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1 on of pannier, a cardiogenic gene encoding a Gata factor.
2 X17CNXC zinc fingers typical of a vertebrate GATA factor.
3 ) and the C-terminal zinc finger of the same GATA factor.
4 ied by the activity of the divergent MED-1,2 GATA factors.
5 tors, the hypoxia-regulated factor HIF1, and GATA factors.
6 ells can be manipulated by the expression of GATA factors.
7 x5/Dlx6 function, it may require one or more GATA factors.
8 binding to DNA and physical association with GATA factors.
9 regulators, Mix-like paired-homeodomain and GATA factors.
10 evelopment through physical interaction with GATA factors.
11 transcriptional activation mediated by other GATA factors.
12 at found with the vertebrate two zinc finger GATA factors.
13 e specification of hematopoietic mesoderm by GATA factors.
14 at the seventh position of the Zn finger of GATA factors.
15 with the differentiation-promoting action of GATA factors.
16 fect is mediated in part by interaction with GATA factors.
20 previously shown that the MED-1,2 divergent GATA factors act apparently zygotically to specify the f
22 genetic and molecular analysis that the two GATA factors act upstream from the flowering time regula
25 e show how integration of Bmp4 signaling and Gata factor activity controls the progression of hematop
28 demonstrate that PBP interacts with all five GATA factors analyzed, GATA-1, GATA-2, GATA-3, GATA-4, a
29 x between the DNA binding domain of a fungal GATA factor and a 13 base-pair oligonucleotide containin
31 Several lines of evidence suggested that GATA factors and AR act cooperatively to activate Pp tra
32 ctors share highly specific association with GATA factors and are substantially interchangeable with
33 n of mouse embryonic stem cells deficient of GATA factors and conclude that GATA-4 is required for ES
34 in tumor cells, suggesting that the loss of GATA factors and dedifferentiation are irreversible proc
35 ior heart field and support a model in which GATA factors and ISL1 serve as the earliest transcriptio
39 nues with Zfh1 activation of Serpent (Srp; a GATA factor), and terminates with Srp activation of U-sh
42 portant functional interplay between Ikaros, GATA factors, and the NOTCH signaling pathway in specifi
43 activities of both mammalian and Drosophila GATA factors are controlled in part by physical interact
44 a4 in mouse embryonic pancreas and show that GATA factors are essential regulators of the proliferati
45 ndings demonstrate that the EGL-18 and ELT-6 GATA factors are essential, genetically redundant regula
48 trophy, demonstrating that cardiac-expressed GATA factors are necessary mediators of this process.
50 ypertrophy-associated genes, suggesting that GATA factors are sufficient regulators of cardiomyocyte
52 t that elt-5 and -6, adjacent genes encoding GATA factors, are essential for the development of the l
53 e to valine in the DNA-binding domain of the GATA factor AreA results in inability to activate some A
58 ng gene duplication and modular evolution of GATA factors based upon inclusion of a class IV zinc fin
59 ese factors activate a sequential cascade of GATA factors, beginning with their immediate targets, th
62 t-expressed genes possess a preponderance of GATA factor binding sites and one GATA factor, ELT-2, fu
66 tors regulate GnRH transcription through two GATA factor-binding motifs that occur in a tandem repeat
69 in animals and fungi and are referred to as GATA factors by virtue of their affinity for promoter el
71 njection ventrally of a dominant-interfering GATA factor (called G2en) induced the formation of secon
74 of a single transcription factor, the ELT-7 GATA factor, can convert the identity of fully different
75 similar to that of vertebrates but only one GATA factor, Ci-GATAa, is expressed in the heart progeni
80 the potential for a regulatory loop in which GATA factors control the expression of their partner pro
81 rated micro RNA expression and function into GATA factor coordinated networks and provided mechanisti
82 ies establish a transcriptional hierarchy of Gata factor dependence during hematopoiesis and demonstr
83 of these and previous reports, we infer that GATA factor dependence is a critical aspect of FOG prote
84 evealed unique +9.5 site activity to mediate GATA factor-dependent chromatin structural transitions.
85 erable progress has been made in elucidating GATA factor-dependent genetic networks that control bloo
86 erable progress has been made in elucidating GATA factor-dependent genetic networks that control red
88 ference to poor ones (proline) by repressing GATA factor-dependent transcription of the genes needed
94 derance of GATA factor binding sites and one GATA factor, ELT-2, fulfills the expected characteristic
95 We have discovered a second gut-specific GATA factor, ELT-7, that profoundly synergizes with ELT-
96 eplace the complete set of endoderm-specific GATA factors: END-1, END-3, ELT-7 and (the probably non-
97 ntaining transcriptional regulators known as GATA-factors ensures efficient utilization of available
98 partially redundant, adjacent genes encoding GATA factors essential for viability, seam cell developm
99 chanisms underlying this restriction and how GATA factors establish genetic networks, we used ChIP-se
103 scriptional regulators and is the only known GATA factor expressed in the distal epithelium of the lu
105 lasmids with wild-type and dominant negative GATA factor expression vectors demonstrated that both GA
107 ng that the MEDs are atypical members of the GATA factor family that do not recognize GATA sequences.
111 elucidated mechanisms by which FOGs regulate GATA factor function and discuss how these factors use t
113 lation is leukemogenic, and its influence on GATA factor function is unknown, this mechanistic link h
116 ive to consider mechanisms underlying normal GATA factor function/regulation and how dissecting such
117 n a genome wide scale that the hematopoietic GATA factors GATA-1 and GATA-2 bind overlapping sets of
118 ion directly at promoters, the hematopoietic GATA factors GATA-1 and GATA-2 often assemble dispersed
120 Herein, we discuss how the hematopoietic GATA factors (GATA-1-3) function via a battery of mechan
121 In this study, we report that a heterologous GATA factor, GATA-4, was competent in supporting the dev
122 We also demonstrate that a closely related GATA factor, GATA4, is expressed transiently in the preh
126 ta support the contention that regulation of GATA-factor gene expression is tightly and dynamically c
127 is, we identified the functionally redundant GATA factor genes egl-18 and elt-6 as Wnt pathway target
128 GATA5, the only one of the six vertebrate GATA factor genes not yet inactivated in mice, is expres
130 Ure2, the protein that negatively regulates GATA factor (Gln3, Gat1)-mediated transcription in Sacch
131 charomyces cerevisiae requires activation by GATA factor Gln3p or Nil1p and is prevented by the prese
132 y does not interfere with the binding of the GATA factor Gln3p to GATAAG sites but acts directly on G
133 ger region highly homologous to those of the GATA factors Gln3p and Nil1p as an antagonist of Nil1p a
134 f a cross-repressive interaction between the GATA factors GNC and GNL and the MADS box transcription
137 n Drosophila, the existence of a cardiogenic GATA factor has been implicated through the analysis of
143 ily conserved domain that determines B-class GATA factor identity and provides a further subclassific
144 servations identify GATA6 as the predominant GATA factor in the maintenance of endodermal gene expres
146 of late endoderm development, but a role for GATA factors in establishing the endoderm is unknown.
150 omplexes that are thought to sequester these GATA factors in the cytoplasm of cells cultured in exces
151 sible loss of expression of HNF3 (Foxa2) and GATA factors in the endoderm and the absence of factors
153 for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify line
154 Herein, we analyzed the role of several GATA factors in the regulation of the erythropoietin gen
155 e first direct demonstration of a target for GATA factors in the vertebrate intestinal epithelium.
156 eracts specifically with the amino finger of GATA factors in the yeast two-hybrid system and in mamma
162 rker genes in animal cap assays, while other GATA factors induce these genes only weakly, if at all.
165 rm cells to show that a DNA-binding site for GATA factors is occupied on a liver-specific, transcript
167 attern, indicating that a normal function of GATA factors is to limit the boundary of the Nkx2.5 expr
168 tional program, mediated at least in part by GATA factors, is critical in presumptive foregut endoder
171 genitourinary system and suggest that other GATA factors may have functions overlapping those of GAT
172 establish fundamental principles underlying GATA factor mechanisms in chromatin and illustrate a com
175 However, our experiments also indicate that GATA factors might normally antagonize transcription of
177 In addition, elt-3, which encodes another GATA factor normally expressed in non-seam epidermis, is
186 ring the regulation of nmr, we find that the GATA factor Pannier is essential for cardiac expression,
188 of Friend of GATA proteins and the role that GATA factors play during cell fate choice, these factors
190 t assembly of a protein complex containing a GATA-factor, presumably GATA-1 or GATA-2, is critical to
191 with GATA factor mutants and novel chimeric GATA factors provided evidence that both GATA-1 and GATA
193 ver, accumulating evidence now suggests that GATA factor regulation may occur by two separate pathway
195 eases during normal aging, and both of these GATA factors repress expression of elt-3, which shows a
196 derm differentiation, including a cascade of GATA factors required for development and maintenance of
197 els determine the threshold concentration of GATA factors required for PrE-like differentiation, and
198 ith the Pp in vitro, (iii) overexpression of GATA factors rescued expression from mutant Pp construct
200 on occurs through specific expression of the GATA factor Serpent (Srp) in the lymph-gland primordium.
205 mbryogenesis and larval development, and the GATA factor Serpent is essential for Ush embryonic expre
209 , or chick embryos depleted specifically for GATA factors, show in addition abnormal foregut developm
211 pathway, including positive feedback loops, GATA factors, SoxB, Brachyury and a previously underemph
213 hromatin sites, we propose that differential GATA factor stability is an important determinant of chr
214 ry of mechanistic permutations, which can be GATA factor subtype, cell type, and locus specific.
216 both Gata1 and Gata2, or independent of both Gata factors, suggesting that multiple pathways regulate
218 ults indicate that FOG-1 is a determinant of GATA factor target gene sensitivity by either facilitati
219 re identify a novel small-molecule-activated GATA factor that is required to regulate the cell type-s
220 ine, as well as to overexpression of the two GATA factors that are normally involved in intestinal di
222 One mode involves cooperative binding by two GATA factors that interact with each other through prote
223 These results indicate that similar to other GATA factors, the GATA-3 gene can be controlled by two p
224 r gene expression is highly regulated by the GATA factors themselves in an interdependent manner.
225 or negative coregulators that cooperate with GATA factors to control right ventricular-specific gene
226 vidual contributions of the three vertebrate GATA factors to endoderm formation have been unclear.
227 FOG-like proteins are corepressors that link GATA factors to histone deacetylation and nucleosome rem
230 In contrast, FOG1 antagonizes the ability of GATA factors to promote mast cell (MC) development.
233 ed by anthracyclines, the ability of ectopic GATA factors to rescue anthracycline-induced apoptosis w
234 The discovery of the GATA binding protein (GATA factor) transcription factor family revolutionized
236 regulation of GATA-2, an essential mast cell GATA factor, via switching of GATA-1 for GATA-2 at a key
237 ave shown that the combined absence of these GATA factors virtually ablates primitive erythroid cell
241 5, a target of the MED-1 and MED-2 divergent GATA factors, was previously found to result in a profou
243 d differentiation can be replaced by another GATA-factor, we generated a knock-in mutation of the GAT
246 nsidering control of the nitrogen-responsive GATA factors when studying the regulation of the protein
247 Neurospora possesses at least five different GATA factors which control different areas of cellular f
248 nal signaling regulates the translation of a GATA factor, which is the specific transcriptional activ
250 y increasing the expression of GATA-binding (Gata) factors, which suppressed expression of the microR
251 otein-protein interactions of the individual GATA factors with additional pathway-specific regulatory
252 with previous studies linking regulation by GATA factors with c-Jun and BRG1, provides genome-wide e
253 mma transcriptional activity, interaction of GATA factors with C/EBP is necessary for their ability t
254 eable and interact with different endodermal GATA factors with only modest differences in affinity.
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