ライフサイエンスコーパス: GC-rich

1 Surprisingly, variants with GC-rich 4-nt palindromes were sustained throughout the s

2 PTEN mRNA contains a highly conserved and GC-rich 5'-untranslated region (5'-UTR).

3 taining these genes were found to consist of GC-rich (54 to 65%) sequences comparing to the average G

4 omprise the tertiary structure, as well as a GC-rich 6 bp stem (stem 1) and an AU-rich 9 bp stem (ste

5 Recently, the genuine leptin gene with a GC-rich ( 70%) repetitive-sequence content was identifie

6 that the WhiB-like proteins exclusive to the GC-rich actinomycete genera play significant roles in pa

7 irths/deaths over their entire length, while GC-rich Alus only in their 3' poly(A) tails and middle A

8 the proximal promoter of the Cdc2L2 gene is GC rich and does not contain TATA and CAAT boxes.

9 The Mycobacterium tuberculosis genome is GC-rich and contains >10,000 sequences that have the pot

10 emonstrated that the 5' regulatory region is GC-rich and contains no TATA or CAAT box, similar to the

11 The 5' site was GC-rich and did not contain a C/EBP consensus sequence;

12 iple promoter and silencer elements that are GC-rich and exhibit considerable single-stranded charact

13 genes mutated in opposite directions-toward GC-rich and GC-poor content, respectively.

14 rabidopsis thaliana genome and the much more GC-rich and heterogeneous rice (Oryza sativa) genome and

15 and homogeneous genomes to the more derived GC-rich and highly heterogeneous ones, with several inde

16 espread expression of CRELD2, this region is GC-rich and lacks a TATA box.

17 sposable element-derived genes are generally GC-rich and mainly derive from GC-rich parental sequence

18 microchromosome, which are known to contain GC-rich and repetitive regions, but at the distal tip of

19 genes; and (3) two regions that were either GC-rich and/or contained tracts of G.

20 PCR amplification over GC-rich and/or long repetitive sequences is challenging

21 n -234 and -23 that lacked TATA element, was GC-rich, and harbored several putative cis-regulatory si

22 e lambda-exo-controlled NS-seq peaks are not GC-rich, and only 35.5% overlap with 6.8% of all G4s, su

23 are AT-rich, the middle four base pairs are GC-rich, and the last six base pairs are AT-rich.

24 gle-copy genes, and because they are now all GC-rich, any derived from AT-rich contexts must have exp

25 this discrepancy is inadequate sequencing of GC-rich areas of the exome.

26 ing sequences, CpG islands, splice sites and GC-rich areas.

27 lysis revealed that ICP27-targeted genes are GC-rich (as are HSV genes), contain cytosine-rich sequen

28 T) and two model junctions, which are AT- or GC-rich at the branch points, to show that binding of th

29 quence-related natural product O-MTases from GC-rich bacteria.

30 rily upon codon usage characteristic of this GC-rich bacterium.

31 inent in the mammalian genome owing to their GC-rich base composition and high density of CpG dinucle

32 ter activation by Osx, suggesting that these GC-rich binding sites were responsible for Satb2 activat

33 bination of approaches, we show that several GC-rich binding transcription factors are involved in po

34 This effect, mediated via LSD1, provides GC-rich binding transcription factors better access to D

35 Screening for GC-rich binding transcription factors that could activat

36 ter activity, through the binding of several GC-rich boxes.

37 , lower levels of EEHV3 and EEHV2, and a new GC-rich branch type, EEHV7.

38 ong to multiple lineages of both AT-rich and GC-rich branches within a new subfamily to be named the

39 how RacA can both specifically recognize its GC-rich centromere and also non-specifically bind the DN

40 lation is in part due to MeCP2's affinity to GC-rich chromatin, a result replicated using published d

41 ly expressed transcription factor that binds GC-rich cis elements.

42 lls showed extensive binding of Smad2/3/4 to GC-rich cis-regulatory elements.

43 AT-rich codons are decoded more quickly than GC-rich codons.

44 t specific targeting and sequencing of these GC-rich cold-spot regions can lead to the identification

45 h mammalian switch regions, because of their GC-rich composition, generates stable R-loops, which pro

46 -2gamma) are transcription factors that bind GC-rich consensus sequences and regulate the expression

47 insert into TA-rich regions within a broader GC-rich context.

48 of several distinct components, including a GC-rich core (core open reading frame [ORF]), an AT-rich

49 ] > AT alternate, d[5'-G(3)(AT)(5)C(3)-3'] > GC-rich d[5'-A(3)G(5)C(5)T(3)-3'].

50 In addition, the GC-rich discriminator destabilized the RNA polymerase-pr

51 cription initiation rate from promoters with GC-rich discriminators, in contrast to the uspA-promoter

52 3 orders of magnitude higher affinity than a GC-rich DNA (A-form, d[5'-A(3)G(5)C(5)T(3)-3']).

53 nonreplicating genomic DNA (LexoG0) enriches GC-rich DNA and G4 motifs genome-wide.

54 n by mithramycin with its ability to bind to GC-rich DNA and globally displace Sp1 family transcripti

55 lation of cytosines makes attraction between GC-rich DNA as strong as that between AT-rich DNA.

56 Here we have shown that hedamycin, a GC-rich DNA binding drug, down-regulated survivin expres

57 C8-linked PBD-MPB hybrids that can stabilize GC-rich DNA by up to 13-fold compared to AT-rich DNA.

58 limates, possibly indicating an advantage of GC-rich DNA during cell freezing and desiccation.

59 nts revealed that hedamycin bound to a 21-bp GC-rich DNA element (-115 to -95) in the survivin promot

60 rase constructs, we have identified an 86-bp GC-rich DNA element (-124 to -39) that mediates the abil

61 Sequence analysis of the TR, a GC-rich DNA element, identified several potential Quadru

62 hat both ZBP-89 and ATM are recruited to the GC-rich DNA elements of the p21(waf1) promoter with HDAC

63 to the transcription start site encodes six GC-rich DNA elements.

64 nc finger transcription factor that binds to GC-rich DNA elements.

65 ite similar, but over time, Alu densities in GC-rich DNA increase in comparison with L1 densities.

66 o propose that long-term Alu accumulation in GC-rich DNA is associated with DNA duplication initiated

67 One of the major selective advantages of GC-rich DNA is hypothesized to be facilitating more comp

68 stress activates the Lmf1 promoter through a GC-rich DNA sequence 264 bp upstream of the transcriptio

69 onsensus Egr-1-binding site element and with GC-rich DNA sequences of the human COL1A2 promoter in vi

70 sed by mithramycin, suggesting regulation by GC-rich DNA sequences.

71 12- and 8-fold higher expression levels from GC-rich DNA targets.

72 aterial) comprising a challenging methylated GC-rich DNA template under a novel 96-well microplate fo

73 el-like factor 15 (KLF15), which can bind to GC-rich DNA within the E2F1 promoter, is required for ma

74 SINEs are more abundant in GC-rich DNA, but the regional GC preference for insertio

75 growth and bone resorption by cross-linking GC-rich DNA, thus blocking binding of Sp-family transcri

76 We have previously shown that hedamycin, a GC-rich DNA-binding antitumor agent, downregulates survi

77 proximately 4 bp of AT-rich DNA or 1-2 bp of GC-rich DNA.

78 eps on AT-rich and 'short and slow' steps on GC-rich DNA.

79 ated by LEDGF/p75 and (iii) more frequent in GC-rich DNA.

80 DNA base pairs with a strong preference for GC-rich DNA.

81 ans and 0.329 in African Americans) within a GC-rich domain containing consensus binding sites for Sp

82 density of a transcriptionally active 95-kb GC-rich domain on chromosome III of the yeast Saccharomy

83 Particularly, the GC-rich dsDNAs are unwound with lower amplitudes under s

84 MGA1 proteins to AT-rich duplex DNA, but not GC-rich duplex DNA, significantly inhibited the methylat

85 r an AT-rich duplex to be more stable than a GC-rich duplex of the same length.

86 ch DNA duplexes associate more strongly than GC-rich duplexes, regardless of the sequence homology.

87 on identified endogenous KLF4 binding to the GC-rich/E-box region of this promoter.

88 This GC-rich element consists of six contiguous runs of guani

89 r activity is mediated via KLF4 binding to a GC-rich element located in the hINV promoter distal regu

90 siveness: a Smad binding element (SBE) and a GC-rich element resembling an OAZ binding site.

91 virulence factor, laccase, via binding to a GC-rich element within the 5'-UAS in response to glucose

92 The potential of the GC-rich element within the bcl-2 promoter region to form

93 Mutation of the GC-rich element, an adjacent AP1 factor binding site, or

94 ed the cyclin B1 promoter through a specific GC-rich element.

95 of nuclear proteins with naturally occurring GC-rich elements in a human genomic DNA.

96 emonstrates that increased binding of Sp3 to GC-rich elements in the betaMyHC promoter is a critical

97 eading to enhanced KLF4 interaction with the GC-rich elements in the p21(Cip1) promoter to activate t

98 NA and protein level and KLF4 binding to the GC-rich elements in the p21(Cip1) proximal promoter.

99 Sp3, and Sp4 and all three proteins bound to GC-rich elements in the VEGFR1 promoter.

100 y, we show that the promoter also contains 5 GC-rich elements that contribute to promoter activity an

101 to have evolved along with these downstream GC-rich elements.

102 5/8 have been thought to preferentially bind GC-rich elements.

103 GC-rich ends are not cut by Artemis alone because of a r

104 The presence of a GC-rich flanking sequence, similar to a haplotype found

105 This GC effect is unimodal: both GC-rich fragments and AT-rich fragments are underreprese

106 at carry gene fragments specifically acquire GC-rich fragments and preferentially insert into the 5'

107 rs, guanine-cytosine (GC) content, number of GC-rich gene-rich isochores, density of polymorphic site

108 the ends of extremely guanine plus cytosine (GC)-rich genes.

109 Further, we found that GC-rich genes and intergenic regions have higher levels

110 eutherian mammals; indeed, the GC content of GC-rich genes appears to have increased in recent times

111 transcription and translation processes, and GC-rich genes implicated in signal transduction and post

112 pens new opportunities for the expression of GC-rich genes in E. coli.

113 ll significant decrease in the GC content of GC-rich genes later in at least three groups of mammals:

114 no general decreasing trend in GC content in GC-rich genes or in other genes among eutherian mammals;

115 at the last common vertebrate ancestor had a GC-rich genome (~65% GC).

116 rion (0.6-microm diameter) encloses a 651-kb GC-rich genome encoding 523 proteins of which 64% are OR

117 as representative structural and functional GC-rich genomic elements.

118 ests that other similar clusters of genes in GC-rich genomic regions are missing from the current gen

119 rlying mechanism for higher mutation rate in GC-rich genomic regions, predict nonlinear accumulation

120 he extremely long ( approximately 1.5-5 kb), GC-rich (>80%) coding variable-number tandem repeat (VNT

121 he successful PCR-amplification of extremely GC-rich (>83%) DNA targets.

122 The presence of GC-rich hairpin sequences between substrate-binding prot

123 nd the C-clamp domain for recognition of the GC-rich Helper motif (5'-RCCGCC-3').

124 rgence states inhabit guanine- and cytosine (GC)-rich, highly recombining subtelomeric regions; low d

125 Despite the GC-rich, highly repetitive sequences of ELPs, we synthes

126 ining RNA hairpins immediately upstream of a GC-rich hybrid formed complexes of reduced stability, wh

127 eudicot genomes (35-42% of G+C content), but GC-rich in the monocot genomes (59-61% of G+C content).

128 gamma-herpesviruses were enriched in short, GC-rich initiation sequences such as CCCAG and depleted

129 uences, rice MULEs capture guanine-cytosine (GC)-rich intergenic sequences, albeit at a much lower fr

130 head), being separated by a short (<500 bp) GC-rich intergenic region that can function as a bidirec

131 of nicK leads to nicking of ICEBs1 between a GC-rich inverted repeat in oriT, and NicK was the only I

132 tional and biochemical analysis identified a GC-rich, inverted 14 bp repeat as the recognition sequen

133 he nonavian reptiles, are expected to lack a GC-rich isochore structure.

134 e number of chromosomes, it is unlikely that GC-rich isochores are vanishing in these mammals.

135 firm the recently suggested disappearance of GC-rich isochores in some mammalian genomes, and more im

136 patterns in mammalian species suggested that GC-rich isochores might be vanishing in mammalian genome

137 isochores than amphibians and fish, and the GC-rich isochores of birds and mammals have been suggest

138 It has been suggested that GC-rich isochores originated in the ancestral amniote ge

139 Birds and mammals have more GC-rich isochores than amphibians and fish, and the GC-r

140 idence that the poikilothermic alligator has GC-rich isochores, like homeothermic birds and mammals.

141 ture of SL1 consists of an upper stem with a GC-rich loop that facilitates dimerization, a lower stem

142 "AT"-rich motif (M1a-d) and 2 copies of an "GC"-rich motif (M2 a,b), which when mutated cause expans

143 ate that both Sp1 and Sp3 proteins bound the GC-rich motif (-66 to -47), and estrogen receptor alpha

144 in a thymus library, all of which bound the GC-rich motif in a sequence-specific manner.

145 l activation requires binding of E2F/DP to a GC-rich motif that facilitates HSF-1 binding to a heat-s

146 on of an EBV early promoter, BHLF1, though a GC-rich motif which binds to SP1 and ZBP-89, although th

147 ry structures of these transcripts yielded a GC-rich motif, which was shown to bind to GR in vitro.

148 smaller portions of this hot spot and other GC rich motifs are able to target RAG-mediated transposi

149 We also show that GC-rich motifs at the 5' ends of footprints are found in

150 the initiation of DNA packaging and for the GC-rich motifs flanking the pac1 T element in terminatio

151 a cells through two evolutionarily conserved GC-rich motifs in conserved Area II, a control region es

152 s for specific binding of Smad3 and Smad4 to GC-rich motifs in the goosecoid promoter, a nodal-regula

153 lement of the Ihh promoter contains multiple GC-rich motifs known as the "Mad/Medea binding box" foun

154 bolished interaction of Sp1 and Sp3 with the GC-rich motifs located within the minimal promoter regio

155 The Dbeta1 promoter contains 3 GC-rich motifs that bind a common set of nuclear protein

156 es demonstrated that Sp1 and Sp3 bind to the GC-rich motifs, a CACCC box and three GC boxes, located

157 and this was primarily dependent on proximal GC-rich motifs.

158 g studies revealed that Smad4 binds to these GC-rich motifs.

159 Ralpha/Sp1 and ERalpha/Sp3 interactions with GC-rich motifs.

160 The GC-rich nonanucleotide (N(9)) sequence, which forms the

161 e Fragile X cell lines, as well as extremely GC-rich nonrepetitive segments of the GNAQ and GP1BB gen

162 promoter element of the KRAS gene contains a GC-rich nuclease hypersensitive site with three potentia

163 DNA G-quadruplexes formed in the GC-rich nuclease hypersensitivity element of the human P

164 TF binding sites are located in GC-rich, nucleosome-depleted, and DNase I sensitive regi

165 experimentally observed association rates of GC-rich oligomers are higher than rates of AT- rich equi

166 by sequence similarities and the presence of GC-rich or repeat sequences, and some sequences are comp

167 switching propensity is higher when dsDNA is GC-rich or when the 3'-overhang of forked DNA is <15 bas

168 However, the translation of genes from GC-rich organisms is inefficient in E. coli.To overcome

169 uencing approaches suited to the analysis of GC-rich organisms.

170 These studies suggest that a GC-rich OriLyt transcript is an important component of g

171 mbled by isothermal assembly guided by short GC-rich overlap sequences.

172 This GC-rich palindrome is completely different from the cons

173 of the selected DIS sequence is a 4- or 6-nt GC-rich palindrome, although not all sequences with thes

174 are generally GC-rich and mainly derive from GC-rich parental sequences.

175 old elements are preferentially found in the GC-rich parts of the genome, while young Alus are more o

176 cAMP-response elements (CRE) and a proximal, GC-rich promoter region, which contained atypical CRE.

177 /TR3/ specificity protein 1 complex bound to GC-rich promoter regions of survivin and other Sp-regula

178 equirement for the NR4A1/Sp4 complex to bind GC-rich promoter regions to elevate transcription of the

179 tween ZBTB4 and Sp transcription factors for GC-rich promoter sequences.

180 r communication between the enhancer and the GC-rich promoter.

181 Instead, a GC-rich proximal region containing a potential Sp1 recog

182 helicase assays demonstrate that BLM unwinds GC-rich rDNA-like substrates that form in the nucleolus

183 ase II transcription activator that binds to GC-rich recognition sites in a number of essential cellu

184 lysis of the VEGF gene promoter identified a GC-rich region (-66 to -47) which was required for E2-in

185 iments demonstrate that the proximal, highly GC-rich region (positions -165 to -139) of the human PDG

186 ion site and another laboratory identified a GC-rich region between the TATA box and transcription in

187 ses of the VEGF promoter demonstrated that a GC-rich region containing four Sp1 response elements, lo

188 EKLF site within a previously characterized GC-rich region in the p21 proximal promoter but also by

189 ugments promoter activity of p21 through the GC-rich region located between nucleotides -84 and -74 w

190 urther point mutation studies found that two GC-rich region mutations disrupted the Satb2 130bp promo

191 Sp1-p300 DNA binding complex on the proximal GC-rich region of the survivin promoter.

192 moter and that targeted deletion of a single GC-rich region spanning -93 to -58 interrupts Sp1- and D

193 taining a half-estrogen response element and GC-rich region that interact with ER and Sp1 proteins.

194 A highly GC-rich region upstream of the P1 promoter plays an impo

195 The human bcl-2 gene contains a GC-rich region upstream of the P1 promoter that has been

196 The human BCL-2 gene contains a 39-bp GC-rich region upstream of the P1 promoter that has been

197 KLF5's promoter lacks a TATA box and has a GC-rich region.

198 ificantly from the mechanism mediated by the GC-rich region.

199 A guanine- and cytosine-rich (GC-rich) region directly upstream of the P1 site has bee

200 ve significant enrichment of heritability in GC-rich regions and in higher-frequency SNPs for both sc

201 The SEGS are characterized by GC-rich regions and the absence of long open reading fra

202 family of transcription factors that bind to GC-rich regions in gene promoters.

203 lated promoter activity occurred through two GC-rich regions located within 633 bp of the transcripti

204 e with worker-biased expression are found in GC-rich regions of the bee genome and also experience hi

205 ions for the accumulation of Alu elements in GC-rich regions of the human genome.

206 CpG islands are GC-rich regions often located in the 5' end of genes and

207 These genes tended to cluster in GC-rich regions that have poor coverage in genome sequen

208 onal point mutants were used to identify two GC-rich regions that were responsible for VEGF promoter

209 ellifera, represents a mosaic of GC-poor and GC-rich regions with rates of recombination an order of

210 thod not only for amplification of extremely GC-rich regions, but also for routine DNA diagnostics an

211 particular: structural variants, variants in GC-rich regions, which have significantly improved cover

212 tate replication through telomeres and other GC-rich regions.

213 ing four hypoxia-response elements and three GC-rich regions.

214 al 1,153-bp sequence and a 600-bp downstream GC-rich repeat sequence, and the 1.7-kb DNA sequences ar

215 dem repeat composed of at least three 7.6-kb GC-rich repeat units reside within a syntenic region of

216 ymorphism analysis with a highly polymorphic GC-rich repetitive sequence located in the plasmid pTBN1

217 y with the proline glutamic acid-polymorphic GC-rich repetitive sequences protein family of M. tuberc

218 binding sites (LBS1 and LBS2 [LBS1/2]) and a GC-rich replication element (RE) upstream of LBS1/2.

219 Additional experiments demonstrated that a GC-rich response element located -6 to -16 (upstream of

220 gh direct, COUP-TF-in-dependent binding to a GC-rich response element.

221 nucleotide variants in a training set from a GC-rich Rhodobacter sphaeroides genome.

222 ng sequence that includes a 12-14-nucleotide GC-rich RNA duplex between the end of the 5' tRNA half a

223 preferred binding site for this protein is a GC-rich RNA hairpin containing a pyrimidine mismatch.

224 rase (RNAP) occurs at sequences coding for a GC-rich RNA hairpin followed by a U-rich tract.

225 ion (OriLyt) also requires the presence of a GC-rich RNA in cis.

226 SELEX analysis identified GC-rich RNA sequences as a common feature of recognition

227 g the AT-rich discriminator of uspA with the GC-rich rrnB-P1 discriminator made the uspA promoter neg

228 ny sequence-specific role, we randomized the GC-rich sequence ((-20)CCGGCTCG(-13)) within the spacer

229 ll except one case shared common polymorphic GC-rich sequence (PGRS) patterns.

230 ific mycobacterial proteins with polymorphic GC-rich sequence (PGRS).

231 e same AT-rich sequence is concatenated to a GC-rich sequence known to undergo a B-to-S transition ra

232 lized a minimal promoter activity to a 21-bp GC-rich sequence located 130 bp upstream of the X protei

233 the transactivation is partly mediated by a GC-rich sequence located in the promoter.

234 GTCT), whereas the Mad MH1 domains bind to a GC-rich sequence resembling Mad binding sites previously

235 Each repeat unit consists of a 7.3 kb GC-rich sequence that binds the insulator protein CTCF a

236 s (LBS1/2) and an adjacent 29- to 32-bp-long GC-rich sequence which we termed the replication element

237 derivative, DB1242, binds specifically to a GC-rich sequence, -GCTCG-.

238 nts showed that PAGE4 preferentially binds a GC-rich sequence.

239 sting of two LANA binding sites (LBSs) and a GC-rich sequence.

240 posase exhibits a target site preference for GC rich sequences and hairpin structures.

241 By contrast, GC-rich sequences (60% GC) are found to undergo a revers

242 multiple transcriptional start sites (TSS), GC-rich sequences and a promoter located within -205/+63

243 RGG box of ICP27 are required for binding to GC-rich sequences and that the N-terminal portion of ICP

244 This suggests that such GC-rich sequences are difficult to sequence and therefor

245 noglobulin and HIV promoters to identify the GC-rich sequences at each end required for Sp-factor tar

246 The presence of GC-rich sequences at the 5' end of genes may influence t

247 The largest cluster involved GC-rich sequences at the 5' ends of introns that co-occu

248 dies have indicated that Sp2 binds poorly to GC-rich sequences bound by Sp1 and Sp3, and further func

249 analysis with the wild-type protein bound to GC-rich sequences did not show any discernible folding.

250 FI sites emerged with a general accretion of GC-rich sequences downstream of the eukaryotic transcrip

251 nergy calculations show that single-stranded GC-rich sequences exhibit more favorable solvation by ch

252 KLF10 occupied GC-rich sequences in the promoter region of the EMT-prom

253 BTEB1 bound to GC-rich sequences in the proximal TrbetaA promoter in vi

254 mily an overlapping sequence specificity for GC-rich sequences in the regulatory regions of multiple

255 , which alkylates DNA in the minor groove at GC-rich sequences resulting in an unusual bending toward

256 bind G-quartet structures but instead binds GC-rich sequences that are flexible in structure.

257 Tax binds to GC-rich sequences that immediately flank the CREs.

258 ecipitation assays, have identified distinct GC-rich sequences used by KLF14 to regulate this promote

259 Despite the gene's repetitive and GC-rich sequences, 13% of RPGR gene copies showed mutati

260 ct gene, which appeared to include extremely GC-rich sequences, using current RACE methods.

261 BMH-21 binds GC-rich sequences, which are present at a high frequency

262 Pif1 did not promote synthesis through GC-rich sequences, which impede strand displacement.

263 of the Xenopus laevis TrbetaA gene has seven GC-rich sequences, which led us to hypothesize that BTEB

264 reference of 3 toward AT-rich sequences over GC-rich sequences.

265 promote recombination more efficiently than GC-rich sequences.

266 der to enhance DNA polymerase extension over GC-rich sequences.

267 poly-U and UUAG sequences and destabilizing GC-rich signals.

268 tion by binding to the promoter via specific GC-rich sites and recruiting the Sin3-histone deacetylas

269 ein signaling recognizes a distinct class of GC-rich sites in addition to GTCT.

270 s effect was abrogated after mutation of the GC-rich sites.

271 The proximal p21(Cip1) promoter GC-rich Sp1 factor binding elements are also required, a

272 t Mor interacts with the minor groove of the GC-rich spacer in the Mor binding site.

273 lements, we find that the presence of a more GC-rich spacer or a spacer with the complement of the P(

274 re, the presence of the P(minor) spacer, the GC-rich spacer, or the complement spacer results in diff

275 Egr-1 bound to the GC-rich SPUR activation element in the SMalphaA promoter

276 The p2b hairpin also contains GC-rich stem 1 and a unique uridine-rich helix with a pe

277 h the surface area exposed upon unfolding of GC-rich stem 1 than either AU-rich stem 2 or the hairpin

278 t bacterial RNA polymerases (RNAPs) encode a GC-rich stem-loop structure followed by a polyuridine [p

279 ingle-stranded terminal loop and a conserved GC-rich stem.

280 poson revealed an insertional preference for GC-rich streptomycete DNA compared to E.coli vector DNA.

281 presentation of SP1/SP3-binding sites and/or GC-rich stretches.

282 ogether, the results provide a model for how GC-rich structural and functional eukaryotic markers eme

283 d structure space, we discovered a family of GC-rich structural cis-regulatory RNA elements, termed s

284 other RGG box proteins; it prefers flexible, GC-rich substrates that do not form stable secondary str

285 promoter and initiates transcription across GC-rich tandem repeats.

286 satellites are a class of highly polymorphic GC-rich tandem repeats.

287 PCR methods for these extremely GC-rich target regions were optimized to give reproducib

288 alance of amplification efficiencies between GC-rich target sequences of different length, we were ab

289 Sp family members bind GC-rich target sequences through their zinc finger domai

290 Early on in the siRNA design, GC-rich target sites were avoided because of their poten

291 However, PCR-amplification of GC-rich templates is often hampered by the formation of

292 mes, pauses are shorter and less frequent on GC-rich templates.

293 Reduced coverage was obtained in the highly GC-rich terminal repeat regions.

294 a long unique coding region (LUR) flanked by GC-rich terminal repeat sequences.

295 Rs in 5'-UTRs of housekeeping genes are more GC rich than those of tissue-specific genes and CGG, the

296 man genome occur more frequently in Alu- and GC-rich than in AT-rich chromosomal regions.

297 these FL-like cells (FLLCs) in nonmalignant GC-rich tissues and the functional consequences of BCL2

298 The resulting Pack-MULEs form independent, GC-rich transcripts with a negative GC gradient.

299 ipped-strand nucleation of duplex DNA within GC-rich trinucleotide repeats may result in the changes

300 TATA nor a CAAT box, but is, instead, highly GC-rich with multiple transcription initiation sites.