ライフサイエンスコーパス: GDM

1 GDM and HDP diagnoses were self-reported for each pregna

2 GDM cases had higher geometric mean U-Cd (0.39 mug/g Cr;

3 GDM may modulate both local and circulating levels of MM

4 GDM occurred among 1,405 (5.2%) women.

5 GDM was associated with a series of retinal arteriolar a

6 GDM was diagnosed using the 2004 American Diabetes Assoc

7 GDM-exposed offspring of mothers with a protein intake i

8 We used 140 GDM cases and 481 randomly selected noncase subcohort me

9 a prospective cohort of pregnant women (186 GDM cases and 191 women who remained eu-glycemic through

10 thylation in placenta and cord blood from 27 GDM exposed and 21 unexposed offspring.

11 At gestational day (GD) 12.5, GDM produced a hyperglycemic, hyperleptinemic maternal s

12 rnal preexisting type 2 diabetes (n = 6496), GDM diagnosed at 26 weeks' gestation or earlier (n = 745

13 In addition, GDM+MIA heightened the maternal inflammatory state and g

14 en, Infant Feeding and Type 2 Diabetes After GDM Pregnancy (SWIFT), which is a prospective cohort of

15 Lactation may prevent DM after GDM delivery.

16 ted with lower 2-year incidences of DM after GDM pregnancy.

17 iod via oral glucose tolerance testing after GDM, which is a time-consuming and inconvenient procedur

18 nt in maternal plasma of normal (n = 13) and GDM (n = 7) pregnancies.

19 ose mothers had both pregravid BMI >/=25 and GDM were at higher risk of an earlier transition to pubi

20 not modify the association between U-Cd and GDM (p = 0.26).

21 he association between body burden of Cd and GDM risk.

22 ysis was conducted on ECFCs from control and GDM pregnancies.

23 differentially expressed between control and GDM-exposed ECFCs.

24 uggest an interaction between gingivitis and GDM.

25 s associated with obesity, hypertension, and GDM in adult women.

26 ciation between a history of infertility and GDM was assessed prospectively among 40,773 eligible pre

27 available epidemiologic studies on iron and GDM.

28 ncreased during gestation in both normal and GDM pregnancies; however, the increase was significantly

29 s from pregnant women with late-onset PE and GDM compared to controls.

30 ulated genes were found in late-onset PE and GDM placentas, which may suggest that these conditions c

31 ack of association between periodontitis and GDM (OR = 0.74; 95% CI = 0.40 to 1.38).

32 ne the association between periodontitis and GDM among non-smoking pregnant females.

33 ficant association between periodontitis and GDM in the meta-analyses of four cross-sectional studies

34 ng the association between periodontitis and GDM.

35 sitive association between periodontitis and GDM.

36 ith no association between periodontitis and GDM.

37 Associations between LCD scores and GDM risk were not significantly modified by age, parity,

38 14, approximately 10-18 weeks earlier before GDM is typically screened for.

39 parameters in a possible association between GDM and gingivitis.

40 ure studies to elucidate differences between GDM and T2D.

41 suggested that a strong link exists between GDM and T2D.

42 ic reduction on intragenic regions from both GDM and preeclampsia compared to healthy controls.

43 ST, 1-2 for NR3C1, and one for ALUs) in both GDM groups, compared with controls, in both analyzed tis

44 athers, with stronger associations when both GDM and GH were present.

45 offspring (HR, 1.21; 95% CI, 0.97-1.52), but GDM diagnosed at 26 weeks or earlier remained so (HR, 1.

46 ildren born after pregnancies complicated by GDM.

47 ernal glucose exposure below that defined by GDM [the Hyperglycemia and Adverse Pregnancy Outcome (HA

48 No genes were significantly regulated by GDM.

49 s in Nrf2 or NQO1 promoters was unaltered by GDM, decreased DJ-1 and increased phosphorylated glycoge

50 clusion, we found associations of a combined GDM/GH indicator with cardiometabolic disease in mothers

51 We evaluated a combined GDM/GH risk indicator in both mothers and fathers becaus

52 Health Organization (WHO) criteria to define GDM: >/=7.0 mmol/L for fasting glucose and/or >/=7.8 mmo

53 cally treated GDM, 98 with insulin-dependent GDM, and 65 without GDM.

54 a history of diabetes, 240 (7.1%) developed GDM.

55 11 years had a 51% higher risk of developing GDM (95% confidence interval: 1.10, 2.07) after adjustme

56 and confer a higher likelihood of developing GDM.

57 Treatment options for gestational diabetes (GDM) are limited.

58 conception and risk of gestational diabetes (GDM) are sparse, although common underlying mechanisms a

59 ing foetus to maternal gestational diabetes (GDM) has been shown to programme future risk of diabetes

60 years of mothers with gestational diabetes (GDM) in a cross-sectional study.

61 hild dyads affected by gestational diabetes (GDM).

62 of mothers with preexisting type 2 diabetes, GDM diagnosed at 26 weeks or earlier, GDM diagnosed afte

63 erance test (OGTT) was performed to diagnose GDM.

64 it from a maternal low protein intake as did GDM-exposed offspring.Overall, our results provide littl

65 Although the role of exosomes during GDM remains to be fully elucidated, exosome profiles may

66 betes, GDM diagnosed at 26 weeks or earlier, GDM diagnosed after 26 weeks, and no diabetes, respectiv

67 nd cholesterol were associated with elevated GDM risk.

68 rt of 1208 Chinese women who had experienced GDM.

69 eight reduction in women who had experienced GDM.

70 or earlier, and 0.98 (95% CI, 0.84-1.15) for GDM diagnosed after 26 weeks relative to no exposure.

71 per 1-kg/m(2) increase) were 32% and 22% for GDM and HDP, respectively.

72 ype 2 diabetes, 1.63 (95% CI, 1.35-1.97) for GDM diagnosed at 26 weeks or earlier, and 0.98 (95% CI,

73 e interval: 1.10, 2.07) after adjustment for GDM risk factors.

74 ing early pregnancy should be considered for GDM prevention.

75 atory mediators and may be a risk factor for GDM.

76 This makes them an ideal model for GDM.

77 between high ALT and overweight/obesity for GDM.

78 Odds ratios for GDM increased with increasing U-Cd tertile (OR = 1.64; 9

79 The USPSTF recommends screening for GDM in asymptomatic pregnant women after 24 weeks of ges

80 lance of benefits and harms of screening for GDM in asymptomatic pregnant women before 24 weeks of ge

81 Early breastfeeding support for GDM women with these risk factors may be needed to ensur

82 dence on the accuracy of screening tests for GDM, the benefits and harms of screening before and afte

83 Exosomes isolated from GDM pregnancies significantly increased the release of p

84 st metabolomics study of the transition from GDM to T2D validated in an independent testing set, faci

85 ics signature to predict the transition from GDM to T2D.

86 of periodontitis was 40% in the case group (GDM) and 46.3% in the control group.

87 ,093 women, 65 (3%) had IGT and 118 (6%) had GDM.

88 Finally, 1332 (7.7%) women had GDM.

89 re good at identifying women who do not have GDM.

90 OGCT is better at identifying women who have GDM.

91 NHGU is further blunted in IGT/GDM.

92 tolerance/gestational diabetes mellitus (IGT/GDM).

93 ), normal pregnant (P), or pregnant with IGT/GDM (pregnant dogs fed a high-fat and -fructose diet [P-

94 In GDM cells, the lipid peroxidation product 4-hydroxynonen

95 .40 SD; 95% CI: -0.03, 0.83 SD; P = 0.07) in GDM-exposed offspring and a tendency for a higher total

96 ox homeostasis were significantly altered in GDM and associated with increased mitochondrial superoxi

97 was 93 +/- 15 g/d (16% +/- 3% of energy) in GDM-exposed women and 90 +/- 14 g/d (16% +/- 2% of energ

98 PLAC8 was highly expressed in GDM-exposed ECFCs, and PLAC8 expression correlated with

99 r, the increase was significantly greater in GDM ( approximately 2.2-fold, approximately 1.5-fold, an

100 terol, and glucose parameters were higher in GDM compared with POT (P <0.05).

101 pregnancy may improve glucose homeostasis in GDM-exposed and male offspring.

102 te the causal role of hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq(-/-) ) and wild-t

103 While IR is impaired in GDM-placenta, it is unaffected in GDM-platelet.

104 nstream elements were significantly lower in GDM-trophoblast and showed no response to the insulin st

105 normal cells, and overexpression of Nrf2 in GDM cells partially restored NQO1 induction.

106 Knockdown of PLAC8 in GDM-exposed ECFCs improved proliferation and senescence

107 ors mediating the down-regulation of SERT in GDM trophoblast.

108 findings with clinical samples show that in GDM-associated defect on IR is tissue type-dependent.

109 should be a leading factor for thrombosis in GDM maternal blood.

110 mpaired in GDM-placenta, it is unaffected in GDM-platelet.

111 We documented 867 incident GDM pregnancies during 10 y follow-up.

112 prepregnancy Mediterranean diet on incident GDM and HDP and proportions mediated through prepregnanc

113 al blockage, is associated with an increased GDM risk.

114 (1.31-2.00)] were associated with increased GDM risk.

115 tanding of environmental factors influencing GDM may facilitate early identification of women at high

116 age (OR: 1.05; 95% CI: 1.01, 1.08), insulin GDM treatment (OR: 3.11; 95% CI: 1.37, 7.05), and subopt

117 ancy was associated with substantially lower GDM risk.

118 self-reported pregravid obesity and maternal GDM with timing of the daughter's transition to pubertal

119 to 44 weeks' gestation, exposure to maternal GDM diagnosed by 26 weeks' gestation was associated with

120 anced electrocatalysts, gas diffusion media (GDM), ionomers, polymer electrolyte membranes (PEMs), an

121 Gestational diabetes mellitus (GDM) affects 3-14% of pregnancies, with 20-50% of these

122 a history of gestational diabetes mellitus (GDM) and females without GDM during pregnancy.

123 females with gestational diabetes mellitus (GDM) and females without GDM.

124 ssociation of gestational diabetes mellitus (GDM) and gestational hypertension (GH) with cardiometabo

125 s and risk of gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) remai

126 Gestational diabetes mellitus (GDM) and metabolic syndrome have been related to periodo

127 ation between gestational diabetes mellitus (GDM) and periodontitis.

128 g the risk of gestational diabetes mellitus (GDM) and preeclampsia.

129 of women with gestational diabetes mellitus (GDM) and systemically healthy counterparts with differen

130 e in utero to gestational diabetes mellitus (GDM) and/or maternal immune activation (MIA).

131 l obesity and gestational diabetes mellitus (GDM) are associated with obesity and diabetes risk in of

132 a history of gestational diabetes mellitus (GDM) are at high risk of developing type 2 diabetes mell

133 psia (PE) and gestational diabetes mellitus (GDM) are common complications of pregnancy, but the mech

134 s of treating gestational diabetes mellitus (GDM) are not well-established.

135 eclampsia and gestational diabetes mellitus (GDM) are the most common clinical conditions in pregnanc

136 nce (IGT) and gestational diabetes mellitus (GDM) during pregnancy from clinical glucose tolerance te

137 Women with gestational diabetes mellitus (GDM) have a high risk of developing postpartum type 2 di

138 odontitis and gestational diabetes mellitus (GDM) in the current literature.

139 o exposure to gestational diabetes mellitus (GDM) is associated with an increased risk of type 2 diab

140 Gestational diabetes mellitus (GDM) is conventionally confirmed with oral glucose toler

141 Gestational diabetes mellitus (GDM) is defined as varying glucose intolerance, with fir

142 evelopment of gestational diabetes mellitus (GDM) is largely unknown.

143 e exposure to gestational diabetes mellitus (GDM) is linked to development of hypertension, obesity,

144 ion of Cd and gestational diabetes mellitus (GDM) is unknown.

145 he effects of gestational diabetes mellitus (GDM) on the epigenome of the next generation, cord blood

146 omplicated by gestational diabetes mellitus (GDM) remains to be established.

147 us (DM) after gestational diabetes mellitus (GDM) remains uncertain.

148 n and risk of gestational diabetes mellitus (GDM) remains unknown.

149 besity and/or gestational diabetes mellitus (GDM) was associated with early puberty in girls.

150 evelopment of gestational diabetes mellitus (GDM), a common pregnancy complication which has short-te

151 ation between gestational diabetes mellitus (GDM), a state of transient hyperglycemia during pregnanc

152 nce (IGT) and gestational diabetes mellitus (GDM), and we used linear regression models to estimate a

153 ng method for gestational diabetes mellitus (GDM), but other options are being considered.

154 ecially after gestational diabetes mellitus (GDM), have been linked to increased risk of adult type 2

155 ls results in gestational diabetes mellitus (GDM), reduced beta-cell proliferation, and failure to ex

156 found that in gestational diabetes mellitus (GDM), whereas free plasma 5-HT levels were elevated, the

157 a history of gestational diabetes mellitus (GDM), which may affect their chances for successful brea

158 oblast of the gestational diabetes mellitus (GDM)-associated placenta, SERT is found entrapped in the

159 also predicts gestational diabetes mellitus (GDM).

160 s involved in gestational diabetes mellitus (GDM).

161 treatment of gestational diabetes mellitus (GDM).

162 en with prior gestational diabetes mellitus (GDM).

163 lic status in gestational diabetes mellitus (GDM).

164 thogenesis of gestational diabetes mellitus (GDM).

165 patients with gestational diabetes mellitus (GDM).

166 menarche and gestational diabetes mellitus (GDM).

167 gnancies with gestational diabetes mellitus (GDM).Six hundred eight women with an index pregnancy aff

168 to women with gestational diabetes mellitus (GDM).The analysis included 918 mother-singleton child dy

169 duced risk of gestational diabetes mellitus (GDM); however, the association of composite healthy life

170 Compared with having neither GDM nor GH, having either was associated with incident d

171 tric indices were higher in the GDM than non-GDM group (P <0.0001).

172 er in the GDM with gingivitis group than non-GDM with gingivitis group (P = 0.044).

173 ng pregnancy was associated with IGT but not GDM.

174 glucose was significantly higher for both O-GDM and O-T1D compared with O-BP (P < 0.05).

175 C1A gene expression in muscle was lower in O-GDM compared with O-BP (P = 0.0003), whereas no differen

176 the increased risk of metabolic disease in O-GDM.

177 te to the decreased PPARGC1A expression in O-GDM.

178 women with gestational diabetes mellitus (O-GDM) or type 1 diabetes (O-T1D) and of women from the ba

179 l recent studies have reported an absence of GDM phenotype in their colony.

180 Multivariable-adjusted RRs (95% CIs) of GDM for comparisons of highest with lowest quartiles wer

181 A first diagnosis of GDM was reported by 357 women (7.5%).

182 We examined the effects of GDM on the proteome, redox status, and nuclear factor er

183 enes that contribute to impaired function of GDM-exposed ECFCs and to evaluate for evidence of altere

184 In women with a history of GDM, greater intakes of total iron, dietary heme iron, a

185 hers do not use the db/+ mouse as a model of GDM unless they are certain the phenotype remains in the

186 ove treatments, appropriate animal models of GDM are crucial.

187 uence of risk variables in the occurrence of GDM is tested through univariate analysis and multivaria

188 ar, may be implicated in the pathogenesis of GDM, with significant associations and incremental predi

189 al-age profile of PdEs in maternal plasma of GDM with normal pregnancies and to determine the effect

190 ow that the decrease in 5-HT uptake rates of GDM trophoblast is the consequence of defective insulin

191 timulation up-regulated 5-HT uptake rates of GDM-platelets as it does in the control group.

192 Similarly, the 5-HT uptake rates of GDM-trophoblast and the SERT expression on their surface

193 ghest decile) experienced a 74% reduction of GDM risk (95% CI; 0.09-0.77) compared with women whose c

194 core was associated with a 21% lower risk of GDM (95% confidence interval: 0.65, 0.96) after adjustme

195 dels were used to determine relative risk of GDM (n = 140 cases) in relation to healthy lifestyle.

196 nean diet was associated with higher risk of GDM (OR: 1.35; 95% CI: 1.02, 1.60) and HDP (OR: 1.41; 95

197 ere related to a substantially lower risk of GDM (ORQ4-Q1 0.04 [0.01, 0.06]).

198 cantly associated with a 39% greater risk of GDM (risk ratio (RR) = 1.39, 95% confidence interval (CI

199 valuate available data examining the risk of GDM associated with dietary iron, iron supplementation,

200 est that body burden of Cd increases risk of GDM in a dose-dependent manner.

201 In a comparison of the multivariable risk of GDM in participants in the fourth and first quartiles of

202 arly identification of women at high risk of GDM.

203 of protein and fat to minimize their risk of GDM.

204 w-carbohydrate dietary patterns with risk of GDM.

205 enarche may identify women at higher risk of GDM.

206 station, on average, with subsequent risk of GDM.

207 ignificantly associated with a lower risk of GDM.

208 ictive models, capturing the future risks of GDM in the temporally aggregated EHRs.

209 r further adjusting for traditional risks of GDM, arteriolar branching angle remained significantly l

210 The adjusted RR of GDM was estimated for quintiles of total fat, specific f

211 nificantly altered in the umbilical veins of GDM and preeclampsia.

212 of 64,232 couples were categorized based on GDM/GH status (neither, either, or both).

213 ts of the prepregnancy Mediterranean diet on GDM and HDP risk.

214 During 12 years of follow-up, information on GDM diagnosis was obtained for each live birth.

215 and clinical periodontal parameters in only GDM group.

216 were exposed to either vehicle, GDM, MIA or GDM+MIA.

217 ated genes in placental biopsies between PE, GDM, or uncomplicated pregnancy (n = 10 each group).

218 machine learning models with EHRs to predict GDM, which will facilitate personalized medicine in mate

219 trimester even within normal range predicted GDM risk, further enhanced by overweight/obesity.

220 eletion in maternal beta-cells also produced GDM, with inadequate beta-cell expansion accompanied by

221 One-third of women with recent GDM experienced delayed OL.

222 verse cohort of postpartum women with recent GDM.

223 present a novel approach to alleviating some GDM-associated complications.

224 exposures in age at menarche and subsequent GDM risk.

225 ly-to-midpregnancy in relation to subsequent GDM risk in a case-control study of 107 case subjects wi

226 higher in the GDM with gingivitis group than GDM without gingivitis group.

227 al weight gain) may impart greater risk than GDM, particularly when glucose levels are modestly eleva

228 n neonatal endothelial progenitor cells that GDM exposure in utero leads to altered gene expression a

229 ere, we investigated a novel hypothesis that GDM-associated defects in platelet IR should change thei

230 In conclusion, we were unable to acquire the GDM phenotype in any of our experiments, and we recommen

231 ned at the time of cesarean section from the GDM and non-diabetic subjects (n = 6 for each group), an

232 However, the GDM-associated defect in insulin signaling hampers the d

233 and saliva sRANKL levels were higher in the GDM group (P <0.05).

234 nd anthropometric indices were higher in the GDM than non-GDM group (P <0.0001).

235 saliva sRANKL (P <0.0001) were higher in the GDM with gingivitis group than GDM without gingivitis gr

236 Saliva IL-6 level was higher in the GDM with gingivitis group than non-GDM with gingivitis g

237 T is found entrapped in the cytoplasm of the GDM-trophoblast.

238 e data, we hypothesize that children born to GDM mothers and exposed to midgestation infections have

239 isk of hyperglycemia among offspring born to GDM mothers in Tianjin, China.

240 xposed to GDM at </=26 weeks, 180 exposed to GDM at >26 weeks, and 2963 unexposed).

241 preexisting type 2 diabetes, 130 exposed to GDM at </=26 weeks, 180 exposed to GDM at >26 weeks, and

242 rming cells (ECFCs) from neonates exposed to GDM exhibit impaired function.

243 pport the idea that intrauterine exposure to GDM has long-lasting effects on the epigenome of the off

244 esents a unique molecular pathway leading to GDM where the defect is located in TRPM6.

245 ewborns of mothers with dietetically treated GDM, 98 with insulin-dependent GDM, and 65 without GDM.

246 Treating GDM results in less preeclampsia, shoulder dystocia, and

247 ttle evidence of short-term harm of treating GDM other than an increased demand for services.

248 Ontology analysis using loci bearing unique GDM- and preeclampsia-specific loss-of-5hmC indicated it

249 mouse brains were exposed to either vehicle, GDM, MIA or GDM+MIA.

250 se-control study includes 360 women, 90 with GDM and 270 controls.

251 iodontitis was significantly associated with GDM (odds ratio = 3.00, 95% confidence interval = 1.19 t

252 ying reasons for infertility associated with GDM included ovulation disorders (RR = 1.52, 95% CI: 1.2

253 All 3 scores were inversely associated with GDM risk after adjustment for several covariables.

254 ALT levels were positively associated with GDM risk without a clear threshold.

255 l-food sources is positively associated with GDM risk, whereas a prepregnancy low-carbohydrate dietar

256 78, 1.61; P = 0.55) were not associated with GDM risk.

257 GF-I/IGFBP-3 were positively associated with GDM risk; adjusted odds ratio (OR) comparing the highest

258 nt exposures were positively associated with GDM.

259 uggest that periodontitis is associated with GDM.

260 influence of risk variables associated with GDM.

261 ing as significant variables associated with GDM: maternal age (OR = 2.65; 95% CI = 1.97 to 3.56), ch

262 PFOS and PFHxS associations with GDM (53 cases) were in a similar direction, but less pre

263 n resistance, which frequently coexists with GDM and obesity, could independently contribute to dysre

264 included 50 females who were diagnosed with GDM and 50 age- and hospital-matched females without dia

265 a prospective cohort of women diagnosed with GDM who delivered at Kaiser Permanente Northern Californ

266 association of cervical mucus disorder with GDM was of borderline significance (RR = 1.70, 95% CI: 0

267 There were 101 females with GDM and 66 females without GDM.

268 iation is not different between females with GDM and females without GDM during pregnancy.

269 e of periodontal status between females with GDM and females without GDM during pregnancy.

270 Females with GDM had significantly higher mean PD and CAL, more sites

271 seems to be more pronounced in females with GDM.

272 l-range risk associations of ALT levels with GDM.

273 d blood samples from infants of mothers with GDM (group 1) and infants with prenatal growth restraint

274 hnicity and maternal education, mothers with GDM had narrower arteriolar caliber (-1.6 mum; 95% Confi

275 identified in matched pairs of mothers with GDM or without GDM (matched on age group, health region,

276 emained significantly larger in mothers with GDM than those without GDM (2.0 degrees ; 95% CI: 0.5 de

277 site healthy lifestyle during pregnancy with GDM has not been examined.

278 case-control study of 107 case subjects with GDM and 214 control subjects without GDM, with blood sam

279 Seventy-one women with GDM and gingivitis (Gg), 30 women with GDM and healthy p

280 with GDM and gingivitis (Gg), 30 women with GDM and healthy periodontium (Gh), 28 systemically and p

281 We identified women with GDM and their newborns.

282 min D supplementation in pregnant women with GDM had beneficial effects on glycemia and total and LDL

283 Magnesium supplementation among women with GDM had beneficial effects on metabolic status and pregn

284 A prospective cohort of 1,035 women with GDM pregnancy were enrolled at 6-9 weeks postpartum (bas

285 Among 110,879 women with GDM, 9173 women (8.3%) were treated with glyburide (n =

286 linical trial was performed in 70 women with GDM.

287 s in magnesium-deficient pregnant women with GDM.

288 s of oxidative stress in pregnant women with GDM.

289 linical trial was conducted in 54 women with GDM.

290 8 with insulin-dependent GDM, and 65 without GDM.

291 m offspring born to mothers with and without GDM.

292 diabetes mellitus (GDM) and females without GDM during pregnancy.

293 between females with GDM and females without GDM during pregnancy.

294 between females with GDM and females without GDM during pregnancy.

295 101 females with GDM and 66 females without GDM.

296 diabetes mellitus (GDM) and females without GDM.

297 degrees , 3.3 degrees ) than mothers without GDM.

298 matched pairs of mothers with GDM or without GDM (matched on age group, health region, and year of de

299 ts with GDM and 214 control subjects without GDM, with blood sample collection at gestational weeks 1

300 arger in mothers with GDM than those without GDM (2.0 degrees ; 95% CI: 0.5 degrees , 3.6 degrees ).