ライフサイエンスコーパス: Fcgamma receptor

1 gion that lacks the ability to interact with Fcgamma receptors.

2 fector function or elimination of binding to Fcgamma receptors.

3 This indicated involvement of the Fcgamma receptors.

4 dified constant region that does not bind to Fcgamma receptors.

5 no major impact on binding to the classical Fcgamma receptors.

6 amma-chain, the common subunit of activating Fcgamma receptors.

7 ller than those observed in the low affinity Fcgamma receptors.

8 known to modulate the effector functions of Fcgamma receptors.

9 ver the antigenic cassette to the activating Fcgamma receptors.

10 ocytes and by PBMC in a reaction mediated by Fcgamma receptors.

11 ls function normally following engagement of Fcgamma receptors.

12 the PA by interaction of MAb with macrophage Fcgamma receptors.

13 have significantly lower binding affinity to Fcgamma receptors.

14 iated through immunoglobulin G engagement of Fcgamma receptors.

15 f CD45 increased markedly upon engagement of Fcgamma receptors.

16 sting that this phenomenon is not limited to Fcgamma receptors.

17 the affinity of the antibody for activating Fcgamma receptors.

18 med at eliciting NAbs that activate specific Fcgamma receptors.

19 derstanding the interaction between IgG4 and Fcgamma receptors.

20 o-acid substitutions that promote binding to Fcgamma receptors.

21 rent affinities between antibodies and their Fcgamma receptors.

22 ry (CHO) cells transfected with a human IgG (Fcgamma) receptor.

23 gered the internalisation and degradation of Fcgamma-receptors.

24 red blood cell (PKLR) gene as well as of the Fcgamma receptor 2A and Fcgamma receptor 2C (FCGR2A, FCG

25 ne as well as of the Fcgamma receptor 2A and Fcgamma receptor 2C (FCGR2A, FCGR2C) and Fcgamma recepto

26 and Fcgamma receptor 2C (FCGR2A, FCGR2C) and Fcgamma receptor 3 (FCGR3) genes using real-time quantit

27 peptide-related sequence A, an allele of the Fcgamma receptor, a polymorphism marker in the beta2-adr

28 Among Fcgamma receptors, a protein kinase C (PKC) phosphorylat

29 Second messengers generated by Fcgamma receptors activated integrins, which formed an a

30 Importantly, we show that Fcgamma receptor activation causes nuclear translocation

31 We report that Fcgamma receptor activation in macrophages enhances lyso

32 une responses and suggest that modulation of Fcgamma receptor activation or expression may be a usefu

33 in required for degradation of MAST205 after Fcgamma receptor activation resides within the N-termina

34 ctivated eosinophils depends on adhesion and Fcgamma receptor activation, requires elevated ROS produ

35 eered a series of Fc variants with optimized Fcgamma receptor affinity and specificity.

36 In summary, preventing the activation of Fcgamma receptors alleviates renal hypertrophy, inflamma

37 It has been shown previously that the Fcgamma receptors also do not contribute to such CRP-med

38 )/Rac2(-/-) mice to produce a new picture of Fcgamma receptor and complement receptor 3 intracellular

39 iple logistic regressions revealed that both Fcgamma receptor and IL-6 -174 polymorphisms were associ

40 evelopment, inhibition of thrombopoiesis and Fcgamma receptor and other polymorphisms will assume inc

41 ng of how an IgG antibody generally docks on Fcgamma receptor and the requirement of immune complex f

42 correlation between b12 variant affinity for Fcgamma receptor and variant function in antibody-depend

43 ytotoxicity function, and binding ability to Fcgamma receptors and C1q of the test oligospecific anti

44 IgG isotypes can differentially bind to Fcgamma receptors and complement, making the selection o

45 g antibodies can enable viral uptake through Fcgamma receptors and down-regulate signaling cascades i

46 , a member of the pentraxin family, binds to Fcgamma receptors and modifies the pathophysiological fu

47 and structurally distinct from the classical Fcgamma receptors and transports immunoglobulin G (IgG)

48 involving candidate genes (GM, KM, HLA, and Fcgamma receptors) and cellular and humoral immune respo

49 gulated kinase phosphorylation downstream of Fcgamma receptor, and no increased NK-cell apoptosis.

50 the IgG1 subclass, including complexes with Fcgamma receptors, and structures for intact antibodies,

51 Because Fcgamma receptors are implicated in disease susceptibili

52 Upon sialylation, the affinities for Fcgamma receptors are reduced, whereas those for alterna

53 anti-inflammatory effects through activating Fcgamma receptors bearing an immunoreceptor tyrosine-bas

54 ll function and may be broadly applicable to Fcgamma-receptor-bearing cells.

55 ly reduced by blocking any of the following: Fcgamma receptor binding (P = 0.048), eosinophil adhesio

56 body with an engineered Fc region to enhance Fcgamma receptor binding affinity.

57 Fc tail, rendering the antibody incapable of Fcgamma receptor binding and antibody-dependent cellular

58 t in this paper chemoenzymatic synthesis and Fcgamma receptor binding of an array of homogeneous IgG-

59 inguishable from those of palivizumab, their Fcgamma receptor binding profiles were very different, w

60 Comparisons with a variant incapable of Fcgamma receptor binding showed that engagement of these

61 Enhanced Fcgamma receptor binding was associated with reduced vir

62 sistant antisera was dependent on activating Fcgamma receptors but not complement.

63 d independently of complement receptor 2 and Fcgamma receptors, but was dependent upon B-cell recepto

64 These results provide a mechanism by which Fcgamma receptors can elevate circulating BLyS levels an

65 Aggregated IgG, the known ligand for Fcgamma receptors, causes parallel okadaic acid-sensitiv

66 us-responsive gammadelta T cells express the Fcgamma-receptor CD16, suggesting that gammadelta T cell

67 ow that murine pDC, as well as myDC, express Fcgamma receptors (CD16/CD32) and can use these receptor

68 oated with IgG bound by its Fc domain to the Fcgamma receptor CD16a.

69 d 3-locus haplotype analysis of the extended Fcgamma receptor cluster did not reveal any significant

70 d mice expressed strikingly higher levels of Fcgamma receptors compared with DCs from adults and were

71 oligomerization with protein G or binding to Fcgamma receptors converted both anti-Fn14 antibodies in

72 cumulation rather than altered expression of Fcgamma receptors, could be mimicked by co-culture of WT

73 We provide evidence that Fcgamma receptor cross-linking triggers a rapid release

74 d a lower degree of actin rearrangement upon Fcgamma receptor crosslinkage.

75 iated cell cytotoxicity reporter assays, and Fcgamma receptor-deficient (Fcer1g(-/-)) mice, we show t

76 Moreover, diabetic Fcgamma receptor-deficient mice had less mesangial matri

77 kidneys and in mesangial cells cultured from Fcgamma receptor-deficient mice.

78 immune complexes in premalignant tissue and Fcgamma receptor-dependent activation of myeloid cells.

79 e large immune complexes was associated with Fcgamma receptor-dependent binding to Kupffer cells in t

80 ficacy of CR9114 against AA60 is mediated by Fcgamma receptor-dependent mechanisms.

81 uently caused by allo- or autoantibodies via Fcgamma receptor-dependent phagocytosis.

82 an IgG1 constant region modified to minimize Fcgamma receptor-dependent platelet destruction (G1Delta

83 as the most abundantly distributed class II Fcgamma receptors, differentially influence Ab-mediated

84 tion of actin cytoskeleton remodeling during Fcgamma receptor-driven phagocytosis.

85 n cytoskeleton remodeling is fundamental for Fcgamma receptor-driven phagocytosis.

86 duced by the activation of the Vav-dependent Fcgamma receptor-elicited NADPH oxidase activity.

87 le activating classic complement pathway and Fcgamma receptor endocytosis.

88 of Rac recruited to the phagosomes formed by Fcgamma receptor engagement and thus is able to regulate

89 vivo half-lives by a mechanism that requires Fcgamma receptor engagement in a humanized mouse model.

90 recruited to the early phagosomes formed via Fcgamma receptor engagement.

91 and tested the consequences of multi-valent Fcgamma-receptor engagement in in vitro and in vivo syst

92 ion also decreased expression of stimulatory Fcgamma receptors, especially FcgammaRIII, and strongly

93 vaccinal effect is mediated by engagement of Fcgamma receptors expressed on antigen-presenting cells.

94 The low-affinity Fcgamma receptors, expressed on immune cells, are import

95 ll depletion is dependent on the presence of Fcgamma receptor-expressing macrophages within the tumor

96 We found that Fcgamma receptor expression on microglia was increased a

97 erentiation, as reflected by upregulation of Fcgamma receptor expression, and substantially inhibited

98 ibution of effector functions mediated by Fc-Fcgamma receptor (Fc-FcgammaR) interactions for optimal

99 -delta in inflammatory responses elicited by Fcgamma receptor (FcgammaR) activation.

100 d anti-CD19 antibody, XmAb5574, has enhanced Fcgamma receptor (FcgammaR) binding affinity, leading to

101 a region overlapping with complement C1q and Fcgamma receptor (FcgammaR) binding sites.

102 Fcgamma receptor (FcgammaR) clustering on monocytes/macr

103 ow that selective blockade of the inhibitory Fcgamma receptor (FcgammaR) FcgammaRIIb with recently de

104 D32a) and inhibitory (CD32b) isoforms of IgG Fcgamma receptor (FcgammaR) II (CD32).

105 We sought to determine the role of Fcgamma receptor (FcgammaR) IIa in IVIg-induced anaphyla

106 We determined whether polymorphisms in Fcgamma receptor (FcgammaR) IIa or FcgammaRIIIa genes we

107 ) binding to neonatal Fc receptor (FcRn) and Fcgamma receptor (FcgammaR) is important for evaluating

108 ferentiation protein (MyD88) pathway and the Fcgamma receptor (FcgammaR) pathway in the induction of

109 and function of SHIP-2 in human myeloid cell Fcgamma receptor (FcgammaR) signaling.

110 CR3, the scavenger receptor A (SRA), and the Fcgamma receptor (FcgammaR), respectively.

111 , leads to the upregulation of an inhibitory Fcgamma receptor (FcgammaR), thereby protecting against

112 paper, we reveal a novel function of Gab2 in Fcgamma receptor (FcgammaR)-initiated phagocytosis in ma

113 We show that Fcgamma receptor (FcgammaR)-mediated activation of human

114 Consequently, in the absence of FcRn, Fcgamma receptor (FcgammaR)-mediated antigen uptake fail

115 Fcgamma receptor (FcgammaR)-mediated entry of infectious

116 cytoskeleton is dynamically remodeled during Fcgamma receptor (FcgammaR)-mediated phagocytosis in a p

117 ay without any concomitant engagement of the Fcgamma receptor (FcgammaR).

118 d neutralization activity required competent Fcgamma receptor (FcgammaR).

119 uires AQP4-bound IgG to engage an astrocytic Fcgamma receptor (FcgammaR).

120 body and its interaction with the inhibitory Fcgamma receptor (FcgammaR)IIB.

121 ily were found to interact with cell-surface Fcgamma receptors (FcgammaR) and activate leukocyte-medi

122 ported by innate immune molecules, including Fcgamma receptors (FcgammaR) and complement.

123 they fail to protect mice lacking activating Fcgamma receptors (FcgammaR) and the complement opsonin

124 ultiplex assay to model the cross-linking of Fcgamma receptors (FcgammaR) by Abs, which is required t

125 ed by TA-targeted mAb, only polymorphisms of Fcgamma receptors (FcgammaR) expressed by patients' lymp

126 nding of the Fcgamma regions to low-affinity Fcgamma receptors (FcgammaR) expressed on effector cells

127 Targeting antigens (Ag) to Fcgamma receptors (FcgammaR) intranasally (i.n.) enhance

128 b Fc region to effectively engage activating Fcgamma receptors (FCgammaR) is essential for antibody e

129 ith C5a failed to modulate the expression of Fcgamma receptors (FcgammaR) or to otherwise alter the a

130 Fcgamma receptors (FcgammaR) provide important immunoreg

131 pecifically neutralizes alpha5 and binds the Fcgamma receptors (FcgammaR) with enhanced affinity.

132 However, SAP and CRP bind the same Fcgamma receptors (FcgammaR) with similar affinities, an

133 phils express both activating and inhibitory Fcgamma receptors (FcgammaR), and their relative express

134 teraction between the anti-TNF Fc-region and Fcgamma receptors (FcgammaR), and whether the absence of

135 ut also accessory cells that bear activating Fcgamma receptors (FcgammaR), providing additional T-cel

136 ression of inhibitory rather than activating Fcgamma receptors (FcgammaR), thereby limiting the effic

137 events phagocytosis mediated by integrin and Fcgamma receptors (FcgammaR), whereas the genetic deleti

138 Fcgamma receptors (FcgammaR)-mediated crosslinking incre

139 ol the mobility and clustering of phagocytic Fcgamma receptors (FcgammaR).

140 therapy, where they engage target cells via Fcgamma receptors (FcgammaR).

141 tic cells and nucleoprotein autoantigens and Fcgamma receptors (FcgammaR).

142 ated by phagocytosis and by cross-linking of Fcgamma receptors (FcgammaR).

143 bility to activate complement and to bind to Fcgamma receptors (FcgammaR).

144 after binding their antigens and co-engaging Fcgamma receptors (FcgammaR).

145 We show that Fcgamma-receptor (FcgammaR) antigen targeting facilitate

146 omeningitis virus (LCMV) suppressed multiple Fcgamma-receptor (FcgammaR) functions.

147 While engagement of the inhibitory Fcgamma-receptor (FcgammaR) IIB is an absolute requireme

148 itis virus (LCMV) exhibit a severe defect in Fcgamma-receptor (FcgammaR)-mediated antibody effector f

149 ne complexes, cDNAs for the four major human Fcgamma receptors (FcgammaRI, FcgammaRIIa, FcgammaRIIb,

150 An unexpected requirement for inhibitory Fcgamma receptor FcgammaRIIB coengagement has recently b

151 clonal antibodies (mAbs) with the inhibitory Fcgamma receptor FcgammaRIIB is required for immune acti

152 TP) involves up-regulation of the inhibitory Fcgamma receptor (FcgammaRIIB) in splenic macrophages.

153 aneously engage both CD20 and the inhibitory Fcgamma receptor, FcgammaRIIb, in a bipolar configuratio

154 rement for the coengagement of an inhibitory Fcgamma receptor, FcgammaRIIB.

155 fect on the affinity of Fc to the inhibitory Fcgamma receptor, FcgammaRIIb.

156 nd phagocytosis by the gamma chain-dependent Fcgamma receptors FcgammaRIIIA and FcgammaRI.

157 We revealed that distinct Fcgamma receptor (FcgammaRs) dependency and mechanisms a

158 f antibodies is dependent on engagement with Fcgamma receptors (FcgammaRs) and activation of the asso

159 ment activation and binding to all classical Fcgamma receptors (FcgammaRs) and to C1q while binding t

160 Fcgamma receptors (FcgammaRs) are key immune receptors r

161 ivation fragment, the anaphylatoxin C5a, and Fcgamma receptors (FcgammaRs) been defined.

162 Fcgamma receptors (FcgammaRs) bind IgG-opsonized particl

163 Fcgamma receptors (FcgammaRs) classically modulate intra

164 In contrast, deficiency of Fcgamma receptors (FcgammaRs) did not affect the product

165 he Fc domain interacts with diverse types of Fcgamma receptors (FcgammaRs) expressed on the surface o

166 city, whereas the constant Fc domain engages Fcgamma receptors (FcgammaRs) expressed on the surface o

167 Fcgamma receptors (FcgammaRs) for IgG couple innate and

168 Four murine Fcgamma receptors (FcgammaRs) have been identified at pr

169 e of immune complexes (ICs) via low-affinity Fcgamma receptors (FcgammaRs) on dendritic cells (DCs) i

170 agement of the Fc segment of antibodies with Fcgamma receptors (FcgammaRs) on immune cells upon bindi

171 n positions Fcs to activate pro-inflammatory Fcgamma receptors (FcgammaRs) on immune cells.

172 heir targets may vary, their engagement with Fcgamma receptors (FcgammaRs) on numerous immune effecto

173 of the individual activating and inhibitory Fcgamma receptors (FcgammaRs) on splenic DC subsets in v

174 Fcgamma receptors (FcgammaRs) play critical roles in hum

175 neutralizing antibody IgG1 b12 and cellular Fcgamma receptors (FcgammaRs) plays an important role in

176 main of an antibody for increased binding to Fcgamma receptors (FcgammaRs) significantly enhanced Fc-

177 Low affinity-activating Fcgamma receptors (FcgammaRs) that bind immune complexes

178 s translated into cellular responses through Fcgamma receptors (FcgammaRs), a structurally and functi

179 immunoprophylaxis treatment in mice lacking Fcgamma receptors (FcgammaRs), complement (C3), both, or

180 ent adhesion and emigration are dependent on Fcgamma receptors (FcgammaRs), particularly FcgammaRIII,

181 specific interactions with distinct types of Fcgamma receptors (FcgammaRs), the Fc domain of immunogl

182 ctor functions of antibodies are mediated by Fcgamma receptors (FcgammaRs), which are found on most i

183 l antibody (mAb) binding to the cell-surface Fcgamma receptors (FcgammaRs), which mediate cytotoxic a

184 ic IgG, we investigated the evolution of the Fcgamma receptors (FcgammaRs)-activating capabilities of

185 gh interaction with activating or inhibitory Fcgamma receptors (FcgammaRs).

186 generation of C5a, and direct engagement of Fcgamma receptors (FcgammaRs).

187 eins are phagocytosed by macrophages through Fcgamma receptors (FcgammaRs).

188 release less IL-1beta after stimulation via Fcgamma receptors (FcgammaRs).

189 mation by activating complement and engaging Fcgamma receptors (FcgammaRs).

190 tibodies that cause thrombocytopenia through Fcgamma receptors (FcgammaRs).

191 ng bacterial clearance through inhibition of Fcgamma receptor (FcgR)-mediated phagocytosis.

192 the membrane of infected cells and bind the Fcgamma receptor (FcR) of the effector cell population.

193 During Fcgamma receptor (FcR)-mediated phagocytosis by macropha

194 Fcgamma Receptor (FcR)-mediated phagocytosis by macropha

195 We also found that the expression of Fcgamma receptors (FcRgamma) on polymorphonuclear leukoc

196 the bidirectional transcytosis of IgG by the Fcgamma receptor FcRn.

197 , and characterized for binding to antigens, Fcgamma receptors, FcRn, and C1q.

198 After 15 weeks, the mice lacking Fcgamma receptors had significantly less albuminuria and

199 nes encoding receptors for immunoglobulin G (Fcgamma receptors) have been genetically and functionall

200 erosclerosis via ligation of proinflammatory Fcgamma receptors; however, IgM is unable to ligate Fcga

201 increased neutrophil phagocytic ability and Fcgamma receptor I (CD64) expression.

202 Fcgamma receptor I (FcgammaRI or CD64) is the sole human

203 We determined the role of Fcgamma receptor I (FcgammaRI) and the basis for couplin

204 al reconstruction microscopy, we report that Fcgamma receptor I (FcgammaRI), FcgammaRII, and SIRPalph

205 arker CD68, macrophage scavenger receptor A, Fcgamma receptors I (CD64) and II (CD32); and also immun

206 plasmacytoid dendritic cell (DC) activation, Fcgamma receptor II (FcgammaRII), endocytosis, or nuclea

207 To test this hypothesis, we expressed the Fcgamma receptor IIA (FcgammaR) in A549 lung epithelial

208 e demonstrated a central role for the immune Fcgamma receptor IIa (FcgammaRIIa) in mediating platelet

209 Platelet activation via Fcgamma receptor IIA (FcgammaRIIA) is a critical event i

210 tor (TNF), mannose-binding lectin (MBL), and Fcgamma receptor IIa (FCGR2A) as well as clinical factor

211 The CD32a immunoglobulin G (IgG) receptor (Fcgamma receptor IIa) is a potential therapeutic target

212 immunoglobulin G and were attenuated by the Fcgamma receptor IIa-blocking antibody IV.3, suggesting

213 -anti-PGN immune complexes signaling through Fcgamma receptor IIa.

214 B cells expressing the intermediate affinity Fcgamma receptor IIB (CD32B), or coincubation with CD32B

215 Mice lacking the inhibitory Fcgamma receptor IIB (FcgammaRIIB) are protected from CR

216 mice globally deficient in the CRP receptor Fcgamma receptor IIB (FcgammaRIIB) were protected from t

217 rough processes mediated by the IgG receptor Fcgamma receptor IIB (FcgammaRIIB), its immunoreceptor t

218 The low-affinity receptor Fcgamma receptor IIb (FcgammaRIIb), with an immunorecept

219 ackground or on a C57BL/6 background lacking Fcgamma receptor IIb (FcgammaRIIb).

220 imulating the upregulation of the inhibitory Fcgamma receptor IIB (FcgammaRIIB).

221 In contrast, only 1E2 protected Fcgamma receptor IIB knockout (FcgammaRIIB KO) mice and

222 9, and CD71 and the underexpression of CD22, Fcgamma receptor IIb, CD79b, and immunoglobulin D that a

223 sentation, and of the immune complex binding Fcgamma receptor III (CD16).

224 Isoforms of the Fcgamma receptor III (FcgammaRIII or CD16) are cell surf

225 is was characterized by decreased neutrophil Fcgamma receptor III (FcgammaRIII) expression that was o

226 sue of Blood, Yu et al describe a novel anti-Fcgamma receptor III (FcgammaRIII)-albumin fusion protei

227 Fcgamma receptor III (FcgammaRIII; CD16) is a receptor e

228 t, certain acute inflammatory mediators (C5, Fcgamma receptor III, mast cells, and histamine) and ada

229 ctivated NK cells to kill SCCVII cells in an Fcgamma receptor III-dependent manner.

230 rther augmented by concomitant activation of Fcgamma receptor IIIa or NK group 2 member D.

231 showed significantly enhanced binding to the Fcgamma receptor IIIa, irrespective of whether plant or

232 the fragment crystallizable [Fc] domain and Fcgamma receptor IIIalpha, respectively) are required fo

233 Deletion of Fcgamma receptor IIIB, associated with systemic lupus er

234 8I) purified from HEK293T cells bound to all Fcgamma receptors in a manner similar to that of clinica

235 as revealed a critical yet variable role for Fcgamma receptors in their efficacy.

236 ole for both complement receptor 3 (CR3) and Fcgamma receptors in uptake was supported by studies usi

237 inding of Fc to FcgammaRIIIa, the activating Fcgamma receptor, independent of Fc core-fucosylation.

238 ngly, immunocytokine antigen specificity and Fcgamma receptor interactions did not seem necessary for

239 mutant Abs have normal thermal stability and Fcgamma receptor interactions.

240 that YopO specifically blocks Rac-dependent Fcgamma receptor internalization pathway but not complem

241 Consistent with Fcgamma receptor involvement, antibody in nonimmune huma

242 mouse models, the identification of another Fcgamma receptor is particularly noteworthy.

243 ted bone marrow-derived dendritic cells from Fcgamma receptor knockout mice inhibited AHR, suggesting

244 n response to stimulation with CX3CL1 or via Fcgamma receptor ligation were severely reduced in Hck(-

245 , suggesting IVIg's action was not caused by Fcgamma receptor-mediated events.

246 tions that can restore either complement- or Fcgamma receptor-mediated functions on a protease-resist

247 subclass was selected to reduce the risk of Fcgamma receptor-mediated overactivation of microglia.

248 ve immunization approaches carry the risk of Fcgamma receptor-mediated overactivation of microglial c

249 ration, T cell and neutrophil migration, and Fcgamma receptor-mediated oxidative burst in macrophages

250 T in a macrophage cell line inhibits the IgG Fcgamma receptor-mediated phagocytic ability of THP1 cel

251 ngements of actin and membrane necessary for Fcgamma receptor-mediated phagocytosis by macrophages.

252 cs, a method was developed for synchronizing Fcgamma receptor-mediated phagocytosis by murine macroph

253 Fcgamma receptor-mediated phagocytosis is a complex proc

254 Fcgamma receptor-mediated phagocytosis is a model for th

255 PTEN, an inositol 3' phosphatase, regulates Fcgamma receptor-mediated phagocytosis, an ITAM-based si

256 localizes to nascent phagocytic cups during Fcgamma receptor-mediated phagocytosis, where it display

257 Notably, all such reports were limited to Fcgamma receptor-mediated phagocytosis.

258 acking SLAT show an elevation in the rate of Fcgamma receptor-mediated phagocytosis.

259 ,4,5)-trisphosphate [PI(3,4,5)P(3)] regulate Fcgamma receptor-mediated phagocytosis.

260 involved in the proximal signaling steps of Fcgamma receptor-mediated phagocytosis.

261 likely opsonizing the Abeta and resulting in Fcgamma receptor-mediated phagocytosis.

262 nstrating a crucial role for this protein in Fcgamma receptor-mediated phagocytosis.

263 horiomeningitis infection can interfere with Fcgamma-receptor-mediated effector activities, potential

264 Remarkably, TFEB silencing represses the Fcgamma-receptor-mediated enhancements in degradation an

265 To test this hypothesis, we employed Fcgamma-receptor-mediated phagocytosis and endocytosis,

266 We discuss the impact of Fcgamma-receptor-mediated trogocytosis on the efficacy o

267 specialized form of trogocytosis occurs when Fcgamma receptors on acceptor cells take up and internal

268 n between the Fc portion of the antibody and Fcgamma receptors on APC.

269 le for the interaction of the Fc domain with Fcgamma receptors on effector cells and the clearance of

270 Ab5574) was generated to increase binding to Fcgamma receptors on immune cells and thus increase Fc-m

271 pressing cell line and by down-modulation of Fcgamma receptors on MDM, respectively.

272 yed on immune effector cells, and binding to Fcgamma receptors on natural killer cells and macrophage

273 rge immune complexes with IL-6 that can bind Fcgamma receptors on phagocytic cells and are rapidly in

274 g integrin wave facilitates the zippering of Fcgamma receptors onto the target and integrates the inf

275 n of P-L fusion did not occur with entry via Fcgamma receptors or dendritic cell-specific intracellul

276 Blocking of Fcgamma receptors or using Fcgamma chain-knockout mesang

277 ligands that activate G-proteins as well as Fcgamma-receptor or integrin ligation that activates tyr

278 erum completely protected wild-type, but not Fcgamma-receptor or neonatal Fc-receptor knock-out mice.

279 sonized C albicans was strictly dependent on Fcgamma receptors, protein kinase C (PKC), and reactive

280 utant antibodies (N297Q) that do not bind to Fcgamma receptors provide a level of protection similar

281 he binding of immune complexes to macrophage Fcgamma receptor results in a subsequent inhibition of l

282 Binding studies using Fcgamma receptors revealed enhanced binding of nonfucosy

283 on resonance [SPR]) and cellularly expressed Fcgamma receptors show decreased (up to 5-fold) and incr

284 phages in vitro, likely due to their role in Fcgamma receptor signal transduction.

285 receptor (BCR)-mediated signaling as well as Fcgamma receptor signaling in monocytes and Fcepsilon re

286 ce with diabetes, suggesting that modulating Fcgamma receptor signaling may be renoprotective in diab

287 s and involves predominantly recognition via Fcgamma receptors, signaling via Syk, PI3K, and protein

288 ism and the rationale for the development of Fcgamma receptor-targeted therapeutics.

289 than monocytes with contributions from CR3, Fcgamma receptors, the MR, and SP-A present in lung alve

290 argeted cells by effector cells that express Fcgamma receptors, thereby allowing malignant cells to e

291 We investigated the contribution of IgG Fcgamma receptors to diabetic renal injury in hyperglyce

292 issue of Immunity, Henault et al. show that Fcgamma-receptor, Toll-like receptor 9, and LC3 conspire

293 Engagement of Fcgamma-receptors triggers a range of downstream signall

294 Formation of these complexes resulted in Fcgamma receptor type I-dependent polarization of macrop

295 Although low-affinity alleles of human Fcgamma receptor types IIA and IIIA (FcgammaRIIA and Fcg

296 By micropatterning IgG, the ligand of Fcgamma receptors, we found that the barrier extended we

297 d for minimal background binding to cellular Fcgamma receptors, we identified the flexible stalk regi

298 ive immune opsonins through engagement of an Fcgamma receptor, which can also enhance Ag uptake and p

299 Percoll gradient and then activated via the Fcgamma receptor with opsonized Staphylococcus aureus af

300 d primarily through a set of closely related Fcgamma receptors with both activating and inhibitory ac