ライフサイエンスコーパス: Forsythia

1 y to the S-layer glycoproteins of Tannerella forsythia.

2 cell adherence and invasion abilities of T. forsythia.

3 nd P. gingivalis, and after 12 months for T. forsythia.

4 dia, Fusobacterium nucleatum, and Tannerella forsythia.

5 dontalis, Streptococcus spp., and Tannerella forsythia.

6 , and levels of P. gingivalis (0.23%) and T. forsythia (0.35%), receiver operating characteristic cur

7 Tannerella forsythia (1.5 x 10(5)) and Veillonella parvula (1.02 x

8 denticola, 1.99 (0.992, 4.00), P = 0.052; T. forsythia, 1.95 (1.0, 3.84), P = 0.05; A. naeslundii, 0.

9 tinomycetemcomitans, (31%; P = 0.025), or T. forsythia (63%; P = 0.030).

10 rboring P. gingivalis (46%; P < 0.001) or T. forsythia (63%; P = 0.043) but not A. actinomycetemcomit

11 dontal treatment were as follows: Tannerella forsythia, 81%; Porphyromonas gingivalis, 78%; and Aggre

12 rphyromonas gingivalis (78%/66%), Tannerella forsythia (98%/84%), Treponema denticola (94%/74%), Parv

13 (miropin) from the human pathogen Tannerella forsythia, a bacterium implicated in initiation and prog

14 vel metalloproteinase secreted by Tannerella forsythia, a well-recognized pathogen strongly associate

15 ductions of PI, GI, total bacterial load, T. forsythia, A. actinomycetemcomitans, and GCF volume.

16 In this study, we showed that T. forsythia activates murine APCs primarily through TLR2-d

17 vels of Porphyromonas gingivalis, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, and to

18 In forsythia and alfalfa, pith parenchyma cells next to the

19 enome of the periodontal pathogen Tannerella forsythia and also identify antibiotic resistance genes,

20 ant association between the reductions of T. forsythia and being free from PD >/=5 mm.

21 association between reductions of Tannerella forsythia and being free from PD >/=5 mm.

22 T. forsythia and C. rectus were detected in 100% of the sam

23 rstanding of immune evasion strategies of T. forsythia and expand the knowledge on molecular mechanis

24 cluding Porphyromonas gingivalis, Tannerella forsythia and Filifactor alocis, as potential pathogens

25 rs to be an important virulence factor of T. forsythia and might have several important implications

26 givalis, Treponema denticola, and Tannerella forsythia and some evidence supporting association of Pr

27 to determine the pathogenic potential of T. forsythia and the in vivo role of the BspA protein in pa

28 cell adherence and invasion properties of T. forsythia and the role of the cell surface-associated pr

29 ens (Porphyromonas gingivalis and Tannerella forsythia), and cancer risk were investigated.

30 gingivalis, Treponema denticola, Tannerella forsythia, and Actinomyces naeslundii.

31 gingivalis, Treponema denticola, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans lev

32 ganisms Porphyromonas gingivalis, Tannerella forsythia, and Campylobacter rectus (P </=0.05).

33 ccus spp., members of the orange complex, T. forsythia, and certain non-oral pathogens were associate

34 dens, C. concisus, Prevotella nigrescens, T. forsythia, and Dialister pneumosintes.

35 odontal pathogens, such as P. nigrescens, T. forsythia, and E. corrodens, as well as C. concisus, C.

36 gingivalis, Treponema denticola, Tannerella forsythia, and Fusobacterium nucleatum to colonize the p

37 vels of Porphyromonas gingivalis, Tannerella forsythia, and Fusobacterium nucleatum were analyzed for

38 such as Porphyromonas gingivalis, Tannerella forsythia, and Prevotella intermedia, were clustered int

39 parvula, Dialister pneumosintes, Tannerella forsythia, and Prevotella nigrescens than SUP sites from

40 diosum, Porphyromonas gingivalis, Tannerella forsythia, and Selenomonas sputigena species than PH sub

41 P. gingivalis, P. intermedia, T. forsythia, and T. denticola were more prevalent in CP; h

42 s (RC) (Porphyromonas gingivalis, Tannerella forsythia, and T. denticola) in inducing disseminating i

43 obacterium, S-layer components in Tannerella forsythia, and tooth tissue-degrading enzymes in the ora

44 mitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were determined using

45 onas micra, P. gingivalis, P. intermedia, T. forsythia, and Treponema denticola.

46 mitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola.

47 pithelial cell attachment and invasion by T. forsythia are dependent on the BspA protein.

48 givalis, Treponema denticola, and Tannerella forsythia are periodontal pathogens associated with the

49 zed that P. gingivalis, T. denticola, and T. forsythia are synergistic in terms of virulence potentia

50 ted with P. gingivalis, T. denticola, and T. forsythia as a consortium.

51 ted with P. gingivalis, T. denticola, and T. forsythia as a polymicrobial infection.

52 sion, evidence is presented in support of T. forsythia as an important organism involved in inducing

53 givalis, Treponema denticola, and Tannerella forsythia, as an oral lavage every other week for 12 wee

54 givalis, Treponema denticola, and Tannerella forsythia, as well as Actinomyces viscosus, Campylobacte

55 evels of P. gingivalis, T. denticola, and T. forsythia, but not A. actinomycetemcomitans, in subgingi

56 Furthermore, mutant strains of T. forsythia, devoid of either mirolysin or karilysin, show

57 onas gingivalis, Prevotella spp., Tannerella forsythia, Dialister spp., Selenomonas spp., Catonella m

58 that F. nucleatum species synergize with T. forsythia during biofilm formation and pathogenesis.

59 givalis, Treponema denticola, and Tannerella forsythia for 12 weeks.

60 sum of Porphyromonas gingivalis, Tannerella forsythia (formally T. forsythensis), and Treponema dent

61 Tannerella forsythia (formerly Bacteroides forsythus) is one of the

62 emerged periodontopathic pathogen Tannerella forsythia (formerly Bacteroides forsythus), a Gram-negat

63 r of Porphyromonas gingivalis and Tannerella forsythia (formerly known as Bacteroides forsythus).

64 ern analysis of tissue extracts from zinnia, forsythia (Forsythia suspensa), tobacco (Nicotiana tabac

65 ence of Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedi

66 mitans, Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, Prevotella intermedi

67 th database indicates that the S-layer of T. forsythia has a unique structure exhibiting no homology

68 givalis, Treponema denticola, and Tannerella forsythia have been strongly implicated as members of a

69 th either P. gingivalis, T. denticola, or T. forsythia in monomicrobial infections or with all three

70 ivalis, Campylobacter rectus, and Tannerella forsythia) in vascular, blood, and subgingival samples.

71 ng and Th2 cells play pathogenic roles in T. forsythia-induced alveolar bone destruction.

72 in TLR2 or STAT6 result in resistance to T. forsythia-induced alveolar bone loss.

73 studies from our laboratory revealed that T. forsythia induces periodontal bone loss in mice and that

74 Furthermore, T. forsythia infection causes a pronounced Th2 bias, eviden

75 Native Forsythia intermedia dirigent protein isoforms were addi

76 Pinoresinol-(+)-lariciresinol reductase from Forsythia intermedia was used as a template for primer c

77 ecoisolariciresinol into (-)-matairesinol in Forsythia intermedia, was purified >6,000-fold to appare

78 (+)-pinoresinol-forming dirigent protein in Forsythia intermedia, whereas the presence of a (-)-pino

79 Tannerella forsythia is a dysbiotic member of the human oral microb

80 Tannerella forsythia is a gram-negative anaerobe strongly associate

81 Tannerella forsythia is a Gram-negative oral anaerobe which contrib

82 Tannerella forsythia is a poorly studied pathogen despite being one

83 though the gram-negative anaerobe Tannerella forsythia is also a vital contributor to periodontal bon

84 owed that coinfection of F. nucleatum and T. forsythia is more potent than infection with either spec

85 ng recognized by all complement pathways, T. forsythia is resistant to killing by human complement, w

86 Tannerella forsythia is strongly associated with chronic periodonti

87 from the human periodontopathogen Tannerella forsythia, is the only bacterial MMP to have been charac

88 ed with periodontal health, while Tannerella forsythia, its closest phylogenetic neighbor, is strongl

89 iously characterized metalloproteinase of T. forsythia, karilysin.

90 ted that P. gingivalis, T. denticola, and T. forsythia not only exist as a consortium that is associa

91 gival crevicular fluid samples containing T. forsythia obtained from patients with periodontitis.

92 ivalis, Treponema denticola, and "Tannerella forsythia" (opinion on name change from Tannerella forsy

93 (A. actinomycetemcomitans, P. gingivalis, T. forsythia, or C. rectus) were detected in subgingival sa

94 gatibacter actinomycetemcomitans, Tannerella forsythia, or Prevotella intermedia) versus those with o

95 P <0.001), P. gingivalis (P = 0.042), and T. forsythia (P <0.001) were significantly higher in smoker

96 ndex (p=0.004), vaginal levels of Tannerella forsythia (p=0.01), serum C-reactive protein (p=0.01), a

97 A. actinomycetemcomitans, P. gingivalis, T. forsythia, P. intermedia, and total bacteria significant

98 terial loads of Porphyromonas gingivalis, T. forsythia, Parvimonas micra, and total bacterial load we

99 s from the host or microbial competitors, T. forsythia possesses a serpin-type proteinase inhibitor c

100 rsus 9.8 x 10(5) cells; P <0.01), Tannerella forsythia (previously T. forsythensis) (16.2 x 10(5) cel

101 s), Porphyromonas gingivalis, and Tannerella forsythia (previously T. forsythensis) in their subgingi

102 for Porphyromonas gingivalis and Tannerella forsythia (previously T. forsythensis) was statistically

103 ingivalis, Prevotella intermedia, Tannerella forsythia (previously T. forsythensis), and Treponema de

104 rmedia, Porphyromonas gingivalis, Tannerella forsythia (previously T. forsythensis), and Treponema de

105 ticola, Porphyromonas gingivalis, Tannerella forsythia (previously T. forsythensis), Prevotella inter

106 gingivalis, Treponema denticola, Tannerella forsythia (previously T. forsythensis), Prevotella inter

107 comitans], Prevotella intermedia, Tannerella forsythia [previously T. forsythensis], Fusobacterium nu

108 unts of Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia (Pi), and Treponema den

109 tpartum, levels of P. gingivalis, Tannerella forsythia, Prevotella intermedia, and Prevotella nigresc

110 mutans, Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, Treponema denticola, a

111 Mean levels of P. gingivalis (r = 0.68), T. forsythia (r = 0.62), F. alocis (r = 0.51, P = 0.001), a

112 um with karilysin, a metalloproteinase of T. forsythia, resulted in a decrease in bactericidal activi

113 The present study shows that the T. forsythia S-layer is very unique, since it appears to be

114 viduals had higher proportions of Tannerella forsythia, Selenomonas noxia, and Neisseria mucosa.

115 that regulates the activity of endogenous T. forsythia serine proteases.

116 Porphyromonas gingivalis (Pg) and Tannerella forsythia, stimulate cytokine production in human monocy

117 T. forsythia strains expressing karilysin at higher levels

118 s of tissue extracts from zinnia, forsythia (Forsythia suspensa), tobacco (Nicotiana tabacum), alfalf

119 ata show that F. nucleatum subspecies and T. forsythia synergistically stimulate the host immune resp

120 Key pathogens P. gingivalis, T. forsythia, T. denticola, P. micra, C. rectus, and E. nod

121 ences were significant for P. gingivalis, T. forsythia, T. denticola, P. micra, C. rectus, and E. nod

122 Porphyromonas gingivalis and Tannerella forsythia (Tannerella forsythensis) were associated with

123 Tannerella forsythia (Tf) is a Gram-negative anaerobe implicated in

124 (Pg), Prevotella intermedia (Pi), Tannerella forsythia (Tf), and Fusobacterium nucleatum (Fn).

125 acter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), and gingival crevicular fluid (GCF) conc

126 of Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), and Treponema denticola (Td) was perform

127 s, Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Treponema denticola (Td), and Dialister

128 ), Campylobacter rectus (Cr), and Tannerella forsythia (Tf).

129 gingivalis, A. actinomycetemcomitans, and T. forsythia than never-smokers.

130 We found the periodontal pathogen Tannerella forsythia to be associated with higher risk of EAC.

131 Vs enhance the attachment and invasion of T. forsythia to epithelial cells.

132 xylem fibers, and phloem fibers in stems of forsythia, tobacco, alfalfa, soybean, and tomato (Lycope

133 was evident in xylem ray parenchyma cells of forsythia, tobacco, and tomato.

134 ncisus, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Candida albicans.

135 mitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Prevotella intermedi

136 mitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Streptococcus oralis

137 mitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Streptococcus oralis, an

138 h as Porphyromonas gingivalis and Tannerella forsythia, use disulfide bonds to stabilize their outer

139 ction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allo

140 skii, Dialister pneumosintes, and Tannerella forsythia were elevated in this group, while Veillonella

141 as gingivalis, Prevotella intermedia, and T. forsythia were significantly more present around implant

142 etween groups were only found for Tannerella forsythia, which was 8.7 times more frequent at peri-imp

143 as gingivalis (P. gingivalis) and Tannerella forsythia who completed initial therapy were randomly as

144 eolar bone loss in mice infected with the T. forsythia wild-type strain, whereas the BspA mutant was

145 periodontal health-associated" taxon with T. forsythia will be valuable in investigating virulence fa

146 d by the long and intimate association of T. forsythia with the human gingiva.