 Fanconi anemia (FA) represents a paradigm of rare geneti

187 Fanconi anemia (FA) results from mutations in the FANC g

188 However, the involvement of Fanconi Anemia (FA) signaling, a unique genetic model sy

189 skews HSC differentiation in mouse models of Fanconi anemia (FA), a genetic disorder associated with

190 athogenesis of many human diseases including Fanconi anemia (FA), a genetic disorder associated with

191 Defective DNA repair causes Fanconi anemia (FA), a rare childhood cancer-predisposin

192 is the predominant clinical manifestation of Fanconi anemia (FA), a rare, recessively inherited disor

193 d activities of translesion synthesis (TLS), Fanconi anemia (FA), and homologous recombination repair

194 icient mice, while phenotypically resembling Fanconi anemia (FA), are also hypersensitive to replicat

195 Patients with the rare genetic disease, Fanconi anemia (FA), are highly susceptible to squamous

196 suffering from a rare human genetic disease, Fanconi anemia (FA), demonstrates the importance of FA g

197 Fanconi anemia (FA), for example, has elucidated a novel

198 he only curative treatment for patients with Fanconi anemia (FA), published series mostly refer to si

199 plex-dependent ubiquitin recognition and the Fanconi anemia (FA)-BRCA ICL repair network.

200 The Fanconi anemia (FA)-BRCA pathway is critical for the rep

201 ell proliferation, whereas the expression of Fanconi anemia (FA)-complex genes was correlated with el

202 line mutations in RAD51C are known to cause Fanconi anemia (FA)-like disorder and breast and ovarian

203 Current methods for detecting mutations in Fanconi anemia (FA)-suspected patients are inefficient a

204 other cancers, and biallelic mutations cause Fanconi anemia (FA).

205 ypersensitivity is a characteristic trait of Fanconi anemia (FA).

206 ess required to suppress diseases, including Fanconi anemia (FA).

207 ations in these genes clinically manifest as Fanconi anemia (FA).

208 ective in the cancer predisposition syndrome Fanconi anemia (FA).

209 an cure bone marrow failure in patients with Fanconi anemia (FA).

210 ociated with the genome instability syndrome Fanconi anemia (FA).

211 e and hyperpigmentation, now better known as Fanconi anemia (FA).

212 mutated in breast and pancreatic cancers and Fanconi anemia (FA).

213 rin (alphaIISp), in cells from patients with Fanconi anemia (FA).

214 se is defective in the human genetic illness Fanconi anemia (FA).

215 t present with bone marrow failure including Fanconi anemia (FA).

216 cers as well as bone marrow failure disorder Fanconi anemia (FA).

217 of unrelated bone marrow transplantation in Fanconi anemia (FA).

218 marrow failure syndromes: (1) defects in the Fanconi anemia (FA)/BRCA DNA repair pathway, (2) defects

219 Surprisingly, depleting BRCA1 or FANCD2 (Fanconi anemia [FA] proteins) or BRG1, a mSWI/SNF subuni

220 enamed here as FANCP) cause a new subtype of Fanconi anemia, Fanconi anemia-P.

221 tein levels of the DNA repair protein BRIP1 [Fanconi anemia gene J (FANC J)] are upregulated after IR

222 deleterious c.2715 + 1G > A mutation in the Fanconi anemia gene, FANCD2, was over two times more com

223 Mutations in thirteen distinct Fanconi anemia genes have been shown to interfere with t

224 describe a previously unappreciated role of Fanconi anemia group A protein (Fanca) during the endomi

225 Of the fifteen FA proteins, Fanconi anemia group C (FANCC) is one of eight FA core c

226 The Fanconi anemia group J (FANCJ) helicase partners with th

227 t other DNA helicases [Bloom syndrome (BLM), Fanconi anemia group J (FANCJ), RECQ1, RecQ, UvrD, or Dn

228 3 ubiquitin-protein ligase RNF168-deficient, Fanconi anemia group J protein (FACJ, BRIP1)-deficient,

229 ion of aldehydes as endogenous genotoxins in Fanconi anemia has provided new insight into disease cau

230 Since patients with Fanconi anemia have a high risk to develop HNSCC, we inv

231 marrow failure and cancer susceptibility of Fanconi anemia have been unclear.

232 Fanconi anemia hematopoietic stem cells display poor sel

233 Central to this pathway is the Fanconi anemia I-Fanconi anemia D2 (FANCI-FANCD2) (ID) c

234 ceptibility gene, BRCA2, are associated with Fanconi anemia, implying that some persons who inherit 2

235 Examining the cancer predisposition syndrome Fanconi anemia in depth revealed that mutant FANCA prote

236 y inactivation underlies CIN in HNSCC of non-Fanconi anemia individuals.

237 Fanconi anemia is a cancer predisposition syndrome cause

238 Fanconi anemia is a genetic disease resulting in bone ma

239 Fanconi anemia is a genetic disorder resulting from bial

240 Fanconi anemia is a human cancer predisposition syndrome

241 Fanconi anemia is a rare genetic disorder that can lead

242 Fanconi anemia is a rare recessive disorder characterize

243 The genomic instability syndrome Fanconi anemia is caused by mutations in any of at least

244 The human hereditary disease Fanconi anemia leads to severe symptoms, including devel

245 homologous recombination, in a patient with Fanconi anemia-like phenotype.

246 In an effort to develop a Fanconi Anemia murine model to study bone marrow failure

247 We excluded Fanconi anemia, mutations of telomere maintenance, and a

248 ni anemia, we propose collaborations between Fanconi anemia, NER, and MMR are necessary to initiate c

249 FANCD2 and FANCI function together in the Fanconi anemia network of deoxyribonucleic acid (DNA) cr

250 disabling the mismatch, nucleotide excision, Fanconi anemia, nonhomologous end joining, or translesio

251 FANCM is a Fanconi anemia nuclear core complex protein required for

252 ndently of the previously identified anti-CO Fanconi anemia of complementation group M (FANCM) helica

253 me; cancer risks appear lower in DBA than in Fanconi anemia or dyskeratosis congenita.

254 demonstrated that chronic GVHD (P = .02) and Fanconi anemia (P = .03) negatively impacted survival.

255 ANCP) cause a new subtype of Fanconi anemia, Fanconi anemia-P.

256 owever, were incomplete or low magnitude for Fanconi anemia pathway (FANC) gene mutations relevant to

257 Rodriguez and D'Andrea introduce the Fanconi anemia pathway and its role in DNA repair and ot

258 ts elucidate the functional link between the Fanconi anemia pathway and the recombination machinery d

259 To this end, the Fanconi Anemia pathway employs a unique nuclear protein

260 y in cells lacking FANCD2, a mediator of the Fanconi anemia pathway for ICL repair.

261 we investigated whether and to which extent Fanconi anemia pathway inactivation underlies CIN in HNS

262 Thus, when the Fanconi anemia pathway is defective, WRN helicase inhibi

263 The Fanconi Anemia pathway is thought to coordinate a comple

264 CD2 and provide a novel mechanism of how the Fanconi anemia pathway modulates DNA damage response and

265 a function of IPO4 and nuclear import in the Fanconi anemia pathway of DNA repair.

266 dy, a role that we show is not shared by the Fanconi anemia pathway or the Slx4-Slx1 nuclease also in

267 define the molecular mechanism by which the Fanconi anemia pathway promotes a key event in replicati

268 The Fanconi anemia pathway, associated with replication stre

269 ced downregulation of a key component of the Fanconi anemia pathway, FANCD2 through mTOR regulation o

270 of the defects seen in cells impaired in the Fanconi anemia pathway, including a pronounced G2-M cell

271 e that FANCL, the E3 ubiquitin ligase of the Fanconi anemia pathway, is constitutively targeted for d

272 s recombination, postreplication repair, the Fanconi anemia pathway, polymerase beta, and FEN1 are cr

273 Incisions depend critically on the Fanconi anemia pathway, whose activation involves ubiqui

274 mic damage during replication, especially in Fanconi anemia pathway-deficient cells.

275 this function independently of the classical Fanconi anemia pathway.

276 f ICLs is required for the activation of the Fanconi anemia pathway.

277 FANCD2 monoubiquitination, a key step of the Fanconi anemia pathway.

278 Here, we characterized two Fanconi anemia patient mutations, R251C and Q255H, that

279 the acquired AA patients is 82%, and for the Fanconi anemia patients it is 58% (P = .01).

280 Thus, cells from Fanconi anemia patients, which lack this critical pathwa

281 found to be mutated in approximately 60% of Fanconi anemia patients.

282 or cause of morbidity and mortality in human Fanconi Anemia patients.

283 separately and with loss of staining for the Fanconi anemia protein FANCD2 (corrected Fisher's exact

284 show that the monoubiquitinated form of the Fanconi Anemia protein FANCD2 acts in opposition to the

285 Here we show that the Fanconi anemia protein Fancd2 and stress transcriptional

286 ence, Knipscheer et al. demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of

287 The USP1/UAF1 complex deubiquitinates the Fanconi anemia protein FANCD2, thereby promoting homolog

288 The SLX4 Fanconi anemia protein is a tumor suppressor that may ac

289 The Fanconi anemia protein PALB2, also known as FANCN, prote

290 The Fanconi anemia protein SLX4 assembles a genome and telom

291 SLX4, the newly identified Fanconi anemia protein, FANCP, is implicated in repairin

292 epair activities that are independent of the Fanconi anemia proteins and that this activity is redund

293 phenotype raises the question of whether the Fanconi anemia proteins are stabilized or recruited as p

294 acentric chromosomes, papillar cells require Fanconi anemia proteins FANCD2 and FANCI, as well as Blm

295 rons, from 27 samples from the International Fanconi Anemia Registry at The Rockefeller University.

296 FAN1 is a major component of the Fanconi anemia-related pathway of DNA damage response (D

297 ) have been identified in patients, with the Fanconi anemia subtype J (FA-J) resulting from homozygou

298 sition to breast and pancreatic cancer or to Fanconi Anemia subtype N.

299 promising initial hit compound targeting the Fanconi anemia ubiquitin-conjugating enzyme Ube2T and de

300 iven that, mutations in XPF can also lead to Fanconi anemia, we propose collaborations between Fancon