ライフサイエンスコーパス: G-protein-coupled receptor kinase 2

1 or expression of a dominant negative form of G protein-coupled receptor kinase 2.

2 in the presence of overexpressed arrestin or G protein-coupled receptor kinase 2.

3 lation of cyclin D1, and decreased levels of G protein-coupled receptor kinase 2.

4 crossdesensitization, which was mediated by G protein-coupled receptor kinase 2.

5 s, phosphorylation was mediated primarily by G protein-coupled receptor kinase 2.

6 chimera in the presence of membrane-anchored G protein-coupled receptor kinase-2.

7 eptor 2 (CXCR2) and had reduced induction of G-protein-coupled receptor kinase 2.

8 2 receptors, with regulatory involvement of G-protein-coupled receptor kinase-2.

9 Moreover, purified G-protein-coupled receptor kinases 2, 3, and 5 were each

10 sion of this domain mimics the C terminus of G protein-coupled receptor kinase 2, a known G betagamma

11 The inhibition of these protein complexes by G protein-coupled receptor kinase 2, a known Galphaq mod

12 stress resulting in increased expression of G-protein-coupled receptor kinase 2, a key negative regu

13 in association with both the D2 receptor and G-protein-coupled receptor kinase 2, a regulator of D2 r

14 G-protein-coupled receptor kinase 2 ablation impedes hea

15 G-protein-coupled receptor kinase 2 ablation represents

16 Tentative identification of the G protein-coupled receptor kinase 2 and 5 (GRK2 and GRK5

17 nsformed human colonocytes, we observed that G protein-coupled receptor kinase 2 and betaARR1/2 termi

18 taARKct, which can inhibit the activation of G protein-coupled receptor kinase 2 and improve betaAR s

19 oteins for ARF1, and both also interact with G protein-coupled receptor kinase 2 and with p21-activat

20 cessary residues can still internalize via a G protein-coupled receptor kinase-2 and beta-arrestin-de

21 interfering RNA-mediated down-regulation of G protein-coupled receptor kinase-2 and beta-arrestins a

22 ealed an increase in phosphorylation of both G-protein-coupled receptor-kinase 2 and beta-arrestin-1,

23 was increased by transient overexpression of G protein-coupled receptor kinase 2, and only Ser352stop

24 , whereas protein kinase A RIalpha subunits, G protein-coupled receptor kinase-2, and clathrin are la

25 negatively regulates the MAP kinase (MAPK), G protein-coupled receptor kinase-2, and NF-kappaB signa

26 terminus of the receptor; kinase activity of G protein-coupled receptor kinase 2, but not of G protei

27 mutants can be rescued by overexpression of G protein-coupled receptor kinase 2, but this increased

28 l downregulation, animals lacking C. elegans G protein-coupled receptor kinase-2 (Ce-grk-2) function

29 ls that the low-efficacy agonist OXY induces G protein-coupled receptor kinase 2-dependent alpha1A-AR

30 Although inhibition of myocardial G protein-coupled receptor kinase-2 enhances cardiac fun

31 on of LPA(1) through selective inhibition of G protein-coupled receptor kinase 2 expression and activ

32 9 activation in neutrophils, which triggers G-protein-coupled receptor kinase 2 expression and CXCR2

33 tenuated catecholamine secretion, as well as G-protein-coupled receptor kinase 2 expression and membr

34 e oxidase subunit-2-mediated upregulation of G-protein-coupled receptor kinase 2 expression in cardio

35 oxidase subunit-2 prevented upregulation of G-protein-coupled receptor kinase 2 expression in condit

36 by lower parasympathetic tone and increased G-protein-coupled receptor kinase 2 expression in mononu

37 ed cardiac contractility and upregulation of G-protein-coupled receptor kinase 2 expression.

38 CXCR2 and G protein-coupled receptor kinase 2 expressions in neutr

39 of a putative member of the GRK family, the G protein-coupled receptor kinase 2 gene (Gprk2).

40 ified the pleckstrin homology (PH) domain of G protein-coupled receptor kinase 2 (Gprk2) as an essent

41 in gustatory responses and drive rhythms in G protein-coupled receptor kinase 2 (GPRK2) expression t

42 The levels of G protein-coupled receptor kinase 2 (Gprk2) messenger RN

43 , clock mutant, odorant-receptor mutant, and G protein-coupled receptor kinase 2 (Gprk2) mutant flies

44 The G protein-coupled receptor kinase 2 (Gprk2) phosphorylat

45 G protein-coupled receptor kinase 2 (Gprk2/GRK2) plays a

46 ough elastase did not promote recruitment of G protein-coupled receptor kinase-2 (GRK(2)) or beta-arr

47 tein kinase C (PKC) activity and expression, G-protein-coupled receptor kinase-2 (GRK-2) membranous t

48 Overexpression of G protein-coupled receptor kinase 2 (GRK2) and GRK3 "sup

49 lar to the beta-adrenergic receptor kinases, G protein-coupled receptor kinase 2 (GRK2) and GRK3, is

50 ta(2)AR underwent a rapid phosphorylation by G protein-coupled receptor kinase 2 (GRK2) and subsequen

51 f CD3 epsilon-associated proteins identified G protein-coupled receptor kinase 2 (GRK2) as a candidat

52 vivo neovascularization model, we identified G protein-coupled receptor kinase 2 (GRK2) as a key angi

53 ndocytosis of a subset of GPCRs and identify G protein-coupled receptor kinase 2 (GRK2) as a kinase t

54 rgic receptor (beta2AR) and other receptors, G protein-coupled receptor kinase 2 (GRK2) can also phos

55 -trisphosphate biosensor eGFP-PH(PLC delta), G protein-coupled receptor kinase 2 (GRK2) can suppress

56 Recently, it was shown that the G protein-coupled receptor kinase 2 (GRK2) contains an R

57 In addition, overexpressing G protein-coupled receptor kinase 2 (GRK2) decreased the

58 Inflammation-induced G protein-coupled receptor kinase 2 (GRK2) downregulatio

59 G protein-coupled receptor kinase 2 (GRK2) is a pharmace

60 G protein-coupled receptor kinase 2 (GRK2) is a serine/t

61 The G protein-coupled receptor kinase 2 (GRK2) is a serine/t

62 Upregulation of G protein-coupled receptor kinase 2 (GRK2) is a well-est

63 We recently reported that adrenal G protein-coupled receptor kinase 2 (GRK2) is up-regulat

64 alian Smo in an activation-dependent manner: G protein-coupled receptor kinase 2 (GRK2) leads to phos

65 G protein-coupled receptor kinase 2 (GRK2) plays a key r

66 cardial signalling mediated by mitochondrial G protein-coupled receptor kinase 2 (GRK2) pro-death act

67 interference previously to demonstrate that G protein-coupled receptor kinase 2 (GRK2) regulates end

68 take inhibitor paroxetine as an inhibitor of G protein-coupled receptor kinase 2 (GRK2) that improves

69 One target of Gbetagamma is G protein-coupled receptor kinase 2 (GRK2), an enzyme th

70 Expression of a dominant negative mutant G protein-coupled receptor kinase 2 (GRK2), GRK2-K220R,

71 nventional" 7TM G-protein-coupled receptors, G protein-coupled receptor kinase 2 (GRK2), participates

72 bnormality that leads to the upregulation of G protein-coupled receptor kinase 2 (GRK2), which is pat

73 tagamma) subunits and their interaction with G protein-coupled receptor kinase 2 (GRK2).

74 en functioning together with kinases such as G protein-coupled receptor kinase 2 (GRK2).

75 activation-dependent targets, p63RhoGEF and G protein-coupled receptor kinase 2 (GRK2).

76 ered by increased expression and activity of G protein-coupled receptor kinase 2 (GRK2).

77 Overexpression of dominant negative G protein-coupled receptor kinase 2 (GRK2)K220M decrease

78 expression system to examine the ability of G protein-coupled receptor kinase-2 (GRK2) and beta-arre

79 G protein-coupled receptor kinase-2 (GRK2) can phosphory

80 We investigated the potential role of G protein-coupled receptor kinase-2 (GRK2) in modulating

81 G protein-coupled receptor kinase-2 (GRK2) is a critical

82 Myocardial G protein-coupled receptor kinase-2 (GRK2) is upregulate

83 G protein-coupled receptor kinase-2 (GRK2) serine-phosph

84 ted in human HF and several animal models is G protein-coupled receptor kinase-2 (GRK2), a kinase ori

85 trophils via the inhibition of expression of G protein-coupled receptor kinase-2 (GRK2), a serine-thr

86 Overexpression of dominant negative G protein-coupled receptor kinase-2 (GRK2), however, ret

87 One such kinase, G protein-coupled receptor kinase-2 (GRK2), is known to

88 We hypothesized that G protein-coupled receptor kinase-2 (GRK2)-mediated unco

89 which can be regulated by the Ser/Thr kinase G protein-coupled receptor kinase-2 (GRK2).

90 G protein-coupled receptor kinases 2 (GRK2) and 5 (GRK5)

91 is associated with selective upregulation of G-protein coupled receptor kinase 2 (GRK2) in both mouse

92 Here, we investigated whether inhibition of G-protein-coupled receptor kinase 2 (GRK2) could counter

93 downregulation was associated with increased G-protein-coupled receptor kinase 2 (GRK2) expression in

94 G-protein-coupled receptor kinase 2 (GRK2) is a G-protei

95 G-protein-coupled receptor kinase 2 (GRK2) is a primary

96 G-protein-coupled receptor kinase 2 (GRK2) is a serine/t

97 Inhibition of G-protein-coupled receptor kinase 2 (GRK2) is an emergin

98 G-protein-coupled receptor kinase 2 (GRK2) is arising as

99 Although G-protein-coupled receptor kinase 2 (GRK2) is the most w

100 We recently identified a novel role for G-protein-coupled receptor kinase 2 (GRK2) that renders

101 sitization and down-regulation (50%) via the G-protein-coupled receptor kinase 2 (GRK2)/PI3K signalin

102 helial cells (SECs) via its interaction with G-protein-coupled receptor kinase-2 (GRK2) that also pos

103 We found that Akt physically interacts with G-protein-coupled receptor kinase-2 (GRK2), and that thi

104 l overexpression of the carboxyl-terminus of G-protein-coupled receptor kinase 2 (GRK2ct), a scavenge

105 The upregulation of G protein-coupled receptor kinase 2 in failing myocardiu

106 downregulation of CXCR2 and upregulation of G protein-coupled receptor kinase 2 in neutrophils was p

107 er, when these cells were cotransfected with G protein-coupled receptor kinase 2, in the absence of a

108 tor peptide derived from carboxy terminus of G protein-coupled receptor kinase 2 obliterates serum-re

109 vengers-namely, the carboxyl terminus of the G protein-coupled receptor kinase 2 or membrane-targeted

110 igenes encoding the carboxyl terminii of the G protein-coupled receptor kinase 2, or beta-arrestin1,

111 tor-arrestin interaction, the recruitment of G protein-coupled receptor kinase 2, or the receptor-ind

112 RF-RDN also inhibited myocardial G protein-coupled receptor kinase 2 pathological signali

113 rdiomyocytes, attenuated Gbetagamma-mediated G-protein-coupled receptor kinase 2-phosphoinositide 3-k

114 ,i-2,3; regulator of G-protein signaling-10; G-protein coupled receptor kinase-2; phospholipase C bet

115 Additionally, a mutation in the G protein-coupled receptor kinase 2/PKC regulatory regio

116 Furthermore, overexpression of G protein-coupled receptor kinase 2 resulted in enhancem

117 RF-RDN reduced oxidative stress, inhibited G protein-coupled receptor kinase 2 signaling, increased

118 However, when the G protein-coupled receptor kinase 2 substrate sequence w

119 nsitions from inhibiting Raf-1 to inhibiting G-protein-coupled receptor kinase 2 upon phosphorylation

120 receptors can be regulated by the actions of G-protein-coupled receptor kinase-2, which triggers dese

121 hosphorylation was inhibited by knockdown of G-protein coupled receptor kinase-2 with siRNA.