ライフサイエンスコーパス: G-protein alpha subunit

1 ning requires Pins or related proteins and a G protein alpha subunit.

2 by mutations in the GNAS exons encoding the G protein alpha subunit.

3 sis has only one gene, GPA1, for a canonical G protein alpha subunit.

4 to xanthine nucleotides in a heterotrimeric G protein alpha subunit.

5 ed by the G protein beta subunit to bind the G protein alpha subunit.

6 ng RGS in close proximity with its substrate G protein alpha subunit.

7 eceptors (GPCRs) and GTP replaces GDP on the G protein alpha-subunit.

8 nes may be the result of a difference in the G-protein alpha subunit.

9 the Gpr1 receptor that is coupled to Gpa2, a G-protein alpha subunit.

10 or protein-protein interactions differ among G protein alpha subunits.

11 by enhancing endogenous GTPase activities of G protein alpha subunits.

12 ecule, and there are several such regions in G protein alpha subunits.

13 elerating proteins (GAPs) for heterotrimeric G protein alpha subunits.

14 by increasing the rate of GTP hydrolysis on G protein alpha subunits.

15 encode positive regulators of heterotrimeric G protein alpha subunits.

16 asma membrane localization of heterotrimeric G protein alpha subunits.

17 g proteins (GAPs) for G(i) and/or G(q) class G protein alpha subunits.

18 were reconstituted with purified recombinant G protein alpha subunits.

19 celerates the rate of GTP hydrolysis by some G protein alpha subunits.

20 S) proteins directly control the activity of G protein alpha subunits.

21 naling by stimulating the GTPase activity of G protein alpha subunits.

22 ctional regulation of activity by homologous G protein alpha subunits.

23 ne proteins, G protein-coupled receptors and G protein alpha subunits.

24 catalyzed binding of GTP gamma S to purified G protein alpha subunits.

25 but have not been reported to regulate other G protein alpha subunits.

26 is to participate in the folding of nascent G protein alpha subunits.

27 hat NUCB1 might interact with heterotrimeric G protein alpha subunits.

28 at collectively bind the four subfamilies of G protein alpha subunits.

29 ing proteins that specifically interact with G protein alpha subunits.

30 otide exchange factor that activates certain G protein alpha-subunits.

31 by acting as GTPase-activating proteins for G protein alpha-subunits.

32 rotein-2 (RAMP2), and the role of individual G protein alpha-subunits.

33 localization or GAP activity toward purified G-protein alpha subunits.

34 ng of the GDP-bound conformation of specific G-protein alpha subunits.

35 forms, VSV and VGV, to interact with various G-protein alpha subunits.

36 region for protein binding to heterotrimeric G-protein alpha subunits.

37 oteins by stimulating the GTPase activity of G-protein alpha subunits.

38 o function as GTPase-activating proteins for G-protein alpha subunits.

39 antibodies that recognize various classes of G-protein alpha-subunits.

40 the four completely sequenced Dictyostelium G-protein alpha-subunits.

41 ological effects by signaling through either G-protein alpha subunit 12 or beta-arrestin 2.

42 pha, and to overexpression of heterotrimeric G-protein alpha subunit 2, inhibitory with respect to ad

43 The four classes of heterotrimeric G-protein alpha subunits act as molecular routers inside

44 of neutrophils in the absence of receptor or G protein alpha subunit activation.

45 his issue, Slessareva et al. now show that a G protein alpha subunit acts at the endosome to stimulat

46 ssed in HEK293 cells, but co-expression of a G protein alpha subunit allows strong PM localization of

47 ed with constitutively active mutants of the G protein alpha subunits alpha s, alpha i1, and alpha o

48 as GTPase-activating proteins (GAPs) for the G-protein alpha-subunits alpha(i) and alpha(q), lack suc

49 The G-protein alpha subunit, alpha(13), regulates cell growt

50 The N termini of two G protein alpha subunits, alphaq and alpha11, differ fro

51 trimeric guanine nucleotide binding protein (G protein) alpha-subunit (alphas), to alanine (alphas-R2

52 The G protein alpha subunits, alphas and alphai2, have stimu

53 in maintaining the membrane attachment of a G protein alpha subunit, alphaz, which is myristoylated

54 influences of dexamethasone on the levels of G-protein alpha-subunits, an effect that may contribute

55 unit is selectively associated with specific G protein alpha subunits and is localized preferentially

56 hare a common RGS domain that interacts with G protein alpha subunits and mediates their biological r

57 coupled to Galphaq and Galphai, and chimeric G protein alpha subunits and murine fibroblasts deficien

58 from that seen in analogous mutants of other G protein alpha subunits and suggests that either regula

59 Large G protein alpha subunits and their attendant regulators

60 ungus Aspergillus nidulans, a heterotrimeric G protein alpha-subunit and an RGS domain protein, encod

61 neurite outgrowth 1) can tether MOR with the G protein alpha-subunit and subsequently regulate the re

62 nt residue (Glu259) is strictly conserved in G protein alpha-subunits and is predicted to be importan

63 One signaling cascade involves a conserved G-protein alpha subunit and cAMP, and senses nutrients d

64 al landscape and the switching function of a G-protein alpha subunit and the influence of a GPCR in t

65 AMP signaling is dependent on receptor (with G-protein alpha subunits and adenylyl cyclase) internali

66 ne triphosphatase activity of heterotrimeric G-protein alpha subunits and are thus recognized as key

67 toxin (PTX) resulted in ADP-ribosylation of G-protein alpha subunits and inhibition (>80%) of lympho

68 eins bind to the inhibitory G(i) subclass of G-protein alpha subunits and slow the release of bound G

69 For example, this domain interacts with G-protein alpha subunits and Src-like kinases and can fu

70 accelerate GTP hydrolysis by heterotrimeric G-protein alpha subunits and thus inhibit signaling by m

71 mbinants expressing individual PTX-resistant G-protein alpha subunits and treated with PTX, and quinp

72 The GTP bound form of the g-protein alpha-subunit and in some cases the free betag

73 g infrequently occurring mutants of trimeric G-protein alpha-subunits and GPCRs.

74 lysis of two protein families (LacI/PurR and G protein alpha subunit), and compared our method with t

75 one was identified as Gnas, which encodes a G protein alpha subunit, and there is clinical and bioch

76 muli, including protein kinase C, forskolin, G protein alpha subunits, and G protein betagamma subuni

77 ein betagamma subunits, wild-type or mutated G-protein alpha subunits, and active protomers of pertus

78 Since rods and cones have different G-protein alpha subunits, and since this subunit (Talpha

79 duced feeding are mediated through different G-protein alpha-subunits, and provide further evidence f

80 G protein alpha-subunits appear to be capable of interac

81 Most heterotrimeric G protein alpha subunits are covalently modified by palm

82 The C termini of G protein alpha subunits are critical for binding to the

83 Many G protein alpha subunits are dually acylated with myrist

84 functional abundances of G proteins because G protein alpha subunits are misfolded and degraded rapi

85 ded to bitter stimuli, suggesting that other G-protein alpha subunits are involved.

86 encoding members of the Galpha(q) family of G protein alpha subunits, are the driver oncogenes in uv

87 palmitoyltransferase activity, assayed using G-protein alpha subunits as a substrate, was found to be

88 nsitive to MOR-1 AS ODN effects, none of the G-protein alpha-subunit AS ODN probes were effective.

89 Gnasxl determines a variant G protein alpha subunit associated with the trans-Golgi

90 NA to suppress expression of the three known G-protein alpha-subunit-associated RhoA guanine nucleoti

91 This may reflect the concentration of G-protein alpha subunits at synapses.

92 When G-protein alpha subunits binds GTP and Mg(2+), they tran

93 to examine the receptor coupling to purified G protein alpha subunits by the bombesin receptor family

94 bial mechanisms, such as ADP ribosylation of G protein alpha-subunits by cholera and pertussis toxins

95 employing combinations of antibodies against G-protein alpha subunits, calcium-binding proteins, and

96 Inactive forms of all G protein alpha subunits can be produced by mutations eq

97 le that the receptor coupling selectivity of G protein alpha subunits can be switched by single amino

98 Second, different G protein alpha subunits can compete with each other for

99 ructural differences between closely related G-protein alpha-subunits can have important consequences

100 Our data suggest that activation of G protein alpha subunits causes them to concentrate in s

101 Alpha-gustducin, a taste cell-expressed G-protein alpha subunit closely related to the alpha-tra

102 Most strikingly, interaction with G protein alpha subunit completely inhibits the enzymati

103 G protein alpha subunits consist of two domains, a GTPas

104 Gi2alpha and other G-protein alpha subunits contain a single region that ge

105 G protein alpha subunits cycle between active and inacti

106 AS ODN probes directed against different G-protein alpha-subunits differentially reduced morphine

107 ranch of the yeast mating pathway in which a G-protein alpha subunit directly activates phosphatidyli

108 enriched GTPase activating protein (GAP) for G-protein alpha subunits, displayed increased microglial

109 demonstrate that the GTP-bound state of the G protein alpha subunit displays no detectable affinity

110 anism, given that the GDP-bound form of many G protein alpha subunits does not contain bound Mg2+.

111 mosensory sensilla, which suggests that this G-protein alpha subunit does not participate in olfactor

112 main functionally suppresses the activity of G-protein alpha subunits, eNOS, and Src-like kinases, su

113 eptor alleles expressed in cells lacking the G protein alpha subunit exhibit a higher equilibrium bin

114 ptahelical receptors among the four Gq class G-protein alpha subunits expressed in mammals.

115 e functional roles subserved by G(alpha)z, a G protein alpha subunit found predominantly in neuronal

116 e on the cloning and characterization of two G protein alpha-subunits from pea: PGA1 and PGA2.

117 itherto undescribed defect in human platelet G-protein alpha-subunit function leading to impaired pla

118 Here we demonstrate that the heterotrimeric G protein alpha subunit G(s)alpha is required in cells o

119 The imprinted mouse gene Gnas produces the G protein alpha-subunit G(S)alpha and several other gene

120 The G protein alpha-subunit G(s)alpha is required for hormon

121 ytochemistry using antisera specific for the G-protein alpha subunits G(alphai), G(alphaq), and G(alp

122 Disruption of the Dictyostelium G-protein alpha-subunit G alpha 3 (g alpha 3-) blocks de

123 d expressing this receptor together with the G-protein alpha-subunit G alpha(16).

124 The G-protein alpha-subunit G(s)alpha is required for the in

125 The downstream promoter for the stimulatory G protein alpha-subunit (G(s)alpha) is unmethylated, alt

126 These products include stimulatory G protein alpha-subunit (G(s)alpha), the G protein requi

127 n of Gnas, the gene encoding the stimulatory G-protein alpha subunit (G(s)alpha), leads to distinct p

128 sduction pathways in P. carinii, we cloned a G-protein alpha subunit (G-alpha) of P. carinii carinii

129 To probe conformational changes in the G-protein alpha-subunit (G(alpha)) associated with activ

130 Solution NMR studies of a (15)N-labeled G-protein alpha-subunit (G(alpha)) chimera ((15)N-ChiT)-

131 l changes in an isotope-labeled, full-length G-protein alpha-subunit (G(alpha)) chimera (ChiT) associ

132 ciency of beta(2)AR interaction with various G-protein alpha-subunits (G(xalpha)), we expressed fusio

133 binding assay, and binding was inhibited by G protein alpha subunit, G alpha i1.

134 e in expression of muscarinic receptors, the G protein alpha-subunit, G-alphai2, and the inward recti

135 nylyl cyclase inhibitory guanine nucleotide (G) protein alpha subunit, G alpha(i2).

136 This report describes the Dictyostelium G-protein alpha-subunit, G alpha3, and demonstrates that

137 We found that the G-protein alpha subunit Galpha(i2) is present in most bi

138 The G protein alpha subunit (Galpha) is composed of two dist

139 The pheromone-responsive G protein alpha subunit (Galpha) of yeast down-regulates

140 activated by exchange of GDP for GTP at the G protein alpha subunit (Galpha), most notably by G prot

141 ins by substituting GTP for GDP bound to the G protein alpha subunit (Galpha), thereby generating two

142 AMP from ATP and is activated by stimulatory G protein alpha subunits (Galpha(s)) and by forskolin (F

143 a cycle of GTP binding and hydrolysis on the G protein alpha-subunit (Galpha).

144 usly showed that guanine nucleotide-binding (G) protein alpha subunit (Galpha)-interacting vesicle-as

145 te xanthine nucleotide-selective unspecified G-protein alpha-subunit (Galpha).

146 accelerate the intrinsic GTPase activity of G-protein alpha-subunits (Galpha) and thus shorten the t

147 In functional studies, the use of a chimeric G protein alpha-subunit, Galpha(qo5), demonstrated that

148 The GTPase activities of two G protein alpha subunits, Galpha12 and Galpha13, are sti

149 ers of the Galpha12 family of heterotrimeric G proteins alpha subunits, Galpha12 and Galpha13, regula

150 xchange factor that binds the heterotrimeric G-protein alpha-subunits, Galpha12 and Galpha13.

151 ic binding of a C-terminal fragment from the G protein alpha subunit (GalphaCT) to trap a light activ

152 The heterotrimeric G protein alpha subunit, Galphai3, has also been localiz

153 elanomas (UMs), but somatic mutations in the G protein alpha subunits Galphaq and Galpha11 (encoded b

154 occupied receptors and the receptor-coupled G-protein alpha subunits Galphaq and Galphai in caveolae

155 Interestingly, the N termini of two G protein alpha subunits, Galphaq and Galpha11, differ f

156 ly, we have reported that the heterotrimeric G protein alpha-subunit, Galphaq/11, can mediate insulin

157 ty through its interaction with the specific G protein alpha subunits, Galphas or Galphai1.

158 lerators of the intrinsic GTPase activity of G protein alpha subunits (GAPs), thus controlling the re

159 Besides the sole prototypical G protein alpha subunit gene, GPA1, the Arabidopsis thal

160 s-of-function mutation in the heterotrimeric G protein alpha-subunit gene Gnai3 have fusions of ribs

161 Ta strain containing a deletion of GPA1, the G protein alpha-subunit gene; however, STE4(SD13) had no

162 ole prototypical heterotrimeric GTP-binding (G) protein alpha subunit gene, GPA1, lack both ABA inhib

163 -DNA null mutations in the sole prototypical G-protein alpha-subunit gene, GPA1.

164 ines of the sole prototypical heterotrimeric G-protein alpha-subunit gene, GPA1.

165 Mutations in G protein alpha subunit genes altered the responses of b

166 tive GDP-bound complex of the heterotrimeric G protein alpha subunit Gi alpha 1 has been investigated

167 e crystal structure of the complex between a G protein alpha subunit (Gi alpha 1) and its GTPase-acti

168 In this report, G protein alpha subunits Gi1alpha, Gsalpha, and Goalpha

169 Mice lacking the heterotrimeric G protein alpha subunit Gialpha2 develop chronic colitis

170 We have identified a new gene encoding the G protein alpha subunit, gna-3, from the filamentous fun

171 ine 243 to histidine (R243H) mutation in the G-protein alpha subunit GNAO1 in breast carcinoma tissue

172 enes encoding the TSH receptor (TSHR) or the Gs protein alpha subunit (GNAS) are found in approximate

173 as caused by the hyperactivation of a single G-protein alpha subunit, Gnas.

174 Recently, it has been shown that the G protein alpha subunit Gpa1 can promote signaling at en

175 sed mass spectrometry to show that the yeast G protein alpha subunit Gpa1 is ubiquitinated at Lys-165

176 The yeast G protein alpha subunit Gpa1 represents a rare example o

177 ngal pathogen Cryptococcus neoformans, three G protein alpha subunits (Gpa1, Gpa2 and Gpa3) have been

178 for proteins that interact with Arabidopsis G protein alpha-subunit (GPA1).

179 les the one described for the heterotrimeric G-protein alpha subunit (GPA1) null mutant gpa1.

180 olated a knock-out mutant of the Arabidopsis G-protein alpha subunit (gpa1-5) and analysed its transc

181 PR89) and interact with the sole Arabidopsis G protein alpha subunit, GPA1, but also have intrinsic G

182 f the G protein; promotes degradation of the G protein alpha subunit, Gpa1, in vivo; and catalyzes Gp

183 Arabidopsis, in addition to one prototypical G protein alpha subunit, GPA1, there are three extra-lar

184 e-associated receptor-coupled heterotrimeric G-protein alpha subunit, Gpa1.

185 ponses in null mutants of the sole canonical G-protein alpha subunit, GPA1.

186 The Saccharomyces cerevisiae G protein alpha subunit Gpa1p is involved in the respons

187 The G protein alpha subunit (Gpa1p) is tandemly modified at

188 ductively interact with the endogenous yeast G protein alpha subunit, Gpa1p, or a mutant Gpa1p subuni

189 ling pathway that directly interact with the G protein alpha-subunit Gpa2p in the yeast Saccharomyces

190 e show that a signaling module formed by the G protein alpha subunit, Gqalpha, and one of its downstr

191 In this study, we report that immunoreactive Gs protein alpha-subunits (Gs alpha) localize to nuclei

192 The stimulatory G protein alpha subunit Gsalpha binds within a cleft in

193 complex with its stimulatory heterotrimeric G protein alpha subunit (Gsalpha) and forskolin was dete

194 The stimulatory G protein alpha-subunit (Gsalpha) couples the beta-adren

195 GNAS1, the gene encoding the heterotrimeric G protein alpha-subunit (Gsalpha) that couples multiple

196 sed in taste receptor cells that contain the G protein alpha subunit gustducin, implying that they fu

197 coupled receptor (GPCR) linked directly to a G protein alpha subunit have been employed for a number

198 t, two different constitutive mutants of the G protein alpha subunit have been reported.

199 lves a signal mediated by the heterotrimeric G protein alpha subunit homolog encoded by GPA2.

200 The gene encoding a G-protein alpha subunit homolog, GPA1, was disrupted by

201 und that GPA2, one of the two heterotrimeric G protein alpha subunit homologs in yeast, regulates pse

202 vated Galpha(q/11) subunits, implicates this G protein alpha subunit in the modulatory pathway.

203 tify the site of ubiquitination in Gpa1, the G protein alpha subunit in yeast Saccharomyces cerevisia

204 ine the cellular trafficking function of the G protein alpha subunit in yeast, Gpa1.

205 ies have implicated the carboxyl terminus of G protein alpha subunits in both mediating receptor-G pr

206 enon, the authors investigated the levels of G protein alpha subunits in platelets and lymphocytes of

207 s to characterize the relative expression of G protein alpha subunits in rat colonocytes, colonocyte

208 fied two genes, gna-1 and gna-2, that encode G protein alpha subunits in the filamentous fungus Neuro

209 perone for several classes of heterotrimeric G protein alpha subunits in vertebrates.

210 was examined by reconstitution with various G protein alpha-subunits in heterotrimeric form with Gbe

211 the abundance of mRNA and/or protein of six G protein alpha-subunits in human CD4(+) and CD8(+) T ce

212 act as GTPase-activating proteins (GAPs) for G protein alpha-subunits in vitro.

213 tment to the cell cortex by a heterotrimeric G-protein alpha subunit in complex with a TPR-GoLoco mot

214 Here, we studied the internal mobility of a G-protein alpha subunit in its apo and nucleotide-bound

215 ta subunits established the involvement of a G-protein alpha subunit in PMT-activation of PLCbeta1.

216 LGs) that show significant similarity to the G-protein alpha subunit in their C-terminal regions.

217 of ribosylation-resistant (PTX-insensitive) G-protein alpha subunits in brain EC restored their abil

218 expression of 5HT(2C) receptor isoforms with G-protein alpha subunits in fibroblasts were studied, an

219 erized the complete set of genes that encode G-protein alpha subunits in the genome of the malaria ve

220 may accelerate the rate of GTP hydrolysis by G protein alpha subunits, in part, by inserting an amino

221 Pase-accelerating protein (GAP) for multiple G protein alpha subunits, including adenylyl cyclase-inh

222 triphosphatase (GTPase) activity of various G protein alpha-subunits, including the photoreceptor G

223 However, the topological fate of activated G protein alpha subunits is disputed.

224 uanosine 5'-diphosphate (GDP) release by the G protein alpha-subunit is not well understood.

225 luoride (AlF4-) activation of heterotrimeric G-protein alpha-subunits is a well established aspect of

226 ain, which is structurally homologous to the G protein alpha subunit, is tethered to the top of the b

227 or more precisely, GDP dissociation from the G protein alpha-subunit, is the key step towards G prote

228 ults, we conclude that corticosterone alters G protein alpha-subunit levels in the rat hippocampus wi

229 To investigate how G protein alpha subunit localization is regulated under

230 Differential coupling of G-protein alpha subunits may be a means of achieving spe

231 G protein alpha subunits mediate activation of signaling

232 Of the known Ptx-sensitive G-protein alpha subunits, MN9D-expressed Galphai2, Galph

233 ssion (Col) wild type and the heterotrimeric G-protein alpha subunit mutant, gpa1, which has ABA-hypo

234 way in lobster olfactory receptor neurons, a G protein alpha subunit of the G(q) family and an inosit

235 ionally, Ubl1 physically interacted with two G protein alpha subunits of F.verticillioides, thus impl

236 -RhoGEFs) that link activated heterotrimeric G protein alpha subunits of the G12 family to activation

237 s a structural motif by which heterotrimeric G protein alpha subunits of the Galpha(12) family can bi

238 Expression of other G protein alpha subunits of the Gq family, at cRNA level

239 These clones encoded (1) the G protein alpha subunits of the Gq, Gi, and Go families,

240 lerate the GTPase activity of heterotrimeric G protein alpha subunits of the i, q, and 12 classes.

241 xchange (GEF) activity toward heterotrimeric G protein alpha subunits of the i, q, and 12/13 classes,

242 dies against pertussis toxin (PTX)-sensitive G protein alpha-subunits or with injection of antisense

243 tibodies to the common GTP-binding region of G-protein alpha subunits, or antibodies to different reg

244 led receptors and among different classes of G protein alpha subunits, our results should be of broad

245 sn347 is a conserved residue present in most G protein alpha subunits outside the alphas family, thes

246 The C-terminal regions of the heterotrimeric G protein alpha-subunits play key roles in selective act

247 The carboxyl terminus of the G protein alpha subunit plays a key role in interactions

248 groups reported that the alpha5 helix in the G protein alpha subunit plays a major role during this a

249 The carboxyl terminus of heterotrimeric G protein alpha subunits plays an important role in rece

250 Thus homologous G protein alpha-subunits promote bidirectional regulatio

251 -binding activities of Ras-like proteins and G protein alpha subunit proteins were examined in polyom

252 develop a simplified method for recombinant G protein alpha subunit purification that was applicable

253 We find that the G protein alpha subunit Ras and helical domains-previous

254 antibodies were used to quantitate levels of G protein alpha subunits regulating adenylylcyclase acti

255 action and possible intracellular effects of G protein alpha subunits remain unclear.

256 The N-terminal regions of the heterotrimeric G-protein alpha-subunits represent one of the major Gbet

257 13, near GNAS1, which encodes G(s)alpha, the G protein alpha-subunit required for receptor-stimulated

258 luding G(s)alpha, the ubiquitously expressed G protein alpha-subunit required for receptor-stimulated

259 4, a mammalian GTPase-activating protein for G protein alpha subunits, requires its N-terminal 33 ami

260 able to recognize individual heterotrimeric G protein alpha subunits resulted in rapid expansion of

261 eptor induces a conformational change in the G protein alpha subunit, resulting in exchange of guanin

262 ells with AlF4- (activator of heterotrimeric G protein alpha subunits) results in a 3-4-fold increase

263 In this study we defined the G-protein alpha-subunit selectivity of purified Sf9 cell

264 the first demonstration of a heterotrimeric G protein alpha subunit specifically targeted to mitocho

265 vestigate how RGS4, a GAP for heterotrimeric G protein alpha subunits, stimulates GTP hydrolysis.

266 rexpression of the transducin heterotrimeric G protein alpha subunit strongly suggesting the transfor

267 , only the Galpha12 family of heterotrimeric G protein alpha subunits strongly induced the SRE, while

268 Types of G proteins (G protein alpha-subunit subtypes) which mediate the acti

269 AtGPA1 is a unique heterotrimeric G protein alpha subunit that is constitutively GTP-bound

270 d the role of palmitoylation of alpha(13), a G protein alpha subunit that regulates many pathways inv

271 tal structure of Gsalpha, the heterotrimeric G protein alpha subunit that stimulates adenylyl cyclase

272 ) and Galphaolf (Golf) are highly homologous G-protein alpha subunits that activate adenylate cyclase

273 ns accelerate the GTPase activity of certain G protein alpha subunits (the reaction responsible for t

274 or forskolin, but, in contrast to the other G-protein alpha-subunits, the response to NGF was not an

275 ein-coupled receptor and GAIP interacts with G protein alpha subunits, their physical linkage in the

276 thways by accelerating the GTP hydrolysis on G protein alpha subunits thereby promoting termination o

277 exchange at the GDP/GTP binding site of the G-protein alpha-subunits, thus displacing the bound GDP

278 ent of ubiquitination and trafficking of the G protein alpha subunit to its site of degradation.

279 recognize and promote nucleotide exchange on G protein alpha subunits to initiate signal amplificatio

280 p115 RhoGEF can directly link heterotrimeric G protein alpha subunits to regulation of Rho.

281 ular mechanisms that govern the targeting of G-protein alpha subunits to the plasma membrane.

282 he ability of AS ODN probes directed against G-protein alpha-subunits to reduce feeding induced by mo

283 d-type mice, but not in mice lacking the rod G-protein alpha subunit, transducin (Galphat), revealing

284 ificance of N-acylation of a well understood G-protein alpha-subunit, transducin (G alpha(t)), we gen

285 This alpha subunit, like most other G protein alpha subunits, undergoes palmitoylation, the

286 change in the intracellular location of the G protein alpha-subunits was detected using immunohistoc

287 one, dexamethasone, of the levels of several G-protein alpha-subunits was studied during differentiat

288 4, a mammalian GTPase activating protein for G protein alpha subunits, was identified by its ability

289 alpha-gustducin, a primarily taste-specific G protein alpha-subunit, was discovered in 1992 and was

290 s demonstrate AlF(4)(-)-dependent binding to G protein alpha subunits, we tested the ability of G pro

291 erum response factor (SRF) by heterotrimeric G protein alpha subunits were characterized in transfect

292 Endogenous G protein alpha subunits were uncoupled from GPCRs by tr

293 Although most G protein alpha-subunits were similarly expressed in all

294 GNAQ and GNA11 are heterotrimeric G protein alpha subunits, which are mutated in a mutuall

295 typically accelerated by interaction of the G protein alpha subunit with a member of the regulator o

296 Partial coincidence of localization of G protein alpha subunits with caveolin (a marker for cav

297 This is the first report of G protein alpha subunits with overlapping functions in e

298 In addition to the interaction of the G protein alpha subunits with the RH domain, activated R

299 a subunits and the direct association of the G protein alphas subunit with the regulator of G protein

300 ons in the activity/levels of the extralarge G protein alpha-subunit (XLalphas) are implicated in var