ライフサイエンスコーパス: G-protein

1 h is governed by the activation state of the G protein.

2 als to the cell interior by interacting with G proteins.

3 sensitized and uncoupled from heterotrimeric G proteins.

4 potency for signalling via Gq/11 and G12/13 G proteins.

5 olarity cell-autonomously via heterotrimeric G proteins.

6 NDPK isoforms and between NDPK isoforms and G proteins.

7 e GIRK2 channels directly, in the absence of G proteins.

8 AST and HMMER on predicting the effectors of G proteins.

9 s (18 g protein, 17 g fat) or egg whites (18 g protein, 0 g fat).

10 -[5,5,5-(2)H3]leucine-labeled whole eggs (18 g protein, 17 g fat) or egg whites (18 g protein, 0 g fa

11 ligomers impart unique kinetic properties on G-protein-activated Kir3 currents.

12 ontrolled by a GPCR-independent mechanism of G protein activation mediated by cytoplasmic factors.

13 Interestingly, no G protein activation was detected upon activation of GPR

14 Although unable to trigger G protein activation, both ligands activate G protein-in

15 g beta-arrestin-2 recruitment over canonical G protein activation.

16 otential channel 1 (TRPC1) proteins requires G protein alpha q subunit (Galphaq)/phospholipase C (PLC

17 hat stimulation of TRPC1-based SOCs requires G protein alpha q subunit (Galphaq)/phospholipase C (PLC

18 ons in the activity/levels of the extralarge G protein alpha-subunit (XLalphas) are implicated in var

19 L-368,899 prevented OT activation of G proteins and did not activate G proteins in the absenc

20 duction does not require preassembly between G proteins and GPCRs.

21 ds to experimentally identified effectors of G proteins and randomly selected non-effector proteins,

22 ing pathways are modulated by heterotrimeric G proteins and the scaffold proteins beta-arrestin 1 and

23 etamine and cocaine similarly depend on both G-protein and beta-arrestin D2R signaling.

24 uiring the mechanistic details of biased D2R/G-protein and D2R/beta-arrestin signaling in vivo has be

25 cally assumed to signal through Gi/o-coupled G-proteins and/or scaffolding proteins, such as beta-arr

26 ing component with a refractory period (e.g. G protein), and 3) inactivation of a factor needed for F

27 clathrin-coated pits, in which receptors and G proteins are confined and preferentially couple.

28 Heterotrimeric G-proteins are essential cellular signal transducers.

29 However, while G-proteins are widespread in plants, RGS proteins have b

30 to produce podosomes, down-regulation of the G-protein ARF1 or the ARF1 guanine nucleotide exchange f

31 lmitoylation, prevents the enhanced receptor G-protein association and blocks acute analgesic toleran

32 his lipid modification distorts the receptor G-protein association, thereby preventing agonist-induce

33 eptors recognize the unique positions of the G-protein barcode through distinct residues, like multip

34 asses are also likely to be relevant for the G-protein-based symmetry-breaking systems of higher euka

35 (HF), induces pathological signaling through G protein betagamma (Gbetagamma) subunits and their inte

36 synapse, accomplished in part by triggering G-protein betagamma subunits (Gbetagamma) interactions w

37 nsequent upregulated interaction between the G-protein betagamma-subunit (Gbetagamma), GPCR-kinase 2,

38 pyl-2-aminotetraline unit led to balanced or G protein-biased dopaminergic ligands depending on the s

39 new chemotypes of KOR antagonists as well as G-protein-biased agonists.

40 pressing fast ps-ns timescale motions at the G protein binding site.

41 ession, protein mislocalization, and reduced G protein binding were identified as likely mechanisms o

42 lar signal-regulated kinase 1/2 (ERK1/2) was G protein-, but not beta-arrestin-, dependent.

43 for detecting activation of a heterotrimeric G-protein by G-protein coupled receptors.

44 Similar to most other small G proteins, Cdc42 binds to many downstream effector prot

45 MeaB is a multifunctional G-protein chaperone, which gates loading of the active 5

46 was essential for the formation of an NDPK-B/G protein complex.

47 These genes encode the beta subunit of the G-protein complex (STE4), the pheromone MAPK scaffold (C

48 Arabidopsis heterotrimeric G-protein complex modulates pathogen-associated molecula

49 lving the formation of a ternary ligand-GPCR-G-protein complex.

50 Signaling properties of G protein complexes carrying mutant Gbeta1 subunits were

51 sion kinetics: (i) reversible, pH-dependent, G-protein conformational change from the known prefusion

52 enylate Synthetase Like (OASL), and Adhesion G Protein Coupled Receptor E5 (ADGRE5).

53 lar cAMP levels, increasing synthesis of the G protein coupled receptor, GPR120, and its recruitment

54 -regulated kinase (ERK) activation following G-protein coupled receptor (GPCR) activation.

55 that is an agonist for the GLP-1 receptor, a G-protein coupled receptor (GPCR).

56 GPR151 is a G-protein coupled receptor for which the endogenous liga

57 Here, we report the involvement of the G-protein coupled receptor G2A (GPR132) in oxaliplatin-i

58 versely showed upregulation of GO terms like G-protein coupled receptor pathway, membrane potential a

59 and that bile salt receptors VDR and Takeda G-protein coupled receptor5 (TGR5) were highly expressed

60 naling molecule that interacts with its five G-protein coupled receptors (S1P1-5) to regulate cell gr

61 onformational-sensitive antibodies targeting G-protein coupled receptors to screen for novel pharmaco

62 activation of a heterotrimeric G-protein by G-protein coupled receptors.

63 indel hotspots were functionally related to G-protein coupled signaling pathways.

64 bulin and native sulfur phasing of the human G protein-coupled adenosine receptor.

65 ein-coupled receptor 30 (GPR30), also called G protein-coupled estrogen receptor 1 (GPER1), is though

66 mone receptor farnesoid X receptor (FXR) and G protein-coupled membrane receptor TGR5 that demonstrat

67 The G protein-coupled pituitary adenylate cyclase-activating

68 The G protein-coupled protein receptor C-X-C chemokine recep

69 Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation underlies m

70 The beta1-adrenergic receptor (beta1AR) is a G protein-coupled receptor (GPCR) and the predominant ad

71 The G protein-coupled receptor (GPCR) MRGPRD is selectively

72 G protein-coupled receptor (GPCR) signaling occurs in co

73 photo-transduction cascade is a prototypical G protein-coupled receptor (GPCR) signaling system, in w

74 there has been a revolution in the field of G protein-coupled receptor (GPCR) structural biology.

75 GPR15 is an orphan G protein-coupled receptor (GPCR) that serves for an HIV

76 e C and ERK, suggesting the involvement of a G protein-coupled receptor (GPCR).

77 Members of the Mas-related G protein-coupled receptor (Mrgpr) family demarcate an i

78 w pathway is distinctly parcellated from the G protein-coupled receptor --> Gs --> adenylate cyclase

79 tein pathway mediating cell survival and the G protein-coupled receptor --> Gs --> adenylate cyclase

80 G protein-coupled receptor 30 (GPR30), also called G pro

81 the R-spondin/leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) axis in driving aber

82 Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a bona fide marke

83 annabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the c

84 Proteinase-Activated Receptor-2 (PAR2 ) is a G protein-coupled receptor activated by serine proteinas

85 Mutations to the adhesion G protein-coupled receptor ADGRG1 (G1; also known as GPR

86 s the major source of the lipid mediator and G protein-coupled receptor agonist sphingosine-1-phospha

87 al photoreceptor rhodopsin (Rho) is a unique G protein-coupled receptor as it utilizes a covalently t

88 formation and an enrichment of a pool of the G protein-coupled receptor at actin-rich cellular protru

89 n/sex hormonebinding globulin-like (PLL) and G protein-coupled receptor autoproteolysis-inducing (GAI

90 behavioral assays identify Gpr158, an orphan G protein-coupled receptor expressed in neurons of the C

91 4 (also known as TEM5/ADGRA2) is an adhesion G protein-coupled receptor family member that plays a pi

92 GPBAR1 (TGR5 or M-BAR) is a G protein-coupled receptor for secondary bile acids that

93 Rhodopsin is a G protein-coupled receptor found in the rod outer segmen

94 sets based on the expression of the adhesion G protein-coupled receptor GPR56, and GPR56(+) TEMRA cel

95 The class C G protein-coupled receptor GPRC6A is a putative nutrient

96 e type 1 taste receptor member 3 (T1R3) is a G protein-coupled receptor involved in sweet-taste perce

97 tagamma) subunits and their interaction with G protein-coupled receptor kinase 2 (GRK2).

98 ding SNVs found in SCZ subjects in the GIT1 (G protein-coupled receptor kinase interacting ArfGAP 1)

99 er, was predicted to target the SC-expressed G protein-coupled receptor LGR5.

100 The G protein-coupled receptor opsin is a phospholipid scram

101 First, a localized signal is generated by a G protein-coupled receptor paired to one or more of the

102 , representing a novel mode of regulation of G protein-coupled receptor signaling by scaffolding prot

103 id receptor (MOPr) is a clinically important G protein-coupled receptor that couples to Gi/o proteins

104 The dopamine D2 receptor (D2R) is a G protein-coupled receptor that is a common target for a

105 al immune modulatory proteins, including the G protein-coupled receptor US28, which scavenges human c

106 ified the 5q14 locus, harboring the adhesion G protein-coupled receptor V1 (ADGRV1) gene, which showe

107 In the absence of adhesion G protein-coupled receptor V1 (adgrv1), another hair bun

108 ), which activate mast cells via Mas-related G protein-coupled receptor X2 (MRGPRX2), is increased in

109 IgE)-independent pathways [e.g., Mas-related G protein-coupled receptor X2 (MRGPRX2)], tetraspanins,

110 Glucose and other sugars are detected by a G protein-coupled receptor, Gpr1, as well as a pair of t

111 KRAS4B membrane association and identified a G protein-coupled receptor, GPR31.

112 In Drosophila melanogaster, a single G protein-coupled receptor, Trapped in endoderm 1 (Tre1)

113 The leucine-rich G protein-coupled receptor-5 (LGR5) is expressed in adul

114 internal calcium in astrocytes, focusing on G protein-coupled receptor-mediated mobilization of calc

115 nosine receptor, a pharmaceutically relevant G protein-coupled receptor.

116 hibitors, and most notably by stimulation of G protein-coupled receptors (GPCR).

117 in receptor (APJ) belongs to family A of the G protein-coupled receptors (GPCRs) and is a potential p

118 G protein-coupled receptors (GPCRs) are central to many

119 G protein-coupled receptors (GPCRs) are considered to fu

120 G protein-coupled receptors (GPCRs) are essential for tr

121 Given the importance of G protein-coupled receptors (GPCRs) as pharmaceutical ta

122 cally involved in the signal transduction of G protein-coupled receptors (GPCRs) at the plasma membra

123 Family A G protein-coupled receptors (GPCRs) control diverse biol

124 ing across cellular membranes, the 826 human G protein-coupled receptors (GPCRs) govern a wide range

125 G protein-coupled receptors (GPCRs) have evolved a seven

126 The superfamily of G protein-coupled receptors (GPCRs) mediates a wide rang

127 G protein-coupled receptors (GPCRs) play an important ro

128 G protein-coupled receptors (GPCRs) play crucial roles i

129 Class B G protein-coupled receptors (GPCRs) respond to paracrine

130 Pairing orphan G protein-coupled receptors (GPCRs) with their cognate e

131 G protein-coupled receptors (GPCRs), a superfamily of ce

132 scular signalling components, and especially G protein-coupled receptors (GPCRs), as next-generation

133 ts predominantly from chronic stimulation of G protein-coupled receptors (GPCRs), including adrenergi

134 t this theory may be applied to nonolfactory G protein-coupled receptors (GPCRs), including those ass

135 G protein-coupled receptors (GPCRs), the largest family

136 Like most class B G protein-coupled receptors (GPCRs), there is limited kn

137 G protein-coupled receptors (GPCRs), which are modulated

138 The function of G protein-coupled receptors (GPCRs)-which represent the

139 ral different agonists, many of which act on G protein-coupled receptors (GPCRs).

140 of cell surface proteins in eukaryotes, the G protein-coupled receptors (GPCRs).

141 y transduces signals from a diverse group of G protein-coupled receptors (GPCRs).

142 idence that SP functions through Mas-related G protein-coupled receptors (Mrgprs) in addition to its

143 G protein-coupled receptors and cyclic guanosine monopho

144 C4a against a panel of both known and orphan G protein-coupled receptors and now provide evidence tha

145 up of cell-surface receptors, including many G protein-coupled receptors and receptor tyrosine kinase

146 Chemokines and their cell surface G protein-coupled receptors are critical for cell migrat

147 erspective have been increasingly applied to G protein-coupled receptors including the adenosine rece

148 ry proposes that the activation of olfactory G protein-coupled receptors occurs by an inelastic elect

149 B (CTSB), which can be induced directly via G protein-coupled receptors on acinar cells or through i

150 Many G protein-coupled receptors require association with oth

151 pha-pheromone was independent of the cognate G protein-coupled receptors Ste2 and of the central beta

152 otably including growth factor receptors and G protein-coupled receptors, control myelination.

153 It is now recognized that similar to most G protein-coupled receptors, D2Rs signal not only throug

154 ar domain was described at several aminergic G protein-coupled receptors, including muscarinic acetyl

155 Allosteric modulators of G protein-coupled receptors, including opioid receptors,

156 initiates signaling upstream of PI3K through G protein-coupled receptors, specifically via the metabo

157 osomal and melanosomal membranes unlike most G protein-coupled receptors, which localize to the plasm

158 ed structural motifs recognized by aminergic G protein-coupled receptors.

159 M), where they are activated by cell surface G protein-coupled receptors.

160 lular purinergic signals that signal through G protein-coupled receptors.

161 (natriuretic peptide receptor 2) and not the G-protein-coupled clearance receptor NPR3 (natriuretic p

162 ddress this gap, we identified GPER/GPR30, a G-protein-coupled estrogen receptor, in goldfish (Carass

163 in (POMC) neurons leads to the activation of G-protein-coupled inward rectifier potassium (GIRK) chan

164 hannel and A1 receptor-mediated opening of a G-protein-coupled inwardly rectifying potassium channel.

165 rotein kinase A (PKA) integrates inputs from G-protein-coupled neuromodulator receptors to modulate s

166 , COX-2, multidrug resistance protein 4, and G-protein-coupled prostaglandin E2 receptors 1 and 2), a

167 The endothelial G-protein-coupled receptor (GPCR) Gpr124 has been report

168 x conformational energy landscape determines G-protein-coupled receptor (GPCR) signalling via intrace

169 l is activated by a signal downstream of the G-protein-coupled receptor (GPCR)-Gq/11-phospholipase C

170 Microarray analyses revealed G-protein-coupled receptor (GPR) signaling as a prominen

171 The G-protein-coupled receptor 39 (GPR39) is a G-protein-cou

172 Leucine-rich repeat containing G-protein-coupled receptor 5 (LGR5), an intestinal stem

173 e G-protein-coupled receptor 39 (GPR39) is a G-protein-coupled receptor activated by Zn(2+).

174 ted receptor 1 (TAAR1) is a highly conserved G-protein-coupled receptor bound by endogenous trace ami

175 Melanocortin-4 receptor (MC4R) is a G-protein-coupled receptor expressed in the brain's hypo

176 We recently identified a novel role for G-protein-coupled receptor kinase 2 (GRK2) that renders

177 nsitions from inhibiting Raf-1 to inhibiting G-protein-coupled receptor kinase 2 upon phosphorylation

178 we find that CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial fo

179 peptide ligands from platelet GP1balpha and G-protein-coupled receptor MAS effectively bound Ig21 by

180 in mammals and discovered that Hedgehog and G-protein-coupled receptor pathways were linked to cilia

181 phorylation, thereby bridging MAP kinase and G-Protein-Coupled Receptor signaling.

182 Each microvillus employs a full G-protein-coupled receptor signalling pathway to adaptiv

183 cro opioid receptor (microR), a prototypical G-protein-coupled receptor that is a physiologically rel

184 nding sites on the A2A adenosine receptor, a G-protein-coupled receptor that is a target for the trea

185 0(-)(8)) in an intron of the adhesion GPR98 (G-protein-coupled receptor V1) gene on chromosome 5q14.3

186 The nociceptin (NOP) receptor is a G-protein-coupled receptor whose natural ligand is the N

187 The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial role in human

188 Three representative MPs, including one G-protein-coupled receptor, were successfully incorporat

189 e epitopes are known, human beta2 adrenergic G-protein-coupled receptor, with promising results.

190 Smoothened (SMO) is a G-protein-coupled receptor-related protein required for

191 mbers of the secretin-like class B family of G-protein-coupled receptors (GPCRs) and have opposing ph

192 Although individual G-protein-coupled receptors (GPCRs) are known to activat

193 G-protein-coupled receptors (GPCRs) are the largest and

194 Although 108 G-protein-coupled receptors (GPCRs) are the targets of 4

195 Resetting of G-protein-coupled receptors (GPCRs) from their active st

196 G-protein-coupled receptors (GPCRs) play critical roles

197 surface expression or ligand specificity of G-protein-coupled receptors (GPCRs).

198 robiota for N-acyl amides that interact with G-protein-coupled receptors (GPCRs).

199 ction via protease-activated and mas-related G-protein-coupled receptors (Mrgprs) to contribute to al

200 Here we analyse the concerted motion of G-protein-coupled receptors and G proteins on the plasma

201 approach to interrogate proteins engaged by G-protein-coupled receptors as they dynamically signal a

202 B (GABAB) receptors, which are heterodimeric G-protein-coupled receptors constructed from R1a and R2

203 We also discover candidate G-protein-coupled receptors for the perception of trispo

204 Transcriptional screening for the expression G-protein-coupled receptors in murine dorsal root gangli

205 The G-protein-coupled receptors LGR4, LGR5 and LGR6 are Wnt

206 G-protein-coupled receptors mediate the biological effec

207 or the V2R without any activity on 155 other G-protein-coupled receptors or on 15 ionic channels.

208 GABAB receptors are G-protein-coupled receptors that mediate inhibitory syna

209 en partial and/or biased agonism in RTKs and G-protein-coupled receptors, as well as new therapeutic

210 nd a highly cell-type-specific expression of G-protein-coupled receptors, implying that ligand-recept

211 R2), a classical chemoattractant receptor of G-protein-coupled receptors, is reported to be involved

212 everal aspects of metabolism by activating 4 G-protein-coupled receptors, the A1, A2A, A2B, and A3 ad

213 ding of the signalling mechanisms of class B G-protein-coupled receptors.

214 The cAMP-elevating, Gs protein-coupled A2a adenosine receptor (A2aR) is an e

215 tinct mechanism that requires the following: Gs-protein-coupled adenosine 2A receptor activation, new

216 cannabinoid receptor 1 (CB1) and antagonized G protein coupling.

217 t CP55,940 while exhibiting an antagonism of G-protein coupling activity.

218 an intracellular binding site that enhances G-protein coupling.

219 r expansion and its potential effects on the G-protein cycle in plants.

220 et containing either 0.8 (RDA) or 1.6 (2RDA) g protein . d(-1), aimed to balance energy needs.

221 Subjects consumed 90 g protein/d (1.0 +/- 0.03 g . d(-1), 125% of the Recomme

222 Cowpea and common bean added 4.6-5.2 g protein/d and 4-5 g indigestible carbohydrate/d to the

223 provided approximately 900 kcal/d and 33-36 g protein/d.

224 n allow the selective activation of specific G-protein dependent or beta-arrestin-mediated cascade pa

225 d by in vivo cocaine exposure is tempered by G protein-dependent inhibitory feedback mechanisms in DA

226 e efficacy of recombinant unglycosylated RSV G protein ectodomain produced in E. coli (in presence an

227 hese receptors co-localize with a variety of G proteins even before receptor activation, and activate

228 gnaling pathways regulated by heterotrimeric G-proteins exist in all eukaryotes.

229 iferation and myelination through modulating G-protein expression and interacting with SOX10, respect

230 Under basal conditions, receptors and G proteins form activity-dependent complexes that last f

231 versible trimerization and clustering of the G-protein fusion loops, leading to an extended intermedi

232 On the other hand, GPCR-G protein fusions have been used extensively to understa

233 To address the importance of the G-proteins Galphai2 and Galphai3 in thymocyte and T cell

234 Despite expression of gene transcripts, G-protein gated K(+) channel (Kir3) and KATP (Kir6) curr

235 G protein-gated inwardly rectifying K(+) (GIRK/Kir3) cha

236 ion between PP1calpha and the heterotrimeric G protein Gbeta1 subunit.

237 dependent on the 5-HT receptor SER-1 and the G protein GOA-1.

238 their canonical signaling components (i.e., G-protein gustducin and phospholipase C beta2).

239 enetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pa

240 ode allow the receptors to bind and activate G proteins in a similar manner, different receptors reco

241 ctivation of G proteins and did not activate G proteins in the absence of OT.

242 accines expressing RSV F (PIV5/F) or G (PIV5/G) protein in the cotton rat and African green monkey mo

243 G protein activation, both ligands activate G protein-independent ACKR3 responses and prompt arresti

244 d-specific receptor conformations leading to G protein-independent signaling and to functional parame

245 to activate one or more G proteins, the GPCR-G-protein interaction is viewed as a bimolecular event i

246 stablished for detecting ligand induced GPCR-G protein interactions in cells.

247 howed that 2PPM is capable of detecting GPCR-G protein interactions.

248 otein interactions at the cognate site, (ii) G-protein interactions at distinct allosteric and cognat

249 parallel mechanisms involving (i) sequential G-protein interactions at the cognate site, (ii) G-prote

250 re, we present evidence that individual GPCR-G-protein interactions can reinforce each other to enhan

251 ic demonstrated that a recombinant VSV where G protein is replaced with EBOV GP (rVSV-EBOV) is safe a

252 Both in G protein-mediated pathways and in beta-arrestin 2 recru

253 an and mouse orthologs had limited effect on G protein-mediated signal transduction, removal of posit

254 However, it is unclear how receptors and G proteins meet, interact and couple.

255 also retain signaling through the endogenous G protein milieu.

256 Efficient delivery of biomacromolecules (e.g., proteins, nucleic acids) into cell cytosol remains a

257 didate and that the expression of both F and G proteins of AMPV-C induces a protective response again

258 ed motion of G-protein-coupled receptors and G proteins on the plasma membrane and provide a quantita

259 ity via binding to macromolecular targets (e.g., proteins or DNA).

260 : 36.88 +/- 4.11 vs men: 21.22 +/- 3.65 nmol/g protein, p = 0.007) was observed.

261 Our previous work indicates that GPS2 (G-protein Pathway Suppressor 2) is a multifunctional pro

262 tors, D2Rs signal not only through canonical G protein pathways but also through noncanonical beta-ar

263 The human respiratory syncytial virus G protein plays an important role in the entry and assem

264 fficiency incorporate biological networks, e.g. protein-protein interaction networks that have recent

265 ntification of key signaling hubs around the G proteins RAP1B and GNB1, the kinases PKCbeta, PAK2, Lc

266 ptor phosphorylation at protein kinase A and G-protein receptor kinase sites in the myocardium.

267 G-proteins regulate various processes ranging from DNA r

268 X3C chemokine motif ((182)CWAIC(186)) in the G protein, RSV binds to the corresponding chemokine rece

269 atiometric FRET imaging experiments with the G-protein sensor.

270 Heterotrimeric G proteins signal at a variety of endomembrane locations

271 duration are controlled by the regulator of G protein signaling (RGS) proteins.

272 Regulator of G protein signaling 2 (RGS2) plays a significant role in

273 GBAi does not interfere with canonical GPCR-G protein signaling but blocks GBA-dependent signaling i

274 The R7 regulator of G protein signaling family (R7-RGS) critically regulates

275 The Tre1-NRY domain via G protein signaling is required for reading and respondi

276 CRs selectively couple to and activate their G protein signaling partners.

277 serine/threonine phosphatases integrate with G protein signaling pathways is less understood.

278 okine receptors do not mediate chemotaxis or G protein signaling, but they recruit arrestin.

279 lished that in Arabidopsis, the regulator of G-protein signaling (RGS1) protein and a lipid-hydrolyzi

280 Regulator of G-protein signaling Gbeta5-R7 is a crucial activator of

281 GABAB receptors that differentially regulate G-protein signaling of the receptor.

282 hether ECRs play a direct regulatory role in G-protein signaling or simply serve as a protective cap

283 estlet shredding, is similarly driven by D2R/G-protein signaling.

284 covery more than 20 years ago, regulators of G protein-signaling (RGS) proteins have received conside

285 ce responses, probably related to degenerate G protein signalling networks.

286 54, n = 3, all values expressed as mean nmol/g protein +/- standard error of the mean, p = 0.040 by A

287 G protein stimulatory alpha-subunit (Galphas)-coupled he

288 subfamily RGS proteins are stabilized by the G-protein subunit Gbeta5, such that the knockout of the

289 Sensors consist of a GPCR and G protein tethered by an ER/K linker flanked by FRET pro

290 Cdc42 is a Rho-family small G protein that has been widely studied for its role in c

291 act with extracellular ligands and couple to G proteins that transmit intracellular signals.

292 nic sites in the N- and C-termini of the RSV-G protein, that were boosted >10-fold by adjuvant and in

293 rs (GPCRs) are known to activate one or more G proteins, the GPCR-G-protein interaction is viewed as

294 xchange of GDP for GTP on the heterotrimeric G protein transducin (GT).

295 nity to the complex of betagamma-subunits of G protein transducin (Gtbetagamma).

296 ata, we conclude that the critical number of G-protein trimers required to overcome membrane resistan

297 vated receptors are largely sequestered from G proteins upon internalization.

298 iple keys (receptors) opening the same lock (G protein) using non-identical cuts.

299 of the four major subtypes of heterotrimeric G proteins was found.

300 The RSV F protein and attachment (G) protein were found to be internalized in both infecte