ライフサイエンスコーパス: GABA-A receptor

1 , unperturbed, and disinhibited (antagonized GABA(A) receptors).

2 osteric site on the gamma-aminobutyric acid (GABA)(A) receptor).

3 DA receptor ion channel and (18)F-GE-194 for GABA-A receptor.

4 he alpha2 beta2 gamma2 subunits of the human GABA-A receptor.

5 tion of S383 within the beta3 subunit of the GABA(A) receptor.

6 -Fos induction in the PVH with disruption of GABA-A receptors.

7 artially mediated by insulin action, but not GABA-A receptors.

8 that MG is a competitive partial agonist at GABA-A receptors.

9 abnormal cerebrospinal fluid potentiation of GABA-A receptors.

10 acterized at native and selected recombinant GABA(A) receptors.

11 a postsynaptic crosstalk between GABA(B) and GABA(A) receptors.

12 ents indicated the presence of extrasynaptic GABA(A) receptors.

13 valent to the benzodiazepine binding site in GABA(A) receptors.

14 their identification, including that of the GABA(A) receptors.

15 The mutation had three major effects on GABA(A) receptors.

16 synapses and serves for the stabilization of GABA(A) receptors.

17 inhibitory glycine and different subtypes of GABA(A) receptors.

18 azepines with effects comparable to those at GABA(A) receptors.

19 cupancy response and the lateral dynamics of GABA(A) receptors.

20 at these manipulations affected NPCs through GABA(A) receptors.

21 nd efficacious potentiators of activation of GABA(A) receptors.

22 density, recombinant, His(8)-beta3 homomeric GABA(A) receptors.

23 onist muscimol in human alpha1beta2/3gamma2L GABA(A) receptors.

24 /-) mice, which have a loss of extrasynaptic GABA(A) receptors.

25 eferentially via high-affinity extrasynaptic GABA(A) receptors.

26 stasis and in neuronal responses mediated by GABA(A) receptors.

27 ponses resulted primarily from activation of GABA(A) receptors.

28 pha1 and beta3 subunits of human alpha1beta3 GABA(A) receptors.

29 ling, diffusion dynamics, and degradation of GABA(A) receptors.

30 ns synaptic inhibition via downregulation of GABA(A) receptors.

31 shed by preventing CaMKII phosphorylation of GABA(A) receptors.

32 urons to regulate plasticity associated with GABA(A) receptors.

33 reduction in surface levels of glutamate and GABA(A) receptors.

34 Thus, GABA(A) receptors activated at synapses were not modulat

35 augments the sympathoinhibitory responses to GABA(A) receptor activation in the PVN in SHRs.

36 ile generally inhibitory in the adult brain, GABA(A) receptor activation is excitatory under certain

37 To determine the effect of GABA(A) receptor activation on membrane potential, perfo

38 GABA(A) receptor activation promoted specific phosphoryl

39 intracellular milieu, we show that synaptic GABA(A) receptor activation triggers postsynaptic depola

40 The effects of gamma-aminobutyric acid (GABA) A receptor activation on physiologic responses dur

41 (2+) buffering, and its sign was inverted by GABA-A receptor activation.

42 Increased Tau phosphorylation by GABA(A) receptor activity was associated with reduced Ta

43 inistration of phenobarbital, an enhancer of GABA(A) receptor activity.

44 uced enhancement of gamma-aminobutyric acid (GABA)-A receptor activity was found in patients with IH

45 profound effects of the exogenously applied GABA(A) receptor agonist muscimol or glycine, either of

46 oxypyrazole (4-AHP) analogues of muscimol, a GABA(A) receptor agonist, has been synthesized and pharm

47 PVN inhibition by bilateral injection of the GABA-A receptor agonist muscimol (0.1 nmol in 50 nl).

48 vation or disinhibition, we microinfused the GABA-A receptor agonist muscimol (C4H6N2O2; 62.5, 125, 2

49 inactivation of BLA, by microinfusion of the GABA-A receptor agonist, muscimol.

50 hich is the equivalent residue in vertebrate GABA(A) receptor alpha-subunits, decreases ginkgolide po

51 ptor (muOR) in PV(b) cells, as well as lower GABA(A) receptor alpha1 subunit in pyramidal neurons pos

52 e defined as a PVBC bouton that overlapped a GABA(A) receptor alpha1 subunit punctum.

53 reas gephyrin, Na-K-2Cl cotransporter 1, and GABA(A) receptor alpha1 subunit, but not K-Cl cotranspor

54 tamic acid decarboxylase (GAD65), PV and the GABA(A) receptor alpha1 subunit.

55 te (pCMBS) with cysteines substituted in the GABA(A) receptor alpha1M1 and beta2M3 segments.

56 of neuroplastin-65 by shRNA causes a loss of GABA(A) receptor alpha2 subunits at GABAergic synapses.

57 tors in mice with a floxed gene encoding the GABA(A) receptor alpha2-subunit (i.e., Gabra2).

58 tion, neuroplastin-65 also co-localizes with GABA(A) receptor alpha5 subunits at extra-synaptic sites

59 intracellular chloride accumulation via the GABA(A) receptor and extracellular potassium accumulatio

60 e in newly synthesized cell surface synaptic GABA(A) receptors and is abolished by preventing CaMKII

61 rebrain binding sites with alpha4-containing GABA(A) receptors and postulate a role for extrasynaptic

62 and anesthetic agent that can both activate GABA(A) receptors and potentiate receptor activation eli

63 The expression of GABA(A) receptors and the efficacy of GABAergic neurotra

64 rapid modulation of cell surface numbers of GABA(A) receptors and tonic current, which are criticall

65 the brain tonically activates extrasynaptic GABA(A) receptors, and activity-dependent changes in amb

66 ent agonist at human alpha(1)beta(2)gamma(2) GABA(A) receptors, and in SAR studies substitutions in t

67 ve compounds were also tested on recombinant GABA(A) receptors, and point mutations around the presum

68 ization of synaptic gamma-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and

69 ts, which typically constitute extrasynaptic GABA-A receptors, and GABA-B R1 and R2 subunits.

70 cating that the REM sleep-inducing effect of GABA(A) receptor antagonism is dependent upon the local

71 method for study of small brain regions, the GABA(A) receptor antagonist bicuculline (50 muM) was inf

72 The GABA(A) receptor antagonist bicuculline methiodide (BMI)

73 ng synaptic activity, via treatment with the GABA(A) receptor antagonist bicuculline, rapidly and rob

74 n be mimicked by single microinfusion of the GABA(A) receptor antagonist picrotoxin into the normal a

75 PSC amplitude by a low affinity, competitive GABA(A) receptor antagonist was higher in GAD67-lacking

76 by unilateral intracerebral infusions of the GABA(A) receptor antagonist, bicuculline methiodide (BIC

77 holineacetic acid (SCH50911), and a specific GABA(A) receptor antagonist, bicuculline, were administe

78 ures similar to the convulsant picrotoxin, a GABA(A) receptor antagonist, so their lack of toxicity i

79 interictal bursts recorded in bicuculline, a GABA(A) receptor antagonist.

80 Ps, also detected at E16, were eliminated by GABA(A) receptor antagonist.

81 In line with this, we show that gabazine, a GABA-A receptor antagonist, is antihyperalgesic in prime

82 (2+) transients persist in the presence of a GABA-A receptor antagonist, though the directional tunin

83 Microinjection of GABA(A) receptor antagonists into PnO induces a long las

84 th these findings, it has been reported that GABA(A) receptor antagonists microdialyzed into PnO resu

85 or GABAergic neurotransmission with NMDA or GABA(A) receptor antagonists potently reduced the LC-ind

86 GABA(A) receptor antagonists selectively augmented SGC i

87 e responsible for the REM sleep induction by GABA(A) receptor antagonists through blocking GABA inhib

88 t still evident when IPSPs were prevented by GABA(A) receptor antagonists.

89 The effects of steroids on the GABA(A) receptor are typically determined by comparing s

90 he inhibitory tone of DGGCs when GABA(B) and GABA(A) receptors are both activated.

91 GABA(A) receptors are pentameric ligand-gated ion channe

92 High-affinity extrasynaptic GABA(A) receptors are persistently activated by the low

93 GABA(A) receptors are responsive to a wide variety of dr

94 Immobilized GABA(A) receptors are stabilized by binding to FRM-3/EPB

95 Here we show that immobile and diffusing GABA(A) receptors are stabilized by distinct synaptic sc

96 Diffusing GABA(A) receptors are stabilized by the synaptic adhesio

97 The GABA(A) receptors are the major inhibitory neurotransmit

98 gamma-Aminobutyric acid type A (GABA(A)) receptors are pentameric ligand-gated ion chann

99 plicate alpha2 and alpha3 subunit containing GABA(A) receptors as key mediators of the reward-related

100 ic isoform neuroplastin-65 co-localizes with GABA(A) receptors as shown in brain sections as well as

101 Antibodies directed against GABA(A) receptor-associated protein, and the glycine-alp

102 RAPs, in particular gamma-aminobutyric acid (GABA)-A-receptor-associated protein-like 2 (Gabarapl2; a

103 equently, this results in rapid insertion of GABA(A) receptors at the cell surface and enhanced tonic

104 urons potently inhibit AP Ca(2+) signals via GABA-A receptors at both spines and dendrites.

105 , 2, 4, and 8 glycines in this region of the GABA(A) receptor beta-subunit progressively decreases GA

106 A GABA(A) receptor beta3 subunit mutation, G32R, has been

107 In addition, the abnormalities in GABA(A) receptor binding in the insula and cerebellum ap

108 In addition, the GABA(A) receptor binding was increased in the bilateral

109 GABA(A) receptor blockade caused a decrease in the firin

110 by conductance analysis during nicotinic and GABA(A) receptor blockade.

111 illatory changes, we examined the effects of GABA-A receptor blockade, finding that picrotoxin (PTX)

112 With GABA-A receptors blocked, both iGluSnFR signals and exci

113 nd contrast them with effects of gabazine, a GABA(A) receptor blocker.

114 differences in SGC firing were abolished in GABA(A) receptor blockers.

115 c analysis suggests that LGC-35 evolved from GABA-A receptors, but the pore-forming domain contains n

116 Our results reveal that neuroplastin and GABA(A) receptors can be co-purified from rat brain and

117 Binding of the agonist GABA to the GABA(A) receptor causes channel gating, whereas competit

118 L-type channels and the rapid modulation of GABA(A) receptor cell surface numbers and tonic current,

119 NF-mTOR signaling is associated with reduced GABA(A) receptor clustering, suggesting functional impai

120 epine site on the gamma-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental

121 Native gamma-aminobutyric acid (GABA)A receptors consisting of alpha4, beta1-3, and delt

122 Whereas GABA(A) receptors containing alpha1, alpha2, or alpha3 s

123 ed-forward inhibition mediated by ionotropic GABA(A) receptors contributes to the temporal precision

124 Signaling through GABA(A) receptors controls neural progenitor cell (NPC)

125 edominantly express beta2-subunit-containing GABA(A) receptors; deletion of the beta2-subunit ablates

126 GABA currents and currents activated by the GABA(A) receptor delta subunit-selective agonist THIP (1

127 This effect was abolished in GABA(A) receptor delta(-/-) mice, which have a loss of e

128 BAergic activity at delta subunit-containing GABA(A) receptors (delta-GABA(A)Rs).

129 h inhibition of alpha2 expression, decreased GABA(A) receptor density, and inhibition of Toll-like re

130 GABA(A) receptor density, B(max), was estimated as 44 +/

131 uggesting a progressive decrease in thalamic GABA-A receptor density.

132 The STP(GABA) led to a minutes-long GABA(A)receptor-dependent increase in spike frequency in

133 nd mature N-methyl-d-aspartate, kainate, and GABA(A) receptors did not reach the synapse, whereas mat

134 Prolonged activation of GABA(A) receptors during epileptiform bursts may even in

135 tamate receptor and gamma-aminobutyric acid (GABA)-A receptor during progression of brain pathology i

136 Additionally, we find that GABA(A) receptor-evoked depolarizations are amplified by

137 ce of a Val at the 2' position in vertebrate GABA(A) receptors explains why these compounds are not s

138 absence of both MADD-4 and NRX-1, NLG-1 and GABA(A) receptors fail to cluster, and GABAergic synapti

139 rated light-sensitive versions of the entire GABA(A) receptor family.

140 natural sleep-wake cycle and, in the case of GABA(A) receptors, for propofol-induced loss of righting

141 GABA(A) receptors form Cl(-) permeable channels that med

142 ion dipicrylamine (DPA) negatively regulates GABA(A) receptor function by a mechanism indistinguishab

143 A levels are consistent with facilitation of GABA(A) receptor function by ethanol.

144 The modulation of GABA(A) receptor function by postsynaptic GABA(B) recept

145 allows scalable interrogation of endogenous GABA(A) receptor function with high spatial, temporal, a

146 of gamma-aminobutyric acid type A receptor (GABA(A)) receptor function.

147 Furthermore, disruption of GABA-A receptor function in the PVH also reduced postwea

148 Recently, functional GABA(A) receptor (GABA(A) R) rundown has been described

149 acological and genetic evidence reveals that GABA(A) receptor (GABA(A)-R) expression and localization

150 igand-gated inhibitory receptor systems, the GABA(A) receptor (GABA(A)R) and glycine receptor (GlyR)

151 site actions (enhancement or suppression) on GABA(A) receptor (GABA(A)R) inhibition in granule cells

152 d t-butylbicyclophosphorothionate (TBPS) are GABA(A) receptor (GABA(A)R) open channel blockers.

153 puts during epileptiform activity can switch GABA(A) receptor (GABA(A)R) signaling from inhibitory to

154 GABA(A) receptors (GABA(A)-Rs) are localized at both syn

155 , the DGC is involved in the organisation of GABA(A) receptors (GABA(A)Rs) and aquaporin-4 (AQP4)-con

156 Whereas both GABA(A) receptors (GABA(A)Rs) and glycine receptors (Gly

157 diates fast (phasic) inhibition via synaptic GABA(A) receptors (GABA(A)Rs) and long-lasting (tonic) i

158 anule cell axons through local activation of GABA(A) receptors (GABA(A)Rs) and the soma through elect

159 s highlighted by the fact that extrasynaptic GABA(A) receptors (GABA(A)Rs) are believed to be key tar

160 GABA(A) receptors (GABA(A)Rs) are major targets of acute

161 ion by stabilizing gamma2 subunit-containing GABA(A) receptors (GABA(A)Rs) at the cell surface, leadi

162 Here we report the photoregulation of GABA(A) receptors (GABA(A)Rs) by a derivative of propofo

163 GABA(A) receptors (GABA(A)Rs) composed of alphabetagamma

164 een postsynaptic NMDA receptors (NMDARs) and GABA(A) receptors (GABA(A)Rs) contributes to the excitat

165 ising through the activation of postsynaptic GABA(A) receptors (GABA(A)Rs) has been well described in

166 Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has emerged as a novel for

167 In the spinal cord dorsal horn, presynaptic GABA(A) receptors (GABA(A)Rs) in the terminals of nocice

168 Alterations of postsynaptic GABA(A) receptors (GABA(A)Rs) likely underlie the impact

169 Activation of GABA(A) receptors (GABA(A)Rs) produces two forms of inhi

170 heterozygous for the gamma2 subunit gene of GABA(A) receptors (GABA(A)Rs) show behavioral, cognitive

171 The subunit composition of recombinant GABA(A) receptors (GABA(A)Rs) strongly affects the deact

172 Microiontophoretic activation of GABA(A) receptors (GABA(A)Rs) with GABA or with the sele

173 lity and endocytosis of surface and synaptic GABA(A) receptors (GABA(A)Rs), but the surface receptor

174 predominantly via synaptic alpha1beta2gamma2 GABA(A) receptors (GABA(A)Rs).

175 e depolarization due to Cl(-) efflux through GABA(A) receptors (GABA(A)Rs).

176 terminant of gamma-aminobutyric acid type A (GABA(A)) receptor (GABA(A)R)-mediated inhibition and cyt

177 lso express altered gamma-aminobutyric acid (GABA)(A) receptor (GABA(A)R)-mediated inhibition.

178 GABA-A receptors (GABA-ARs) are typically expressed at s

179 ubunits, which typically constitute synaptic GABA-A receptors, GABA-A alpha4 and delta subunits, whic

180 ht that inhibitory neurotransmission through GABA-A receptors (GABAAR) modulates early TEPs (<50 ms a

181 alpha4betadelta GABA(A) receptors (GABARs) have low CNS expression, but

182 plasmalemmal localization of alpha4betadelta GABA(A) receptors (GABARs) occurs in the hippocampal pyr

183 Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABARs) sensing ambient levels of GAB

184 Expression of the pi subunit of the GABA(A) receptor (GABRP) is associated with the BLBC/TN

185 Interestingly, the size of GABA(A) receptor gamma2 subunit clusters that colocalize

186 ng with vesicular amino acid transporter and GABA(A)-receptor gamma2 subunit immunoreactivities.

187 We have found that the gamma2 subunit of the GABA(A) receptor (gamma2-GABA(A)R) specifically interact

188 taining Hodgkin-Huxley and AMPA receptor and GABA(A) receptor gated channels.

189 rons in the VTA via facilitation of synaptic GABA(A) receptors have induced neuroplasticity in dopami

190 ceptor docking in an alpha(1)beta(2)gamma(2) GABA(A) receptor homology model along with the obtained

191 ynaptic inhibition of histaminergic cells by GABA(A) receptors, however, was essential for habituatio

192 hat selective inactivation of GABAB, but not GABA(A), receptors impairs firing rate homeostasis by di

193 he binding to the benzodiazepine site on the GABA(A) receptors in 5 different brain regions was studi

194 ionate binding to the His(8)-beta3 homomeric GABA(A) receptors in a concentration-dependent manner (I

195 t for a clathrin-mediated internalization of GABA(A) receptors in expression of LTD(GABA).

196 nses in MSNs were primarily mediated through GABA(A) receptors in feedforward inhibition.

197 ole for extrasynaptic alpha4delta-containing GABA(A) receptors in GHB pharmacology and physiology.

198 from the zolpidem sensitivity, postsynaptic GABA(A) receptors in NG2 cells contain the gamma2-subuni

199 olecular techniques to analyze properties of GABA(A) receptors in NG2 cells of the juvenile mouse hip

200 mplicates a specific subtype and location of GABA(A) receptors in PnO of rat in the control of REM sl

201 s, these data suggest that the activation of GABA(A) receptors in the LS increases aggression regardl

202 strategies designed to target extrasynaptic GABA(A) receptors in the treatment of sleep disorders an

203 We found decreased binding of GABA(A) receptors in Tourette patients bilaterally in th

204 functional screening of various recombinant GABA(A) receptors in Xenopus laevis oocytes using the tw

205 steric modulator of gamma-aminobutyric acid (GABA)-A receptors in cerebrospinal fluid.

206 We monitored changes in NMDA receptor and GABA-A receptor in a clinically relevant model of trauma

207 ction of changes in active NMDA receptor and GABA-A receptor in the injured brain.

208 Three populations of GABA-A receptors in astrocytes were identified: classic

209 Unilateral blockade of GABA-A receptors in the ARCN increased the BLMAP and hea

210 In addition, disruption of GABA-A receptors in the PVH reduced feeding.

211 eptors enhance the function of extrasynaptic GABA(A) receptors, including delta subunit-containing re

212 Negative allosteric modulators of GABA-A receptors, including clarithromycin, have been re

213 tracellular applications of p4, a blocker of GABA(A) receptor internalization.

214 ble with a beta subunit to form a subtype of GABA(A) receptor involved in generating the "tonic" outw

215 y noncompetitively blocking the ligand-gated GABA(A) receptor ion channel, leading to altered express

216 The GABA(A) receptor is a multisubunit protein that transduc

217 fluence along the dendrite and the impact of GABA(A) receptors is dependent on activation of L-type c

218 Thus, regulated trafficking of GABA(A) receptors is essential for understanding brain f

219 on of extrasynaptic delta-subunit-containing GABA(A) receptors leads to glutamate receptor plasticity

220 IC is a valid model system to identify novel GABA(A) receptor ligands.

221 GABA(A) receptors located in the postsynaptic membrane m

222 We hypothesize that GABA(A) receptors located on cholinergic boutons in the

223 ow that global UBC expression of glycine and GABA(A) receptors matches the pharmacological profile of

224 GABA(A) receptors mediate fast inhibitory synaptic trans

225 Tonic inhibitory GABA(A) receptor-mediated currents are observed in numer

226 The synchronized GABA(A) receptor-mediated currents give rise to a major

227 While the reversal potential of GABA(A) receptor-mediated currents is identical in both

228 The GABA(A) receptor-mediated hyperpolarization activates I(

229 ehensive optogenetic toolkit for controlling GABA(A) receptor-mediated inhibition in the brain.

230 are crucial for maintaining the efficacy of GABA(A) receptor-mediated inhibition.

231 tin dose-dependently diminished basal-evoked GABA(A) receptor-mediated inhibitory postsynaptic potent

232 e to NGF, via activation of TrkA, attenuates GABA(A) receptor-mediated inhibitory synaptic currents a

233 edominantly, if not exclusively, spontaneous GABA(A) receptor-mediated input, the cellular sources or

234 GABA(A) receptor-mediated IPSCs evoked by electrical or

235 om layer V pyramidal cells, and monosynaptic GABA(A) receptor-mediated IPSCs were elicited.

236 fically expressed in DAergic SACs produced a GABA(A) receptor-mediated monosynaptic inhibitory respon

237 i)) that forms the basis for hyperpolarizing GABA(A) receptor-mediated responses.

238 We discovered that a NPY-GFP+ cell evoked a GABA(A) receptor-mediated slow inhibitory postsynaptic c

239 ct to the dlBnST, increased the frequency of GABA(A) receptor-mediated spontaneous inhibitory postsyn

240 eroidogenesis, which leads to an increase in GABA(A) receptor-mediated synaptic inhibition in lamina

241 rmacologically induced augmentation of local GABA(A)-receptor-mediated transmission is sufficient to

242 Tonic gamma-aminobutyric acid (GABA)A receptor-mediated signalling controls neuronal ne

243 rtex that express the alpha6delta-containing GABA(A) receptors mediating tonic inhibition.

244 GABA-A receptors mediating synaptic or extrasynaptic tra

245 we identified several structurally distinct GABA(A) receptor modulators as novel regulators of Tau p

246 ient GABA levels and predicted extrasynaptic GABA(A) receptor numbers when considering the ability of

247 conferred a high Zn(2)(+) sensitivity to the GABA(A) receptors of NG2 cells.

248 predominantly generated by GABA-independent GABA(A) receptor openings.

249 GABA(A) receptors play a crucial role in the actions of

250 cades, research has identified extrasynaptic GABA(A) receptor populations that enable neurons to sens

251 e that includes the gamma-aminobutyric acid (GABA)A receptor-positive allosteric modulators, eszopicl

252 recent modeling study of the beta3 homomeric GABA(A) receptor postulated a high-affinity propofol bin

253 roprotective pharmacophore acting in part by GABA(A) receptor potentiation.

254 Xenopus oocyte assay, we found an absence of GABA-A receptor potentiation with CSF from patients with

255 d ion channel (GLIC), a bacterial homolog of GABA(A) receptors, provided an opportunity to explore st

256 imal model the effect of chronic infusion of GABA(A) receptor (R) agonist and antagonist in the vesti

257 erologously expressed rat alpha1beta2gamma2L GABA(A) receptors, ranging from essentially inert to hig

258 ffect can be accounted for by changes to the GABA(A) receptor reversal potential and demonstrates an

259 acetylcholine receptors, glycine receptors, GABA(A) receptors, serotonin-3 (5-HT(3)) receptors, and

260 Blockade of GABA(A) receptors shortened the preictal phase, abolishe

261 d by mGluR1/5 antagonists or augmentation of GABA(A) receptor signaling, and identify allopregnanolon

262 N) and it could be prevented by facilitating GABA(A) receptor signalling in the PBN within a critical

263 We first show that GABA-A receptors strongly inhibit action potential (AP)-

264 oplastin-65 can co-localize with a subset of GABA(A) receptor subtypes and might contribute to anchor

265 nes bind nonselectively to several different GABA(A) receptor subtypes.

266 is plasticity, demonstrating its reliance on GABA(A) receptor subunit composition.

267 n which the "photoswitch-ready" version of a GABA(A) receptor subunit genomically replaces its wild-t

268 ic boutons were found to be colocalized with GABA(A) receptor subunit protein gamma2.

269 Here we investigate the input and GABA(A) receptor subunit specificity of inhibitory synap

270 Our results reveal a novel GABA(A) receptor subunit- and input-specific form of inh

271 we found that CRF1 neurons exhibit an alpha1 GABA(A) receptor subunit-mediated tonic conductance that

272 The postsynaptic gamma2-GABA(A)-receptor subunit and the presynaptic vesicular i

273 th proteomic analyses and identified several GABA(A) receptor subunits as possible candidates.

274 (3) mRNA encoding alpha1, beta2, and gamma2 GABA(A) receptor subunits increased by 15-30%; (4) the d

275 s and the complementary genetically modified GABA(A) receptor subunits.

276 ole of putative trafficking sequences in two GABA(A) receptor subunits: alpha4 and delta.

277 A levels of 7 of the most commonly expressed GABA-A receptor subunits, and both GABA-B receptor subun

278 These consisted primarily of glutamate and GABA-A receptor subunits.

279 PKA-AKAP-CaN complex is uniquely situated at GABA(A) receptor synapses in VTA DA neurons to regulate

280 nzodiazepine derivative acting through a non-GABA(A) receptor target.

281 are potent and efficacious modulators of the GABA(A) receptor that act by allosterically enhancing ch

282 low-affinity benzodiazepine-binding site in GABA(A) receptors that mediates inhibitory effects of th

283 vidence suggests that neurosteroids modulate GABA(A) receptors through binding interactions with tran

284 nes modulate gamma-aminobutyric acid type A (GABA(A)) receptors throughout the brain.

285 ght contribute to anchoring and/or confining GABA(A) receptors to particular synaptic or extra-synapt

286 binding pocket were introduced into GLIC and GABA(A) receptors to test for binding specificity.

287 Cortical interneurons activate GABA-A receptors to rapidly control electrical and bioch

288 R neurons recruit both GABA and GABA-A receptors to their axon terminals in the EB, and

289 Yet, blockade of the GABA(A) receptors transforms GDPs to epileptiform discha

290 tsynapses and is required for clustering the GABA(A) receptor UNC-49.

291 The GABA(A) receptor undergoes conformational changes upon t

292 vity for alpha(1)beta(2)gamma(2) over rho(1) GABA(A) receptors was observed for the 5-chloro, 5-bromo

293 interaction between postsynaptic GABA(B) and GABA(A) receptors, we recorded GABA(A) currents elicited

294 histaminergic neurons deficient in synaptic GABA(A) receptors were significantly more excitable and

295 gamma-Aminobutyric acid (GABA)A receptors were blocked by bicuculline.

296 Clusters of GABA-A receptors were distributed in the perinuclear spa

297 n alpha1 beta2 gamma2 or alpha2 beta2 gamma2 GABA-A receptors were recorded in response to 6 successi

298 We conclude that activation of GABA A receptors with alprazolam can result in widesprea

299 dent stimulation of gamma-aminobutyric acid (GABA) A receptors with the benzodiazepine alprazolam can

300 s have shown that this delay is dependent on GABA(A) receptors within the LGN.