ライフサイエンスコーパス: G-protein-coupled receptor kinase

1 n and the carboxyl-terminal region of bovine G-protein-coupled receptor kinase).

2 onist stimulation and phosphorylation by the G protein-coupled receptor kinases.

3 ion, and provide membrane contact points for G protein-coupled receptor kinases.

4 lated by protein kinase C (PKC) and P2Y12 by G protein-coupled receptor kinases.

5 the search for molecules that interact with G-protein-coupled receptor kinases.

6 Here, we provide evidence that G protein-coupled receptor kinase 1 (GPRK1), which is mo

7 RK, also known as G protein-coupled receptor kinase 1 (GRK1), is a compone

8 Phosphorylation of rhodopsin by G protein-coupled receptor kinase 1 (GRK1, or rhodopsin

9 gamma-subunits), cone phosphodiesterase, and G protein-coupled receptor kinase 1, whereas cone pigmen

10 Prenylated PDE6 subunits and G-protein coupled receptor kinase 1 (GRK1) were unable t

11 - and S-opsins), cone transducin (Galphat2), G-protein-coupled receptor kinase 1 (GRK1) and guanylate

12 off by phosphorylation by rhodopsin kinase [G-protein-coupled receptor kinase 1 (GRK1)] and subseque

13 (-/-)) mice and double-knockout mice lacking G-protein-coupled receptor kinase 1 (Nrl(-/-)Grk1(-/-)).

14 hodiesterase 6alpha' (PDE6alpha'), and GRK1 (G-protein-coupled receptor kinase 1; opsin kinase) are n

15 d levels of transducin, PDE6alpha', and cone G-protein coupled receptor kinase-1 (GRK1).

16 ified the pleckstrin homology (PH) domain of G protein-coupled receptor kinase 2 (Gprk2) as an essent

17 in gustatory responses and drive rhythms in G protein-coupled receptor kinase 2 (GPRK2) expression t

18 The levels of G protein-coupled receptor kinase 2 (Gprk2) messenger RN

19 , clock mutant, odorant-receptor mutant, and G protein-coupled receptor kinase 2 (Gprk2) mutant flies

20 The G protein-coupled receptor kinase 2 (Gprk2) phosphorylat

21 G protein-coupled receptor kinase 2 (Gprk2/GRK2) plays a

22 lar to the beta-adrenergic receptor kinases, G protein-coupled receptor kinase 2 (GRK2) and GRK3, is

23 ta(2)AR underwent a rapid phosphorylation by G protein-coupled receptor kinase 2 (GRK2) and subsequen

24 f CD3 epsilon-associated proteins identified G protein-coupled receptor kinase 2 (GRK2) as a candidat

25 vivo neovascularization model, we identified G protein-coupled receptor kinase 2 (GRK2) as a key angi

26 ndocytosis of a subset of GPCRs and identify G protein-coupled receptor kinase 2 (GRK2) as a kinase t

27 rgic receptor (beta2AR) and other receptors, G protein-coupled receptor kinase 2 (GRK2) can also phos

28 -trisphosphate biosensor eGFP-PH(PLC delta), G protein-coupled receptor kinase 2 (GRK2) can suppress

29 Recently, it was shown that the G protein-coupled receptor kinase 2 (GRK2) contains an R

30 In addition, overexpressing G protein-coupled receptor kinase 2 (GRK2) decreased the

31 Inflammation-induced G protein-coupled receptor kinase 2 (GRK2) downregulatio

32 G protein-coupled receptor kinase 2 (GRK2) is a pharmace

33 G protein-coupled receptor kinase 2 (GRK2) is a serine/t

34 Upregulation of G protein-coupled receptor kinase 2 (GRK2) is a well-est

35 We recently reported that adrenal G protein-coupled receptor kinase 2 (GRK2) is up-regulat

36 alian Smo in an activation-dependent manner: G protein-coupled receptor kinase 2 (GRK2) leads to phos

37 G protein-coupled receptor kinase 2 (GRK2) plays a key r

38 cardial signalling mediated by mitochondrial G protein-coupled receptor kinase 2 (GRK2) pro-death act

39 interference previously to demonstrate that G protein-coupled receptor kinase 2 (GRK2) regulates end

40 take inhibitor paroxetine as an inhibitor of G protein-coupled receptor kinase 2 (GRK2) that improves

41 One target of Gbetagamma is G protein-coupled receptor kinase 2 (GRK2), an enzyme th

42 Expression of a dominant negative mutant G protein-coupled receptor kinase 2 (GRK2), GRK2-K220R,

43 nventional" 7TM G-protein-coupled receptors, G protein-coupled receptor kinase 2 (GRK2), participates

44 bnormality that leads to the upregulation of G protein-coupled receptor kinase 2 (GRK2), which is pat

45 activation-dependent targets, p63RhoGEF and G protein-coupled receptor kinase 2 (GRK2).

46 ered by increased expression and activity of G protein-coupled receptor kinase 2 (GRK2).

47 tagamma) subunits and their interaction with G protein-coupled receptor kinase 2 (GRK2).

48 en functioning together with kinases such as G protein-coupled receptor kinase 2 (GRK2).

49 Overexpression of dominant negative G protein-coupled receptor kinase 2 (GRK2)K220M decrease

50 nsformed human colonocytes, we observed that G protein-coupled receptor kinase 2 and betaARR1/2 termi

51 taARKct, which can inhibit the activation of G protein-coupled receptor kinase 2 and improve betaAR s

52 on of LPA(1) through selective inhibition of G protein-coupled receptor kinase 2 expression and activ

53 CXCR2 and G protein-coupled receptor kinase 2 expressions in neutr

54 The upregulation of G protein-coupled receptor kinase 2 in failing myocardiu

55 downregulation of CXCR2 and upregulation of G protein-coupled receptor kinase 2 in neutrophils was p

56 tor peptide derived from carboxy terminus of G protein-coupled receptor kinase 2 obliterates serum-re

57 vengers-namely, the carboxyl terminus of the G protein-coupled receptor kinase 2 or membrane-targeted

58 RF-RDN also inhibited myocardial G protein-coupled receptor kinase 2 pathological signali

59 Furthermore, overexpression of G protein-coupled receptor kinase 2 resulted in enhancem

60 RF-RDN reduced oxidative stress, inhibited G protein-coupled receptor kinase 2 signaling, increased

61 However, when the G protein-coupled receptor kinase 2 substrate sequence w

62 sion of this domain mimics the C terminus of G protein-coupled receptor kinase 2, a known G betagamma

63 The inhibition of these protein complexes by G protein-coupled receptor kinase 2, a known Galphaq mod

64 was increased by transient overexpression of G protein-coupled receptor kinase 2, and only Ser352stop

65 terminus of the receptor; kinase activity of G protein-coupled receptor kinase 2, but not of G protei

66 er, when these cells were cotransfected with G protein-coupled receptor kinase 2, in the absence of a

67 igenes encoding the carboxyl terminii of the G protein-coupled receptor kinase 2, or beta-arrestin1,

68 tor-arrestin interaction, the recruitment of G protein-coupled receptor kinase 2, or the receptor-ind

69 ls that the low-efficacy agonist OXY induces G protein-coupled receptor kinase 2-dependent alpha1A-AR

70 s, phosphorylation was mediated primarily by G protein-coupled receptor kinase 2.

71 or expression of a dominant negative form of G protein-coupled receptor kinase 2.

72 in the presence of overexpressed arrestin or G protein-coupled receptor kinase 2.

73 lation of cyclin D1, and decreased levels of G protein-coupled receptor kinase 2.

74 crossdesensitization, which was mediated by G protein-coupled receptor kinase 2.

75 Additionally, a mutation in the G protein-coupled receptor kinase 2/PKC regulatory regio

76 G protein-coupled receptor kinases 2 (GRK2) and 5 (GRK5)

77 is associated with selective upregulation of G-protein coupled receptor kinase 2 (GRK2) in both mouse

78 Here, we investigated whether inhibition of G-protein-coupled receptor kinase 2 (GRK2) could counter

79 downregulation was associated with increased G-protein-coupled receptor kinase 2 (GRK2) expression in

80 G-protein-coupled receptor kinase 2 (GRK2) is a G-protei

81 G-protein-coupled receptor kinase 2 (GRK2) is a primary

82 G-protein-coupled receptor kinase 2 (GRK2) is a serine/t

83 Inhibition of G-protein-coupled receptor kinase 2 (GRK2) is an emergin

84 G-protein-coupled receptor kinase 2 (GRK2) is arising as

85 Although G-protein-coupled receptor kinase 2 (GRK2) is the most w

86 We recently identified a novel role for G-protein-coupled receptor kinase 2 (GRK2) that renders

87 sitization and down-regulation (50%) via the G-protein-coupled receptor kinase 2 (GRK2)/PI3K signalin

88 l overexpression of the carboxyl-terminus of G-protein-coupled receptor kinase 2 (GRK2ct), a scavenge

89 G-protein-coupled receptor kinase 2 ablation impedes hea

90 G-protein-coupled receptor kinase 2 ablation represents

91 9 activation in neutrophils, which triggers G-protein-coupled receptor kinase 2 expression and CXCR2

92 tenuated catecholamine secretion, as well as G-protein-coupled receptor kinase 2 expression and membr

93 e oxidase subunit-2-mediated upregulation of G-protein-coupled receptor kinase 2 expression in cardio

94 oxidase subunit-2 prevented upregulation of G-protein-coupled receptor kinase 2 expression in condit

95 by lower parasympathetic tone and increased G-protein-coupled receptor kinase 2 expression in mononu

96 ed cardiac contractility and upregulation of G-protein-coupled receptor kinase 2 expression.

97 nsitions from inhibiting Raf-1 to inhibiting G-protein-coupled receptor kinase 2 upon phosphorylation

98 stress resulting in increased expression of G-protein-coupled receptor kinase 2, a key negative regu

99 in association with both the D2 receptor and G-protein-coupled receptor kinase 2, a regulator of D2 r

100 rdiomyocytes, attenuated Gbetagamma-mediated G-protein-coupled receptor kinase 2-phosphoinositide 3-k

101 eptor 2 (CXCR2) and had reduced induction of G-protein-coupled receptor kinase 2.

102 ealed an increase in phosphorylation of both G-protein-coupled receptor-kinase 2 and beta-arrestin-1,

103 l downregulation, animals lacking C. elegans G protein-coupled receptor kinase-2 (Ce-grk-2) function

104 ough elastase did not promote recruitment of G protein-coupled receptor kinase-2 (GRK(2)) or beta-arr

105 G protein-coupled receptor kinase-2 (GRK2) can phosphory

106 We investigated the potential role of G protein-coupled receptor kinase-2 (GRK2) in modulating

107 G protein-coupled receptor kinase-2 (GRK2) is a critical

108 Myocardial G protein-coupled receptor kinase-2 (GRK2) is upregulate

109 G protein-coupled receptor kinase-2 (GRK2) serine-phosph

110 ted in human HF and several animal models is G protein-coupled receptor kinase-2 (GRK2), a kinase ori

111 trophils via the inhibition of expression of G protein-coupled receptor kinase-2 (GRK2), a serine-thr

112 Overexpression of dominant negative G protein-coupled receptor kinase-2 (GRK2), however, ret

113 One such kinase, G protein-coupled receptor kinase-2 (GRK2), is known to

114 We hypothesized that G protein-coupled receptor kinase-2 (GRK2)-mediated unco

115 which can be regulated by the Ser/Thr kinase G protein-coupled receptor kinase-2 (GRK2).

116 interfering RNA-mediated down-regulation of G protein-coupled receptor kinase-2 and beta-arrestins a

117 Although inhibition of myocardial G protein-coupled receptor kinase-2 enhances cardiac fun

118 negatively regulates the MAP kinase (MAPK), G protein-coupled receptor kinase-2, and NF-kappaB signa

119 chimera in the presence of membrane-anchored G protein-coupled receptor kinase-2.

120 hosphorylation was inhibited by knockdown of G-protein coupled receptor kinase-2 with siRNA.

121 ,i-2,3; regulator of G-protein signaling-10; G-protein coupled receptor kinase-2; phospholipase C bet

122 tein kinase C (PKC) activity and expression, G-protein-coupled receptor kinase-2 (GRK-2) membranous t

123 helial cells (SECs) via its interaction with G-protein-coupled receptor kinase-2 (GRK2) that also pos

124 We found that Akt physically interacts with G-protein-coupled receptor kinase-2 (GRK2), and that thi

125 receptors can be regulated by the actions of G-protein-coupled receptor kinase-2, which triggers dese

126 2 receptors, with regulatory involvement of G-protein-coupled receptor kinase-2.

127 PS treatment also depleted G protein-coupled receptor kinase 3, as well as attenuat

128 rotein-coupled receptor kinase 2, but not of G protein-coupled receptor kinases 3, 5, or 6; and stoic

129 We discovered that G-protein-coupled receptor kinase 3 (GRK3; or beta-adren

130 restin recruitment is required; mice lacking G-protein-coupled receptor kinase 3 also failed to incre

131 Coexpression of G-protein-coupled receptor kinase 4 (GRK4) with wild typ

132 bout D1R desensitization, especially through G-protein-coupled receptor kinase 4 (GRK4), comparativel

133 G protein-coupled receptor kinase 5 (GRK5) deficiency ha

134 Membrane G protein-coupled receptor kinase 5 (GRK5) deficiency is

135 d by serine 129 phosphorylation by the human G protein-coupled receptor kinase 5 (GRK5) in yeast.

136 cation to a morpholino induced knock-down of G protein-coupled receptor kinase 5 (GRK5) in zebrafish

137 G protein-coupled receptor kinase 5 (GRK5) is a regulato

138 G protein-coupled receptor kinase 5 (GRK5) is a serine/t

139 G protein-coupled receptor kinase 5 (GRK5) plays a key r

140 tion of beta-ARs, mRNA and protein levels of G protein-coupled receptor kinase 5 (GRK5) were found is

141 G protein-coupled receptor kinase 5 GRK5 plays a key rol

142 re, we demonstrate that arrestin-2 and GRK5 (G protein-coupled receptor kinase 5), proteins that regu

143 We found that G protein-coupled receptor kinases 5 and 6 (GRK5/6), tra

144 endent of G protein activation, requires the G protein-coupled receptor kinases 5 and 6.

145 We demonstrate that EPCR occupancy recruits G-protein coupled receptor kinase 5, thereby inducing be

146 e-miRs, but not their pri-miRs, in beta1AR-, G-protein-coupled receptor kinase 5/6-, and beta-arresti

147 man beta-amyloid precursor protein gene with G protein-coupled receptor kinase-5 (GRK5) knockout mice

148 Rbeta is phosphorylated on seryl residues by G protein-coupled receptor kinase-5 (GRK5), but mechanis

149 have previously shown that overexpression of G protein-coupled receptor kinase 6 (GRK6) enhanced the

150 pidly phosphorylated by protein kinase C and G protein-coupled receptor kinase 6 (GRK6) upon CXCL12 t

151 we find that CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial fo

152 ion by expressing betaARKct, an inhibitor of G protein-coupled receptor kinase activation, but was no

153 Inhibition of endogenous GRK6 (G-protein-coupled receptor kinase) activity, by the intr

154 the beta(2)-adrenoceptor (AR) interacts with G protein-coupled receptor kinases and arrestins in an a

155 cle beta-2-adrenergic receptors, mediated by G protein-coupled receptor kinases and arrestins, is pre

156 G protein-coupled receptor regulation by G protein-coupled receptor kinases and beta-arrestins ca

157 without promoting receptor interaction with G protein-coupled receptor kinases and beta-arrestins sh

158 on to beta-agonists is primarily mediated by G protein-coupled receptor kinases and beta-arrestins th

159 on of the receptor, as shown by knockdown of G protein-coupled receptor kinases and phosphorylation-d

160 s are often negatively regulated by specific G protein-coupled receptor kinases and subsequent bindin

161 the contributions of cAMP-dependent kinase, G protein-coupled receptor kinases, and beta-arrestin to

162 Although G protein-coupled receptor kinases are known to play an

163 G protein-coupled receptor kinases are well characterize

164 )Q mutant is constitutively internalized via G protein coupled-receptor kinase-, arrestin-2-, dynamin

165 rovide insights into the roles played by the G protein-coupled receptor kinase/arrestin and protein k

166 efficacy for adenylyl cyclase activation and G protein-coupled receptor kinase/arrestin-mediated dese

167 ell as overexpression of a dominant negative G-protein-coupled receptor kinase construct that sequest

168 bled in a signaling complex with Gbetagamma, G protein-coupled receptor kinase, cyclic adenosine mono

169 microscopy and indirectly by observations of G protein-coupled receptor kinase-derived polypeptides.

170 is characteristic is the high selectivity of G protein-coupled receptor kinases for the activated rec

171 renoceptor binding density by 25%, increases G protein coupled receptor kinase (GRK) activity by 50%

172 Raf1 and G protein-coupled receptor kinase (GRK) 2 are direct int

173 Knockdown of G protein-coupled receptor kinase (GRK) 2, GRK3, or GRK6

174 e TGR5 association with beta-arrestin 1/2 or G protein-coupled receptor kinase (GRK) 2/5/6, as determ

175 Previously we have shown that G protein-coupled receptor kinase (GRK) 6 plays a major

176 coupled receptor kinase, GRK4gamma, increase G protein-coupled receptor kinase (GRK) activity and cau

177 blocked by dominant-negative forms of either G protein-coupled receptor kinase (GRK) or arrestin, and

178 Because G protein-coupled receptor kinase (GRK) phosphorylation

179 kinase (PKA) site phosphoserine 262 and the G protein-coupled receptor kinase (GRK) site phosphoseri

180 GRK2 is a G protein-coupled receptor kinase (GRK) that is broadly

181 escribe the 2.6-A crystal structure of human G protein-coupled receptor kinase (GRK)-6, a key regulat

182 We investigated the role of G protein-coupled receptor kinase (GRK)-mediated phospho

183 2)AR/G(i) coupling was also dependent on the G protein-coupled receptor kinase (GRK)-mediated phospho

184 rboxyl-terminal serines 355, 356, and 364 in G protein-coupled receptor kinase (GRK)-mediated phospho

185 tion and a less potent, occupancy-dependent, G protein-coupled receptor kinase (GRK)-mediated phospho

186 tor family are regulated ("desensitized") by G protein-coupled receptor kinase (GRK)-mediated recepto

187 rotein activation (cyclic AMP accumulation), G protein-coupled receptor kinase (GRK)-mediated recepto

188 beta-arrestins bind to G protein-coupled receptor kinase (GRK)-phosphorylated s

189 )/Galpha(q)-protein kinase C (PKC) and V(1A)/G protein-coupled receptor kinase (GRK)/beta-arrestin si

190 in striking differences in activation of the G protein-coupled receptor kinase (GRK)/ss-arrestin syst

191 Myocardial G protein-coupled receptor kinase (GRK)2 is a critical r

192 They recruit elevated levels of cytosolic G protein-coupled receptor kinase (GRK)2 to agonist-stim

193 owed that CXCR1 couples predominantly to the G protein-coupled receptor kinase (GRK)2, whereas CXCR2

194 G protein-coupled receptor kinases (GRK) regulate divers

195 tion typically requires phosphorylation by a G-protein-coupled receptor kinase (GRK) and interaction

196 process, which involves phosphorylation by a G-protein-coupled receptor kinase (GRK) followed by arre

197 ation into endosomes is dependent upon prior G-protein-coupled receptor kinase (GRK)-mediated phospho

198 phosphorylation by members of the family of G protein-coupled receptor kinases (GRK1-GRK7).

199 lated kinase Erk potentiated activity of the G protein-coupled receptor kinase GRK2 and inhibited neu

200 In addition, shRNA-mediated knockdown of the G protein-coupled receptor kinases (GRK2 and GRK3) had n

201 Overexpression of a G-protein-coupled receptor kinase (GRK2) was able to sta

202 Presynaptic expression of dominant negative G-protein-coupled-receptor kinase (GRK2-Lys220Arg) or be

203 te that under some conditions, at least, the G protein-coupled receptor kinase GRK4 does not display

204 ension, single nucleotide polymorphisms of a G protein-coupled receptor kinase, GRK4gamma, increase G

205 by two distinct mechanisms in HEK-293 cells: G protein-coupled receptor kinase (GRK6)-mediated recept

206 in epithelial cells, others and particularly G protein-coupled receptor kinase, GRK6, appeared select

207 on of G protein coupled receptors (GPCRs) by G protein coupled receptor kinases (GRKs) and the subseq

208 trimeric guanine nucleotide-binding protein (G protein)-coupled receptor kinases (GRKs) is a universa

209 ent donors expressed different levels of the G protein-coupled receptor kinases (GRKs) 2, 3, 5, and 6

210 ted with the VPAC(1) receptor (VPAC(1)R) and G protein-coupled receptor kinases (GRKs) 2, 3, 5, and 6

211 G protein-coupled receptor kinases (GRKs) and arrestins

212 The G protein-coupled receptor kinases (GRKs) and beta-arres

213 Two candidates are G protein-coupled receptor kinases (GRKs) and Regulators

214 G protein-coupled receptor kinases (GRKs) are dynamic re

215 G protein-coupled receptor kinases (GRKs) are important

216 G protein-coupled receptor kinases (GRKs) are important

217 G protein-coupled receptor kinases (GRKs) are key regula

218 G protein-coupled receptor kinases (GRKs) are members of

219 G protein-coupled receptor kinases (GRKs) are negative r

220 hosphorylation by protein kinase A (PKA) and G protein-coupled receptor kinases (GRKs) desensitize be

221 G protein-coupled receptor kinases (GRKs) desensitize be

222 There is ongoing debate about the role of G protein-coupled receptor kinases (GRKs) in agonist-ind

223 study, we investigated the role of different G protein-coupled receptor kinases (GRKs) in CXCR1- and

224 vide in vivo evidence for the involvement of G protein-coupled receptor kinases (GRKs) in opioid depe

225 examined the effects of wild type and mutant G protein-coupled receptor kinases (GRKs) on the phospho

226 G protein-coupled receptor kinases (GRKs) phosphorylate

227 G protein-coupled receptor kinases (GRKs) phosphorylate

228 G protein-coupled receptor kinases (GRKs) phosphorylate

229 G protein-coupled receptor kinases (GRKs) phosphorylate

230 G protein-coupled receptor kinases (GRKs) play a central

231 G protein-coupled receptor kinases (GRKs) play a pivotal

232 G protein-coupled receptor kinases (GRKs) regulate cell

233 G protein-coupled receptor kinases (GRKs) represent a cl

234 n of beta-adrenergic receptors (beta ARs) by G protein-coupled receptor kinases (GRKs) results in the

235 G protein-coupled receptor kinases (GRKs) specifically b

236 G protein-coupled receptor kinases (GRKs) specifically p

237 G protein-coupled receptor kinases (GRKs) specifically p

238 Many GPCRs are phosphorylated by G protein-coupled receptor kinases (GRKs), a process tha

239 horylation of mu-opioid receptors (MOPRs) by G protein-coupled receptor kinases (GRKs), followed by a

240 es phosphorylation of activated receptors by G protein-coupled receptor kinases (GRKs), followed by b

241 G protein-coupled receptor kinases (GRKs), in concert wi

242 This process is initiated by G protein-coupled receptor kinases (GRKs), some of which

243 s) after the receptors are phosphorylated by G protein-coupled receptor kinases (GRKs), thereby regul

244 g phosphorylated by members of the family of G protein-coupled receptor kinases (GRKs).

245 orylation by both protein kinase A (PKA) and G protein-coupled receptor kinases (GRKs).

246 GRK2-K220R, demonstrating the involvement of G protein-coupled receptor kinases (GRKs).

247 proteins: the heterotrimeric G proteins, the G-protein-coupled receptor kinases (GRKs) and the arrest

248 hemokine receptor desensitization induced by G-protein-coupled receptor kinases (GRKs) in the feedbac

249 The small family of G-protein-coupled receptor kinases (GRKs) regulate cell

250 A kinase screen identified G-protein-coupled receptor kinases (GRKs) targeting S471

251 the receptors plus their phosphorylation by G-protein-coupled receptor kinases (GRKs).

252 ogether, D71A receptor was phosphorylated by G protein-coupled receptor kinases in response to TRH.

253 Using in-solution proteomics, GIT1 (G Protein Coupled Receptor Kinase Interacting ArfGAP 1)

254 ding SNVs found in SCZ subjects in the GIT1 (G protein-coupled receptor kinase interacting ArfGAP 1)

255 The G-protein-coupled receptor kinase interacting protein-1

256 The ArfGAP paxillin kinase linker (PKL)/G protein-coupled receptor kinase-interacting protein (G

257 Here we show that the G protein-coupled receptor kinase-interacting protein (G

258 teracting exchange factor beta (betaPIX) and G protein-coupled receptor kinase-interacting protein (G

259 Here, we report that GluN3A binds G protein-coupled receptor kinase-interacting protein (G

260 The G protein-coupled receptor kinase-interacting protein 1

261 s paxillin, focal adhesion kinase (FAK), and G protein-coupled receptor kinase-interacting protein 1

262 GIT1 (G protein-coupled receptor kinase-interacting protein 1)

263 GIT (G protein-coupled receptor kinase-interacting protein) a

264 Recently, a G protein-coupled receptor kinase-interacting protein, G

265 nstrate that presynaptic deletion of the two G protein-coupled receptor kinase-interacting proteins (

266 ine-nucleotide exchange factor (betaPIX) and G protein-coupled receptor kinase-interacting target 1 (

267 Cell signaling molecules c-src, G-protein-coupled receptor kinase-interacting protein (G

268 gnalling complex with paxillin that included G-protein-coupled receptor kinase-interacting protein (G

269 exchange factor (known as Pix or RtGEF) and G-protein-coupled receptor kinase-interacting protein (G

270 The G-protein-coupled receptor kinase-interacting protein 1

271 a complex with the synaptic adaptor protein G-protein-coupled receptor kinase-interacting protein 1

272 rocytes and neural stem cells, we identified G-protein-coupled receptor kinase-interacting protein 1

273 cond showing that eNOS directly bound to the G-protein-coupled receptor kinase-interacting protein 1

274 We also identified GIT1 (G-protein-coupled receptor kinase-interacting protein 1)

275 G-protein-coupled receptor kinase-interacting protein 2

276 n focal adhesion kinase (FAK), paxillin, and G-protein-coupled receptor kinase-interacting proteins G

277 Here we report that G protein-coupled receptor kinase-interactor 2 (GIT2) wa

278 sociated tyrosine phosphosubstrate-1)/Git-1 (G protein-coupled receptor kinase-interactor-1), thus ma

279 G protein-coupled receptor kinase interactors (GITs) reg

280 tion, TIN-X supports exploration of data for G-protein coupled receptors, kinases, ion channels, and

281 a2AR that couples to Gs but does not undergo G protein-coupled receptor kinase-mediated phosphorylati

282 Agonists desensitize betaAR through G protein-coupled receptor kinase-mediated uncoupling an

283 ng sites and phosphorylation of beta(2)AR by G protein-coupled receptor kinase, not by PKA.

284 signal transduction proteins (particularly, G protein-coupled receptors, kinases or proteins involve

285 ve state, in complex with cognate G protein, G-protein-coupled receptor kinase or arrestin), endocyto

286 PLC-beta1ct), the NH(2)-terminal fragment of G protein-coupled receptor kinase, or the regulator of G

287 Moreover, whereas G protein-coupled receptor kinase overexpression can pro

288 Beta-arrestins bind to activated G protein-coupled receptor kinase-phosphorylated recepto

289 However, the G protein-coupled receptor kinase phosphorylation of bet

290 By using mutants of the beta(1)AR lacking G protein-coupled receptor kinase phosphorylation sites

291 ceptors (D2 DARs) have been shown to undergo G-protein-coupled receptor kinase phosphorylation in an

292 GRK2, a G protein-coupled receptor kinase, plays a critical role

293 protein kinase A site serine 261/262 and the G-protein-coupled receptor kinase site serine 355/356 an

294 uires beta(1)AR phosphorylation at consensus G protein-coupled receptor kinase sites and beta-arresti

295 's cytoplasmic tail on previously documented G protein-coupled receptor kinase sites; (ii) recruitmen

296 rotein-coupled receptor kinase 2 (GRK2) is a G-protein-coupled receptor kinase that is ubiquitously e

297 phorylation of agonist-occupied receptors by G-protein-coupled receptor kinases, they bind beta-arres

298 Although mechanisms for linking G-protein-coupled receptor kinases to the activated rece

299 ns were initially shown, in conjunction with G protein-coupled receptor kinases, to be involved in th

300 , we have identified that two members of the G protein-coupled receptor kinases were involved in regu