ライフサイエンスコーパス: G-quadruplex

1 ble of forming four-stranded DNA structures (G-quadruplexes).

2 , via the formation of a K(+)-ion-stabilized G-quadruplex.

3 ional features, including an unknown form of G-quadruplex.

4 specifically to human telomeric antiparallel G-quadruplex.

5 cytosine across from a replication-stalling G-quadruplex.

6 ling enzymes, FANCJ partially stabilizes the G-quadruplex.

7 tive, four-stranded, helical fold known as a G-quadruplex.

8 alternative four-stranded structure known as G-quadruplex.

9 -ray crystal structures of a left-handed DNA G-quadruplex.

10 o distribute between a monomeric and dimeric G-quadruplex.

11 a stable DNA secondary structure known as a G-quadruplex.

12 ture of this peptide bound to a parallel DNA G-quadruplex.

13 ires interaction of TRF2 with a p21 promoter G-quadruplex.

14 sting selectivity for human telomeric hybrid G-quadruplex.

15 tion of various secondary structures such as G-quadruplexes.

16 orm stable four-stranded structures known as G-quadruplexes.

17 tives that can be used as optical probes for G-quadruplexes.

18 e property of individual human telomeric DNA G-quadruplexes.

19 highly stable secondary structures including G-quadruplexes.

20 emblies, such as G-ribbons, G4-quartets, and G-quadruplexes.

21 tro into non-canonical DNA structures called G-quadruplexes.

22 s in concentrated solutions of various model G-quadruplexes.

23 e, which can be used as an optical probe for G-quadruplexes.

24 rmation of perfectly aligned tetra-molecular G-quadruplexes.

25 telomeric G-quadruplex from other telomeric G-quadruplexes.

26 compound stabilizes the three existing KRAS G-quadruplexes.

27 , analogous to (but different from) that for G-quadruplexes.

28 f broadening the definition of irregular RNA G-quadruplexes, a bioinformatic search was performed to

29 n determining the biochemical specificity of G-quadruplex activity.

30 structures including interstrand crosslinks, G quadruplexes and DNA triplexes.

31 monstrate the formation of a parallel folded G-quadruplex and a B-form duplex DNA stacked coaxially.

32 pregnanol derivatives that recognize the MYC G-quadruplex and BCL2 i-motif promoter DNA structures lo

33 iosis-specific DSBs fold into intramolecular G-quadruplex and i-motif structures, both in vitro and i

34 monstrate mutual exclusivity between the MYC G-quadruplex and i-motif, providing a rationale for a mo

35 ffect of these G-rich sequences is caused by G-quadruplex and is dose dependent.

36 lve diverse DNA structures (duplex, hairpin, G-quadruplex and single-stranded), ligand types (ion, sm

37 selectively stabilize human telomeric hybrid G-quadruplex and strongly inhibit telomerase activity wi

38 These studies show that T-oligo can form a G-quadruplex and that the antitumor effects of T-oligo m

39 ce formed between putative parallel stranded G-quadruplexes and a duplex DNA sequence constructed fro

40 show increased selectivity toward the viral G-quadruplexes and display remarkable antiviral activity

41 ion translated into stabilization of the LTR G-quadruplexes and increased promoter silencing activity

42 cur near G-rich sequences capable of forming G-quadruplexes and JBP2 is needed, as it does not occur

43 ribe the mechanism by which FANCJ recognizes G-quadruplexes and mediates their stepwise unfolding, bu

44 e method in different structural contexts of G-quadruplexes and their complexes.

45 (DSB) in Saccharomyces cerevisiae folds into G-quadruplex, and the C-rich sequence complementary to t

46 FNAs mainly include DNAzymes, G-quadruplexes, and mismatched base pairs and nanomateri

47 de insight into the sequence requirements of G-quadruplexes, and should facilitate the analysis of su

48 Using an anti-G-quadruplex antibody, we showed that T-oligo can form G

49 P1G4 and previously identified Pu39 G-quadruplexes appear to form independently in adjacent

50 Using NMR spectroscopy, the P1G4 G-quadruplex appears to be a novel dynamic equilibrium o

51 The results demonstrated that each G-quadruplex aptamer can capture two adenosine molecules

52 The hemin/G-quadruplex-aptamer nucleoapzyme also stimulates the ch

53 RNA-binding protein footprints revealed that G quadruplexes are enriched in heterogeneous nuclear rib

54 Because low stability G-quadruplexes are hardly detectable by mass spectrometr

55 G-quadruplexes are nucleic acids structures stabilized b

56 rginine to L-citrulline by a series of hemin/G-quadruplex-arginine aptamer conjugated nucleoapzymes.

57 plex at the 5'-end, followed by the stronger G-quadruplex at the 3'-end via various intermediates.

58 then proceeded through disrupting the weaker G-quadruplex at the 5'-end, followed by the stronger G-q

59 two guanine electron donors into crystalline G-quadruplex-based organic frameworks, wherein the elect

60 We previously found that two neighboring G-quadruplexes behave as a molecular switch controlling

61 ion termination due to formation of a hybrid G-quadruplex between the nascent RNA and the nontemplate

62 cetamidine-containing side chains (CATDs) as G-quadruplex binders and have examined their anticancer

63 compounds were synthesized and evaluated as G-quadruplex binders.

64 G-Quadruplex-binding compounds are currently perceived a

65 Here we identified an 18-amino acid G-quadruplex-binding domain of RHAU and determined the s

66 chanistic insight, we studied the effects of G-quadruplex-binding ligands on hTERT expression and obs

67 The in vitro G-quadruplex-binding properties of the synthesized compo

68 G-quadruplex can readily form in the P1G4 sequence under

69 This suggests that G-quadruplexes can serve as effective hole conduits in o

70 thermal, pH (i-motif), K(+) ion/crown ether (G-quadruplexes), chemical (pH-doped polyaniline), or bio

71 at least 6 cycling times by heat to transfer G-quadruplex conformation to single strand of DNA sequen

72 ty with no modification of the physiological G-quadruplex conformation.

73 Folding of the LTR promoter into dynamic G-quadruplex conformations has been shown to suppress it

74 ng of an NMS construct and that of truncated G-quadruplex constructs revealed a quadruplex-quadruplex

75 toehold strand displacement assembly of two G-quadruplex containing hairpin DNAs.

76 on (EMT)-associated CD44 isoform switch in a G-quadruplex-dependent manner, which results in inhibiti

77 to screen for small molecules able to induce G-quadruplex-dependent transcriptional reprogramming.

78 ic guanine-rich sequences that can fold into G-quadruplex DNA (G4DNA).

79 t the first example of a reduction-activated G-quadruplex DNA binder.

80 G-quadruplex DNA folds into different topologies that ar

81 Moreover, G-quadruplex DNA has been implicated in the alignment of

82 to 10-fold and on bimolecular anti-parallel G-quadruplex DNA structures and three-stranded D-loop ap

83 small molecules that can selectively bind to G-quadruplex DNA structures.

84 retains limited accessibility, of telomeric G-quadruplex DNA to complementary single stranded DNA an

85 Since then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapid

86 ateral elements, exhibits strong affinity to G-quadruplex DNA, it displays a much weaker affinity for

87 In promoter G-quadruplex DNA, the NEIL glycosylases primarily remove

88 ther substrates such as replication fork and G-quadruplex DNA, triplex DNA was a preferred substrate

89 hundreds of ligands which can interact with G-quadruplex DNA, yet very few which target i-motif.

90 d platinum(II) complex has good affinity for G-quadruplex DNA.

91 hen, the assembly of antibody and alkylthiol/G-quadruplex DNA/hemin on gold nanoparticles was used as

92 Targeting G-quadruplex DNAs for cancer treatment is a very promisi

93 G-quadruplex DNAs form four-stranded helical structures

94 ticles (MNPs) as supporting matrix and hemin/G-quadruplex DNAzyme as signal amplifier for determinati

95 e colorimetric determination system based on G-quadruplex DNAzyme integrated with a smartphone was de

96 DNA present in a sample, by exposing a hemin/G-quadruplex DNAzyme, which then catalyzes the generatio

97 the presence of hemin, form catalytic hemin/G-quadruplex DNAzymes with peroxidase activity.

98 amine to aminochrome using a series of hemin/G-quadruplex-dopamine aptamer nucleoapzymes.

99 We successfully generated a series of G-quadruplex-duplex containing crystals, both alone and

100 iazole rings shows higher affinity for c-MYC G-quadruplex, exhibits fluorescence "turn-on" response w

101 o present a general overview of the helicase/G-quadruplex field.

102 of the duplex to unmask the PQS, adopting a G-quadruplex fold in which apurinic/apyrimidinic endonuc

103 hibits substantially reduced perturbation of G-quadruplex folding.

104 es that govern the formation of stable Tel22 G-quadruplexes, folding intermediates, and ligand-quadru

105 hate footprinting revealed some evidence for G-quadruplex formation in (G3T)n sequences, this was not

106 molecule strongly stabilized and accelerated G-quadruplex formation in both Na(+) and K(+) ion-contai

107 h sequences, in a time dependent manner, and G-quadruplex formation was detected.

108 rnative DNA structures, we have investigated G-quadruplex formation within negatively supercoiled DNA

109 upercoiling alone is not sufficient to drive G-quadruplex formation.

110 es: (i) the intramolecular parallel-stranded G-quadruplex formed by the 22-mer four-repeat human telo

111 nd (ii) the intermolecular parallel-stranded G-quadruplex formed by the TG4T oligonucleotides.

112 Our investigation has been performed for G-quadruplexes formed by folding of GGG(TTAGGG)3 single

113 cribe not only the basic structural motif of G-quadruplexes formed by, e.g., telomeric DNA sequences,

114 t high-affinity compounds that bind putative G-quadruplex forming sequences only rarely have a high d

115 Here we demonstrate that RNA elements with G-quadruplex-forming capacity promote exon inclusion.

116 Destroying G-quadruplex-forming capacity while keeping G tracts int

117 of sequences but can also be found for other G-quadruplex-forming motifs, arguing for widespread appl

118 wth, which helps explain why we detected few G-quadruplex-forming regions in bacterial transcriptomes

119 We found a new 28-mer G-quadruplex-forming sequence, P1G4, immediately upstrea

120 when OG is formed in guanine-rich, potential G-quadruplex-forming sequences (PQS) in promoter-coding

121 instead undergone evolutionary depletion of G-quadruplex-forming sequences.

122 expected to be more prevalent than putative G-quadruplex-forming sequences.

123 Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, her

124 The G-quadruplex frameworks also demonstrate potential as ca

125 hat Delta1a can discriminate human telomeric G-quadruplex from other telomeric G-quadruplexes.

126 mall-molecule optical probe (DAOTA-M2) and a G-quadruplex from the promoter region of the c-myc oncog

127 een proposed that expanded transcripts adopt G-quadruplex (G-Q) structures and associate with protein

128 G-quadruplexes/G-quadruplex-ligand complexes were also c

129 We find that PARP3 regulates G quadruplex (G4) DNA in response to DNA damage, which s

130 WRN RECQ helicase protein binds and unwinds G-quadruplex (G4) DNA substrates in vitro, and we identi

131 efficiently to both double-stranded DNA and G-quadruplex (G4) DNA.

132 nce-based computational model to predict DNA G-quadruplex (G4) formation.

133 A DNA G-quadruplex (G4) formed at the oncogene c-MYC promoter

134 ro presence of a stable secondary structure, G-quadruplex (G4) in the 5' UTR of P1-HNF4A, the predomi

135 G-quadruplex (G4) is a higher-order nucleic acid structu

136 The G-quadruplex (G4) is a non-canonical nucleic acid struct

137 d at transcriptional start sites and contain G-quadruplex (G4) motifs.

138 G-quadruplex (G4) structural motifs have been linked to

139 MYC's promoter is governed by a higher order G-quadruplex (G4) structure in the NHE III1 region.

140 RPA is able to unfold G-quadruplex (G4) structures formed by telomeric DNA seq

141 This motif can form G-quadruplex (G4) structures in vitro.

142 hysical properties typically associated with G-quadruplex (G4) structures render them a significant b

143 Guanine rich nucleic acid sequences can form G-quadruplex (G4) structures that interfere with DNA rep

144 onstrate that spiroketal does not affect the G-quadruplex (G4) thermal stability.

145 econdary, four-stranded DNA structure termed G-quadruplex (G4), which has been implicated in genomic

146 G-quadruplex (G4)-containing substrates mimicking the ma

147 G-quadruplex (G4)-forming genomic sequences, including t

148 , whose stacking leads to the formation of a G-quadruplex (G4).

149 G-quadruplexes (G4) are polymorphic four-stranded struct

150 de chains was designed to target DNA and RNA G-quadruplexes (G4) in the promoter and 5'-UTR mRNA of t

151 G-quadruplexes (G4) within oncogene promoters are consid

152 Guanine-rich oligonucleotides can form G-quadruplexes (G4), which are stabilized by the hydroge

153 r complex (Pt-DA) has been incorporated into G-quadruplex G4K(+) borate hydrogels by using borate est

154 G quadruplexes (G4s) can present potent blocks to DNA re

155 G-quadruplexes (G4s) are extremely stable DNA or RNA sec

156 G-quadruplexes (G4s) are higher-order DNA structures typ

157 The role of G-quadruplexes (G4s) in biological systems has been wide

158 cular complexes containing both i-motifs and G-quadruplexes (G4s) is demonstrated.

159 G-quadruplexes (G4s), DNA secondary structures displayin

160 ent helicase highly specific for DNA and RNA G-quadruplexes (G4s).

161 guanosines strongly tend to fold into stable G-quadruplexes (G4s).

162 ions between the human telomeric RNA (TERRA) G-quadruplex (GQ) and its ligands, it was found that the

163 G-quadruplex (GQ) is a four stranded DNA secondary struc

164 G-quadruplex (GQ) is a four-stranded DNA structure that

165 The potential use of G-quadruplex (GQ) stabilizing small molecules as anti-ca

166 Both WRN and BLM have been shown to resolve G-quadruplex (GQ) structures.

167 stranded DNA (ssDNA) binding proteins unfold G-quadruplex (GQ) structures.

168 onic acid) (ABTS)-H2O2 reaction catalyzed by G-quadruplex halves.

169 In the NHE III1 only the G-quadruplex has been extensively studied, whereas the r

170 ps or non-canonical DNA structures including G-quadruplexes has been proposed as the major underlying

171 knowledge about the structural properties of G-quadruplexes has helped to design and develop a repert

172 The structural and topological diversity of G-quadruplexes have attracted great attention for decade

173 Although RNA G-quadruplexes have been implicated in posttranscription

174 While the G-quadruplexes have been well characterized, the i-motif

175 talline phase behaviors of two other related G-quadruplexes: (i) the intramolecular parallel-stranded

176 These data suggest a critical role for RNA G quadruplexes in regulating alternative splicing.

177 ly stable species (parallel and antiparallel G-quadruplex in K+ and Na+, respectively).

178 with strong G/C skew and propensity to form G-quadruplex in non-template DNA, corroborating with all

179 on governed by the EF1a interaction with the G-quadruplex in the NRF2 5' UTR during oxidative stress.

180 the potential functions and applications of G-quadruplexes in basic and applied biosciences.

181 trategies for the selective stabilization of G-quadruplexes in cells.

182 g from enhanced eIF4A-dependent unwinding of G-quadruplexes in the 5' untranslated region of GW182 mR

183 h-order DNA structures into two constituting G-quadruplexes in the promoter of the human telomerase r

184 Given the relevance of G-quadruplexes in the regulation of biological processes

185 of mammalian RNA regions that can fold into G-quadruplexes in vitro, but in contrast to previous ass

186 d the identification and characterization of G-quadruplexes in vivo as well as in vitro, and at a muc

187 The current belief is that RNA G-quadruplexes include loops of l to 7 nucleotides in le

188 hanical and thermodynamic stabilities of the G-quadruplex inside the nanocage increase with decreasin

189 or molecularly crowded buffer solutions, the G-quadruplex inside the nanocage is significantly more s

190 plicational or co-transcriptional folding of G-quadruplex inside the polymerase machinery in cells.

191 ,2,3-de]quinazoline, was found to be a novel G-quadruplex interactive agent that interfered with tran

192 This dual i-motif/G-quadruplex-interactive compound presents a new mechani

193 itory effect can be markedly enhanced by the G-quadruplex-interactive compound TMPyP4.

194 clearly demonstrate that what defines a RNA G-quadruplex is much broader than what we previously bel

195 Even if the composition of a RNA G-quadruplex is not quite completely understood, the res

196 ign of ligands targeting human telomeric DNA G-quadruplexes is a complex problem due to the structura

197 e compound on the Mid-region i-motif and the G-quadruplexes leads to downregulation of KRAS gene expr

198 we demonstrate that three of the most potent G-quadruplex ligands (360A, Phen-DC3, and pyridostatin)

199 lity to perform high-throughput screening of G-quadruplex ligands for the development of drug molecul

200 This is the first example of G-quadruplex ligands that show increased selectivity tow

201 ce of DNA secondary structures, specifically G-quadruplex-like DNA, within the CTD coding region.

202 igoguanine motifs at their 5'-ends, assemble G-quadruplex-like structures and interact with the trans

203 matic search was performed to find potential G-quadruplexes located in the untranslated regions of hu

204 The unique P1G4 G-quadruplex may provide a specific target for small mol

205 Interestingly, a G-quadruplex motif at the hTERT promoter was essential f

206 otif for specific interactions with guanine (G)-quadruplexes, mRNA elements implicated in the disease

207 by small-molecule-mediated stabilization of G-quadruplex nucleic acid secondary structures triggers

208 esses occurring at specific locations within G-quadruplex nucleic acids, providing valuable probes fo

209 tational dynamics of guanine amino groups in G-quadruplex nucleic acids.

210 via hnRNPA1-mediated destabilization of the G-quadruplex on the KRAS promoter.

211 up to form unique DNA secondary structures: G-quadruplexes on the G-rich strand and i-motifs on the

212 G-quadruplex or G4 DNA is a non-B secondary DNA structur

213 The presence of G-quadruplex or i-motif structures upstream of the green

214 by ectopic oncogenic expression of cyclin E, G-quadruplexes, or R-loop formation facilitate the ALT p

215 nism of hTERT epigenetic control involving a G-quadruplex promoter motif, which potentially can be ta

216 The residues responsible for G-quadruplex recognition also participate in interaction

217 e structural basis for tight gold(I) complex/G-quadruplex recognition and its selectivity are describ

218 However, the structural basis for specific G-quadruplex recognition by proteins has not been unders

219 ndria, transcription termination events at a G-quadruplex region near the replication origin are thou

220 quencing (rG4-seq), a transcriptome-wide RNA G-quadruplex (rG4) profiling method that couples rG4-med

221 RNA G-quadruplex (RG4) structures are involved in multiple b

222 RNA G-quadruplex (rG4) structures are of fundamental importa

223 several G4 motifs capable to form stable RNA G-quadruplex (RG4) structures that can serve as targets

224 Preferential binding of G-quadruplex RNA is conserved, surprisingly using differ

225 xafluoroisopropanol mixture highly increased G-quadruplex sensitivity with no modification of the phy

226 r 1 alpha (EF1a) as a protein binding to the G-quadruplex sequence.

227 We introduce RNA G-quadruplex sequencing (rG4-seq), a transcriptome-wide

228 Thus, the G-quadruplex serves as an effective conduit for positive

229 anar tetramers, which we term supramolecular G-quadruplexes (SGQs).

230 rmore, we demonstrated that mutating PIF1, a G-quadruplex-specific helicase, results in increased CTD

231 is gene can be controlled by ligand-mediated G-quadruplex stabilization.

232 Here, we show that CX-5461 is a G-quadruplex stabilizer, with specific toxicity against

233 ll lines in vitro and behaves as a selective G-quadruplex stabilizer.

234 G-quadruplex stabilizers are an established opportunity

235 These results suggest a potential role for G-quadruplex stabilizers in the treatment of KSHV-associ

236 tigation led to the identification of potent G-quadruplex stabilizers with high selectivity over dupl

237 Our results showed that these G-quadruplex stabilizing compounds led to the activation

238 Overall, these data show that G-quadruplex stabilizing compounds retard the progressio

239 endency to obstruct DNA replication, we used G-quadruplex stabilizing compounds to examine their effe

240 Modulation of G-quadruplex structural integrity may control cellular p

241 reatly expanded our current understanding of G-quadruplex structure and function.

242 Hemin/G-quadruplex structure as HRP mimicking-DNAzyme signific

243 Here we demonstrate the presence of a G-quadruplex structure in the 5' untranslated region (UT

244 Additionally, we have identified a G-quadruplex structure in the 5' untranslated region of

245 exit channel to prevent formation of the RNA G-quadruplex structure required for termination and thus

246 of ATP, the ATP-binding aptamer folds into a G-quadruplex structure that is resistant to Exo I digest

247 The sequences that adopted a G-quadruplex structure were cloned into a luciferase dua

248 Although different ions can stabilize a G-quadruplex structure, the preferred bound ions are typ

249 in aqueous-media, which first implements the G-quadruplex structure-switching biosensing principle in

250 verify the signaling principle competency of G-quadruplex structure-switching in graphene electronic

251 ncludes a G-rich portion that likely forms a G-quadruplex structure.

252 Indeed, stabilization of G-quadruplex structures activates PARP1 and leads to acc

253 e, N-Methyl mesoporphyrin IX, binds to these G-quadruplex structures and generates significantly ampl

254 guanine-rich oligonucleotides, non-canonical G-quadruplex structures are based on G-quartets formed b

255 G-quadruplex structures are composed of coplanar guanine

256 The first indication of how G-quadruplex structures could be unfolded enzymatically

257 says reveal that the POT1-TPP1 complex binds G-quadruplex structures formed in buffers containing Na(

258 an affinity that is fivefold higher than for G-quadruplex structures formed in the presence of K(+).

259 Here, we show that specific G-quadruplex structures formed in the RET promoter regio

260 selected derivatives have been shown to trap G-quadruplex structures in the nucleus of cancer cells.

261 repeats of the sequence d(TTAGGG) that form G-quadruplex structures made of stacked guanines with mo

262 Evidence suggests that G-quadruplex structures may act as 'knots' within genomi

263 ts provide further support for the idea that G-quadruplex structures may have a critical role in tran

264 ediether (Sd) hole acceptor separated by DNA G-quadruplex structures possessing 2-to-4 tetrads by mea

265 nucleolin is able to specifically recognize G-quadruplex structures present in the LTR promoter.

266 sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked b

267 n telomere DNA fragments fold into different G-quadruplex structures with parallel, hybrid, and antip

268 a neuroblastoma cell line, in particular at G-quadruplex structures, and recombinant CSB can melt G-

269 ded by the ordered rylene diimide arrays and G-quadruplex structures, respectively.

270 We also show that CST unfolds G-quadruplex structures, thus providing a mechanism for

271 ly interact with Pb(2+) ions and switch into G-quadruplex structures.

272 itro by in-line probing for the formation of G-quadruplex structures.

273 lex structures, and recombinant CSB can melt G-quadruplex structures.

274 n of proviral genome by inducing/stabilizing G-quadruplex structures.

275 e production of DNA assemblies with numerous G-quadruplex structures.

276 catalyst to selectively bind and cleave the G-quadruplex telomere sequence.

277 rescence lifetimes are observed in vitro for G-quadruplexes than for double- and single-stranded nucl

278 e investigate the sequence requirements of a G-quadruplex that can both bind GTP and promote peroxida

279 h hole sharing among the guanines within the G-quadruplex that is kinetically competitive with the fo

280 Model RNA G-quadruplexes that were unfolded in eukaryotic cells we

281 Also contrasting with telomeric G-quadruplexes, the parallel-stranded Pu24-myc G-quadrup

282 s were recently developed to track and label G-quadruplexes: these higher-order nucleic acid structur

283 ater binding preference towards DNA than RNA G-quadruplexes, thus indicating two levels of selectivit

284 duce conformational changes of telomeric DNA G-quadruplexes to an antiparallel structure (as determin

285 quadruplexes, the parallel-stranded Pu24-myc G-quadruplex, to which Phen-DC3 is known to bind by end-

286 After mechanically targeting the two G-quadruplexes together, the same interaction was observ

287 ondary structure is substantially faster for G-quadruplex topologies formed in the presence of Na(+)

288 ivity over duplex DNA and preference for one G-quadruplex topology over others.

289 uter G-quartets of the unimolecular parallel G-quadruplex under study.

290 Finally, we compare the mesophases of the G-quadruplexes, under PEG-induced crowding conditions, w

291 ethylcaffein-8-ylidene)2 ](+) and Tel 23 DNA G-quadruplex was solved.

292 Introducing the term 'clustered damage to G-quadruplexes' we report here on the structural effects

293 dulate translation in cellulo Some irregular G-quadruplexes were observed to either promote or repres

294 a robust machinery that globally unfolds RNA G-quadruplexes, whereas some bacteria have instead under

295 ture can result in the unfolding of existing G-quadruplexes which can lead to telomere shortening.

296 induce targeted mechanical unfolding of the G-quadruplex while leaving the nanocage unperturbed.

297 click-chemistry coupling, we sandwiched one G-quadruplex with two dsDNA handles while leaving the ot

298 g both human telomeric and oncogene promoter G-quadruplexes with different folding topologies as targ

299 e revealed multiple motifs predicted to form G-quadruplexes, with the greatest potential detected for

300 study on oxidative damage of human telomere G-quadruplexes without mediation of external molecules.