ライフサイエンスコーパス: Fc gamma RIIA

1 as an adapter to recruit PI 3-K to activated Fc gamma RIIA.

2 t antibodies, which activate platelets in an Fc gamma RIIA-dependent manner, can lead to thrombosis,

3 , antibodies to the heparin-PF4 complex, and Fc gamma RIIA are necessary and sufficient to recapitula

4 activation of platelets with anti-Fc gamma RIIA antibodies resulted in the noncovalent ass

5 rther analysis of the platelet activation by Fc gamma RIIA demonstrated that Fc gamma RIIA is also in

6 Cocrosslinking Fc gamma RIIA with CD59 or CD48, two other GPI-linked pr

7 +]i, tyrosine phosphorylation of crosslinked Fc gamma RIIA was diminished when cocrosslinked with Fc

8 levels not reached by stimulation of either Fc gamma RIIA or Fc gamma RIIIB alone.

9 s were stably transfected with cDNA encoding Fc gamma RIIA and/or Fc gamma RIIIB.

10 sgenic mouse lines were created that express Fc gamma RIIA on platelets and macrophages at human phys

11 ions about the perimeter of cells expressing Fc gamma RIIA.

12 kD bind to the SH2 domain of Grb2 following Fc gamma RIIA stimulation of platelets.

13 This individual's homozygosity for Fc gamma RIIA-R/R131 leads to the prediction that the re

14 otype in a healthy individual homozygous for Fc gamma RIIA R/R131 in whom a C to A substitution at co

15 lts indicate that Syk kinase is required for Fc gamma RIIA-mediated phagocytic signaling and that Fc

16 coupled to the platelet Fc receptor for IgG (Fc gamma RIIA).

17 tion showed a highly significant decrease in Fc gamma RIIA-H131 as the likelihood for lupus nephritis

18 with Fc gamma RIIA as well as an increase in Fc gamma RIIA-associated PI 3-K activity.

19 D, which undergo tyrosine phosphorylation in Fc gamma RIIA stimulated cells.

20 Thrombosis and shock in Fc gamma RIIA tg mice in the context of the FcR gamma-ch

21 also facilitated anti-CD9-mediated shock in Fc gamma RIIA tg mice.

22 N at a concentration of 0.2 microM inhibited Fc gamma RIIA-mediated phagocytosis by 90% and completel

23 Anti-CD9 injected into Fc gamma RIIA tg crossed with FcR gamma-chain knockout (

24 We identified a novel Fc gamma RIIA genotype in a healthy individual homozygou

25 The skewing in the distribution of Fc gamma RIIA alleles identifies this gene as a risk fac

26 ional study, we compared the distribution of Fc gamma RIIA alleles in African Americans with SLE to t

27 The altered distribution of Fc gamma RIIA alleles was most striking in lupus nephrit

28 ntrols demonstrated a skewed distribution of Fc gamma RIIA alleles, with only 9% of SLE patients homo

29 ITAM), as found in the cytoplasmic domain of Fc gamma RIIA and in the gamma chain associated with Fc

30 on motif (ITAM) in the cytoplasmic domain of Fc gamma RIIA.

31 eparin/ PF4 antibodies and the expression of Fc gamma RIIA-H131 in patients with HITT compared with p

32 However, in a genetically engineered form of Fc gamma RIIA containing a mutation in the cytoplasmic L

33 No difference in the allele frequency of Fc gamma RIIA-H131 or R131 was identified among 13 patie

34 While the ITAM of Fc gamma RIIA was required for the increase in [Ca2+]i,

35 telet activation induced by cross-linking of Fc gamma RIIA by anti-heparin/platelet factor 4 (PF4) an

36 that factors in addition to cross-linking of Fc gamma RIIA receptors contribute to the pathogenesis o

37 Anti-CD9 antibody activated platelets of Fc gamma RIIA transgenic (tg) mice and, following inject

38 ion that a common functional polymorphism of Fc gamma RIIA, involving either an arginine (R) or histi

39 ooperates with the transmembrane Fc gamma R (Fc gamma RIIA) to mediate many of the functional effects

40 of the gene for the immune complex receptor Fc gamma RIIA exhibited markedly reduced binding of BOB9

41 plasmic domain of the leukocyte IgG receptor Fc gamma RIIA that affects the amplitude of calcium spik

42 n by the platelet low-affinity IgG receptor, Fc gamma RIIA.

43 ng site on human IgG1 for human Fc gamma RI, Fc gamma RIIA, Fc gamma RIIB, Fc gamma RIIIA, and FcRn r

44 These data demonstrate that Fc gamma RIIA association with GPI-linked proteins facil

45 ctivation by Fc gamma RIIA demonstrated that Fc gamma RIIA is also inducibly coupled to the serine/th

46 ce is essential in SLE, we hypothesized that Fc gamma RIIA genes are important disease susceptibility

47 yrosine-based activation motif (ITAM) of the Fc gamma RIIA cytoplasmic tail abolished synergy.

48 ) consistent with a protective effect of the Fc gamma RIIA-H131 gene.

49 These results make it unlikely that the Fc gamma RIIA-H131 isoform or IgG2 anti-heparin/PF4 anti

50 3-K activities to Fc gamma RIIA is regulated by tyrosine phosphorylation o

51 Binding of both p72syk and PI 3-K to Fc gamma RIIA was reconstituted with synthetic phosphope

52 on, the lung vasculature of anti-CD9-treated Fc gamma RIIA tg x gamma-KO mice contained extensive pla

53 lutamine (Q) to lysine (K) in one of the two Fc gamma RIIA genes.

54 [Ca2+]i rise, as did crosslinking CD59 with Fc gamma RIIA on PMN, suggesting that interactions betwe

55 n the noncovalent association of PI 3-K with Fc gamma RIIA as well as an increase in Fc gamma RIIA-as