ライフサイエンスコーパス: GABA(B) receptor agonist

1 thing medium or mimicked by adding baclofen (GABA(B) receptor agonist; 100 microM) to normally-record

2 Baclofen, a GABAB receptor agonist, activated G-protein gated inward

3 ]CGP54626 was inhibited by several mammalian GABA(B) receptor agonists and antagonists.

4 To explore this possibility a number of GABAB receptor agonists and antagonists were examined fo

5 quantify the relative binding affinities of GABA(B) receptor agonists, antagonists and the effect of

6 Effects of spinal administration of the GABA(B) receptor agonist baclofen (0.1-10 microg/50 micr

7 The GABA(B) receptor agonist baclofen (20 mum) enhanced GABA

8 u-opioid receptor agonist DAMGO (93%) or the GABA(B) receptor agonist baclofen (83%) with a membrane

9 arizing response of GABAergic neurons to the GABA(B) receptor agonist baclofen 24 hr after treatment.

10 In C57BL/6 mice, pretreatment with GABA(B) receptor agonist baclofen blocked the rewarding

11 ent with a subthreshold concentration of the GABA(B) receptor agonist baclofen blocks ethanol but not

12 The GABA(B) receptor agonist baclofen decreased the rate of

13 The GABA(B) receptor agonist baclofen facilitates the extinc

14 L-type Ca(2+) channel current induced by the GABA(B) receptor agonist baclofen or by guanosine 5'-3-O

15 of VDCCs nor their inhibition by either the GABA(B) receptor agonist baclofen or intracellular guano

16 With G-protein inhibition induced by the GABA(B) receptor agonist baclofen or the adenosine A1 re

17 -estradiol (E(2)) reduced the potency of the GABA(B) receptor agonist baclofen to activate G protein-

18 crease in intracellular calcium, whereas the GABA(B) receptor agonist baclofen was ineffective, sugge

19 values and a GIRK-dependent response to the GABA(B) receptor agonist baclofen, but not DAMGO.

20 mitter release from POMC neurons, as did the GABA(B) receptor agonist baclofen.

21 In contrast, the GABAB receptor agonist baclofen (1-100 microM) exerted a

22 GABA and the GABAB receptor agonist baclofen activated a potassium co

23 The GABAB receptor agonist baclofen also inhibited inward cu

24 Simultaneous injection of the GABAB receptor agonist baclofen at doses of 2.5, 5.0 and

25 ong-term ( approximately 5 years) use of the GABAb receptor agonist baclofen by SCI patients reduced

26 used by a lack of GIRK activity, because the GABAB receptor agonist baclofen continued to elicit thes

27 ne methiodide had little effect, whereas the GABAB receptor agonist baclofen dramatically attenuated

28 f the GABAA receptor agonist muscimol or the GABAB receptor agonist baclofen elicited intense, dose-r

29 The orthosteric GABAB receptor agonist baclofen has been shown to suppre

30 E2 reduced rapidly the potency of the GABAB receptor agonist baclofen to activate G-protein-co

31 ve activation, are minimally affected by the GABAB receptor agonist baclofen, and express NMDA recept

32 ted the effects of estrogen on DAMGO- or the GABAB receptor agonist baclofen-stimulated [35S]GTPgamma

33 sitivity of SOM-IPSCs, but not PV-IPSCs to a GABAb receptor agonist baclofen.

34 eed, the calcium influx was inhibited by the GABAB receptor agonist baclofen.

35 ulation of astrocytes, or application of the GABAB-receptor agonist baclofen, potentiated miniature i

36 a 5-HT2C receptor antagonist (SB242084) or a GABAB receptor agonist (baclofen), but not a GABAA recep

37 s were reversibly inhibited by the selective GABA(B) receptor agonists (+/-)-baclofen or CGP 27492 (1

38 The GABA(B) receptor agonist (-)-baclofen (5-10 microM) depr

39 Systemic administration of the GABA(B) receptor agonist, baclofen (10 mg/kg, i.p.), sig

40 In young animals, the GABA(B) receptor agonist, baclofen, inhibited the amplit

41 Baclofen is a GABAB receptor agonist commonly used to relief spasticit

42 lcium Green-1 dextran revealed that 5HT1 and GABA(B) receptor agonists decreased presynaptic calcium

43 Whereas GABAB receptor agonists exert a significant effect on ci

44 The application of GABAB receptor agonists failed to affect the membrane pr

45 Application of baclofen, a specific GABA(B) receptor agonist, inhibited significantly neuron

46 ect of LH reversible inactivation by GABAA + GABAB receptor agonists (muscimol + baclofen) on this ef

47 versible inactivation of CeA or BLA by GABAA+GABAB receptor agonists (muscimol+baclofen, 0.03+0.3 nmo

48 e protective effect of baclofen, a selective GABA(B) receptor agonist, on the induced Fos protein inc

49 The selective GABAB receptor agonist R-baclofen previously reversed so

50 The GABAB receptor agonist (R)-baclofen (10 microM) reduced

51 GABA(B) receptor agonists reduce receptor phosphorylatio

52 GABA(A) and GABA(B) receptor agonists stimulate feeding following mi

53 e prevention, we examined whether baclofen-a GABAB receptor agonist that reduces mesolimbic dopamine

54 Inhibition of calcium currents by GABAB receptor agonists was accompanied by an apparent c

55 rminals can be readily modulated, opioid and GABA(B) receptor agonists were applied.

56 of GHB was mimicked by baclofen, a selective GABAB receptor agonist, whereas the high affinity GHB re