ライフサイエンスコーパス: Friend virus

1 the spleen-focus-forming virus component of Friend virus.

2 virus envelope protein and a live attenuated Friend virus.

3 ral recovery controlled by the resistance to Friend virus 3 (rfv3) gene, the rfv3 gene has been mappe

4 Recovery from Friend virus 3 (Rfv3) is a single autosomal gene encodin

5 ted that mouse APOBEC3 encodes Recovery from Friend virus 3 (Rfv3), a classical resistance gene in mi

6 These results suggest that Friend virus activates both sf-STK and the EPOR to cause

7 were unable to maintain long-term control of Friend virus and developed gross splenomegaly with high

8 s of gammaretrovirus envelope proteins (from Friend virus and GALV or xenotropic viruses) assemble in

9 he early stages of transformation induced by Friend virus are characterized in vitro by the Epo-indep

10 In the present studies, we used Friend virus as a model to analyze characteristics of a

11 We have used mice infected with Friend virus as a model to study immunotherapeutic appro

12 Swiss Jim Lambert (SJL) and Friend Virus B (FVB) mice progressively demyelinate with

13 Friend virus B and MT transgenic mice were given the glu

14 Friend virus B wild-type mice (untreated, bile duct-liga

15 Wild-type and P-glycoprotein knockout female Friend virus B-type mice.

16 injected intravenously into immunocompetent Friend virus B-type mice.

17 late HCC development in two Mdr2-KO strains: Friend virus B-type/N (FVB) and C57 black 6 (B6).

18 role during primary immune responses against Friend virus but is dispensable during vaccine-primed se

19 Recovery from leukemia induced by Friend virus complex (FV) requires strong CD4(+) helper,

20 f the mice against challenge with pathogenic Friend virus complex was determined to be 10(3) focus-fo

21 Friend virus disease can be considered as a model for hu

22 that is initiated by the interaction of the Friend virus-encoded glycoprotein gp55 with the erythrop

23 ation, such as interaction with the env gene Friend virus envelope glycoprotein (F-gp55) of spleen fo

24 infected cells by forming a complex with the Friend virus envelope glycoprotein, gp55, and the erythr

25 recombinant vaccinia virus vector expressing Friend virus envelope protein and a live attenuated Frie

26 mice infected both in vitro and in vivo with Friend virus failed to give rise to erythropoietin-indep

27 sts infected with the anemia-inducing strain Friend virus (FAV cells), RPS19 mRNA and protein express

28 haracteristic progression and specificity of Friend virus for the erythroid lineage have allowed for

29 Friend virus (FV) and lactate dehydrogenase-elevating vi

30 ) impairs early adaptive immune responses to Friend virus (FV) coinfection.

31 Using unresolving noncytopathic Friend virus (FV) infection in mice, we showed that unre

32 -viral activity of CD4+ T cells during acute Friend Virus (FV) infection, they were absolutely requir

33 ome activated and proliferate in response to Friend virus (FV) infection.

34 y effects by gamma interferon (IFN-gamma) on Friend virus (FV) infection.

35 mmune responses and recovery from concurrent Friend virus (FV) infections were investigated.

36 7-deficient mice with a retroviral pathogen, Friend virus (FV), I determined that TLR7 potently inhib

37 ted with the polycythemia-inducing strain of Friend virus (FVP), p53 null mice exhibited accelerated

38 we show that the Kit+ pathogenic targets of Friend virus in the spleen are distinct from the pathoge

39 nitors, termed stress BFU-E, are targets for Friend virus in the spleen.

40 xtent, B cells were also susceptible to late Friend virus-induced disease.

41 ts through these sites, are not required for Friend virus-induced erythroblastosis.

42 t host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice.

43 ncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.

44 Fv-2 resistance to Friend virus-induced erythroleukemia acts through nonimm

45 A role for p53 in the in vivo progression of Friend virus-induced erythroleukemia has been suggested

46 During the initial stage of Friend virus-induced erythroleukemia in mice, interactio

47 In Friend virus-induced erythroleukemia, the spleen focus-f

48 tion factor PU.1 is strongly associated with Friend virus-induced erythroleukemia.

49 mutant mice resistant to the development of Friend virus-induced erythroleukemia.

50 entiation is the cause for the resistance to Friend virus-induced erythroleukemia.

51 n this study, we used the highly immunogenic Friend virus-induced FBL-3 tumor as a model to study the

52 Rfv3 is involved in recovery from Friend virus-induced leukemia and has been demonstrated

53 nd to be the most frequently altered ones in Friend virus-induced leukemias.

54 ation of the EPOR and STAT5 are required for Friend virus-induced polycythemia.

55 ld not maintain control and developed severe Friend virus-induced splenomegaly and erythroleukemia by

56 of infected cells during the progression of Friend-virus-induced erythroleukemia.

57 Friend virus induces an erythroleukemia in susceptible m

58 Infection of mice with Friend virus induces the activation of CD4(+) regulatory

59 In this report, we show that Friend virus induces the bone morphogenetic protein 4 (B

60 Friend virus induces the development of erythroleukemia

61 s required for the Epo-independent growth of Friend virus-infected cells and that the activation of S

62 -Stk to participate in the transformation of Friend virus-infected cells requires the kinase activity

63 h Sf-Stk in the Epo-independent expansion of Friend virus-infected cells, and suggest a pivotal role

64 iculocytes formed in vitro by enucleation of Friend virus-infected erythroblasts were purified and re

65 roerythroblasts isolated from the spleens of Friend virus-infected mice fed an amino acid-based, fola

66 Control proerythroblasts were obtained from Friend virus-infected mice fed the same diet plus 2 mg f

67 Gab2 is expressed in spleens from Friend virus-infected mice, co-immunoprecipitates with S

68 porting the progression of acute leukemia in Friend virus-infected mice.

69 demonstrate that erythroleukemias arising in Friend virus-infected p53 null mice are biologically and

70 mutation observed in cell lines derived from Friend virus-infected p53 wild type mice, it was not a u

71 ity of responses necessary for recovery from Friend virus infection has implications for both immunot

72 Using a Friend virus infection model of murine leukemia, the ons

73 Friend virus infection of adult immunocompetent mice is

74 Friend virus infection of mice induces the expansion and

75 onstrate that, following recovery from acute Friend virus infection, a small number of B cells evade

76 n-independent colonies at any time following Friend virus infection, suggesting that mutation of the

77 t to also maintain erythroleukemia following Friend virus infection.

78 r Epo-independent colony formation following Friend virus infection.

79 (+) T cell response rather than the level of Friend virus infection.

80 Folate deficiency around the time of Friend virus-infection delayed the onset but increased t

81 In chronic Friend virus infections CD4(+) T regulatory (Treg) cells

82 the ability to control acute and persistent Friend virus infections.

83 e for IFN-gamma in the control of persistent Friend virus infections.

84 re unable to maintain long-term control over Friend virus infections.

85 Friend virus infects erythroid progenitor cells, followe

86 re, we extend those findings by showing that Friend virus infects two distinct populations of bone ma

87 The erythroleukemia induced by Friend virus is a multistage disease characterized by an

88 Friend virus is an acutely oncogenic retrovirus that cau

89 rrelated with a 10-fold reduction of chronic Friend virus levels in the liver compared with the splee

90 vention of retroviral persistence by using a Friend virus model that we recently developed.

91 We have used the Friend virus model to determine the basic mechanisms by

92 s using adoptive transfer experiments in the Friend virus mouse model.

93 throleukemia induced by the anemia strain of Friend virus occurs in two stages.

94 ry erythroid progenitor cells in response to Friend virus.Oncogene advance online publication, 12 Dec

95 Previous studies suggested that the Friend virus oncoprotein, gp55, constitutively activates

96 Thus, even very low levels of persistent Friend virus posed a significant threat during immunosup

97 ind that the env gene of an anemic strain of Friend virus, Rauscher virus envelope glycoprotein, does

98 ress erythropoiesis pathway in the spleen by Friend virus results in the rapid expansion of stress BF

99 receptors, and we confirmed our results in a Friend virus retroviral model of infection in mice.

100 We developed a Friend virus-sensitive, p53-deficient mouse model to dir

101 We developed a Friend virus-sensitive, p53-deficient mouse model to inv

102 w that in vitro expression of Sf-Stk confers Friend virus sensitivity to erythroid progenitor cells f

103 The present in vitro experiments with a Friend virus-specific CD4(+) T-cell clone revealed that

104 f the induced bursts with those induced with Friend virus suggested that either sarcoma virus such as

105 The Friend virus susceptibility 2 (Fv2) locus encodes a domi

106 Among these are the Friend virus susceptibility factor 1/lentivirus suscepti

107 The Friend virus susceptibility gene 2 (Fv2) controls the po

108 Several of these loci, including the Friend virus susceptibility gene 2 (Fv2), dominant white

109 Recently, we demonstrated that the Friend virus susceptibility locus, Fv2, which is require

110 to control retrovirus replication, including Friend-virus-susceptibility-1, Fv1, on mouse chromosome

111 Induced differentiation of Friend virus-transformed erythroleukemia cells is accomp

112 infected with the anemia-inducing strain of Friend virus was investigated.

113 of Sf-Stk to induce colonies in response to Friend virus, while the Grb2 binding site from EGFR rest