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1 Freund's complete adjuvant were used to induce joint inf
2 Freund's incomplete adjuvant (FIA) is one such example t
3 adjuvants: alum, Freund's complete adjuvant, Freund's incomplete adjuvant, and monophosphoryl-lipid A
4 tigen given in four typical adjuvants: alum, Freund's complete adjuvant, Freund's incomplete adjuvant
5 s in immunogenic formulations based on alum, Freund's adjuvant, or two different types of liposomes.
6 ent studies in Cell by Joachimiak et al. and Freund et al., a new class of TRiC substrate is identifi
10 by 6 wk after a challenge with human GAA and Freund's adjuvant; in contrast, administration of the AA
11 n were noted, for dams immunized with gB and Freund's adjuvant, compared with dams immunized with gB
12 oPn) major outer membrane protein (MOMP) and Freund's adjuvant can protect mice against a genital cha
13 abbits that were mock immunized with PBS and Freund's adjuvant or with PPSV23 and Freund's adjuvant a
14 e conserved protein virulence factor PLY and Freund's adjuvant is able to reduce corneal inflammation
15 ith pneumococcal capsular polysaccharide and Freund's adjuvant fails to produce opsonizing antibodies
16 PBS and Freund's adjuvant or with PPSV23 and Freund's adjuvant at 48 hours after infection (P </= 0.0
17 ), whereas rabbits immunized with PPSV23 and Freund's adjuvant failed to show differences in clinical
19 eas of the rabbits immunized with psiPLY and Freund's adjuvant were significantly lower than scores o
23 weeks of age using type II chicken collagen, Freund's complete adjuvant, and, on occasion, a lipopoly
25 ates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat mo
26 bazone) ((64)Cu-PTSM) at 24 h after complete Freund adjuvant injection using a small-animal PET devic
28 injection of an inflammatory agent, complete Freund's adjuvant, into the masseter muscle and perfused
29 ted in the K/BxN serum-transfer and complete Freund's adjuvant (CFA)-evoked active immunization model
30 (8-60 min), carrageenan (3 hr), and complete Freund's adjuvant (CFA; 3 d) into the rat hindpaw as wel
31 injection of donor splenocytes and complete Freund's adjuvant eliminates autoimmunity and permanentl
32 , and immunization with antigen and complete Freund's adjuvant induced interferon-gamma-secreting, an
33 with soluble B. malayi antigen and complete Freund's adjuvant resulted in significantly fewer IL-4-p
35 DO11.10) along with OVA peptide and complete Freund's adjuvant, observing a dramatic increase in OVA-
36 inflammatory stimuli, formalin and complete Freund's adjuvant, were reduced or abolished in AC1&8 DK
42 inducing liver histologic change as complete Freund's adjuvant (CFA), the standard adjuvant used for
45 alin-induced spontaneous behaviors, complete Freund's adjuvant-induced heat and mechanical hypersensi
46 persistent inflammation induced by complete Freund's adjuvant (CFA) increased GABAergic miniature IP
47 ng hindlimb inflammation induced by complete Freund's adjuvant (CFA) injections in the hindpaw and hi
48 persistent inflammation induced by Complete Freund's adjuvant (CFA) modulates GABA signaling differe
50 211 suppressed allodynia induced by complete Freund's adjuvant and the chemotherapeutic agent paclita
53 sed thermal hyperalgesia induced by complete Freund's adjuvant injection and reduced response to acid
54 mechanical hyperalgesia induced by complete Freund's adjuvant was accompanied by C5a upregulation an
55 -inducing chromic gut; and (4) CFA (complete Freund's adjuvant), intradermal complete Freund's adjuva
56 agonist of TRPA1) and reversed CFA (Complete Freund's Adjuvant)-induced inflammation and thermal hype
58 f the mTOR signaling pathway during complete Freund's adjuvant (CFA)-induced chronic inflammatory pai
59 PD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation.
61 r findings were that 48 h following complete Freund's adjuvant (CFA)-induced inflammation, the propor
62 e phase inflammatory pain following complete Freund's adjuvant injection and the late phase neuropath
66 by injection of collagen type II in complete Freund adjuvant, and cell suspensions from the inflamed
69 with Arg(12) mutant ras peptide in complete Freund's adjuvant (CFA) develop T cells within 10 d that
70 th a uveitogenic regimen of IRBP in complete Freund's adjuvant (CFA) exhibited CD25+ regulatory cells
71 ed with a single dose of vaccine in complete Freund's adjuvant (CFA) generated antigen-specific gamma
72 more efficient than free peptide in complete Freund's adjuvant (CFA) in inducing T cell activation an
73 low-pathology BL/6 mice with SEA in complete Freund's adjuvant (CFA) once before, and once again duri
74 myelin basic protein emulsified in complete Freund's adjuvant (CFA) or passively by the transfer of
75 s the protective response, CneF, in complete Freund's adjuvant (CFA) or the immunogen that induces th
76 rough preinjection with beta-gal in complete Freund's adjuvant (CFA) or through preinjection with sol
77 face adhesin A (PsaA) emulsified in complete Freund's adjuvant (CFA) provides protection against syst
78 to the epitope peptide delivered in complete Freund's adjuvant (CFA), and IgM production was even gre
79 g protein1-20 peptide (IRBP1-20) in complete Freund's adjuvant (CFA), with or without a preceding ATR
85 onferred by yMSP1(19) emulsified in complete Freund's adjuvant (CFA/incomplete Freund's adjuvant).
87 h schistosome egg antigens (SEA) in complete Freund's adjuvant (SEA/CFA) correlates with elevated pro
88 (HLA-A-like) peptides emulsified in complete Freund's adjuvant 7 d before transplantation (n = 5 to 7
89 rived protein extract emulsified in complete Freund's adjuvant and found that these mice developed ca
90 n A/J mice immunized with myosin in complete Freund's adjuvant in that myosin-specific antibodies and
91 ice with myocarditogenic peptide in complete Freund's adjuvant induced the infiltration of IL-17A-pro
92 bovine collagen (CII) emulsified in complete Freund's adjuvant inhibited T helper type 1 differentiat
93 ming of recipients with beta-gal in complete Freund's adjuvant resulted in an increased frequency of
94 57BL/6 mice with murine vimentin in complete Freund's adjuvant resulted in anti-vimentin antibodies a
95 eceptor retinoid-binding protein in complete Freund's adjuvant to test their efficacy in suppressing
98 pes when injected subcutaneously in complete Freund's adjuvant was significantly enhanced if administ
100 on with schistosome egg antigens in complete Freund's adjuvant, coinfection with the nematodes also r
101 odendrocyte glycoprotein peptide in complete Freund's adjuvant, correlating with milder experimental
102 When WEB2170 was added to OVA in complete Freund's adjuvant, enhanced IgG2a but not IgG1 productio
103 e subcutaneous route with rHag B in complete Freund's adjuvant, immunized with rHag B and orally infe
104 ection and not when administered in complete Freund's adjuvant, indicating that molecular mimicry-ind
105 allenged with antigen emulsified in complete Freund's adjuvant, the overall pattern was similar, exce
116 ng this model, induced by injecting complete Freund's adjuvant (CFA) into one hind paw, we systematic
117 induced by subcutaneously injecting complete Freund's adjuvant (CFA) into the hind paws of rats.
118 induced by subcutaneously injecting complete Freund's adjuvant (CFA) into the hind paws of rats.
119 atory pain was induced by injecting complete Freund's adjuvant subcutaneously into one hind paw of ra
120 etermined, using the intraarticular complete Freund adjuvant arthritis mice model, whether the radiot
121 ete Freund's adjuvant), intradermal complete Freund's adjuvant-induced hindlimb inflammation 1 and 4
122 ipheral inflammation (intraplanatar complete Freund's adjuvant) is substantially diminished in the nu
123 mal hyperalgesia after intraplantar complete Freund's adjuvant injection (ED(50) = 41 mg/kg, i.p.).
126 pain: (i) intraplantar injection of complete Freund's adjuvant (CFA) as a model of adjuvant- and path
133 nduced by a unilateral injection of complete Freund's adjuvant (CFA) into the masseter muscle under m
135 Hindpaw intraplantar injection of complete Freund's adjuvant (CFA) produced peripheral inflammation
136 mined the relative contributions of complete Freund's adjuvant (CFA)-induced inflammatory pain and op
140 ion induced by hindpaw injection of complete Freund's adjuvant (CFA): artemin expression increased 10
143 nduced by subcutaneous injection of Complete Freund's Adjuvant in the left hind paw of Sprague-Dawley
144 mation was produced by injection of complete Freund's adjuvant into one hindpaw in rats, and neurons
146 nd paw swelling to paw injection of complete Freund's adjuvant, a model of peripheral inflammatory pa
147 pheral nerve injury or injection of Complete Freund's Adjuvant, although they display intact nocicept
148 rculosis, an essential component of complete Freund's adjuvant, converted CD11b(hi)CD11c(-) monocytes
152 jection of formalin, carrageenan or complete Freund's adjuvant (CFA), without affecting basal pain pe
153 njection of capsaicin, formalin, or complete Freund's adjuvant more effectively than unconjugated CGR
158 toreceptor retinoid-binding protein/complete Freund's adjuvant (IRBP/CFA) or adoptive transfer of T c
161 d dose-dependently potently reduced complete Freund's adjuvant (CFA) induced chronic inflammatory pai
162 The 3d mutation slightly reduced complete Freund's adjuvant (CFA)-mediated antigen presentation, b
163 (ED50 = 30 micromolkg s.c.) reduced complete Freund's adjuvant-induced thermal hyperalgesia in the ra
167 ced thermal hypersensitivity in the complete Freund's adjuvant (CFA) model of inflammatory pain (1.3-
169 of sera from immunized mice in the complete Freund's adjuvant and Montanide ISA51 groups and after a
170 Several agonists were active in the complete Freund's adjuvant model of chronic inflammatory thermal
171 in the tail immersion assay, in the complete Freund's adjuvant model of inflammatory pain and in the
175 ore potent than that obtained using Complete Freund's Adjuvant with gp100, whereas no response was ob
176 nalysis of allografts from vimentin/complete Freund's adjuvant mice demonstrated increased numbers of
177 rom donor hearts placed in vimentin/complete Freund's adjuvant recipients contained anti-vimentin ant
178 used a model of arthritis in which complete Freund's adjuvant (CFA) was injected into the rat ankle
180 h S-antigen (S-Ag), emulsified with complete Freund adjuvant, and treated simultaneously with killed
182 C harvested from mice injected with complete Freund's adjuvant (CFA) enhanced type-1 cytokine respons
183 rats were injected bilaterally with complete Freund's adjuvant (CFA) into the TMJ or served as uninje
186 usly injection of (1) GA mixed with complete Freund's adjuvant (CFA), (2) CFA alone, or (3) saline.
188 cord slices from rats injected with complete Freund's adjuvant in one hindpaw and from uninflamed con
190 albumin with alum or ovalbumin with complete Freund's adjuvant to induce T helper type 2 or T helper
191 se models require immunization with complete Freund's adjuvant, whereas others suggest that a decreas
193 were immunized with IRBP mixed with complete Freund's adjuvant; eyes were enucleated on day 7 after i
194 isolated from rats with or without complete Freund's adjuvant (CFA) hindpaw inflammation, in respons
197 livered singly or in combination with either Freund's adjuvant or alum, indicated that augmented bact
200 (NZB x NZW)F1 mice were treated with either Freund's incomplete adjuvant (IFA) or phosphate buffered
201 nflammatory agent (carrageenan; CARR or FCA; Freund's complete adjuvant) or nerve injury (axotomy; AX
204 f nonhuman primates with E. coli MSP1(42) in Freund's adjuvant protected six of seven Aotus monkeys f
205 with trinitrophenyl-bovine serum albumin in Freund's complete adjuvant were significantly inhibited
206 experiment, mice were immunized with CII in Freund's complete adjuvant (CFA) and treated with a sing
208 riod, either before immunization with CII in Freund's complete adjuvant or after initiation of arthri
211 ng DBA/1 mice with type II collagen (CII) in Freund's complete adjuvant, followed 3 weeks later by CI
212 emulsion of bovine type II collagen (CII) in Freund's incomplete adjuvant at the base of the tail.
213 e were immunized with cardiac myosin (CM) in Freund's adjuvant and received heterotopic, minor antige
214 re immunized with murine type II collagen in Freund's complete adjuvant, resulting in a chronic relap
216 n be achieved when MSP1(19) is emulsified in Freund adjuvant but not when it is adsorbed to aluminum
217 h purified recombinant LppQ-N' formulated in Freund's adjuvant and challenged them with M. mycoides s
218 vaccines, we tested gD2 in alum/MPL, gD2 in Freund's adjuvant, and dl5-29 (a replication-defective H
219 nized and boosted with a GABHS homogenate in Freund's adjuvant, whereas controls received Freund's ad
221 d groups of rabbits (n = 7) with each MAP in Freund's adjuvant and then exposed all rabbits to a 200-
222 of methylated bovine serum albumin (mBSA) in Freund's complete adjuvant and then challenged on day 21
224 rimmune sera of rabbits immunized with PA in Freund's adjuvant, with peak neutralization titers 23-,
226 x rabbits vaccinated with the MAP peptide in Freund's adjuvant developed high-titer, high-avidity ant
232 us CpG 1826, 0 of 4 (0%) with CFA/incomplete Freund's adjuvant, 0 of 4 (0%) with CpG 1826 mixed with
233 g oligodeoxynucleotides (CpGs) in incomplete Freund adjuvant and treated the mice with systemic inter
234 ccine administered to neonates in incomplete Freund's adjuvant (IFA) induced such cells in reduced nu
235 -chain peptide 9-23 emulsified in incomplete Freund's adjuvant (IFA) was also potent at preventing on
236 BP KO mice immunized with IRBP in incomplete Freund's adjuvant (IFA), lacking mycobacteria (whereas t
237 Treatment with E2 peptide2 in incomplete Freund's adjuvant (IFA), resulted in higher antibody pro
239 ed with gp100 melanoma peptide in incomplete Freund's adjuvant (peptide/IFA), which is commonly used
242 istration of the B9-23 peptide in incomplete Freund's adjuvant enhanced their insulin autoantibody re
243 e fragments of target antigens in incomplete Freund's adjuvant has resulted in severe anaphylactic re
244 a high dose of HEL emulsified in incomplete Freund's adjuvant, a strong splenic proliferative respon
245 in saline or intraperitoneally in incomplete Freund's adjuvant, with large quantities of the immunodo
249 esence or absence of LT(R192G) or incomplete Freund's adjuvant were not protected against lethal chal
251 num hydroxide, calcium phosphate, incomplete Freund's adjuvant, and the oil-in-water emulsion MF59.
252 dose) or gp100:209-217(210M) plus incomplete Freund's adjuvant (Montanide ISA-51) once per cycle, fol
254 , inactivated and formulated with incomplete Freund adjuvant, was administered intramuscularly every
258 mulated as a stable emulsion with incomplete Freund's adjuvant (Montanide ISA 51; Seppic SA, Paris, F
259 tion with ESO(157-170) mixed with incomplete Freund's adjuvant (Montanide ISA51) in 18 HLA-DP4+ EOC p
262 o the induction of arthritis with incomplete Freund's adjuvant, with similar effects in arthritis ind
264 serum from animals immunized with the nHgbAI/Freund's vaccine; however, anti-nHgbAI from both studies
265 ower antibody ELISA activity than the nHgbAI/Freund's, the nHgbAI/MPL vaccine provided protection aga
266 itic knee joint was produced by injection of Freund's complete adjuvant (CFA) into the knee joint of
270 the NOD mouse model by coupling injection of Freund's complete adjuvant with infusion of allogeneic s
273 however, detected in pristane-induced and/or Freund's incomplete adjuvant oil-induced arthritis.
274 ene expression in mice receiving formalin or Freund's complete adjuvant (CFA) as an inflammatory stim
275 9)-specific antibody production 12-fold over Freund adjuvant given i.p., 3-fold over Freund adjuvant
276 over Freund adjuvant given i.p., 3-fold over Freund adjuvant given subcutaneously (s.c.), 300-fold ov
277 h, once immediately post- and again 2 h post-Freund's adjuvant at GB 30, at the junction of the later
280 ral Brain Prize 2011 to Peter Somogyi, Tamas Freund and Gyorgy Buzsaki 'for their wide-ranging, techn
283 search for an adjuvant that is comparable to Freund's adjuvant in potency and is safe for use in huma
286 train 35000HP (nHgbAI) and administered with Freund's adjuvant provided complete protection against a
287 These two antigens were each emulsified with Freund's adjuvant and used to vaccinate Aotus nancymai m
288 human type II collagen (CII) emulsified with Freund's complete adjuvant (CFA), and compared with PGIA
290 inated either with yMSP1(19) formulated with Freund adjuvant, with alum, or with ODN plus alum and ch
292 islet transplantation and immunization with Freund's complete adjuvant along with multiple injection
293 d White rabbits were actively immunized with Freund's adjuvant mixed with pneumolysin toxoid (psiPLY)
294 e experiment, Lewis rats were immunized with Freund's complete adjuvant followed by administration of
295 BALB/cJ and MRL/MpJ mice were immunized with Freund's complete adjuvant in the presence or absence of
300 We previously reported that vaccination with Freund's adjuvant plus the recombinant N-terminus of the
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