ライフサイエンスコーパス: Francisella

1 e type of cells that are first infected with Francisella.

2 ng MglA/SspA and FevR (PigR) interactions in Francisella.

3 ion against the live vaccine strain (LVS) of Francisella.

4 mmatory pathways in the extreme virulence of Francisella.

5 a mechanism of evasion for cytosol-invasive Francisella.

6 fferent cellular stress response pathways in Francisella.

7 rated, inflammatory response advantageous to Francisella.

8 n of the outer membrane component lipid A in Francisella.

9 contribution of mast cell/TLR regulation of Francisella.

10 rved among the species and subpopulations of Francisella.

11 Thus, Francisella acid phosphatases play a major role in intra

12 Unexpectedly, our results demonstrate that Francisella activates the NLRP3 inflammasome in human ce

13 cking for the virulence factors expressed by Francisella and how these factors are secreted and deliv

14 ted effectors mediating interactions between Francisella and its host significantly advances our unde

15 ses against DNA viruses and bacteria such as Francisella and Listeria.

16 bI enoyl-ACP reductase enzyme inhibitors for Francisella and other select agents.

17 we identified the early interactions between Francisella and the host following two different routes

18 ation in response to Legionella, Salmonella, Francisella, and Listeria.

19 including Burkholderia, Shigella, Listeria, Francisella, and Mycobacterium species.

20 An anti-Francisella antibody (FB11) was used for the detection t

21 stress resistance by affecting secretion of Francisella antioxidant enzymes SodB and KatG.

22 dy, we examined the interaction of wild-type Francisella asiatica and a Delta iglC mutant strain with

23 entified in many biothreat agents, including Francisella, Brucella, Bacillus, Burkholderia, and Yersi

24 ic receptors alter the intracellular fate of Francisella by delivering bacteria through phagocytic pa

25 ilure to upregulate pfkfb3 We also show that Francisella capsule is required for this process.

26 Of special note were genes in a locus of the Francisella chromosome, FTT1236, FTT1237, and FTT1238.

27 iated uptake delayed maturation of the early Francisella-containing phagosome (FCP) and restricted ph

28 hesis and required for rapid escape from the Francisella-containing phagosome (FCP).

29 Francisella contains only three response regulators, mak

30 inhibition further supporting the binding of Francisella DnaK to alkaline phosphatase.

31 substantially but not completely impair the Francisella-elicited IL-1beta response, suggesting the i

32 However, Francisella-encoded factors and mechanisms responsible f

33 We detected a Francisella endosymbiont in 174 ticks (70%), and Rickett

34 (+) T cell responses and that elucidation of Francisella epitopes that elicit high-avidity CD4(+) T c

35 However, the Francisella factors and the mechanisms through which F.

36 The Francisella FTT0831c/FTL_0325 gene encodes amino acid mo

37 Together, these data suggest a model of Francisella gene regulation that includes a TCS consisti

38 response making the host more susceptible to Francisella growth.

39 acid phosphatase secretion by intracellular Francisella has not been shown.

40 ts establish NLRP3 as a cytosolic sensor for Francisella in human cells, a role not observed in mouse

41 e receptor 2 agonists during rapid growth of Francisella in vitro and in vivo.

42 m likely evolved from a pathogenic strain of Francisella, indicating that tick endosymbionts can evol

43 In summary, virulent Francisella induces a unique pulmonary inflammatory resp

44 d IFN-gamma in the lungs during inhalational Francisella infection and that these cytokines additivel

45 gain more insight into the host response to Francisella infection during the acute stage, transcript

46 In mice, Francisella infection leads to seemingly exclusive activ

47 Francisella infection of THP-1 cells elicits IL-1beta pr

48 mine the IL-1beta response of human cells to Francisella infection.

49 Francisella infections are characterized by a delayed im

50 The importance of the MEP pathway to Francisella is demonstrated by the fact that MEP pathway

51 in the current study, we identified a novel Francisella-like endosymbiont (FLEs-Hd) from the tick Ha

52 lla tularensis, as well as Coxiella-like and Francisella-like endosymbionts (CLEs and FLEs, respectiv

53 Francisella-like endosymbionts (FLEs) with significant h

54 bors, including Francisella philomiragia and Francisella-like endosymbionts found in ticks.

55 A when expressing both the hydrolase and the Francisella lipid A 1-phosphatase (LpxE).

56 The lipid A moiety of Francisella LPS is linked to the core domain by a single

57 These results suggest that the attenuated Francisella LVS induces significant host cell signaling

58 of FITC-dextran and amiloride inhibition of Francisella LVS uptake.

59 fashion to in vivo observations, addition of Francisella lysate to exogenous alkaline phosphatase (ti

60 Various in vitro models of Francisella-macrophage interactions have been developed,

61 alkaline phosphatase as well as reduction of Francisella-mediated alkaline phosphatase inhibition fur

62 owever, to establish an intracellular niche, Francisella must overcome the oxidative stress posed by

63 on with the fish-specific bacterial pathogen Francisella noatunensis, primary leukocytes from adult z

64 demonstrated that the Cas9 endonuclease from Francisella novicida (FnCas9) is capable of targeting en

65 A resolution crystal structures of Cas9 from Francisella novicida (FnCas9), one of the largest Cas9 o

66 tion of the DNA-sensing AIM2 inflammasome by Francisella novicida and contributed to the activation o

67 rm to explore the intracellular lifestyle of Francisella novicida and discovered that the iglC gene i

68 we characterized the pantothenate pathway in Francisella novicida and F. tularensis and identified an

69 Using known virulence mutants of Francisella novicida and Histoplasma capsulatum, we conf

70 acement, we screened the Cpf1 nucleases from Francisella novicida and Lachnospiraceae bacterium ND200

71 two model intracellular bacterial pathogens, Francisella novicida and Salmonella typhimurium.

72 Using Francisella novicida as a model organism, a bacterial li

73 We describe a rare case of Francisella novicida bacteremia following a near-drownin

74 sistance to the cytosolic bacterial pathogen Francisella novicida Genetic deletion or pharmacological

75 la tularensis (A1a, A1b, A2, and type B) and Francisella novicida has identified multiple differences

76 ays and superior antibiotic activity against Francisella novicida in cell culture.

77 Francisella novicida is a rare cause of human illness de

78 stem of the intracellular bacterial pathogen Francisella novicida is involved in enhancing envelope i

79 ) and E. coli panE functionally complemented Francisella novicida lacking any KPR.

80 Here we show that the type II-B FnCas9 from Francisella novicida possesses novel properties, but its

81 We identified growth conditions under which Francisella novicida produces abundant OMV.

82 and they fail to provide protection against Francisella novicida upon adoptive transfer.

83 we demonstrate that the Cas protein Cas9 of Francisella novicida uses a unique, small, CRISPR/Cas-as

84 coccus thermophilus II-A CRISPR1 (Cas9), and Francisella novicida V-A (Cpf1) systems.

85 ida (herein referred to by its earlier name, Francisella novicida) attenuated strains, the DeltaiglB

86 of a lipid A phosphate with galactosamine in Francisella novicida, a model organism for the study of

87 ium and transfection of LPS, AIM2 activators Francisella novicida, mouse cytomegalovirus and DNA, and

88 We used a model intracellular pathogen, Francisella novicida, to begin characterizing the type I

89 ve bacteria vs the closely related bacterium Francisella novocida.

90 for polysaccharide biosynthesis and that the Francisella O antigen, capsule, or both are important fo

91 IglE is exported to the Francisella outer membrane as an approximately 13.9-kDa

92 The virulence factors mediating Francisella pathogenesis are being investigated, with an

93 tanding of the functions of these enzymes in Francisella pathogenesis.

94 owth by binding directly to promoters on the Francisella Pathogenicity Island (FPI) and positively re

95 pe VI secretion system (T6SS) encoded by the Francisella pathogenicity island (FPI) is critical for t

96 F. novicida DeltaiglB, a Francisella pathogenicity island (FPI) mutant, is defici

97 e growth is dependent upon the regulation of Francisella pathogenicity island (FPI) virulence genes,

98 is virulence stems from genes encoded on the Francisella pathogenicity island (FPI).

99 pothetical protein encoded by the duplicated Francisella pathogenicity island (FPI).

100 The Francisella pathogenicity island, required for bacterial

101 onal iglI, iglJ, or pdpC, three genes of the Francisella pathogenicity island.

102 ave been reported to play important roles in Francisella phagosomal escape, inhibition of the respira

103 screpant results on the timing and extent of Francisella phagosomal escape.

104 mily (MFS) transporters, and the nine-member Francisella phagosomal transporter (Fpt) subfamily posse

105 novicida and other near neighbors, including Francisella philomiragia and Francisella-like endosymbio

106 firmed with MALDI-TOF/MS spectra acquired on Francisella philomiragia ATCC 25015 and on Francisella t

107 Francisella philomiragia is a saprophytic gammaproteobac

108 We previously identified a Francisella protein, FTN_0818, as being essential for in

109 vides new information to help understand how Francisella regulates its virulence genes in response to

110 An unusual set of Francisella regulators-the heteromeric macrophage growth

111 ave been performed with avirulent strains of Francisella, relatively little has been done with strain

112 lasmic membrane protein RipA is required for Francisella replication within macrophages and other cel

113 strains, we combined the control of in vitro Francisella replication within macrophages with gene exp

114 o cope with their intracellular environment, Francisella requires multiple virulence factors, which a

115 n trans from attTn7 under the control of the Francisella rpsL promoter, thereby establishing that the

116 which is found in the iglABCD operon in the Francisella sp. pathogenicity island (FPI).

117 s or pseudogenes was found to differ between Francisella species and F. tularensis subspecies and sub

118 TT1388), which is conserved in all sequenced Francisella species and is the sole KPR in Schu S4.

119 Francisella species express lipid A molecules with uniqu

120 acillus, presumptively identified as a novel Francisella species via 16S rRNA and multilocus gene seq

121 ctrum could enable (i) the identification of Francisella species, and (ii) the prediction of their vi

122 RipA is conserved among all sequenced Francisella species, and RipA-like proteins are present

123 unknown function but highly conserved among Francisella species, was identified in this screen to be

124 of virulent strain Schu S4 and are unique to Francisella species.

125 ion that had not been previously observed in Francisella species.

126 ure was associated with altered abundance of Francisella-specific transcripts, including those associ

127 pneumoniae) suggesting the inhibition may be Francisella-specific.

128 sed by the intracellular bacterial pathogens Francisella spp. and Brucella spp. to manipulate compone

129 y, promoting cytosolic growth in the case of Francisella spp. and facilitating cellular egress and ce

130 Francisella spp. are highly infectious and virulent bact

131 Because some Francisella strains are very virulent, this species is c

132 Francisella strains exhibit differences in IL-1beta prod

133 Following generation of various Francisella strains expressing well-characterized lympho

134 distinguish between virulent and nonvirulent Francisella strains is desirable.

135 t the same size as the genomes of pathogenic Francisella strains, about one-third of its protein-codi

136 bsp. tularensis CCUG 2112, the most virulent Francisella subspecies.

137 As an intracellular pathogen, Francisella survives and replicates in phagocytic cells,

138 o required for early replication of virulent Francisella Taken together, our data demonstrate that me

139 s been conducted using attenuated strains of Francisella that do not cause disease in humans.

140 st simultaneous measurement of both host and Francisella transcriptome changes that occur during in v

141 Moreover, in reconstituted 293T cells, Francisella triggers assembly of the NLRP3 inflammasome

142 Genotyping of Francisella tularensis (A1a, A1b, A2, and type B) and Fr

143 Francisella tularensis (Ft) is a highly infectious intra

144 Francisella tularensis (Ft), the Gram-negative facultati

145 ymbionts (FLEs) with significant homology to Francisella tularensis (gamma-proteobacteria) have been

146 onstrated that targeting fixed (inactivated) Francisella tularensis (iFT) organisms to FcR in mice i.

147 w-derived macrophages (BMDMs) to inactivated Francisella tularensis (iFt)-containing immune complexes

148 ion of the lipid A 1-phosphatase, LpxE, from Francisella tularensis allowed us to construct recombina

149 aureus (MRSA) and priority pathogens such as Francisella tularensis and Burkholderia pseudomallei.

150 cted in membranes of Helicobacter pylori and Francisella tularensis and may be responsible for the re

151 r nodosus and FtPilE from the human pathogen Francisella tularensis at 2.3 and 1 A resolution, respec

152 O-antigen of the lipopolysaccharide (LPS) of Francisella tularensis bacteria, a Tier 1 Select Agent o

153 Schu S4 strain of the intracellular pathogen Francisella tularensis by host macrophages involves CR3/

154 urface exposed and required for virulence of Francisella tularensis by subverting the host innate imm

155 Francisella tularensis causes a lethal human disease kno

156 Francisella tularensis causes lethal pneumonia following

157 Francisella tularensis causes the human disease tularemi

158 The intracellular bacterial pathogen Francisella tularensis causes tularemia, a zoonosis that

159 R recruitment, we evaluated Escherichia coli-Francisella tularensis chimeric variants of tmRNA and Sm

160 Infection with Francisella tularensis elicits innate and adaptive immun

161 The intracellular pathogen Francisella tularensis encodes a disulfide bond formatio

162 he identification of novel inhibitors of the Francisella tularensis FabI target.

163 se appears to contribute to the virulence of Francisella tularensis following pulmonary infection.

164 The pathogenesis of Francisella tularensis has been associated with this bac

165 In both cases, forward primer for Francisella tularensis holarctica genomic DNA was surfac

166 Francisella tularensis in an intracellular bacterial pat

167 re required for intracellular replication of Francisella tularensis in J774A.1 macrophages.

168 ion of the lipid A 1-phosphatase, LpxE, from Francisella tularensis in Y. pestis yields predominantly

169 Francisella tularensis induces the synthesis of prostagl

170 used by the Gram-negative bacterial pathogen Francisella tularensis Infection of macrophages and thei

171 ocked Th17 cell generation in the lung after Francisella tularensis infection, and inhibited the incr

172 ences in the epidemiology of F. novicida and Francisella tularensis infections.

173 Francisella tularensis is a bacterium capable of infecti

174 Francisella tularensis is a bacterium replicating within

175 Francisella tularensis is a category A biodefence agent

176 Francisella tularensis is a facultative bacterial pathog

177 Francisella tularensis is a facultative intracellular ba

178 Francisella tularensis is a facultative intracellular ba

179 Francisella tularensis is a facultative intracellular ba

180 Francisella tularensis is a facultative intracellular ba

181 Francisella tularensis is a facultative intracellular, G

182 Francisella tularensis is a Gram-negative bacterium and

183 Francisella tularensis is a gram-negative bacterium that

184 Francisella tularensis is a Gram-negative coccobacillus

185 Francisella tularensis is a highly infectious bacterium

186 Francisella tularensis is a highly infectious intracellu

187 Francisella tularensis is a highly virulent Gram-negativ

188 Francisella tularensis is a highly virulent Gram-negativ

189 Francisella tularensis is a potential bioterrorism agent

190 Francisella tularensis is a remarkably infectious facult

191 Francisella tularensis is able to survive and replicate

192 Francisella tularensis is an important human pathogen re

193 Pulmonary exposure to Francisella tularensis is associated with severe lung pa

194 A fundamental step in the life cycle of Francisella tularensis is bacterial entry into host cell

195 Francisella tularensis is capable of rampant intracellul

196 Francisella tularensis is classified as a category A pri

197 A licensed vaccine against Francisella tularensis is currently not available.

198 The adaptive immune response to Francisella tularensis is dependent on the route of inoc

199 The bacterium Francisella tularensis is recognized for its virulence,

200 Francisella tularensis is the causative agent of the deb

201 Francisella tularensis is the causative agent of tularem

202 Francisella tularensis is the causative agent of tularem

203 Francisella tularensis is the causative agent of tularem

204 Francisella tularensis is the causative agent of tularem

205 Francisella tularensis is the etiological agent of tular

206 IKKs in myeloid cells in vivo in response to Francisella tularensis Live Vaccine Strain (Ft. LVS) inf

207 subset in the lungs of mice during pulmonary Francisella tularensis live vaccine strain (LVS) infecti

208 We employed Francisella tularensis live vaccine strain (LVS) to stud

209 of mice infected with sublethal doses of the Francisella tularensis live vaccine strain (LVS).

210 ammation, priming with glycolipid (FtL) from Francisella tularensis live vaccine strain induces splen

211 hown that priming with glycolipid (FtL) from Francisella tularensis live-vaccine strain (i) induces F

212 The Francisella tularensis pathogenicity island (FPI) encode

213 Francisella tularensis produces a lipopolysaccharide (LP

214 the production of IL-4, effectively control Francisella tularensis replication.

215 virulence determinants from the select agent Francisella tularensis SCHU S4.

216 study, we describe novel inhibitors against Francisella tularensis SchuS4 FabI identified from struc

217 The Gram-negative pathogen Francisella tularensis secretes a siderophore to obtain

218 llular bacterial pathogens, such as virulent Francisella tularensis spp. tularensis (Ftt).

219 n lung tissue from mice exposed to virulent (Francisella tularensis ssp tularensis SchuS4).

220 , which encode putative TPR-like proteins in Francisella tularensis subsp. holarctica FSC200.

221 -flight (MALDI-TOF) mass spectrometry on the Francisella tularensis subsp. holarctica LVS defined thr

222 Two Francisella tularensis subsp. novicida (herein referred

223 In this study, we demonstrated that Francisella tularensis subsp. novicida, for which a comp

224 b O-PS gene cluster from the highly virulent Francisella tularensis subsp. tularensis (type A) strain

225 n Francisella philomiragia ATCC 25015 and on Francisella tularensis subsp. tularensis CCUG 2112, the

226 Francisella tularensis subsp. tularensis is a highly inf

227 Francisella tularensis subsp. tularensis is the etiologi

228 n of the virulent prototypical type A strain Francisella tularensis subsp. tularensis Schu S4 affects

229 Inactivation of both copies of iglE rendered Francisella tularensis subsp. tularensis Schu S4 avirule

230 Francisella tularensis subsp. tularensis Schu S4 is a zo

231 scribe the isolation and characterization of Francisella tularensis subsp. tularensis strain Schu S4

232 In Francisella tularensis subsp. tularensis, DsbA has been

233 AIM2 inflammasome during infection with the Francisella tularensis subspecies novicida (F. novicida)

234 onal exposure to lethal doses of aerosolized Francisella tularensis subspecies tularensis, strain SCH

235 almonella, Yersinia pestis, and the virulent Francisella tularensis subspecies.

236 taxonomical level with the identification of Francisella tularensis subspecies.

237 cus efforts on the highly virulent bacterium Francisella tularensis tularensis.

238 ts ortholog FTT_0166c in the highly virulent Francisella tularensis type A strain SchuS4 are required

239 elates of vaccine-induced protection against Francisella tularensis using murine splenocytes and furt

240 The Gram-negative bacterium Francisella tularensis utilizes its antioxidant armature

241 Thus, IglE is essential for Francisella tularensis virulence.

242 of animals as early as 4 hrs post-exposure, Francisella tularensis was associated with an almost com

243 rticularly good antibacterial effect against Francisella tularensis, a Category A biowarfare pathogen

244 Francisella tularensis, a Gram-negative bacterium, is th

245 spp., Toxoplasma gondii, Coxiella burnetii, Francisella tularensis, and Neospora caninum, estimate c

246 lian pathogens such as Coxiella burnetii and Francisella tularensis, as well as Coxiella-like and Fra

247 We found that viable Francisella tularensis, as well as Salmonella enterica b

248 anisms (Bacillus anthracis, Yersinia pestis, Francisella tularensis, Brucella spp., Burkholderia spp.

249 ains of Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia mallei, Burkholderi

250 protection against infection with attenuated Francisella tularensis, but their role in infection medi

251 FipB, an essential virulence factor of Francisella tularensis, is a lipoprotein with two conser

252 tularemia, a zoonose caused by the bacterium Francisella tularensis, largely refer to Parinaud's ocul

253 eumonic tularemia is caused by inhalation of Francisella tularensis, one of the most infectious micro

254 to various assemblies of the loblolly pine, Francisella tularensis, rice and budgerigar genomes.

255 ss despite its close genetic relationship to Francisella tularensis, the agent of tularemia.

256 Francisella tularensis, the bacterial cause of tularemia

257 Francisella tularensis, the causative agent of a fatal h

258 Francisella tularensis, the causative agent of tularemia

259 Francisella tularensis, the causative agent of tularemia

260 Francisella tularensis, the causative agent of tularemia

261 Francisella tularensis, the causative agent of tularemia

262 Francisella tularensis, the causative agent of tularemia

263 Francisella tularensis, the causative agent of tularemia

264 Francisella tularensis, the causative agent of tularemia

265 Francisella tularensis, the etiological agent of tularem

266 In Francisella tularensis, the putative DNA-binding protein

267 including virulent strains of the bacterium Francisella tularensis, to enable colonization and infec

268 ogens, such as the highly virulent bacterium Francisella tularensis, to ensure their replication and

269 Following pulmonary infection with Francisella tularensis, we observed an unexpected but si

270 Francisella tularensis, which is a Gram negative bacteri

271 _1680/FTT_0166c as a new virulence factor in Francisella tularensis.

272 ed by a Gram-negative coccoid rod bacterium, Francisella tularensis.

273 been reported with Dichelobacter nodosus and Francisella tularensis.

274 uivalent but highly divergent sequences from Francisella tularensis.

275 on by using the live vaccine strain (LVS) of Francisella tularensis.

276 0) in cutaneous and pulmonary infection with Francisella tularensis.

277 by infection by the gram-negative bacterium, Francisella tularensis.

278 infections using Rift Valley fever virus and Francisella tularensis.

279 ress and virulence by the bacterial pathogen Francisella tularensis.

280 ent of tularemia and category A select agent Francisella tularensis.

281 a category A intracellular mucosal pathogen, Francisella tularensis.

282 el organism for the study of highly virulent Francisella tularensis.

283 ellular pathogens Listeria monocytogenes and Francisella tularensis.

284 he highly infectious intracellular bacterium Francisella tularensis.

285 ss caused by the category A biodefense agent Francisella tularensis.

286 the highly infectious and zoonotic pathogen Francisella tularensis.

287 (EHEC and UPEC), Salmonella typhimurium, and Francisella tularensis.

288 mulation would protect the host from inhaled Francisella tularensis.

289 TLR2-activating human intracellular pathogen Francisella tularensis.

290 cated in the O-antigen biosynthetic locus of Francisella tularensis.

291 in Bacillus anthracis, Yersinia pestis, and Francisella tularensis.

292 r the intramacrophage growth and survival of Francisella tularensis.

293 llenge with the live vaccine strain (LVS) of Francisella tularensis.

294 es of the Gram-negative facultative anaerobe Francisella tularensis: F. tularensis subsp. tularensis

295 pectrum efficacy against Bacillus anthracis; Francisella tularensis; Coxiella burnetii; and Ebola, Ma

296 C3-dependent Francisella uptake alone was insufficient to induce macr

297 analysis of purified OMV/T identified known Francisella virulence factors among the constituent prot

298 ly identified a gene (FTN_0818) required for Francisella virulence that seemed likely involved in bio

299 infection, is also involved in coordinating Francisella virulence; however, its role has been unclea

300 ment is a particularly effective opsonin for Francisella, we asked whether complement-dependent uptak