ライフサイエンスコーパス: G1 cell cycle arrest

1 ond, HKL decreased CDK2 activity, leading to G1 cell cycle arrest.

2 DK2, and partially overcome the PTEN-induced G1 cell cycle arrest.

3 xia include adaptive metabolic changes and a G1 cell cycle arrest.

4 nditions or by glucocorticoids that induce a G1 cell cycle arrest.

5 Finally, activation of PPARgamma resulted in G1 cell cycle arrest.

6 n of the de novo synthesis of PA resulted in G1 cell cycle arrest.

7 f the principal mediators of the p53 induced G1 cell cycle arrest.

8 de-stained cells revealed that I3C induces a G1 cell cycle arrest.

9 -kappaB activity, Bcl-xL downregulation, and G1 cell cycle arrest.

10 which lack endogenous receptors, result in a G1 cell cycle arrest.

11 ceptor-mediated response associated with the G1 cell cycle arrest.

12 vity correlated with the ability to induce a G1 cell cycle arrest.

13 vFLIP also leads to p21/p27 upregulation and G1 cell cycle arrest.

14 primary MDS/AML samples via induction of G0/G1 cell cycle arrest.

15 15(INK4B) and induction of a p53-independent G1 cell cycle arrest.

16 is was caspase dependent and associated with G1 cell cycle arrest.

17 of RB phosphorylation and more pronounced G0/G1 cell cycle arrest.

18 ate cancer-derived cell lines and induced G0/G1 cell cycle arrest.

19 to TGF-beta by overcoming a TGF-beta-induced G1 cell cycle arrest.

20 dylinositol 3-kinase signaling and to induce G1 cell cycle arrest.

21 kade in ribosome component biosynthesis, and G1 cell cycle arrest.

22 xpression by RNA interference also led to G0-G1 cell cycle arrest.

23 tion of cell proliferation accompanied by G0-G1 cell cycle arrest.

24 riptional activity and induced p53-dependent G1 cell cycle arrest.

25 p21CIP1 being required to ensure a sustained G1 cell cycle arrest.

26 the cyclin-dependent kinase inhibitor p21 in G1 cell cycle arrest.

27 to respond by imposition of a p21-dependent G1 cell cycle arrest.

28 SmgGDS depletion characteristically causes a G1 cell cycle arrest.

29 s levels, inhibits PKB activity, and induces G1 cell cycle arrest.

30 a) inhibits cell proliferation by inducing a G1 cell-cycle arrest.

31 g IFN-gamma and IL-2 production and inducing G1 cell-cycle arrest.

32 topoietic defect is because of p53-dependent G1 cell-cycle arrest.

33 tants also display prominent apoptosis and a G1 cell-cycle arrest.

34 oliferation of BM endothelium by inducing G0/G1 cell-cycle arrest.

35 believed to be the cause of the p16-mediated G1 cell cycle arrest after reintroduction of p16 into p1

36 a specific inhibitor of mTOR kinase, induces G1 cell cycle arrest and apoptosis in two rhabdomyosarco

37 f miR-23b in bladder cancer cells induced G0/G1 cell cycle arrest and apoptosis while inhibiting cell

38 BCR) on immature WEHI 231 B cells results in G1 cell cycle arrest and apoptosis.

39 a cells by miR inhibitors was accompanied by G1 cell cycle arrest and cell death, and was attenuated

40 ellular proliferation was associated with G0/G1 cell cycle arrest and decrease expression of cell cyc

41 -irradiation of these cells failed to induce G1 cell cycle arrest and did not lead to an increase in

42 These signals must be attenuated to induce G1 cell cycle arrest and expression of the RAG endonucle

43 p27Kip1 results in a p27Kip1 level-dependent G1 cell cycle arrest and growth inhibition similar to th

44 However, the G1 cell cycle arrest and induction of p27Kip1 produced b

45 d DNA damage in IGF-1R-negative cells caused G1 cell cycle arrest and S phase fork stalling.

46 of U937 human leukemic cells results in late G1 cell cycle arrest and terminal monocyte/macrophage-li

47 eta isoforms is crucial for the induction of G1 cell cycle arrest and that this negative cell cycle r

48 rtant role in the anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition through

49 or p27Kip1 in the anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition.

50 PPAR-gamma activators induced G0/G1 cell-cycle arrest and apoptosis and suppressed ACTH s

51 bition in vitro and in tumors in mice caused G1 cell-cycle arrest and eliminated Ki-67 mRNA in RB1-po

52 G1 cell-cycle arrest and p21 mRNA induction were also ob

53 markedly decreased interleukin-2 production, G1 cell-cycle arrest and subsequent apoptotic death in r

54 The latter mechanism involves p38-dependent G1 cell-cycle arrest and subsequent intrinsic mitochondr

55 6OTD caused DNA damage, G1 cell cycle arrest, and apoptosis in GSCs but not in N

56 RNA hindered cellular proliferation, induced G1 cell cycle arrest, and attenuated migration and colon

57 v1 is required for mating, pheromone-induced G1 cell cycle arrest, and for sterol trafficking.

58 posure reduced proliferation rate, induced a G1 cell cycle arrest, and increased cytoplasmic vacuoliz

59 creases the rate of p53 translation, induces G1 cell-cycle arrest, and augments irradiation-induced a

60 ors-induced growth inhibition and undergo G0/G1 cell-cycle arrest, apoptosis and cellular senescence,

61 G1 cell cycle arrest appeared to be mediated by p21 and

62 In many cell types, p53 mediates G1 cell cycle arrest as the predominant cellular respons

63 ors in Caenorhabditis elegans, we identified G1 cell-cycle arrest as a precisely regulated requiremen

64 n HER2-overexpressing breast cancers through G1 cell cycle arrest associated with induction of p27Kip

65 p16 expression, cell growth inhibition, and G1 cell cycle arrest by 5-Aza-CdR in the T24 bladder tum

66 recognized tumour suppressor that induces a G1 cell cycle arrest by inhibiting the phosphorylation o

67 mammary epithelial cell lines by inducing a G1 cell cycle arrest, characterized by decreased cyclin

68 Restoration of GATA-1 activity induced G1 cell cycle arrest coincident with repression of c-Kit

69 ere defective for the DeltaMEKK3:ER*-induced G1 cell cycle arrest compared to their wild-type counter

70 xpression of the TOR-toxic domain leads to a G1 cell cycle arrest, consistent with an inhibition of T

71 d mitochondrial dysfunction, which result in G1 cell cycle arrest, DNA fragmentation, and oxidative s

72 f sensitive cell lines with PFI-1 results in G1 cell-cycle arrest, downregulation of MYC expression,

73 ck the ability to initiate pheromone-induced G1 cell cycle arrest, due to failure to polarize PI(4,5)

74 RT cell lines, reexpression of hSNF5 induces G1 cell cycle arrest, elevated p16INK4a, and activated r

75 ted levels of RelA, but not c-Rel, induced a G1 cell cycle arrest followed by apoptosis.

76 Mnk1/2 kinase inhibition in AML cells causes G1 cell cycle arrest followed by induction of apoptosis.

77 thetic enzyme inhibitors causes p21-mediated G1 cell cycle arrest followed by p21-mediated changes in

78 JAZ functions to mediate G1 cell-cycle arrest followed by apoptosis in a p53-depe

79 troviral transduction is sufficient to cause G1 cell cycle arrest, followed by apoptosis.

80 ctivation of the p53 and pRB pathways, and a G1 cell cycle arrest, followed by induction of cellular

81 /CIP1 plays a major role in the induction of G1 cell cycle arrest following DNA damage and is known t

82 ration, changes in RA-regulated genes, and a G1 cell cycle arrest in a manner similar to parental NT2

83 mma-irradiation, suggesting that the partial G1 cell cycle arrest in Atm-/- cells following gamma-irr

84 n epidermoid carcinoma A431 cells results in G1 cell cycle arrest in both asynchronously growing and

85 Transforming growth factor beta induced a G1 cell cycle arrest in C/EBP alpha antisense transfecte

86 TDs induced G0/G1 cell cycle arrest in LNCaP cells and decreased cells

87 the first time that DFMO and SAM486A induce G1 cell cycle arrest in NB cells through p27Kip1 and Rb

88 Although Q deprivation causes G1 cell cycle arrest in non-transformed cells, its impac

89 deficient mice revealed no radiation-induced G1 cell cycle arrest in p53 null (-/-) cells.

90 NS knockdown led to G1 cell cycle arrest in p53-positive cells but not in ce

91 Sulindac metabolites caused G1 cell cycle arrest in proliferating cells but were com

92 ocorticoid receptors and undergo a stringent G1 cell cycle arrest in response to glucocorticoids that

93 not essential for the activation of p53 and G1 cell cycle arrest in response to ionizing radiation.

94 genicity, migration, spheroid formation, and G1 cell cycle arrest in several mesothelioma cell lines,

95 c1-carrying mice, which leads to a defective G1 cell cycle arrest in splenic B cells and increased pr

96 Treatment with WR1065 resulted in G1 cell cycle arrest in the p53-positive cell line but n

97 ts of E2F repression lag behind the onset of G1 cell cycle arrest in timed Rb reexpression experiment

98 This identifies a novel pathway for G1 cell cycle arrest in transformed keratinocytes follow

99 e retinoblastoma tumour suppressor, inducing G1 cell cycle arrest in tumour cells.

100 y, dyskerin suppression caused p53-dependent G1 cell-cycle arrest in p53 wild-type cells, and a p53-i

101 e activity conferred increased apoptosis and G1 cell-cycle arrest in primary cutaneous anaplastic T-c

102 pha, an apoptosis-inducing cytokine, induces G1 cell-cycle arrest in proliferating EC.

103 eventing pRb phosphorylation and producing a G1 cell-cycle arrest in tissue culture cell systems.

104 e gene transcription to control a reversible G1 cell-cycle arrest, independent of p21(CIP) function.

105 ion by small interfering RNA overcame the G0/G1 cell cycle arrest induced by ICI182,780, suggesting t

106 The magnitude of G1 cell cycle arrest induced by trastuzumab or 4D5 is we

107 The initiation and maintenance of G1 cell cycle arrest is a key feature of animal developm

108 The G1 cell cycle arrest is in part caused by the p53-depend

109 th of PC-3 prostate cancer cells by inducing G1 cell cycle arrest leading to apoptosis, and regulates

110 2 can act independently of p53 and block the G1 cell cycle arrest mediated by members of the retinobl

111 ion of in vitro and in vivo cell growth with G1 cell cycle arrest mediated by the suppression of cycl

112 We found that G1 cell cycle arrest occurred concomitant with an increa

113 nally activated form of C/EBP alpha caused a G1 cell cycle arrest of BDS1 hepatoma cells in the absen

114 ion vector blocked the dexamethasone-induced G1 cell cycle arrest of hepatoma cells but did not alter

115 nt that we have shown previously to induce a G1 cell cycle arrest of human breast cancer cell lines,

116 f CDK2 specific kinase activity as part of a G1 cell cycle arrest of human breast cancer cells.

117 t artemisinin treatment triggers a stringent G1 cell cycle arrest of LNCaP (lymph node carcinoma of t

118 factor is required for the steroid-mediated G1 cell cycle arrest of minimal-deviation rat hepatoma c

119 a is necessary to mediate the glucocorticoid G1 cell cycle arrest of rat hepatoma cells and implicate

120 d receptor signaling pathway that mediates a G1 cell cycle arrest of rat hepatoma cells and the trans

121 ing growth factor-beta, which also induced a G1 cell cycle arrest of the hepatoma cells, failed to el

122 n-defective adenovirus vector resulted in G0/G1 cell cycle arrest of VSMCs and fibroblasts.

123 -mediated DNA damage response induces either G1 cell cycle arrest or apoptosis.

124 is to inhibit cell growth, either through a G1 cell cycle arrest or apoptotic cell death.

125 to be responsible for the radiation-induced G1 cell cycle arrest or delay.

126 ealed a severe defect of DNA repair and a G0/G1 cell cycle arrest, particularly in LIG4- and DNA-PK c

127 hypophosphorylated pRb and elicited an early G1 cell cycle arrest, provided cyclin E:Cdk2 complexes w

128 nescence corroborated by the induction of G0/G1 cell-cycle arrest, Rb dephosphorylation, flat and enl

129 silencing ASC with short hairpin RNA induced G1 cell cycle arrest, reduced cell viability, and suppre

130 NK4A-ARF(Null) lung cancer cells triggered a G1 cell-cycle arrest regardless of p19(ARF) status.

131 However, inhibition of MEK results in G1 cell cycle arrest, rendering infected cells temporari

132 NA and protein occurs before TGFbeta-induced G1 cell cycle arrest, requires transcription, and is med

133 utant protein to elicit a DNA damage-induced G1 cell cycle-arrest response is also partially impaired

134 ated with, and can promote, cardiomyocyte G0/G1 cell cycle arrest suggesting that centrosome disassem

135 s, the p53 tumor suppressor protein exerts a G1 cell cycle arrest that is dependent on its ability to

136 cally expressed ARF to restore a p53-imposed G1 cell cycle arrest that is otherwise abrogated by MDM2

137 rative transcription factor able to induce a G1 cell-cycle arrest that is dependent on Mitf-mediated

138 In 5L hepatoma cells, TCDD induces a G1 cell cycle arrest through a mechanism that involves t

139 diated by ILT2-HLA-G interaction showed a G0/G1 cell cycle arrest through dephosphorylation of AKT, G

140 r (bZIP) transcription factor that causes G0/G1 cell cycle arrest through induction of the tumor supp

141 both drugs were mediated by induction of G0/G1 cell cycle arrest through upregulation of p27 and dow

142 led to apoptosis, knockdown in GBMNS led to G1 cell cycle arrest through upregulation of p27 and hyp

143 one inducing p27Kip1/retinoblastoma-coupled G1 cell cycle arrest via a mechanism that regulates the

144 Induction of G1 cell cycle arrest was also observed in PC-3 cells tre

145 G1 cell cycle arrest was associated with a decrease in t

146 The G1 cell cycle arrest was concomitant with an increase in

147 se activation was delayed, but the extent of G1 cell cycle arrest was similar in C7-MycER(TM) cells.

148 itial growth suppression was attributable to G1 cell cycle arrest, whereas subsequent growth suppress

149 DIM or the anti-estrogen tamoxifen induced a G1 cell cycle arrest with no changes in the associated c

150 expression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A), p21(CIP1/WAF1), an

151 hibiting Skp2-p27 interaction and can induce G1 cell cycle arrest with wild-type kinetics.

152 (50) concentration of this extract induced a G1 cell cycle arrest, with a concomitant decrease in the

153 growth inhibition, polyamine depletion, and G1 cell cycle arrest without apoptosis in cell lines LAN

154 (DFMO) depleted polyamine pools and induced G1 cell cycle arrest without causing apoptosis.

155 om solid tumors, ABBV-075 triggers prominent G1 cell-cycle arrest without extensive apoptosis.