ライフサイエンスコーパス: GDF-5

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1 skeletal defects resulting from mutations in GDF-5.

2 cells, and may do so by acting downstream of GDF-5.

3 utations in growth/differentiation factor-5 (Gdf-5) (6), the mouse homologue of hCDMP-1.

4 on, comparative in situ localizations of the GDF-5, 6, and 7 mRNAs suggest that these molecules are i

5 Analysis of tissue induced by GDF-5, 6, or 7, containing implants by currently availab

6 sting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.

7 Mutations in GDF-5, a member of the TGF-beta superfamily, result in t

8 ngth and shortened propeptides), BMP-10, and GDF-5 allowed us to conclude that all, except for BMP-2

9 Re-expression of GDF-5 and Atx is observed in the WE samples by 60h after

10 es that underwent SE surgery did not express GDF-5 and Atx.

11 lopmental program of forming joints, we used GDF-5 and Autotaxin (Atx) as joint tissue specific marke

12 een prodomains of BMP-2, -4, -7, and -10 and GDF-5 and fibrillins, raising the possibility that laten

13 tional activity assays with BMP-2, BMP-7 and GDF-5 as ligands.

14 he propeptides of BMP-2, -4, -7, and -10 and GDF-5, but not GDF-8, and located the BMP/GDF binding si

15 ifferent stages of development, we show that GDF-5 can increase both the size of the early cartilage

16 that at later stages of skeletal development GDF-5 can increase proliferation of chondrocytes.

17 To investigate how GDF-5 controls skeletogenesis, we overexpressed GDF-5 du

18 -5 controls skeletogenesis, we overexpressed GDF-5 during chick limb development using the retrovirus

19 Finally, our data show that levels of GDF-5 expression/activity are important in controlling t

20 we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may re

21 early steps of chondrogenesis, we show that GDF-5 increases chondrogenesis in a dose-dependent manne

22 In contrast, pulse labelling experiments of GDF-5-infected limbs showed that at later stages of skel

23 Thus, here we show two mechanisms of how GDF-5 may control different stages of skeletogenesis.

24 owever, cell suspension cultures showed that GDF-5 might act at these stages by increasing cell adhes

25 ated with the joint master regulator protein GDF-5 were implanted close to incipient joints in mouse

26 ubfamily, including BMP-2, BMP-4, BMP-7, and GDF-5, with similar kinetics and ligand binding domains

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