ライフサイエンスコーパス: Francisella tularensis

1 ress and virulence by the bacterial pathogen Francisella tularensis.

2 ent of tularemia and category A select agent Francisella tularensis.

3 a category A intracellular mucosal pathogen, Francisella tularensis.

4 el organism for the study of highly virulent Francisella tularensis.

5 ellular pathogens Listeria monocytogenes and Francisella tularensis.

6 he highly infectious intracellular bacterium Francisella tularensis.

7 ss caused by the category A biodefense agent Francisella tularensis.

8 the highly infectious and zoonotic pathogen Francisella tularensis.

9 (EHEC and UPEC), Salmonella typhimurium, and Francisella tularensis.

10 mulation would protect the host from inhaled Francisella tularensis.

11 TLR2-activating human intracellular pathogen Francisella tularensis.

12 cated in the O-antigen biosynthetic locus of Francisella tularensis.

13 is caused by the category A biodefense agent Francisella tularensis.

14 on of T helper 1 (Th1) cell immunity against Francisella tularensis.

15 in the protective innate immune response to Francisella tularensis.

16 in Bacillus anthracis, Yersinia pestis, and Francisella tularensis.

17 r the intramacrophage growth and survival of Francisella tularensis.

18 with the facultative intracellular bacterium Francisella tularensis.

19 with Gram-negative Salmonella typhimurium or Francisella tularensis.

20 er vacuolar pathogens, Coxiella burnetii and Francisella tularensis.

21 llenge with the live vaccine strain (LVS) of Francisella tularensis.

22 _1680/FTT_0166c as a new virulence factor in Francisella tularensis.

23 ed by a Gram-negative coccoid rod bacterium, Francisella tularensis.

24 been reported with Dichelobacter nodosus and Francisella tularensis.

25 uivalent but highly divergent sequences from Francisella tularensis.

26 on by using the live vaccine strain (LVS) of Francisella tularensis.

27 0) in cutaneous and pulmonary infection with Francisella tularensis.

28 by infection by the gram-negative bacterium, Francisella tularensis.

29 infections using Rift Valley fever virus and Francisella tularensis.

30 from individuals infected with the bacteria Francisella tularensis, a category A biodefense pathogen

31 th the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat a

32 rticularly good antibacterial effect against Francisella tularensis, a Category A biowarfare pathogen

33 Francisella tularensis, a gram-negative bacterium, is th

34 Francisella tularensis, a Gram-negative bacterium, is th

35 Francisella tularensis, a gram-negative facultative intr

36 e attenuated vaccine is needed for combating Francisella tularensis, a highly infectious bacterial pa

37 macrophages the intracellular life cycle of Francisella tularensis, a highly infectious bacterium th

38 of genes that contribute to the virulence of Francisella tularensis, a highly infectious pathogen and

39 Francisella tularensis, a highly virulent facultative in

40 Francisella tularensis, a small gram-negative intracellu

41 Genotyping of Francisella tularensis (A1a, A1b, A2, and type B) and Fr

42 In disease mediated by Francisella tularensis, Ab can effectively protect again

43 chanisms by which virulent type A strains of Francisella tularensis accomplish this evasion are not u

44 ion of the lipid A 1-phosphatase, LpxE, from Francisella tularensis allowed us to construct recombina

45 However, a comparative genome analysis of Francisella tularensis allowed us to predict the existen

46 vation in response to intracellular pathogen Francisella tularensis also required AIM2.

47 Francisella tularensis, an aerobic, non-spore-forming, g

48 Francisella tularensis, an intracellular pathogen, is hi

49 aureus (MRSA) and priority pathogens such as Francisella tularensis and Burkholderia pseudomallei.

50 cted in membranes of Helicobacter pylori and Francisella tularensis and may be responsible for the re

51 and Prevention Category A bioterrorism agent Francisella tularensis and prototype of a superfamily of

52 Francisella tularensis and related intracellular pathoge

53 Simulation tests for Francisella tularensis and Yersinia pestis, using a well

54 agilis, Bacillus anthracis, Yersinia pestis, Francisella tularensis, and Brucella abortus), the last

55 spp., Toxoplasma gondii, Coxiella burnetii, Francisella tularensis, and Neospora caninum, estimate c

56 for Yersinia pestis and 250 fingerprints for Francisella tularensis are presented.

57 Francisella tularensis are the causative agent of the zo

58 dentified the two major lipid A species from Francisella tularensis as asymmetric tetraacylated struc

59 hances murine susceptibility to infection by Francisella tularensis as indicated by accelerated morta

60 lian pathogens such as Coxiella burnetii and Francisella tularensis, as well as Coxiella-like and Fra

61 We found that viable Francisella tularensis, as well as Salmonella enterica b

62 r nodosus and FtPilE from the human pathogen Francisella tularensis at 2.3 and 1 A resolution, respec

63 ae, Pseudomonas aeruginosa, Yersinia pestis, Francisella tularensis, Bacillus anthracis and Vibrio ch

64 O-antigen of the lipopolysaccharide (LPS) of Francisella tularensis bacteria, a Tier 1 Select Agent o

65 The inhalation of Francisella tularensis biovar A causes pneumonic tularem

66 racis, Yersinia pestis, Burkholderia mallei, Francisella tularensis, Brucella abortus, and ricin.

67 ned for Bacillus anthracis, Yersinia pestis, Francisella tularensis, Brucella melitensis, Clostridium

68 anisms (Bacillus anthracis, Yersinia pestis, Francisella tularensis, Brucella spp., Burkholderia spp.

69 ains of Bacillus anthracis, Yersinia pestis, Francisella tularensis, Burkholderia mallei, Burkholderi

70 protection against infection with attenuated Francisella tularensis, but their role in infection medi

71 Schu S4 strain of the intracellular pathogen Francisella tularensis by host macrophages involves CR3/

72 urface exposed and required for virulence of Francisella tularensis by subverting the host innate imm

73 Francisella tularensis can cause severe disseminated dis

74 Francisella tularensis causes a lethal human disease kno

75 egative, facultative intracellular bacterium Francisella tularensis causes acute, lethal pneumonic di

76 Francisella tularensis causes lethal pneumonia following

77 Francisella tularensis causes systemic disease in humans

78 Francisella tularensis causes the human disease tularemi

79 The facultative intracellular bacterium Francisella tularensis causes the zoonotic disease tular

80 Francisella tularensis causes tularemia, a highly contag

81 The intracellular bacterial pathogen Francisella tularensis causes tularemia, a zoonosis that

82 R recruitment, we evaluated Escherichia coli-Francisella tularensis chimeric variants of tmRNA and Sm

83 Francisella tularensis contains four putative acid phosp

84 Francisella tularensis contains several highly pathogeni

85 pectrum efficacy against Bacillus anthracis; Francisella tularensis; Coxiella burnetii; and Ebola, Ma

86 Francisella tularensis, detected by specific antibodies,

87 Infection with Francisella tularensis elicits innate and adaptive immun

88 The intracellular pathogen Francisella tularensis encodes a disulfide bond formatio

89 Following uptake, Francisella tularensis enters a phagosome that acquires

90 chanisms by which the intracellular pathogen Francisella tularensis evades innate immunity are not we

91 VS and Schu S4 strains of the human pathogen Francisella tularensis express a siderophore when grown

92 es of the Gram-negative facultative anaerobe Francisella tularensis: F. tularensis subsp. tularensis

93 he identification of novel inhibitors of the Francisella tularensis FabI target.

94 se appears to contribute to the virulence of Francisella tularensis following pulmonary infection.

95 Francisella tularensis (Ft) is a highly infectious intra

96 The bacterium Francisella tularensis (Ft) is a potential weapon of bio

97 The macrophage proinflammatory response to Francisella tularensis (Ft) live vaccine strain (LVS) wa

98 Francisella tularensis (Ft), a gram-negative intracellul

99 Francisella tularensis (Ft), a Gram-negative intracellul

100 Francisella tularensis (Ft), the causative agent of tula

101 Francisella tularensis (Ft), the Gram-negative facultati

102 cid phosphatase from the category A pathogen Francisella tularensis (FtHAP) has been implicated in in

103 ymbionts (FLEs) with significant homology to Francisella tularensis (gamma-proteobacteria) have been

104 The pathogenesis of Francisella tularensis has been associated with this bac

105 Francisella tularensis has been shown to target multiple

106 accinations with the intracellular bacterium Francisella tularensis have been studied using the live

107 In both cases, forward primer for Francisella tularensis holarctica genomic DNA was surfac

108 the comparison between the genome of LVS and Francisella tularensis holarctica strain FSC200, which d

109 onstrated that targeting fixed (inactivated) Francisella tularensis (iFT) organisms to FcR in mice i.

110 w-derived macrophages (BMDMs) to inactivated Francisella tularensis (iFt)-containing immune complexes

111 Francisella tularensis in an intracellular bacterial pat

112 re required for intracellular replication of Francisella tularensis in J774A.1 macrophages.

113 ion of the lipid A 1-phosphatase, LpxE, from Francisella tularensis in Y. pestis yields predominantly

114 Francisella tularensis induces the synthesis of prostagl

115 Two key routes of Francisella tularensis infection are through the skin an

116 used by the Gram-negative bacterial pathogen Francisella tularensis Infection of macrophages and thei

117 ocked Th17 cell generation in the lung after Francisella tularensis infection, and inhibited the incr

118 ences in the epidemiology of F. novicida and Francisella tularensis infections.

119 Francisella tularensis infects wild animals and humans t

120 In observing Francisella tularensis interactions with nonphagocytic c

121 Francisella tularensis is a bacterial pathogen that caus

122 Francisella tularensis is a bacterium capable of infecti

123 Francisella tularensis is a bacterium replicating within

124 Francisella tularensis is a category A agent of biowarfa

125 Francisella tularensis is a category A biodefence agent

126 Francisella tularensis is a category A biothreat agent f

127 Francisella tularensis is a category A intracellular muc

128 Francisella tularensis is a facultative bacterial pathog

129 Francisella tularensis is a facultative intracellular ba

130 Francisella tularensis is a facultative intracellular ba

131 Francisella tularensis is a facultative intracellular ba

132 Francisella tularensis is a facultative intracellular ba

133 Francisella tularensis is a facultative intracellular pa

134 The highly infectious bacterium Francisella tularensis is a facultative intracellular pa

135 Francisella tularensis is a facultative intracellular pa

136 Francisella tularensis is a facultative intracellular pa

137 Francisella tularensis is a facultative intracellular pa

138 Francisella tularensis is a facultative intracellular, G

139 Francisella tularensis is a Gram-negative bacterium and

140 Francisella tularensis is a gram-negative bacterium that

141 Francisella tularensis is a Gram-negative bacterium that

142 Francisella tularensis is a Gram-negative coccobacillus

143 Francisella tularensis is a gram-negative coccobacillus

144 Francisella tularensis is a gram-negative intracellular

145 Francisella tularensis is a Gram-negative intracellular

146 Francisella tularensis is a gram-negative intracellular

147 Francisella tularensis is a gram-negative intracellular

148 Francisella tularensis is a gram-negative pathogen that

149 Francisella tularensis is a gram-negative, highly infect

150 Francisella tularensis is a highly infectious bacterial

151 Francisella tularensis is a highly infectious bacterium

152 Francisella tularensis is a highly infectious gram-negat

153 Francisella tularensis is a highly infectious intracellu

154 Francisella tularensis is a highly infectious pathogen t

155 Francisella tularensis is a highly virulent bacterial pa

156 Francisella tularensis is a highly virulent Gram-negativ

157 Francisella tularensis is a highly virulent Gram-negativ

158 Francisella tularensis is a pathogen optimally adapted t

159 Francisella tularensis is a pathogenic bacterium whose v

160 Francisella tularensis is a potential bioterrorism agent

161 Francisella tularensis is a remarkably infectious facult

162 Francisella tularensis is able to survive and replicate

163 Francisella tularensis is an important human pathogen re

164 Francisella tularensis is an intracellular gram-negative

165 Francisella tularensis is an intracellular gram-negative

166 Francisella tularensis is an intracellular pathogen that

167 Francisella tularensis is an intracellular pathogen whos

168 Francisella tularensis is an intracellular, Gram-negativ

169 Francisella tularensis is an obligate, intracellular bac

170 Pulmonary exposure to Francisella tularensis is associated with severe lung pa

171 A fundamental step in the life cycle of Francisella tularensis is bacterial entry into host cell

172 The facultative intracellular bacterium Francisella tularensis is capable of causing systemic in

173 Francisella tularensis is capable of rampant intracellul

174 Francisella tularensis is classified as a category A pri

175 A licensed vaccine against Francisella tularensis is currently not available.

176 The adaptive immune response to Francisella tularensis is dependent on the route of inoc

177 the highly infectious intracellular pathogen Francisella tularensis is directly related with the abil

178 y infection with the intracellular bacterium Francisella tularensis is not clear.

179 The gamma-proteobacterium Francisella tularensis is one of the most infectious hum

180 The innate immune response to Francisella tularensis is primarily mediated by TLR2, th

181 The bacterium Francisella tularensis is recognized for its virulence,

182 Francisella tularensis is the bacterial pathogen that ca

183 Francisella tularensis is the causative agent of the deb

184 Francisella tularensis is the causative agent of tularem

185 Francisella tularensis is the causative agent of tularem

186 Francisella tularensis is the causative agent of tularem

187 The intracellular pathogen Francisella tularensis is the causative agent of tularem

188 Francisella tularensis is the causative agent of tularem

189 The Gram-negative bacterium Francisella tularensis is the causative agent of tularem

190 Francisella tularensis is the causative agent of tularem

191 Francisella tularensis is the causative agent of zoonoti

192 Francisella tularensis is the etiologic agent of the hig

193 Francisella tularensis is the etiological agent of tular

194 Francisella tularensis is the intracellular gram-negativ

195 st resistance to the intracellular bacterium Francisella tularensis is well established.

196 FipB, an essential virulence factor of Francisella tularensis, is a lipoprotein with two conser

197 Inhalational pneumonic tularemia, caused by Francisella tularensis, is lethal in humans.

198 any other gram-negative bacteria, the LPS of Francisella tularensis isolated from in vitro cultures i

199 tularemia, a zoonose caused by the bacterium Francisella tularensis, largely refer to Parinaud's ocul

200 .) and intradermal (i.d.) inoculation of the Francisella tularensis live vaccine strain (Ft-LVS).

201 IKKs in myeloid cells in vivo in response to Francisella tularensis Live Vaccine Strain (Ft. LVS) inf

202 teria Mycobacterium tuberculosis (M. tb.) or Francisella tularensis Live Vaccine Strain (LVS) in macr

203 subset in the lungs of mice during pulmonary Francisella tularensis live vaccine strain (LVS) infecti

204 Here we characterize Francisella tularensis live vaccine strain (LVS) infecti

205 We employed Francisella tularensis live vaccine strain (LVS) to stud

206 of mice infected with sublethal doses of the Francisella tularensis live vaccine strain (LVS).

207 und TNF (memTNF) during adaptive immunity to Francisella tularensis live vaccine strain (LVS).

208 ammation, priming with glycolipid (FtL) from Francisella tularensis live vaccine strain induces splen

209 A Francisella tularensis live vaccine strain mutant (sodB(

210 hown that priming with glycolipid (FtL) from Francisella tularensis live-vaccine strain (i) induces F

211 and public health pathogens-Influenza virus, Francisella tularensis, Mycobacterium tuberculosis, Micr

212 eumonic tularemia is caused by inhalation of Francisella tularensis, one of the most infectious micro

213 The Francisella tularensis pathogenicity island (FPI) encode

214 Francisella tularensis produces a lipopolysaccharide (LP

215 Francisella tularensis replicates in macrophages and den

216 the production of IL-4, effectively control Francisella tularensis replication.

217 s, successful protective immune responses to Francisella tularensis require rapid and efficient induc

218 to various assemblies of the loblolly pine, Francisella tularensis, rice and budgerigar genomes.

219 virulence determinants from the select agent Francisella tularensis SCHU S4.

220 study, we describe novel inhibitors against Francisella tularensis SchuS4 FabI identified from struc

221 Strains of Francisella tularensis secrete a siderophore in response

222 The Gram-negative pathogen Francisella tularensis secretes a siderophore to obtain

223 llular bacterial pathogens, such as virulent Francisella tularensis spp. tularensis (Ftt).

224 n lung tissue from mice exposed to virulent (Francisella tularensis ssp tularensis SchuS4).

225 gions of two slightly more distantly related Francisella tularensis strains were also compared agains

226 shown to be associated with highly virulent Francisella tularensis strains, including Schu S4, while

227 rotein sequence in LVS compared to the other Francisella tularensis strains.

228 nd illustrate its use on three datasets from Francisella tularensis, Streptococcus pyogenes, and Esch

229 F. novicida protected against challenge with Francisella tularensis subsp. holarctica and F. novicida

230 , which encode putative TPR-like proteins in Francisella tularensis subsp. holarctica FSC200.

231 ble to the live attenuated vaccine strain of Francisella tularensis subsp. holarctica in their abilit

232 -flight (MALDI-TOF) mass spectrometry on the Francisella tularensis subsp. holarctica LVS defined thr

233 eral highly pathogenic subspecies, including Francisella tularensis subsp. holarctica, whose distribu

234 ated LVS) derived from a virulent isolate of Francisella tularensis subsp. holarctica.

235 Two Francisella tularensis subsp. novicida (herein referred

236 Lipid A of Francisella tularensis subsp. novicida contains a galact

237 Francisella tularensis subsp. novicida U112 phospholipid

238 "Francisella tularensis subsp. novicida" intranasal infec

239 In this study, we demonstrated that Francisella tularensis subsp. novicida, for which a comp

240 cted with the fluorescently labeled pathogen Francisella tularensis subsp. novicida.

241 b O-PS gene cluster from the highly virulent Francisella tularensis subsp. tularensis (type A) strain

242 Comparative genome hybridization of the Francisella tularensis subsp. tularensis and F. tularens

243 n Francisella philomiragia ATCC 25015 and on Francisella tularensis subsp. tularensis CCUG 2112, the

244 Francisella tularensis subsp. tularensis is a highly inf

245 Francisella tularensis subsp. tularensis is a highly vir

246 Although Francisella tularensis subsp. tularensis is known to cau

247 Francisella tularensis subsp. tularensis is the etiologi

248 Clinical isolates of highly virulent type A Francisella tularensis subsp. tularensis organisms were

249 n of the virulent prototypical type A strain Francisella tularensis subsp. tularensis Schu S4 affects

250 Inactivation of both copies of iglE rendered Francisella tularensis subsp. tularensis Schu S4 avirule

251 Francisella tularensis subsp. tularensis Schu S4 is a zo

252 scribe the isolation and characterization of Francisella tularensis subsp. tularensis strain Schu S4

253 dings concerning the four subspecies and two Francisella tularensis subsp. tularensis subpopulations

254 In Francisella tularensis subsp. tularensis, DsbA has been

255 the previously reported O-antigen cluster in Francisella tularensis subsp. tularensis.

256 AIM2 inflammasome during infection with the Francisella tularensis subspecies novicida (F. novicida)

257 In Francisella tularensis subspecies novicida lipid A is pr

258 onal exposure to lethal doses of aerosolized Francisella tularensis subspecies tularensis, strain SCH

259 almonella, Yersinia pestis, and the virulent Francisella tularensis subspecies.

260 taxonomical level with the identification of Francisella tularensis subspecies.

261 Francisella tularensis subverts the immune system to rap

262 The intracellular bacterium Francisella tularensis survives and replicates within ma

263 The intracellular bacterium Francisella tularensis survives in mammals, arthropods,

264 ss despite its close genetic relationship to Francisella tularensis, the agent of tularemia.

265 Francisella tularensis, the bacterial cause of tularemia

266 Francisella tularensis, the causative agent of a fatal h

267 Francisella tularensis, the causative agent of tularemia

268 Francisella tularensis, the causative agent of tularemia

269 Francisella tularensis, the causative agent of tularemia

270 Francisella tularensis, the causative agent of tularemia

271 istinct lack of activation of these cells by Francisella tularensis, the causative agent of tularemia

272 Francisella tularensis, the causative agent of tularemia

273 Francisella tularensis, the causative agent of tularemia

274 Francisella tularensis, the causative agent of tularemia

275 ased, whole-genome resequencing platform for Francisella tularensis, the causative agent of tularemia

276 Francisella tularensis, the causative agent of tularemia

277 Francisella tularensis, the causative agent of tularemia

278 Francisella tularensis, the causative agent of tularemia

279 Francisella tularensis, the causative agent of tularemia

280 Francisella tularensis, the causative agent of tularemia

281 Francisella tularensis, the causative agent of tularemia

282 Francisella tularensis, the etiologic agent of tularemia

283 Francisella tularensis, the etiological agent of tularem

284 Francisella tularensis, the etiological agent of tularem

285 Francisella tularensis, the highly virulent etiologic ag

286 In Francisella tularensis, the putative DNA-binding protein

287 The ability of Francisella tularensis to replicate in macrophages has l

288 including virulent strains of the bacterium Francisella tularensis, to enable colonization and infec

289 ogens, such as the highly virulent bacterium Francisella tularensis, to ensure their replication and

290 cus efforts on the highly virulent bacterium Francisella tularensis tularensis.

291 ts ortholog FTT_0166c in the highly virulent Francisella tularensis type A strain SchuS4 are required

292 elates of vaccine-induced protection against Francisella tularensis using murine splenocytes and furt

293 The Gram-negative bacterium Francisella tularensis utilizes its antioxidant armature

294 l for inflammasome activation in response to Francisella tularensis, vaccinia virus and mouse cytomeg

295 Francisella tularensis variants were readily taken up by

296 Thus, IglE is essential for Francisella tularensis virulence.

297 of animals as early as 4 hrs post-exposure, Francisella tularensis was associated with an almost com

298 Following pulmonary infection with Francisella tularensis, we observed an unexpected but si

299 Francisella tularensis, which is a Gram negative bacteri

300 ctions with the live vaccine strain (LVS) of Francisella tularensis within the mouse liver are the fo