ライフサイエンスコーパス: GABA transporter

1 n AgRP neuron-specific deletion of vesicular GABA transporter.

2 s efflux is mediated through reversal of the GABA transporter.

3 ependent synaptic release or reversal of the GABA transporter.

4 ins, such as synaptophysin and the vesicular GABA transporter.

5 ociated protein, and SLC6A11, a postsynaptic GABA transporter.

6 n AgRP neuron-specific deletion of vesicular GABA transporter.

7 released through the reversal of astroglial GABA transporters.

8 prolonged or totally unaffected by block of GABA transporters.

9 hway is independent of potassium channels or GABA transporters.

10 responsible for this current is regulated by GABA transporters.

11 is a noncompetitive inhibitor of the betaine/GABA transporter 1 (BGT1).

12 AAV-DN1 impairs GABA(A)R alpha2 subunit and GABA transporter 1 (GAT-1) clustering, but increases GAB

13 In addition, puncta of GABA transporter 1 (GAT-1) were localized to GABAergic s

14 of the perisynaptic plasma membrane such as GABA transporter 1 (GAT1), were not present.

15 m using tiagabine, which blocks the synaptic GABA transporter 1, and so increases endogenous GABA lev

16 ic acid decarboxylase-65 (GAD65), GAD67, and GABA transporter 1.

17 ng enzyme glutamic acid decarboxylase (GAD); GABA transporter 1; the anchoring protein for GABA and g

18 ng enzyme glutamic acid decarboxylase (GAD); GABA transporter 1; the anchoring protein for GABA and g

19 Postnatal expression of the plasmalemmal GABA transporter-1 (GAT-1), GAT-3, and the vesicular GAB

20 evidence, to a dysfunction of the astrocytic GABA transporter-1 (GAT-1).

21 number, location, and lengths of inhibitory GABA transporter-1 immunoreactive axo-axonic structures

22 ER export motifs (in concatemers of SERT and GABA transporter-1) supported recruitment of both SEC24C

23 nner by NO-711, a selective inhibitor of the GABA transporter-1.

24 ter-1a, the betaine/GABA transporter and the GABA transporter-4.

25 biosynthetic enzyme for GABA, the vesicular GABA transporter, a transcription factor that determines

26 tonic currents in the vlPAG are dependent on GABA transporter activity and are modulated by agonists

27 GAT-1 is a sodium- and chloride-coupled GABA transporter and a member of the neurotransmitter:so

28 mately 40%, whereas the density of vesicular GABA transporter and bassoon coimmunoreactive axon termi

29 s of the glycine transporter-1a, the betaine/GABA transporter and the GABA transporter-4.

30 opulations of cells were immunoreactive to a GABA transporter and, thus, likely GABAergic.

31 ppocampal cultures that endogenously express GABA transporters and on mammalian cells stably expressi

32 led coexpression of SNAP-25, VGAT (vesicular GABA transporter), and GAD65/67 (glutamic acid decarboxy

33 3) Glutamate decarboxylase 67, vesicular GABA transporter, and parvalbumin, but not calbindin, ar

34 extracellular calcium and was blocked by the GABA transporter antagonist SKF-89976a (5 microm).

35 elivery of saporin-conjugated anti-vesicular GABA transporter antibodies (SAVAs) in vitro as well as

36 indicate that highly homologous subtypes of GABA transporters are sorted differently when expressed

37 - and Cl--dependent gamma-aminobutyric acid (GABA) transporters are known to exist in the rat and mou

38 Our data establish a role for GABA transporters as regulators of neuronal excitability

39 GABA transporter blockade also caused desensitization by

40 icular monoamine transporter 2 and vesicular GABA transporter, but they lacked immunostaining for any

41 hat transcriptional control of the vesicular GABA transporter by NO regulates GABA transmission and a

42 hat valproate increases the turnover rate of GABA transporters by an allosteric mechanism.

43 y enhance the activity of neuronal and glial GABA transporters by up to 10%.

44 The GABA transporter can reverse with depolarization, causin

45 monoamine transporter 2) and VGAT (vesicular GABA transporter), consistent with vesicular storage of

46 GABA transporters control extracellular GABA levels by c

47 GABA transporters control extracellular GABA, which regu

48 vironment in which their uniquely positioned GABA transporters control the degree of GABA(A)R activat

49 SNAP5114 alone reduced by half the GABA transporter current in NEC, whilst it abolished it

50 In patch-clamped astrocytes, the GABA transporter current was abolished by combined appli

51 Here, the GABA transporter current was directly investigated in th

52 s reduced by the activity of GAT-1 and GAT-3 GABA transporters, demonstrating that alterations of GAB

53 ditionally, blockade of both GAT-1 and GAT-3 GABA transporters did not unmask this tonic current.

54 ansport systems and imply that monoamine and GABA transporters evolved by selection and conservation

55 amate acid decarboxylase (GAD) and vesicular GABA transporter expression, these findings put intracor

56 dysplastic cortex and striking reductions in GABA transporter expression.

57 coupling of ion and substrate fluxes in the GABA transporter family.

58 Members of the gamma-aminobutyric acid (GABA) transporter family are polytopic membrane proteins

59 These data suggest that the GABA transporter fine-tunes its function in response to

60 cloning and functional characterization of a GABA transporter from C. elegans (ceGAT-1) and on the fu

61 Recent evidence suggests that GABA transporter function can be regulated, although the

62 kinase C (PKC), shown previously to modulate GABA transporter function, exerts its modulatory effects

63 The GABAA receptor, GABA transporter, GABA transaminase, parvalbumin, and re

64 Aergic interneurons, and GABA(A)-, vesicular GABA transporter-, GAD65-, and GAT3-immunoreactive struc

65 the glutamate transporter EAAC-1 (25%), and GABA transporter GAT-1 ( approximately 10%).

66 significant decrease in the primary neuronal GABA transporter GAT-1 and in both subunits of the GABA(

67 The GABA transporter GAT-1 belongs to the neurotransmitter:s

68 Tonic current induced by application of the GABA transporter GAT-1 blocker NO711 (1-[2([(diphenylmet

69 ion is due to compromised GABA uptake by the GABA transporter GAT-1 in the genetic models tested, and

70 The sodium- and chloride-coupled GABA transporter GAT-1 is a member of the neurotransmitt

71 It was previously shown that the rat GABA transporter GAT-1 is located in the presynaptic mem

72 The GABA transporter GAT-1 mediates electrogenic transport o

73 a" residue in transmembrane domain 10 of the GABA transporter GAT-1 provides extra bulk, probably in

74 labeled by cholecystokinin and the neuronal GABA transporter GAT-1, which project axo-somatic and ax

75 tores of calcium or by blocking the neuronal GABA transporter GAT-1.

76 in HEK 293 cells stably transfected with the GABA transporter GAT-1.

77 The gamma-aminobutyric acid (GABA) transporter GAT-1 is a prototype of neurotransmitt

78 is demonstrated for GAT1, the most important GABA transporter (GAT) subtype.

79 Immunohistochemical staining for GABA transporters (GAT-1 and GAT-3) revealed a low level

80 ) and GAD(67) isoforms), the plasma membrane GABA transporters (GAT-1 and GAT-3), and the vesicular G

81 f two high affinity gamma-aminobutyric acid (GABA) transporters (GAT-1 and GAT-3) in the rat hippocam

82 d decarboxylase (GAD-65 and GAD-67), and the GABA transporter, GAT-1.

83 enhanced extracellular GABA reuptake via the GABA transporter, GAT-1.

84 viously unrecognized role for the astrocytic GABA transporter, GAT-3.

85 this report, we have localized the other two GABA transporters, GAT-2 and GAT-3, in transfected MDCK

86 The rat brain GABA transporter GAT1 and other members of this family a

87 cient removal of synaptic transmitter by the GABA transporter GAT1 depends on the previous binding of

88 d this hypothesis by examining the rat brain GABA transporter GAT1 endogenously expressed in hippocam

89 ts, the N-terminal cytoplasmic domain of the GABA transporter GAT1 regulated substrate transport rate

90 We show that the trafficking of the GABA transporter GAT1 resembles the trafficking of neuro

91 cells stably expressing the cloned rat brain GABA transporter GAT1.

92 tion systems expressing the cloned rat brain GABA transporter GAT1.

93 iated currents, and charge movements for the GABA transporter GAT1.

94 meation of substrates during function of the GABA transporter GAT1.

95 on of the rat brain gamma-aminobutyric acid (GABA) transporter GAT1 expressed endogenously in hippoca

96 in is the rat brain gamma-aminobutyric acid (GABA) transporter GAT1.

97 that intracellular domains of the rat brain GABA transporter (GAT1) contribute to the transport proc

98 f this process for both wild-type and mutant GABA transporters (GAT1) expressed in Xenopus oocytes us

99 The GABA transporters (GAT1, GAT2, GAT3, and BGT1) have most

100 gene and transfected with the cDNA for a rat GABA transporter, GAT1, cloned downstream of a T7 RNA po

101 s differentially regulated by two astrocytic GABA transporters, GAT1 and GAT3, which are localized ne

102 es is released through an astrocyte-specific GABA transporter GAT3/4, and significantly enhances toni

103 In the adult cerebral cortex, GABA transporters (GATs) are expressed by both neurons a

104 vestigated the role of neuronal and/or glial GABA transporters (GATs) in modulating these inhibitory

105 dge on how e[GABA] is regulated by different GABA transporters (GATs) in vivo is limited.

106 Astrocytic uptake of GABA through GABA transporters (GATs) is an important mechanism regul

107 GABA transporters (GATs) play a critical role in the tra

108 The GABA transporters (GATs) regulate the concentration of G

109 es a protein of high similarity to mammalian GABA transporters (GATs).

110 plasmic, the existence of an islet vesicular GABA transporter has been postulated.

111 ns through conditional deletion of vesicular GABA transporter has no effect on spontaneous IPSCs reco

112 inhibitory synapses, identified by vesicular GABA transporter immunoreactive puncta.

113 indicated by the colocalization of vesicular GABA transporter immunoreactivity predominantly in extra

114 xin 1A inhibits GABA uptake of an endogenous GABA transporter in neuronal cultures from rat hippocamp

115 Inhibition of mGAT1, the most abundant GABA transporter in the brain, enhances GABA signaling a

116 its, glutamic acid decarboxylase (GAD) and a GABA transporter in the brains of female rhesus macaques

117 Here we report the immunolocalization of a GABA transporter in the tobacco hornworm, Manduca sexta

118 ent of glutamate receptors, calcium, and the GABA transporter in this GABA uptake and release.

119 nsport blocker NO-711 to examine the role of GABA transporters in shaping synaptic responses mediated

120 hrough neuronal and glial uptake mechanisms, GABA transporters in the pia-arachnoid may help to regul

121 en calcium-permeable glutamate receptors and GABA transporters in these cells.

122 , the most abundant gamma-aminobutyric acid (GABA) transporter in the central nervous system, reveale

123 is one of the major gamma-aminobutyric acid (GABA) transporters in the brain and is responsible for r

124 ase) 65 and 67 isoforms, and VGAT (vesicular GABA transporter) in interneurons from the stratum radia

125 r glutamate transporter 3 with the vesicular GABA transporter, indicating that GABA, glycine and glut

126 emmal and vesicular gamma-aminobutyric acid (GABA) transporters influence neurotransmission by regula

127 ) receptors, and were prolonged by the GAT-1 GABA transporter inhibitor NO711 (10 microm).

128 extracellular GABA levels, thus tiagabine, a GABA transporter inhibitor, was evaluated as a control t

129 mmalian GABA transporters, we found that the GABA transporter is localized to subsets of centrally de

130 The highly homologous GABA transporter isoforms, GAT-2 and GAT-3, localize to

131 Our results show that GABA transporters limit the extent of inhibitory transmi

132 Instead, these cells express the membrane GABA transporters mGAT1 (Slc6a1) and mGAT4 (Slc6a11) and

133 ese results raise the possibility that other GABA transporters might rely analogously upon conserved

134 t of valproate on a gamma-aminobutyric acid (GABA) transporter (mouse GAT3) expressed in Xenopus laev

135 The distribution of gamma-aminobutyric acid (GABA) transporter mRNAs (mGATs) was studied in mouse bra

136 Thus, the GABA transporter normally operates near its equilibrium

137 ve feedback through the interplay of Glu and GABA transporters of adjacent astroglia can result in sh

138 Selective inhibition of GAT-1 GABA transporters on amacrine cells increases this tonic

139 gamma-Aminobutyric acid (GABA) transporters on neurons and glia at or near the sy

140 cell type-specific deletion of the vesicular GABA transporter or by expression of botulinum toxin in

141 Plasma membrane GABA transporters participate in neural signaling throug

142 y elevated GABA synthetic enzymes, vesicular GABA transporter, perineuronal nets, and enhanced GABA t

143 blocking action potentials or the vesicular GABA transporter, phasic and tonic currents decreased in

144 GABA transporters play an important but poorly understoo

145 presynaptic endings; GAD-positive, vesicular GABA transporter-positive inhibitory endings are unaffec

146 , correlating with increased VGAT (vesicular GABA transporter) puncta.

147 dentified a selective reduction of vesicular GABA transporter punctae on parvalbumin positive neurons

148 We also identified a reduction of vesicular GABA transporter punctae specifically on parvalbumin pos

149 closely spaced presynaptic densities without GABA transporters, raising the possibility that neurotra

150 The vesicular GABA transporter recruits UNC-46 to synaptic vesicle pre

151 GABA synthetic enzyme Gad2 and the vesicular GABA transporter (Slc32a1).

152 e show here that snf-11 encodes a functional GABA transporter; SNF-11-mediated GABA transport is Na+

153 Current produced by a gamma-aminobutyrate (GABA) transporter stably transfected into a mammalian ce

154 m:symporters, GAT-1 and other members of the GABA transporter subfamily all contain an extra amino ac

155 fflux from neighboring cells via reversal of GABA transporters, subsequently leading to the stimulati

156 Combined application of NO-711 (a selective GABA transporter subtype 1 (GAT-1) antagonist) and SNAP-

157 GABA transporter subtype 1 (GAT1) knock-out (KO) mice di

158 GABA transporter subtype 1 (GAT1) molecules were counted

159 trocyte-like cells express the high-affinity GABA transporter subtype GAT4 on processes ensheathing n

160 and characterized pharmacologically on mouse GABA transporter subtypes mGAT1-4.

161 olabeled substrates and is applicable to all GABA transporter subtypes.

162 e possibility that the glial cells express a GABA transporter that could regulate GABA levels to whic

163 ther ion-coupled transporters, including the GABA transporter, the dopamine transporter, and the Na+/

164 sorting factor that localizes the vesicular GABA transporter to synaptic vesicles.

165 pinephrine (NE) and gamma-aminobutyric acid (GABA) transporters to METH administration(s) were determ

166 e additional support for the hypothesis that GABA transporters traffic in parallel with neurotransmit

167 at modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-ves

168 nantly presynaptically located, is the major GABA transporter under baseline, quiescent conditions.

169 ion with antibodies to MCH and the vesicular GABA transporter (vGABAT).

170 nd that CLC-3 colocalized with the vesicular GABA transporter VGAT in the CA1 region of the hippocamp

171 l cortex (mPFC), expression of the vesicular GABA transporter VGAT was unchanged; however, there was

172 transporter, VIAAT (also known as vesicular GABA transporter VGAT) transports GABA or glycine into s

173 urons, marked by expression of the vesicular GABA transporter VGAT, drastically suppresses drinking,

174 manner that is independent of the vesicular GABA transporter VGAT.

175 ubjects were immunolabeled for the vesicular GABA transporter (vGAT) and GAD67.

176 identified by the presence of the vesicular GABA transporter (VGAT) and NPY was found in 13-15% of V

177 We used the vesicular GABA transporter (VGAT) as a marker for inhibitory presy

178 Disruption of a putative vesicular GABA transporter (vGAT) homologue DdvGAT reduces secrete

179 co-staining for synaptophysin and vesicular GABA transporter (VGAT) revealed a group of small-sized

180 f a unique amino acid motif in the vesicular GABA transporter (VGAT) that controls its synaptic local

181 porters (GAT-1 and GAT-3), and the vesicular GABA transporter (VGAT) was evaluated by using immunohis

182 The expression level of vesicular GABA transporter (VGAT) was upregulated, and no change i

183 Comparison of this vesicular GABA transporter (VGAT) with a vesicular transporter for

184 ing elevates the expression of the vesicular GABA transporter (VGAT) within recurrent collaterals of

185 campal interneurons, expression of vesicular GABA transporter (vGAT), and extracellular GABA release

186 receptor (NR) subunits, GAD65, the vesicular GABA transporter (VGAT), and the neuronal glutamate tran

187 as glutamic acid decarboxylase and vesicular GABA transporter (VGAT), markers of GABAergic neurons.

188 d optogenetic activation of septal vesicular GABA transporter (vGAT)-containing neurons or their proj

189 1 and 2 (VGLUT-1, VGLUT-2), or the vesicular GABA transporter (VGAT).

190 ng into synaptic vesicles (SVs) by vesicular GABA transporter (VGAT).

191 y labeled varicosities followed by vesicular GABA transporter (VGAT).

192 n labeling for both VGLUT3 and the vesicular GABA transporter (VGAT).

193 ivity (IR) (approximately 27%) and vesicular GABA transporter (VGAT)/p38 IR (approximately 41%) was f

194 e transporter 2 (VMAT2)] and GABA [vesicular GABA transporter (VGAT)].

195 ChC cartridges immunoreactive for vesicular GABA transporter (vGAT+), which is present in all cartri

196 Selective siRNA knockdown of the vesicular GABA transporter (vgat, SLC32A1) in histaminergic neuron

197 neurons in the LH that express the vesicular GABA transporter (VGAT; a marker for GABA-releasing neur

198 crease in vesicular gamma-aminobutyric acid (GABA) transporter (vGAT) and glutamic acid decarboxylase

199 ctive for vesicular gamma-aminobutyric acid (GABA) transporter (VGAT) in patch and matrix throughout

200 tion of a vesicular gamma-aminobutyric acid (GABA) transporter (VGAT) to horizontal cell processes in

201 (VGLUT1), vesicular gamma-aminobutyric acid (GABA) transporter (VGAT), and vesicular acetylcholine tr

202 The vesicular gamma-aminobutyric acid (GABA) transporter (VGAT), which transports the inhibitor

203 lation of vesicular gamma-aminobutyric acid (GABA) transporter (VGAT)-expressing BNST neurons using h

204 onsible for packaging either GABA (vesicular GABA transporter [vGAT]) or glutamate (vesicular glutama

205 tamic acid decarboxylase; GAD, and vesicular GABA transporter; VGaT).

206 VGLUT3 is found together with the vesicular GABA transporter (VIAAT) on synaptic vesicle membranes i

207 th high sequence homology to known mammalian GABA transporters, we found that the GABA transporter is

208 In addition, inhibition of the GAT-1 GABA transporter, which strongly regulates GABA(C) recep

209 ainst a characterized high-affinity M. sexta GABA transporter with high sequence homology to known ma