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1 nosine receptor, a pharmaceutically relevant G protein-coupled receptor.
2 BD are mediated through this lipid-activated G protein-coupled receptor.
3 or allosteric binding sites across aminergic G protein-coupled receptor.
4 weak antagonist action specific to the LPA1 G protein-coupled receptor.
5 onale for the design of such compounds for a G protein-coupled receptor.
6 resolvin (RvE) 1, and activation of cognate G protein-coupled receptors.
7 k mechanism through a heteromeric complex of G protein-coupled receptors.
8 lular purinergic signals that signal through G protein-coupled receptors.
9 ed structural motifs recognized by aminergic G protein-coupled receptors.
10 M), where they are activated by cell surface G protein-coupled receptors.
11 l trafficking relies on signals initiated by G-protein coupled receptors.
12 ction pairs between 93 neuropeptides and 133 G-protein coupled receptors.
13 activation of a heterotrimeric G-protein by G-protein coupled receptors.
14 ding of the signalling mechanisms of class B G-protein-coupled receptors.
15 to be a common feature among certain class A G-protein-coupled receptors.
16 tion is mediated by oxytocin and vasopressin G-protein-coupled receptors.
20 (CI): -0.84, -0.45) and of cg19859270 in the G protein-coupled receptor 15 gene (GPR15) (M = -0.21, 9
22 2)-12-hydroxyeicosatetraenoic acid (12-HETE)-G-protein-coupled receptor 31 (GPR31) signaling axis as
24 the R-spondin/leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) axis in driving aber
27 show that the leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) identifies intestina
31 annabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the c
33 Proteinase-Activated Receptor-2 (PAR2 ) is a G protein-coupled receptor activated by serine proteinas
35 d experimental set-up allows for analysis of G protein-coupled receptor activation in the absence and
38 s the major source of the lipid mediator and G protein-coupled receptor agonist sphingosine-1-phospha
39 tional profiles for mammalian biogenic amine G protein-coupled receptor agonists and antagonists, som
40 ion of epithelial or fibroblastic cells with G protein-coupled receptor agonists, including angiotens
45 that latrophilin-2 (Lphn2), a cell-adhesion G protein-coupled receptor and presumptive alpha-latroto
47 C4a against a panel of both known and orphan G protein-coupled receptors and now provide evidence tha
48 up of cell-surface receptors, including many G protein-coupled receptors and receptor tyrosine kinase
49 ve shown that Galpha13 is essential for both G-protein-coupled receptor and receptor tyrosine kinase-
52 cellular cascades known to integrate 'slow' (G-protein-coupled receptors) and 'fast' (ionotropic rece
55 of both endogenous and synthetic agonists of G protein-coupled receptors are integral to analysis of
58 al photoreceptor rhodopsin (Rho) is a unique G protein-coupled receptor as it utilizes a covalently t
59 approach to interrogate proteins engaged by G-protein-coupled receptors as they dynamically signal a
60 en partial and/or biased agonism in RTKs and G-protein-coupled receptors, as well as new therapeutic
61 formation and an enrichment of a pool of the G protein-coupled receptor at actin-rich cellular protru
62 n/sex hormonebinding globulin-like (PLL) and G protein-coupled receptor autoproteolysis-inducing (GAI
63 gral membrane proteins: the beta2-adrenergic G protein-coupled receptor (beta2AR), the peptide transp
64 ted receptor 1 (TAAR1) is a highly conserved G-protein-coupled receptor bound by endogenous trace ami
67 suppressing the expression of transmembrane G protein-coupled receptors (class A/1 rhodopsin-like),
70 B (GABAB) receptors, which are heterodimeric G-protein-coupled receptors constructed from R1a and R2
73 It is now recognized that similar to most G protein-coupled receptors, D2Rs signal not only throug
75 mediator of follicular B-cell migration, the G protein-coupled receptor Epstein-Barr virus-induced ge
77 behavioral assays identify Gpr158, an orphan G protein-coupled receptor expressed in neurons of the C
79 4 (also known as TEM5/ADGRA2) is an adhesion G protein-coupled receptor family member that plays a pi
80 cagon receptor, GCGR, belongs to the class B G-protein-coupled receptor family and plays a key role i
82 ntify small molecule agonists of the cognate G-protein coupled receptor for H2-RLX (relaxin family pe
90 cription factor Cubitus interruptus (Ci) and G protein coupled receptor (GPCR) family protein Smoothe
91 ne-1-phosphate (S1p), signalling through the G protein coupled receptor (GPCR) S1pr2, plays a key rol
93 The beta1-adrenergic receptor (beta1AR) is a G protein-coupled receptor (GPCR) and the predominant ad
94 nds to produce different effects on the same G protein-coupled receptor (GPCR) has interesting therap
98 photo-transduction cascade is a prototypical G protein-coupled receptor (GPCR) signaling system, in w
99 there has been a revolution in the field of G protein-coupled receptor (GPCR) structural biology.
100 r (SMO) belongs to the Class Frizzled of the G protein-coupled receptor (GPCR) superfamily, constitut
105 osing roles in regulating various aspects of G protein-coupled receptors (GPCR) expression and signal
110 intense scratching in mice by activating the G-protein coupled receptor (GPCR) MrgprA3; it is not kno
113 mediating this effect via activation of the G-protein-coupled receptor (GPCR) MasR, angiotensin-(1-2
115 by either chemogenetic activation of ciliary G-protein-coupled receptor (GPCR) signaling or the selec
116 x conformational energy landscape determines G-protein-coupled receptor (GPCR) signalling via intrace
117 ng to the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR) that signals primarily
118 al photoreceptor rhodopsin is a prototypical G-protein-coupled receptor (GPCR) that stabilizes its in
119 ein receptor 75 (GPR75), currently an orphan G-protein-coupled receptor (GPCR), as a specific target
120 l is activated by a signal downstream of the G-protein-coupled receptor (GPCR)-Gq/11-phospholipase C
122 in receptor (APJ) belongs to family A of the G protein-coupled receptors (GPCRs) and is a potential p
123 multiple reported and novel rhodopsin family G protein-coupled receptors (GPCRs) and the polycystic k
129 cally involved in the signal transduction of G protein-coupled receptors (GPCRs) at the plasma membra
134 ing across cellular membranes, the 826 human G protein-coupled receptors (GPCRs) govern a wide range
135 terplay between signaling and trafficking by G protein-coupled receptors (GPCRs) has focused mainly o
137 ) of GCGR and GLP-1R, two members of class B G protein-coupled receptors (GPCRs) in mammalian cells w
148 sensitization, endocytosis and signalling of G protein-coupled receptors (GPCRs), and they scaffold a
149 scular signalling components, and especially G protein-coupled receptors (GPCRs), as next-generation
150 le in desensitization and internalization of G protein-coupled receptors (GPCRs), beta-arrestins are
151 ts predominantly from chronic stimulation of G protein-coupled receptors (GPCRs), including adrenergi
152 t this theory may be applied to nonolfactory G protein-coupled receptors (GPCRs), including those ass
155 amine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the exc
157 amined the ciliary enrichment signals of two G protein-coupled receptors (GPCRs)-the somatostatin rec
165 e is known whether signaling proteins [e.g., G protein-coupled receptors (GPCRs)] exhibit natural var
171 mbers of the secretin-like class B family of G-protein-coupled receptors (GPCRs) and have opposing ph
176 The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRK
182 e-activated receptors (PARs) are a family of G-protein-coupled receptors (GPCRs) that are irreversibl
184 h activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanin
190 Glucose and other sugars are detected by a G protein-coupled receptor, Gpr1, as well as a pair of t
191 lar cAMP levels, increasing synthesis of the G protein coupled receptor, GPR120, and its recruitment
194 sets based on the expression of the adhesion G protein-coupled receptor GPR56, and GPR56(+) TEMRA cel
196 w pathway is distinctly parcellated from the G protein-coupled receptor --> Gs --> adenylate cyclase
197 tein pathway mediating cell survival and the G protein-coupled receptor --> Gs --> adenylate cyclase
198 terminal truncation of G1 and other adhesion G protein-coupled receptors has been shown to significan
200 nd a highly cell-type-specific expression of G-protein-coupled receptors, implying that ligand-recept
201 terization of transporters, ion channels, or G-protein-coupled receptors in cotranslationally formed
202 Transcriptional screening for the expression G-protein-coupled receptors in murine dorsal root gangli
203 lation as an additional mechanism of Galphai-G-protein-coupled receptor inactivation.Opioid receptors
204 erspective have been increasingly applied to G protein-coupled receptors including the adenosine rece
205 ar domain was described at several aminergic G protein-coupled receptors, including muscarinic acetyl
207 RGS9-2 controls the function of several G-protein-coupled receptors, including dopamine receptor
208 at eosinophils (Eos) express numerous orphan G-protein-coupled receptors, including Epstein-Barr viru
209 r tyrosine-based activation motif (ITAM) and G-protein-coupled receptors, increased adhesion and aggr
212 e type 1 taste receptor member 3 (T1R3) is a G protein-coupled receptor involved in sweet-taste perce
214 R2), a classical chemoattractant receptor of G-protein-coupled receptors, is reported to be involved
217 ding SNVs found in SCZ subjects in the GIT1 (G protein-coupled receptor kinase interacting ArfGAP 1)
221 nsitions from inhibiting Raf-1 to inhibiting G-protein-coupled receptor kinase 2 upon phosphorylation
222 we find that CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial fo
223 protein kinase A site serine 261/262 and the G-protein-coupled receptor kinase site serine 355/356 an
224 helial cells (SECs) via its interaction with G-protein-coupled receptor kinase-2 (GRK2) that also pos
227 tion, TIN-X supports exploration of data for G-protein coupled receptors, kinases, ion channels, and
228 sphingosine 1-phosphate (S1P) receptor-1, a G protein-coupled receptor known to promote the barrier
232 effects upon binding and activating CXCR1, a G protein-coupled receptor, located in the cell membrane
233 (LPA) in decidualization, acting through its G-protein-coupled receptor LPA3 in the uterine epitheliu
234 peptide ligands from platelet GP1balpha and G-protein-coupled receptor MAS effectively bound Ig21 by
235 thosteric and allosteric topography within a G protein-coupled receptor, may represent a novel approa
238 internal calcium in astrocytes, focusing on G protein-coupled receptor-mediated mobilization of calc
241 idence that SP functions through Mas-related G protein-coupled receptors (Mrgprs) in addition to its
242 ction via protease-activated and mas-related G-protein-coupled receptors (Mrgprs) to contribute to al
243 C-1, a beta-barrel membrane protein, and the G-protein-coupled receptor NTR1, an alpha-helical membra
244 ry proposes that the activation of olfactory G protein-coupled receptors occurs by an inelastic elect
245 he nanobody Nb37 suggests that signalling by G-protein-coupled receptors occurs preferentially at the
246 B (CTSB), which can be induced directly via G protein-coupled receptors on acinar cells or through i
248 The focus is on the immunohistochemistry of G-protein-coupled receptors, one of the largest families
250 or the V2R without any activity on 155 other G-protein-coupled receptors or on 15 ionic channels.
251 First, a localized signal is generated by a G protein-coupled receptor paired to one or more of the
252 versely showed upregulation of GO terms like G-protein coupled receptor pathway, membrane potential a
253 in mammals and discovered that Hedgehog and G-protein-coupled receptor pathways were linked to cilia
256 naling molecule that interacts with its five G-protein coupled receptors (S1P1-5) to regulate cell gr
257 nificant alterations in signal transduction, G protein coupled receptors, serotonin and glycosaminogl
258 tion of synaptic transmission by presynaptic G-protein coupled receptors shapes information flow thro
259 R7-RGS-binding protein (R7BP) that regulate G protein-coupled receptor signaling by accelerating dea
260 , representing a novel mode of regulation of G protein-coupled receptor signaling by scaffolding prot
261 We propose that this bifurcation of the Tre1 G protein-coupled receptor signaling response via G prot
265 The dopamine D2 receptor (D2R), like many G-protein-coupled receptors, signals through G-protein-
266 identified the gene dmsr-1, which encodes a G-protein coupled receptor similar to an insect RFamide
267 initiates signaling upstream of PI3K through G protein-coupled receptors, specifically via the metabo
268 pha-pheromone was independent of the cognate G protein-coupled receptors Ste2 and of the central beta
270 lear farnesoid X receptor (Fxr) and membrane G-protein-coupled receptor (Takeda G-protein-coupled rec
272 armaceutical drug targets, the corresponding G-protein-coupled receptors (termed aminergic GPCRs) bel
274 al biased signaling via isoforms of the same G protein-coupled receptor that are simultaneously expre
275 id receptor (MOPr) is a clinically important G protein-coupled receptor that couples to Gi/o proteins
277 cro opioid receptor (microR), a prototypical G-protein-coupled receptor that is a physiologically rel
278 nding sites on the A2A adenosine receptor, a G-protein-coupled receptor that is a target for the trea
279 one secretagogue receptor 1a (GHS-R1a), is a G-protein-coupled receptor that is differentially expres
280 ce lacking GPR88, a striatum-enriched orphan G-protein-coupled receptor that modulates striatal mediu
282 act that S1PRs are pertussis toxin-sensitive G protein-coupled receptors, the effects of AAL-R were p
284 everal aspects of metabolism by activating 4 G-protein-coupled receptors, the A1, A2A, A2B, and A3 ad
285 onformational-sensitive antibodies targeting G-protein coupled receptors to screen for novel pharmaco
286 porters, potassium and calcium channels, and G-protein-coupled receptors to modulate exocytosis.
288 screened 29 proteins with known functions in G protein-coupled receptor trafficking for their role in
290 al immune modulatory proteins, including the G protein-coupled receptor US28, which scavenges human c
291 ified the 5q14 locus, harboring the adhesion G protein-coupled receptor V1 (ADGRV1) gene, which showe
293 0(-)(8)) in an intron of the adhesion GPR98 (G-protein-coupled receptor V1) gene on chromosome 5q14.3
294 Internalization of transferrin and these G protein-coupled receptors was also inhibited in cells
295 Three representative MPs, including one G-protein-coupled receptor, were successfully incorporat
296 osomal and melanosomal membranes unlike most G protein-coupled receptors, which localize to the plasm
298 e epitopes are known, human beta2 adrenergic G-protein-coupled receptor, with promising results.
299 ), which activate mast cells via Mas-related G protein-coupled receptor X2 (MRGPRX2), is increased in
300 IgE)-independent pathways [e.g., Mas-related G protein-coupled receptor X2 (MRGPRX2)], tetraspanins,
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