ライフサイエンスコーパス: GABA neuron

1 by increasing synaptic inhibition from local GABA neurons.

2 rrelated with the appearance of degenerating GABA neurons.

3 ropathic pain through NR1 phosphorylation in GABA neurons.

4 ected robust orexigenic potential for the ZI GABA neurons.

5 creased substance P NK1-R internalization on GABA neurons.

6 some direct synaptic influence on VTA DA and GABA neurons.

7 hat is likely to excite DA cells and inhibit GABA neurons.

8 h nAChRs that desensitize less than those on GABA neurons.

9 ification of all hippocampal interneurons as GABA neurons.

10 uced below a detectable level in a subset of GABA neurons.

11 uced below a detectable level in a subset of GABA neurons.

12 ill result in a powerful inhibition of these GABA neurons.

13 processed for immunocytochemical staining of GABA neurons.

14 oradrenaline (tyrosine hydroxylase; TH), and GABA neurons.

15 fonylureas increase transmitter release from GABA neurons.

16 n the development of embryonic monoamine and GABA neurons.

17 by analysis of immunoreactive 5-HT, TH, and GABA neurons.

18 re mediated by the activation of presynaptic GABA neurons.

19 hCpG methylation was detected in GLU versus GABA neurons.

20 cessing and is composed of dopamine (DA) and GABA neurons.

21 differences in eCB synthesis between DA and GABA neurons.

22 synergistic overinhibition of nigro-thalamic GABA neurons.

23 leus (DR), which contains both serotonin and GABA neurons.

24 ng-lasting polysynaptic complex EPSCs in SNr GABA neurons.

25 1)(-)/(-)) mice for CB(1) receptors in brain GABA neurons.

26 progenitors generated similar populations of GABA neurons.

27 nucleus incertus, a population of tegmental GABA neurons.

28 but showed TRH axons terminating on or near GABA neurons.

29 mRNAs, markers for gamma-aminobutyric acid (GABA) neurons.

30 of glutamatergic synaptic plasticity in VTA GABA neurons, a currently understudied cell type that is

31 tent stimulation led to body weight gain; ZI GABA neuron ablation reduced weight.

32 inhibition of dopamine reuptake affected SNr GABA neuron activity in a D(1)-like receptor-dependent m

33 homologue of unc-47 is expressed by central GABA neurons and confers vesicular GABA transport in tra

34 in the opioid-induced inhibition of midbrain GABA neurons and consequent disinhibition of dopamine (D

35 ults revealed that social defeat engaged DRN GABA neurons and drove GABAergic sensitization that stre

36 sive disorder, implicate dendritic targeting GABA neurons and GABA synthesis, and, together, suggest

37 inhibit axon regeneration of both C. elegans GABA neurons and mammalian cortical neurons.

38 currents were significantly depressed in VTA GABA neurons and remained depressed for 7 days.

39 study the migrational trajectories of DA and GABA neurons and show that they occupy ventral mesenceph

40 ic, glutamatergic drive to both DRN 5-HT and GABA neurons and that this architecture was conducive to

41 mine neurons in embryonic rat brain, because GABA neurons and their receptors appear in brainstem dur

42 ith the function of gamma-aminobutyric acid (GABA) neurons and alter the brain oscillations.

43 inhibited STN-triggered burst firing in SNr GABA neurons, and CP93129's inhibitory effect was strong

44 the magnitude of electrical coupling between GABA neurons, and GJ blockers increased the threshold fo

45 ted non-CpG sites were identified in GLU and GABA neurons, and non-CpG methylation was a better predi

46 inhibitory input onto VTA dopamine (DA) and GABA neurons, and that the GABAergic projection drives f

47 brane domains, that the gene is expressed by GABA neurons, and that the protein colocalizes with syna

48 the level of gene expression in a subset of GABA neurons, and the resulting changes in GABA neurotra

49 TRH excited LH GABA neurons, and this was also reduced by NCX inhibitor

50 >SNr projection, reduces burst firing in SNr GABA neurons, and thus may play a critical role in movem

51 r this change is present in all or only some GABA neurons, and whether long-term treatment with halop

52 of a subpopulation of perisomatic-targeting GABA neurons, and, when activated, suppresses the releas

53 Given the critical role that PV-containing GABA neurons appear to play in regulating the cognitive

54 ptic terminals on the remaining dendrites of GABA- neurons appeared not to undergo major age-related

55 isturbed but whether specific populations of GABA neurons are affected is not known.

56 These results suggest that the LH GABA neurons are critical for storing and later dissemin

57 The chandelier class of GABA neurons are of particular interest because their ax

58 e observations show that, unexpectedly, ESR1-GABA neurons are only essential for the positive feedbac

59 s were not altered, suggesting that afferent GABA neurons are the primary targets.

60 noradrenergic and gamma-amino-butyric acid (GABA) neurones are implicated in the system's regulation

61 cystokinin class of gamma-aminobutyric acid (GABA) neurons, are lower in the dorsolateral prefrontal

62 pression is relatively unaltered in most PFC GABA neurons but is reduced below a detectable level in

63 OIG-1 is secreted from GABA neurons, but its anti-plasticity function is cell a

64 ional deletion of CB(1) receptors from brain GABA neurons, but not from several other neuronal popula

65 s and indirectly inhibits them through local GABA neurons, but the relative magnitudes of the two mec

66 5-HT2CR expressing gamma-aminobutyric acid (GABA) neurons, but not 5-HT2CR expressing dopamine (DA)

67 eding and locomotor activity similar to LHA (GABA) neurons, but without inducing compulsive-like beha

68 s and evoked synaptic glutamate release onto GABA neurons by activation of Y1 and Y5 receptors.

69 hat the dynamic interplay between VTA DA and GABA neurons can control the initiation and termination

70 Here we show that SNr GABA neurons coexpress dopamine D(1) and D(5) receptor m

71 % of parvalbumin-containing septohippocampal GABA neurons colocalized the mu receptor, which at the u

72 These GABA neurons communicate with dopamine neurons, where th

73 e mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations.

74 indings indicate that the discharging of VTA GABA neurons correlates with psychomotor behavior and th

75 sensory cortical development, and thus that GABA neurons could provide an important substrate for ex

76 investigate whether these same hypothalamic GABA neurons decrease their activity postcastration in f

77 Our results indicate that the mechanism of GABA neuron degeneration is calcium-dependent and requir

78 ath is also consistent with our finding that GABA neuron degeneration requires the mitochondrial fiss

79 ggered complex EPSCs and burst firing in SNr GABA neurons, demonstrating the effects of endogenous 5-

80 e intimate relationship between dopamine and GABA neuron development revealed here may offer novel in

81 rect activation of GIRK channels in midbrain GABA neurons did not enhance motor activity.

82 r the selective ablation of GIRK channels in GABA neurons, diminished morphine-induced motor activity

83 Furthermore, optogenetic stimulation of VTA GABA neurons directly suppressed the activity and excita

84 Furthermore, optogenetic silencing of DRN GABA neurons disinhibited neighboring 5-HT neurons and p

85 w that in vivo optogenetic activation of VTA GABA neurons disrupts reward consummatory behavior but n

86 e (GAD) 65-positive neurons, indicating that GABA neurons do not express either transporter.

87 laterally stimulating ventral tegmental area GABA neurons dramatically reduces anticipatory licking t

88 Early-born gamma-aminobutyric acid (GABA) neurons (EBGNs) are major components of the hippoc

89 doses of nicotine, by stimulating DA but not GABA neurons, exaggerates these phenotypes and produces

90 Here, we demonstrate that mouse VTA GABA neurons express a GIRK channel formed by GIRK1 and

91 gy is the dysfunction of cortical inhibitory GABA neurons expressing parvalbumin, which are essential

92 D(1)-like receptor blockade reduced SNr GABA neuron firing frequency and increased their firing

93 e often associated with abnormalities in SNr GABA neuron firing intensity and/or pattern.

94 mine, or halothane significantly reduced VTA GABA neuron firing rate and converted their activity int

95 VTA GABA neuron firing rate decreased 53% during slow-wave s

96 and EPSC frequencies were increased in hilar GABA neurons from slices ipsilateral to the injury versu

97 model, we found that tangential migration of GABA neurons from the basal to the dorsal forebrain and

98 orter, but Prlr deletion from these dopamine/GABA neurons had no effect on feedback regulation of pro

99 ularly involving parvalbumin (PV)-expressing GABA neurons, has been proposed as a key mechanism under

100 to dopamine (DA) or gamma-aminobutyric acid (GABA) neurons have not yet been investigated.

101 arized GABA neurons including neuroendocrine GABA neurons identified by antidromic median eminence st

102 rter, a transcription factor that determines GABA neuron identity, a classic inhibitory GABA receptor

103 of a homogeneous population of presumed VTA GABA neurons, implicated in cortical arousal, increases

104 We show that acute inhibition of vHPC GABA neurons in adult mice results in behavioral changes

105 To solidify the importance of these VTA GABA neurons in behavioral function, we employed the neu

106 vidence is lacking for a causal role of vHPC GABA neurons in behaviors associated with schizophrenia.

107 se findings establish a causal role for vHPC GABA neurons in controlling behaviors relevant to schizo

108 lso generated a new mouse model for studying GABA neurons in narcoleptic mice, which could serve as a

109 Whole-cell recording of GABA neurons in nigral slices confirmed that NOP recepto

110 altered in the majority of prefrontal cortex GABA neurons in schizophrenic subjects but is reduced be

111 MOR agonists could modulate the activity of GABA neurons in the Acb via receptors located mainly at

112 odulators reduces the activity of inhibitory GABA neurons in the ARC by multiple presynaptic and post

113 ncy within the TIDA population, the dopamine/GABA neurons in the arcuate nucleus represent a subpopul

114 These observations demonstrate that Sst-GABA neurons in the brainstem are crucial for regulating

115 The activity of the Sst-GABA neurons in the DMV is inhibited by both melanocorti

116 ggest that swim stress engages CRF inputs to GABA neurons in the dorsolateral DR that function to inh

117 We provide the first characterization of GABA neurons in the DRN that monosynaptically inhibit 5-

118 that hcrt fibers projected to both 5-HT and GABA neurons in the DRN.

119 hippocampus of mice in which BFCNs and some GABA neurons in the medial septum had been destroyed by

120 enic mice, we demonstrate that glutamate and GABA neurons in the MnPO/OVLT reciprocally regulate wate

121 of the granule cell layer preceding that of GABA neurons in the molecular layer.

122 Immunolabeling indicates that GABA neurons in the rostromedial tegmental nucleus (RMTg

123 h-affinity sites may be on axon terminals of GABA neurons in the SN.

124 Thus, a network of electrically coupled GABA neurons in the ventral brain may form the elusive n

125 resulted from ethanol-induced excitation of GABA neurons in the ventral tegmental area.

126 We show here that GABA neurons in the VTA, midbrain, hypothalamus, and tha

127 tion did not affect the activity of presumed GABA neurons in the VTA.

128 w that inhibition of the terminals of the LH GABA neurons in ventral-tegmental area (VTA) facilitates

129 ch was taken to trace the projections of ARN GABA neurons in vivo.

130 chemogenetic activation of LHA (Gal) or LHA (GABA) neurons in mice to compare their role in feeding b

131 Gamma-aminobutyric acid (GABA) neurons in the ventral tegmental area (VTA) provid

132 a subpopulation of gamma-aminobutyric acid (GABA) neurons in the VTA increases in anticipation of BS

133 Parvalbumin (PV)-containing cortical GABA neurons include chandelier cells (PVChCs) and baske

134 y reduced the firing rate and hyperpolarized GABA neurons including neuroendocrine GABA neurons ident

135 al that can act in the brain, also inhibited GABA neurons, including identified neuroendocrine cells,

136 pulations of DA and gamma-aminobutyric acid (GABA) neurons, including those projecting to the prefron

137 eeking behavior, but only activation of LHA (GABA) neurons increased overall chow consumption.

138 pulse ratio of the monosynaptic EPSCs in SNr GABA neurons, indicating a presynaptic 5-HT1B receptor-m

139 Activation of LHA (GABA) neurons induced compulsive-like locomotor behavior

140 tory synaptic activity was detected in hilar GABA neurons ipsilateral to the injury after glutamate p

141 est that excitatory drive to surviving hilar GABA neurons is enhanced by convergent input from both p

142 tion in females showed that leptin action on GABA neurons is not necessary for estradiol-mediated sup

143 tered inhibition from parvalbumin-containing GABA neurons is thought to contribute to impaired gamma

144 The molecular identity of LHA (GABA) neurons is heterogeneous and largely undefined.

145 certain classes of gamma-aminobutyric acid (GABA) neurons is very complex.

146 Here, we show that tVTA GABA neurons lose their capacity to disinhibit, but not

147 These findings suggest that VTA GABA neurons may be involved in the attentive processes

148 alance between D1 and D2 receptors can alter GABA neuron migration from the basal forebrain to the ce

149 romotes and D2 receptor activation decreases GABA neuron migration from the medial and caudal ganglio

150 r dopamine receptor activation can influence GABA neuron migration is not known.

151 corroborating the in vivo data on tangential GABA neuron migration.

152 orable environment for dopamine to influence GABA neuron migration.

153 e effects of dopamine receptor activation on GABA neuron migration.

154 se 67)-synthesizing cells, we identified ARC GABA neurons (n > 300) and used whole-cell recording to

155 m the inhibition of the activity of NPY/AgRP/GABA neurons (NAG) in the arcuate nucleus of the hypotha

156 Analysis of GABA neuron numbers in the cerebral wall of the dopamine

157 argets that included a preferential input to GABA neurons of both mesoaccumbens and mesoprefrontal po

158 GABA neurons of epithalamus are derived from the embryon

159 ases recovered GABA(B)R-GIRK currents in VTA GABA neurons of METH-injected mice.

160 GABA neurons of the cerebral cortex and other telencepha

161 In contrast to the local axons of GABA neurons of the cortex and hippocampus, lateral hypo

162 We report that leptin targets DA and GABA neurons of the VTA, inducing phosphorylation of sig

163 GABA neurons of ventral thalamus (reticular nucleus, ven

164 A selective loss of VTA GABA neurons on Day 14 was demonstrated through reduced

165 ract the pronounced inhibitory effect of Sst-GABA neurons on vagal pre-motor neurons in the DMV that

166 GABA+ neurons, on the other hand, may have evolved patte

167 other sub-populations of prefrontal cortical GABA neurons or abnormalities in the parvalbumin-contain

168 e zona incerta (ZI) gamma-aminobutyric acid (GABA) neurons or their axonal projections to paraventric

169 We used mossy fiber bouton to GABA neuron paired recordings in the CA3 to demonstrate

170 ession of the 5-HT3R is selective within the GABA neuron population in the rat telencephalon.

171 survive transplantation, there were abundant GABA neurons present in the graft.

172 rphin-saporin (DS) to selectively lesion VTA GABA neurons prior to assessing spontaneous motor activi

173 We found that VTA GABA neurons project widely to forebrain and brainstem t

174 ndelier subclass of gamma-aminobutyric acid (GABA) neurons provides potent inhibitory control over py

175 that this results from an action of SSRIs on GABA neurons rather than as a secondary consequence of m

176 ynaptic inputs from anterior neocortex while GABA neurons receive disproportionally higher input from

177 We found that VTA-DA (and VTA-GABA) neurons receive excitatory, inhibitory, and modula

178 consequences of selective activation of VTA GABA neurons remains unknown.

179 GABA neurons responded positively to both antagonists, b

180 ic inhibition of LH gamma-aminobutyric acid (GABA) neurons restricted to cue presentation disrupts th

181 lts show that optogenetic stimulation of Sst-GABA neurons results in a robust inhibition of action po

182 However, examination of the proportion of GABA neurons revealed an unexpected late peak at postnat

183 s a direct correlation between increased VTA GABA neuron slowing and increased delta wave power.

184 The GABA neuron-specific LEPR knock-out females and males sh

185 Esr1(lox/lox) line to generate animals with GABA-neuron-specific or glutamate-neuron-specific deleti

186 (B)R signaling removes an intrinsic brake on GABA neuron spiking, which may augment GABA transmission

187 essels have greater disturbances in cortical GABA neurons suggests that these cell-type distinct path

188 se onto neighboring gamma-aminobutyric acid (GABA) neurons than onto serotonin cells.

189 Given that rostral LS contains GABA neurons that are projection neurons or local intern

190 ifferent but overlapping populations of vHPC GABA neurons that express either PV or GAD65 by selectiv

191 ns in parvalbumin-positive fast-spiking (FS) GABA neurons that may cause abnormal gamma oscillations.

192 at in distinct regions of the telencephalon, GABA neurons that react to cannabinoids may also be resp

193 he input sector by activation of hippocampal GABA neurons that terminate exclusively on apical dendri

194 urons induced a direct inward current in SNr GABA neurons that was sensitive to D(1)-like blockade.

195 We identified a subpopulation of LHA (GABA) neurons that coexpress the neuropeptide galanin (L

196 roduce LHA (Gal) neurons as a subset of LHA (GABA) neurons that lack direct innervation of the ventra

197 eurons may represent a subpopulation of LHA (GABA) neurons that mediates food reward independent of d

198 he threshold for electrical coupling between GABA neurons, the degree of responding for IC self-stimu

199 lthough thought to contain only dopamine and GABA neurons, the VTA also includes a recently discovere

200 MDD, particularly affecting SST/NPY-related GABA neurons, thus linking the neurotrophic and GABA hyp

201 ivation of P2X receptors excited presynaptic GABA neurons to increase GABA release, which was excitat

202 ally released dopamine tonically excites SNr GABA neurons via D(1)-D(5) receptor coactivation that en

203 During exercise, muscle afferents excite NTS GABA neurons via substance P and microinjection of a sub

204 dose- and time-related selective loss of VTA GABA neurons was accomplished using this novel neurotoxi

205 postnatal day 60 and the final proportion of GABA neurons was higher in auditory cortex.

206 Excitation of GABA neurons was mediated by GABAA receptor activation a

207 GABAergic inputs from the NAc and local VTA GABA neurons were differentially modulated and activated

208 r of undermethylated CpG sites in GLU versus GABA neurons were identified.

209 f the axon terminals of other populations of GABA neurons were not altered in the schizophrenic subje

210 Retrogradely labeled GABA neurons were not numerous, and most non-tyrosine hy

211 Immunocytochemically labelled nonpyramidal GABA neurons were present from postnatal day 1 throughou

212 In freely behaving rats, VTA GABA neurons were relatively fast firing (29 +/- 6 Hz du

213 GAD+ and GABA+ neurons were most prominently distributed in Rt.

214 was found largely on nondopaminergic (i.e., GABA) neurons, whereas NOP mRNA was located on DA neuron

215 the axon terminals of parvalbumin-containing GABA neurons, which are known to have low levels of GAD6

216 tide and marker of gamma-amino butyric acid (GABA) neurons, which specifically inhibit pyramidal neur

217 At the cellular level, the density of GABA neurons with detectable levels of GAD67 mRNA is ~30

218 suggests heterogeneity of both serotonin and GABA neurons with respect to the inputs they receive.

219 N15 suggest that some of the early-appearing GABA neurons within the developing molecular layer of th

220 aring population of gamma-aminobutyric acid (GABA) neurons within the developing molecular layer.

221 The absolute numbers of CR+, PV+, CB+, and GABA+ neurones within individual layers in a column of c

222 (Gal) neurons define a subpopulation of LHA (GABA) neurons without direct VTA innervation that mediat