ライフサイエンスコーパス: Fmoc

1 Fmoc-4-(1-chloroethyl)-phenylalanine (5) was synthesized

2 Fmoc-based solid-phase synthesis methodology was used to

3 Fmoc-D-Hyv(O-TBDMS) was used for the synthesis of the co

4 Fmoc-F(2)Pab was prepared by an improved synthesis and c

5 Fmoc-N-epsilon-(Hynic-Boc)-Lys is a highly versatile tec

6 Fmoc-O-(2-bromoisobutyryl)-serine tert-butyl ester (10)

7 Fmoc-protected amino acids were condensed into appropria

8 Fmoc-protected DOTAla suitable for solid phase peptide s

9 Fmoc-Trp(C2-BODIPY)-OH contains a BODIPY (4,4-difluoro-4

10 airs of deuterated alanines by using 60-100% Fmoc-l-Ala-d(4) at selected sequence positions.

11 essed in a detailed thermodynamic study of a Fmoc-L-tryptophan (Fmoc-L-Trp) imprinted polymer, eluted

12 omers were measured by frontal analysis on a Fmoc-L-Trp imprinted polymer, using different organic mo

13 sic carbon nucleophiles add efficiently to a Fmoc-protected N,O-acetal compound.

14 tected phospho-mannosides are coupled with a Fmoc protected threonine derivative, followed by the use

15 ical synthesis of the fluorogenic amino acid Fmoc-Trp(C2-BODIPY)-OH (3-4 d), the preparation of the l

16 ryptophan (Trp)-based fluorogenic amino acid Fmoc-Trp(C2-BODIPY)-OH and its incorporation into peptid

17 -fluorenylmethoxycarbonyl)-anthranilic acid (Fmoc-anthranilic acid) with an IC(50) value of approxima

18 A nonproteinogenic amino acid, Fmoc-Se-phenylselenocysteine (SecPh), can be prepared in

19 onstituent Fmoc-protected nucleoamino acids (Fmoc-Ser(B)-OH, where B = thymine, cytosine, and uracil)

20 i.e., Fmoc-modified individual amino acids, Fmoc-modified di- and tripeptides, and Fmoc-modified tet

21 equired for the deprotection of the N(alpha)-Fmoc group.

22 (Fmoc)-based solid-phase synthesis; N(alpha)-Fmoc-dl-hydroxy-dl-Lys(N(epsilon)-tert-butyloxycarbonyl)

23 thylamine with the acid chloride of N(alpha)-Fmoc-L-leucine provided a N(alpha)-Fmoc-N-(benzoyloxy)-L

24 N(alpha)-Fmoc-L-leucine provided a N(alpha)-Fmoc-N-(benzoyloxy)-L-leucinamide in 90% yield.

25 10 vol % NH(4)OH/MeOH) provided the N(alpha)-Fmoc-N-(hydroxy)-L-leucinamide in 87% yield.

26 ractical synthesis of the precursor N(alpha)-Fmoc-Thr(Ac(3)-alpha-D-GalNAc) allowed us to produce suf

27 We have used unresolved N alpha-Boc,N'alpha-Fmoc-aminoglycine, and N alpha-Boc,N'alpha-(CH3)Fmoc-ami

28 Herein, we report the synthesis of N-alpha-Fmoc-L-gamma-carboxyglutamic acid gamma,gamma'-tert-buty

29 in we report the facile synthesis of N-alpha-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine 1

30 henylethyl-2-cyanoethyl)-L-serine 1, N-alpha-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-threonin

31 hyl-2-cyanoethyl)-L-threonine 2, and N-alpha-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-tyrosine

32 An Fmoc group, an effective drug-interactive motif, is also

33 This amino acid has been prepared as an Fmoc-protected building block and may readily be incorpo

34 N-Terminal Ser residues containing an Fmoc carbamate are converted into 2-(9'-fluorenylmethylo

35 luorescent amino acids can be obtained in an Fmoc-protected form for convenient use as building block

36 probe are expanded with the synthesis of an Fmoc-protected amino acid derivative (5), which contains

37 mers of Fmoc-tryptophan (Fmoc-L,D-Trp) on an Fmoc-L-Trp-imprinted polymer were investigated over a wi

38 oc and Cbz strategy and semiorthogonal to an Fmoc strategy.

39 tecting group strategy for linear PAAs to an Fmoc/Alloc/Boc strategy.

40 onglycosylated analog were prepared using an Fmoc (9-fluorenylmethoxycarbonyl) protected solid phase

41 peltin E (1, 5) were synthesized by using an Fmoc-based solid-phase strategy in 7 steps, in 20% and 2

42 The four peptides were synthesized using an Fmoc/t-Bu-based solid-phase strategy, purified by revers

43 were also inhibited by ACA, ONO-RS-082, and Fmoc-anthranilic acid, whereas the Na(+)/citrate transpo

44 derivatives Fmoc-m-Abc(2K(Boc))-OH (1a) and Fmoc-o-Abc(2K(Boc))-OH (1b).

45 orthogonally protected with Alloc/allyl and Fmoc groups.

46 psules with shell walls bearing both Boc and Fmoc triggering groups.

47 r solid-phase synthesis bearing Fmoc/Boc and Fmoc/Alloc protecting groups expanding recently used Fmo

48 quences and is compatible with both Boc- and Fmoc- synthetic strategies on a variety of resins.

49 the unsaturated side chains of the Boc- and Fmoc-protected derivatives of enyne and diyne coupling p

50 into peptide chains by coupling N-(Cbz- and Fmoc-alpha-aminoacyl)benzotriazoles with amino acids, wh

51 Mixed anhydrides from BOP-Cl and Fmoc-alphaalphaAA-OH are used for anchoring alphaalphaAA

52 lving iterative PyBOP-mediated couplings and Fmoc deprotections, is rapid (about 5 d), operationally

53 used protease digestion of glycoproteins and Fmoc chemistry.

54 lete peptide coupling reactions in 6 min and Fmoc-removal reactions in 4 min under temperature-contro

55 The use of Nap and Fmoc as temporary protecting groups made it possible to

56 hybrid peptides derived from Fmoc-Neu2en and Fmoc-Glu(OtBu)-OH.

57 iates derived from Fmoc-L-phenylalaninal and Fmoc-L-valinal, and a resin supported Horner-Wadsworth-E

58 tionalized with carboxylic acid, pyrene, and Fmoc-protected cysteine moieties via thiol-ene reactions

59 aziridines was achieved with Boc, tosyl, and Fmoc groups.

60 cids, Fmoc-modified di- and tripeptides, and Fmoc-modified tetra- and pentapeptides.

61 In general, the appended Fmoc group allowed for further elaboration of the N-hydr

62 m-Abc(2K) and o-Abc(2K) are prepared as Fmoc-protected derivatives Fmoc-m-Abc(2K(Boc))-OH (1a) a

63 ffected to base-sensitive substrates such as Fmoc-protected alaninal, citral, 5-cholesten-3-one, urid

64 -butyl 4-hydroxyproline were synthesized (as Fmoc-, Boc-, and free amino acids) in 2-5 steps.

65 c acid (Hmp)/2-methylpiperidine (2-MP) based Fmoc chemistry procedure to prepare the C-terminal Hmp p

66 tives such as HOBt or Oxyma during the basic Fmoc-removal treatment were found to be very effective f

67 ing blocks for solid-phase synthesis bearing Fmoc/Boc and Fmoc/Alloc protecting groups expanding rece

68 ith common N-protecting groups, such as Boc, Fmoc, Cbz, and benzyl, as well as various OH protecting

69 h as acetates (Ac, Piv) and carbamates (Boc, Fmoc), respectively.

70 y, Boc-(Fmoc)-aminoglycine amide 13 and Boc-(Fmoc)-aminoglycine methyl ester 14 were resolved using p

71 Independently, Boc-(Fmoc)-aminoglycine amide 13 and Boc-(Fmoc)-aminoglycine

72 The enantiospecific synthesis of (R)-Boc-(Fmoc)-aminoglycine 7 was achieved.

73 ere synthesized using Phe(p-NH(2)) and a Boc/Fmoc orthogonal protection strategy which allowed for la

74 So, all compounds but Fmoc-L-Trp(OPfp) find three different types of adsorptio

75 of the purified isoxazolidinones followed by Fmoc protection affords enantiomerically pure Fmoc-beta(

76 Metal complex decomposition followed by Fmoc protection affords the enantiomerically pure amino

77 Acidolytic deprotection followed by Fmoc-protection provided building blocks suitable for so

78 scently labeled ADM analogues synthesized by Fmoc/t-Bu solid phase peptide synthesis were used to ana

79 A diverse set of (fluorenylmethoxy)carbonyl (Fmoc) protected amino alcohols was found to load rapidly

80 c-aminoglycine, and N alpha-Boc,N'alpha-(CH3)Fmoc-aminoglycine as templates for the introduction of b

81 or 9-fluorenylmethoxycarbonyl chloroformate (Fmoc-Cl).

82 nt, namely, 9-fluorenylmethyl chloroformate (Fmoc-Cl).

83 self more readily deblocked than the classic Fmoc analogue.

84 s of this approach, a lysine-hynic conjugate Fmoc-N-epsilon-(Hynic-Boc)-Lys was synthesized for incor

85 Effective syntheses of constituent Fmoc-protected nucleoamino acids (Fmoc-Ser(B)-OH, where

86 -chlorotrityl chloride resin by conventional Fmoc-based solid-phase peptide synthesis.

87 pared as the protected amino acid derivative Fmoc-Sox-OH and integrated into peptide sequences.

88 ) are prepared as Fmoc-protected derivatives Fmoc-m-Abc(2K(Boc))-OH (1a) and Fmoc-o-Abc(2K(Boc))-OH (

89 nctional molecules from three aspects, i.e., Fmoc-modified individual amino acids, Fmoc-modified di-

90 An efficient Fmoc-based solid-phase peptide synthetic strategy is the

91 Here we describe a simple and efficient Fmoc solid-phase peptide synthesis (SPPS)-based method f

92 as common peptide fragments bound to either Fmoc or the surface linker.

93 glutamic acid gamma,gamma'-tert-butyl ester (Fmoc-Gla(O(t)Bu)(2)-OH), a suitably protected analogue f

94 , Fmoc-L-tryptophan pentafluorophenyl ester (Fmoc-L-Trp(OPfp)), and their antipodes.

95 rogen in the presence of a tert-butyl ester, Fmoc protection of the lactam, and a lanthanide-catalyze

96 lated amino acids and peptides (see example, Fmoc=9-fluorenylmethoxycarbonyl).

97 The final Fmoc-protected (2S,5R)-6-azido-5-hydroxylysine derivativ

98 dard solid-phase 9-fluorenylmethoxycarbonyl (Fmoc) chemistry.

99 this small-scale 9-fluorenylmethoxycarbonyl (Fmoc) strategy is comparable to that of the peptide synt

100 is following the 9-fluorenylmethoxycarbonyl (Fmoc) strategy, which we demonstrate by the synthesis of

101 ted into CD52 by 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis.

102 braries by using 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase synthesis techniques.

103 e preparation of 9-fluorenylmethoxycarbonyl (Fmoc)-protected 1-aminoalkylphosphinic acids.

104 into a peptide by fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis.

105 levulinoyl (Lev) ester, fluorenylmethyloxy (Fmoc)- and allyloxy (Alloc)-carbonates, and 2-methyl nap

106 oups N(alpha)-9-fluorenylmethyloxycarbonate (Fmoc), 2-methylnaphthyl ether (Nap), levulinoyl ester (L

107 synthesis of N-9-fluorenylmethyloxycarbonyl (Fmoc) alpha-amino diazoketones.

108 alled by using 9-fluorenylmethyloxycarbonyl (Fmoc) and allyloxycarbonyl (Alloc) as a versatile set of

109 with N(alpha)-9-fluorenylmethyloxycarbonyl (Fmoc) chemistry, featuring appropriate combinations of o

110 ified with the 9-fluorenylmethyloxycarbonyl (Fmoc) group possess eminent self-assembly features and s

111 ssembled using 9-fluorenylmethyloxycarbonyl (Fmoc)-based solid-phase synthesis; N(alpha)-Fmoc-dl-hydr

112 oxy (Cbz), and 9-fluorenylmethyloxycarbonyl (Fmoc).

113 corporation of a fluorenylmethyloxycarbonyl (Fmoc) motif at the interfacial region of PEG5K-VE2 led t

114 otected with the fluorenylmethyloxycarbonyl (Fmoc) group.

115 em (e.g., from 4.74 for Fmoc-Trp to 2.53 for Fmoc-Gly)).

116 he octanol-water system (e.g., from 4.74 for Fmoc-Trp to 2.53 for Fmoc-Gly)).

117 u)(2)-OH), a suitably protected analogue for Fmoc-based solid-phase peptide synthesis.

118 an-2-carboxylic acid as a building block for Fmoc solid phase peptide synthesis.

119 threonine, and tyrosine building blocks for Fmoc-based solid-phase peptide synthesis to allow conven

120 found that three types of sites coexist for Fmoc-L-Trp but only two types of sites for Fmoc-D-Trp, e

121 nfluence on the site density (especially for Fmoc-D-Trp) than does HBD.

122 namic properties of copolymers imprinted for Fmoc-l-tryptophan and prepared by two different methods.

123 en egg yolk together with the Nbz linker for Fmoc chemistry solid phase synthesis of the glycopeptide

124 these peptides, we employed a new linker for Fmoc-based thioester peptide synthesis.

125 hest energy sites (sites that exist only for Fmoc-L-Trp), increasing the concentration of acetic acid

126 amic acid (Gla), appropriately protected for Fmoc-based solid-phase peptide synthesis (SPPS), is desc

127 enic amino acids appropriately protected for Fmoc-based solid-phase peptide synthesis is described.

128 are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.

129 is totally stable to conditions required for Fmoc-SPPS.

130 r Fmoc-L-Trp but only two types of sites for Fmoc-D-Trp, except at the lowest acetic acid concentrati

131 The highest energy sites for Fmoc-L-Trp in MeCN are inactive in CH(2)Cl(2), CHCl(3),

132 -D-glucitol-gamma-glutamate 20, suitable for Fmoc-strategy solid-phase peptide synthesis (SPPS), was

133 We report a one-step synthesis for Fmoc-fluorosulfated tyrosine.

134 cilitated by devising a simple synthesis for Fmoc-selenomethionine and substituting leucine residues

135 eine residue under basic conditions used for Fmoc deprotection.

136 The K(d) values for Fmoc-VPRpTPVGGGK-NH2 and Ac-VPRpTPV-NH2 were determined

137 of Kd values for the 19 peptides of the form Fmoc-DXYA is demonstrated.

138 Wang resin-bound intermediates derived from Fmoc-L-phenylalaninal and Fmoc-L-valinal, and a resin su

139 of alpha/delta hybrid peptides derived from Fmoc-Neu2en and Fmoc-Glu(OtBu)-OH.

140 PNTs have been made from Fmoc dipeptides, cyclic peptides, and lock-washer helica

141 Starting from Fmoc-tyrosine phosphate and phenylalanine amide in the p

142 anine (5) was synthesized in four steps from Fmoc-tyrosine.

143 e tert-butyl ester (10) was synthesized from Fmoc-Ser(OTrt)-OH in three steps.

144 hogonal protection schemes (up to five from: Fmoc, Boc Alloc, pNZ, o-NBS, and Troc), together with th

145 moc-L-phenyalanine, Fmoc-glycine (Fmoc-Gly), Fmoc-L-tryptophan pentafluorophenyl ester (Fmoc-L-Trp(OP

146 L-serine, Fmoc-L-phenyalanine, Fmoc-glycine (Fmoc-Gly), Fmoc-L-tryptophan pentafluorophenyl ester (Fm

147 iently synthesized by using the glycosylated Fmoc-asparagine as a key building block.

148 linker at a Lys residue epsilon-amine, (ii) Fmoc-SPPS elongation of a desired solubilizing sequence,

149 (2K(Boc))-OH (1c) as ordinary amino acids in Fmoc-based solid-phase peptide synthesis.

150 scent amino acids can be readily obtained in Fmoc-protected form for convenient use as building block

151 ide fragments and have used them as units in Fmoc solid-phase peptide synthesis.

152 rcially available building blocks, including Fmoc-protected amino acids, 2-nitrobenzenesulfonyl chlor

153 solid-phase peptide synthesis to incorporate Fmoc-hydroxyproline (4R-Hyp).

154 -5), and the prolyl oligopeptidase inhibitor Fmoc-Ala-Pyr-CN (IC(50) = 50 nm) also blocked purified P

155 t-butylated beta-amino acid (betaFa) and its Fmoc- and Boc-protected forms were designed and synthesi

156 using a mixture of 70%/30% unlabeled/labeled Fmoc-protected residues.

157 -hemiglutarate to the amino terminus of [Lys(Fmoc)5]RC-160 yielding AN-163 and AN-258, respectively,

158 of racemates, including mandelic acid (Man), Fmoc-phenylalanine, 1,1'-bi-2-naphthol (binol), and TTSB

159 This SAM1 linker is applied in the manual Fmoc-based solid-phase peptide synthesis of Leu-enkephal

160 In this method, Fmoc-protected C-terminal cysteine esters are anchored t

161 plate is highest for the imprinted molecule (Fmoc-L-Trp).

162 N-Fmoc-(2S,3S,4R)-3,4-dimethylglutamine (6) was synthesize

163 erein the first synthesis of a C-activated N-Fmoc-protected trans-(2S,3S)-3-aminotetrahydrofuran-2-ca

164 ng to single diastereoisomers of N-Boc and N-Fmoc protected spiroisoxazolinoproline amino acids.

165 Chiral N-Tfa- and N-Fmoc-protected (alpha-aminoacyl)benzotriazoles 1a-j unde

166 The crystalline N-Fmoc-cis-4-fluoropyrrolidine-2-carbonyl fluoride 2a is a

167 n of a dideuterated methionine equivalent, N-Fmoc-(4,4-(2)H(2))methionine, to the desired labeled AHL

168 by coupling N-9-fluorenylmethoxycarbonyl (N-Fmoc)-DOX-14-O-hemiglutarate or 2-pyrrolino-DOX-14-O-hem

169 e area, was synthesized in the presence of N-Fmoc and O-Et protected phosphoserine and phosphotyrosin

170 further demonstrated by the preparation of N-Fmoc-alpha-amino diazoketones also from alpha-amino acid

171 The synthesis of N-Fmoc-O-(N'-Boc-N'-methyl)-aminohomoserine in 35% overall

172 he preparation of a diastereomeric pair of N-Fmoc-protected dipeptidyl diazoketones.

173 ntroduce a new general tool, Fmoc-Ddae-OH, N-Fmoc-1-(4,4-dimethyl-2,6-dioxocyclo-hexylidene)-3-[2-(2-

174 OSu furnished fully protected (S)- and (R)-N-Fmoc-S-trityl-alpha-methylcysteine in overall 20% yield.

175 applied to the synthesis of the respective N-Fmoc-protected alpha-amino diazoketones from L-isoleucin

176 otection of free amino phosphinates as the N-Fmoc derivative was achieved by in situ trimethylsilylat

177 The N-Fmoc-protected epsilon-amino acid was synthesized in hig

178 Three N-Fmoc unnatural amino acids (1-3) that contain varying li

179 VKDVYI-NH(2) (8), were achieved utilizing N-(Fmoc-alpha-aminoacyl)benzotriazoles.

180 The overall affinity of Fmoc-L-trp in CH(2)Cl(2), CHCl(3), and THF is dominated

181 n contrast, in MeCN, the overall affinity of Fmoc-L-Trp is dominated by adsorption on the highest ene

182 The overall affinity of Fmoc-L-Trp is dominated by the contribution of the low-d

183 Analogues of Fmoc-Orn(Mtt)-OH can be incorporated into a growing pept

184 g-Pro-Asp-Phe): (i). side-chain anchoring of Fmoc-Asp-OAl via its free beta-carboxyl as a p-alkoxyben

185 residue, which was selected on the basis of Fmoc-tBu SPPS compatibility and photolysis efficiency.

186 s allows for orthogonal on-resin cleavage of Fmoc and Alloc protecting groups during solid-phase synt

187 ores were then "reopened" by the cleavage of Fmoc groups with a piperidine solution.

188 gmuir isotherm model, except for the data of Fmoc-L-Trp(OPfp) that are best modeled by a simple Langm

189 isting questions impeding the development of Fmoc-modified simple biomolecules are discussed, and cor

190 sotherm parameters of the two enantiomers of Fmoc-tryptophan (Fmoc-L,D-Trp) on an Fmoc-L-Trp-imprinte

191 the Nle(epsilon-N3) or the incorporation of Fmoc-Nle(epsilon-N3)-OH during the stepwise build-up of

192 piperidine solution as well as the number of Fmoc moieties within the pores.

193 haride, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical pro

194 ed by UV/visible spectroscopy, and a plot of Fmoc released versus time showed a sigmoidal shape.

195 cient synthetic route for the preparation of Fmoc-protected l-gamma-carboxyglutamic acid, which is am

196 is scalable, and enables the preparation of Fmoc-protected unnatural amino acids in three steps.

197 the alkanethiol SAM (after de-protection of Fmoc-HWRGWVA) was 1.2x10(-6)M.

198 uki-Miyaura cross-coupling (SMC) reaction of Fmoc-protected bromo- or iodophenylalanines is reported.

199 is formed by coupling the diazonium salt of Fmoc-Phe(pNH(2))-OAllyl to a MBHA-polystyrene resin prev

200 F(2) laser single photon ionization (SPI) of Fmoc-derivatized peptides covalently bound to surfaces.

201 e development of more efficient syntheses of Fmoc-protected amino acids.

202 Synthesis of Fmoc-3,4;5,6-di-O-isopropylidene-1-amino-1-deoxy-D-gluci

203 chiral complex, the asymmetric synthesis of Fmoc-Gla(O(t)Bu)(2)-OH was completed in nine steps from

204 A one-step synthesis of Fmoc-protected aryl/heteroaryl-substituted phenylalanine

205 An efficient synthesis of Fmoc-protected mpAbc was executed in which the biaryl co

206 w-density highest energy sites while that of Fmoc-D-Trp is dominated by the most abundant, low-energy

207 ed and then functionalized with two types of Fmoc (9-fluorenylmethyloxycarbonyl) terminated silanes w

208 t one peptide (8), which required the use of Fmoc chemistry.

209 The use of Fmoc-OSU as a traceless capping agent resulted in cleane

210 nosylamine 2 by readily available N- (Cbz or Fmoc-alpha-aminoacyl) benzotriazoles under microwave irr

211 hylene(diNosyl)-spermine(triBoc) with Dde or Fmoc orthogonal protecting groups.

212 We show that PEG2k-Fmoc-NLG alone is effective in enhancing T-cell immune r

213 delivery of paclitaxel (PTX) using the PEG2k-Fmoc-NLG nanocarrier leads to a significantly improved a

214 In addition, PEG5K-Fmoc-VE2/DOX mixed micelles showed more sustained releas

215 antitumor activity was demonstrated by PEG5K-Fmoc-VE2/DOX in both drug-sensitive (4T1.2 and PC-3) and

216 umor accuulation for DOX formulated in PEG5K-Fmoc-VE2 micelles.

217 (DOX) could be effectively loaded into PEG5K-Fmoc-VE2 micelles at a DLC of 39.9%, which compares favo

218 More importantly, DOX-loaded PEG5K-Fmoc-VE2 micelles showed an excellent safety profile wit

219 ug resistant cell line, suggested that PEG5K-Fmoc-VE2 may have the potential to reverse multidrug res

220 MTT assay showed that PEG5K-Fmoc-VE2/DOX exerted significantly higher levels of cyto

221 yrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmoc-glycine (Fmoc-Gly), Fmoc-L-tryptophan pentafluoroph

222 lly protected trinucleotide phosphoramidite (Fmoc-TAG; Fmoc = 9-fluorenylmethoxycarbonyl) was develop

223 ion of D-Hyv(O-TBDMS) with Fmoc-OSu produced Fmoc-D-Hyv(O-TBDMS) in 26% yield from D-Val.

224 improved synthesis of orthogonally protected Fmoc-Dyp-acetonide (9) and of several Fmoc-d-Hot horizon

225 e scale, and the resulting racemic protected Fmoc-DSA subunit was separated by supercritical fluid ch

226 moc protection affords enantiomerically pure Fmoc-beta(2)-amino acids, which are useful for beta-pept

227 valent grafting of peptides with a removable Fmoc or acetylated N-termini via their C-termini to prod

228 ]-OH (11), starting with the papain-resolved Fmoc-DAgl(Boc).

229 ure transmembrane peptide from a small-scale Fmoc synthesis.

230 alogues were Fmoc-L-tyrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmoc-glycine (Fmoc-Gly), Fmoc-L-try

231 tected Fmoc-Dyp-acetonide (9) and of several Fmoc-d-Hot horizontal lineTap-ketals for solid-phase pep

232 After simple Fmoc deprotection, the glycans were printed on NHS-activ

233 e incorporated into the peptides by standard Fmoc solid phase peptide synthesis.

234 chain elongation of the peptide by standard Fmoc/tBu solid-phase chemistry; (iii). removal of the N-

235 rrogate amino acids are amenable to standard Fmoc peptide synthesis strategy, and the resulting compo

236 esized by solid-phase methods using standard Fmoc chemistry and purified by RP-HPLC; all intermediate

237 solid-phase peptide synthesis using standard Fmoc chemistry.

238 inomethyl resin and elongated using standard Fmoc protocols.

239 d into a neurotensin analogue using standard Fmoc-based protocols.

240 aged phospho-peptide sequence using standard Fmoc-based SPPS procedures.

241 as well as full compatibility with standard Fmoc solid-phase peptide synthesis (SPPS).

242 ng strategy that is compatible with standard Fmoc solid-phase peptide synthesis.

243 lding blocks, fully compatible with standard Fmoc solid-phase peptide synthesis.

244 nctionality that is compatible with standard Fmoc-based peptide synthesis.

245 provides a straightforward entry to storable Fmoc-amino acid selenoesters which are effective chemose

246 s of inactivators with the general structure Fmoc-L-Asp-CH(2)-X were designed to inactivate ICE.

247 eld, which can be readily used in subsequent Fmoc solid-phase peptide synthesis.

248 -(9-fluorenylmethoxycarbonyloxy)succinimide (Fmoc-OSU), to generate a series of sequence-specific tru

249 This was accomplished by synthesizing Fmoc-Cys(NDBF)-OH and incorporating that residue into pe

250 ted trinucleotide phosphoramidite (Fmoc-TAG; Fmoc = 9-fluorenylmethoxycarbonyl) was developed to scan

251 chemistry; (iii). removal of the N-terminal Fmoc group; (iv). coupling of Trt-Cys(Xan)-OH; (v). sele

252 The Fmoc group in P6 peptide makes several hydrophobic inter

253 The Fmoc protection strategy also allows for selective modif

254 The Fmoc-D-Hyv(O-TBDMS) diastereomers were separated by prep

255 s of the solid were completely filled by the Fmoc-protected organosilanes.

256 material, the process readily delivered the Fmoc-protected free acid derivatives of AHMOD ((2S)-amin

257 ide bond formation techniques, including the Fmoc/tBu strategy for solid phase peptide synthesis, is

258 ectronic structure calculations indicate the Fmoc label is behaving as an ionization tag for the enti

259 herent hydrophobicity and aromaticity of the Fmoc moiety which can promote the association of buildin

260 reactions highlight the compatibility of the Fmoc protecting group with moderately basic reaction con

261 s also used to determine the presence of the Fmoc protecting groups and the efficiency of its removal

262 The synthesis of the Fmoc-protected C-glycosyl tyrosines 1 and 2, together wi

263 ide-catalyzed transamidation reaction of the Fmoc-protected lactam, using ammonia and dimethylaluminu

264 Experimental isotherm data of the Fmoc-tryptophan (Fmoc-Trp) enantiomers were measured by

265 Following PED, the Fmoc group was removed from the N-terminus and any react

266 ents that are commonly used for removing the Fmoc group during SPPS.

267 masking groups, which are orthogonal to the Fmoc one.

268 se di- and tripeptides (with and without the Fmoc protecting group) directly on the polymer beads.

269 ablished, and analogs were generated through Fmoc-based solid phase peptide synthesis.

270 eracetylated form of this glycan attached to Fmoc-threonine in an attempted synthesis.

271 (2S,3R, 2R,3S), which were then converted to Fmoc derivatives and used in two separate syntheses.

272 this work, we introduce a new general tool, Fmoc-Ddae-OH, N-Fmoc-1-(4,4-dimethyl-2,6-dioxocyclo-hexy

273 s of the two enantiomers of Fmoc-tryptophan (Fmoc-L,D-Trp) on an Fmoc-L-Trp-imprinted polymer were in

274 mental isotherm data of the Fmoc-tryptophan (Fmoc-Trp) enantiomers were measured by frontal analysis

275 ymers, one imprinted with Fmoc-L-tryptophan (Fmoc-L-Trp) (MIP), the other nonimprinted (NIP), of comp

276 thermodynamic study of a Fmoc-L-tryptophan (Fmoc-L-Trp) imprinted polymer, eluted with four differen

277 These analogues were Fmoc-L-tyrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmoc-glycine (Fmoc-G

278 e encoding-decoding system in which a unique Fmoc-amino acid tag is covalently attached to the C term

279 gues were first synthesized using unresolved Fmoc-Agl(N(beta)Me,Boc)-OH, and the diastereomers were s

280 domain of phospholamban (PLB), we have used Fmoc (N-(9-fluorenyl)methoxycarbonyl) solid-phase peptid

281 oc protecting groups expanding recently used Fmoc/Boc protecting group strategy for linear PAAs to an

282 Using Fmoc-Cys(Bhc-MOM)-OH, peptides containing a Bhc-protecte

283 e 68 to quinone 70, and carbamoylation using Fmoc-NCO.

284 s synthesized as a shared intermediate using Fmoc solid phase chemistry on a 2-chlorotrityl resin.

285 efficiently incorporated into peptides using Fmoc-chemistry-based solid-phase peptide synthesis, and

286 a diastereomeric mixture of CF3-PsiPro using Fmoc-protected amino acid chloride without base gave the

287 beads is quantified by UV spectroscopy using Fmoc-monitoring of the immobilized dopamine and serotoni

288 The protein is synthesized using Fmoc-based solid-phase peptide synthesis and assembled u

289 for the SPPS of C-terminal thioesters using Fmoc/t-Bu chemistry.

290 The coupling of this amine with various Fmoc amino acids, followed by cleavage of the alpha-amin

291 These analogues were Fmoc-L-tyrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmo

292 cell internalization and are compatible with Fmoc solid phase peptide synthesis.

293 ia a thioglycinamide bond is compatible with Fmoc-chemistry solid-phase peptide synthesis.

294 ves can be used alone or in conjunction with Fmoc-Abc(2K(Boc))-OH (1c) as ordinary amino acids in Fmo

295 trityl alcohol and alpha-amine function with Fmoc-OSu furnished fully protected (S)- and (R)-N-Fmoc-S

296 rwise identical polymers, one imprinted with Fmoc-L-tryptophan (Fmoc-L-Trp) (MIP), the other nonimpri

297 port and the amino acids were protected with Fmoc- and tert-butyl groups.

298 kylphosphinic acids, which then reacted with Fmoc-Cl to provide corresponding products in excellent y

299 red using solid-phase peptide synthesis with Fmoc alpha-amino protection.

300 Reaction of D-Hyv(O-TBDMS) with Fmoc-OSu produced Fmoc-D-Hyv(O-TBDMS) in 26% yield from

301 DOX in comparison to the counterpart without Fmoc motif.