ライフサイエンスコーパス: G-protein beta-gamma

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1 Phosducin (Pdc) is a G protein beta gamma dimer (G beta gamma) binding protei

2 The Saccharomyces cerevisiae G protein beta gamma dimer, Ste4p/Ste18p, acts downstrea

3 The G protein beta gamma-dimer is required for receptor inte

4 ector modulation for the conserved family of G protein beta gamma dimers.

5 We recently reported that G-protein beta-gamma (Gbetagamma) subunits bind directly

6 referential binding to GTP-Gs alpha) and the G protein beta gamma subunit complex (preferential bindi

7 of Gq alpha with phospholipase C-beta 1, the G protein beta gamma subunit complex, or m1 muscarinic c

8 K+ channel, IKACh, is directly activated by G protein beta gamma subunits (Gbeta gamma).

9 In the yeast Saccharomyces cerevisiae, the G protein beta gamma subunits are essential for pheromon

10 herein that sequestration of heterotrimeric G protein beta gamma subunits in intact cells strongly i

11 in mouse egg activation since inhibition of G protein beta gamma subunits partially inhibits sperm-i

12 her protein greatly reduced its affinity for G protein beta gamma subunits, consistent with the newly

13 hatidylinositol 3-kinase (PI 3-kinase) or by G protein beta gamma subunits.

14 IRK) channels are gated by direct binding of G protein beta-gamma subunits (Gbetagamma), signaling li

15 dent MAPK activation via a pathway requiring G-protein beta gamma subunits (G beta gamma) and many of

16 factor activity, whereas cotransfection with G-protein beta gamma subunits caused a constitutive acti

17 ivation of PLC isoforms beta 2 and beta 3 by G-protein beta gamma subunits has also been reported.

18 To investigate the role of G-protein beta gamma subunits in delta-opioid signal tra

19 have examined the part played by endogenous G-protein beta gamma subunits in neurotransmitter-mediat

20 t does require (i) pertussis toxin-sensitive G protein beta gamma-subunits, (ii) a staurosporine- and

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