ライフサイエンスコーパス: GDP-bound form

1 sent the crystal structure of RasS17N in the GDP-bound form.

2 an active, GTP-bound form, and an inactive, GDP-bound form.

3 ebGAP, converting Rheb from a GTP-bound to a GDP-bound form.

4 ally activated GTP-bound Ras to the inactive GDP-bound form.

5 ally disordered state similar to that of the GDP-bound form.

6 ctive GTP-bound conformation and an inactive GDP-bound form.

7 direct allosteric effect that stabilizes the GDP-bound form.

8 ith an active GTP-bound form and an inactive GDP-bound form.

9 ogue of cofactor D, specifically when in the GDP-bound form.

10 hes cycling between active GTP- and inactive GDP-bound forms.

11 a(i1), G alpha(i2), and G alpha(i3) in their GDP-bound forms.

12 e conformational differences between GTP and GDP-bound forms.

13 t ARF6-T27N, which is predicted to be in the GDP-bound form, also stimulated apical endocytosis, thou

14 e (GTPase) Ran in its guanosine diphosphate (GDP)-bound form and to karyopherin beta.

15 s are GTPases that cycle between an inactive GDP-bound form and an active GTP-bound conformation.

16 movement by oscillating between an inactive GDP-bound form and an active GTP-bound form.

17 kDa proteins which cycle between an inactive GDP-bound form and an active GTP-bound state.

18 Arfs cycle between an inactive, cytoplasmic, GDP-bound form and an active, membrane-associated, GTP-b

19 for the GTP-bound form of Ypt1p than for the GDP-bound form, and is specific to a subgroup of exocyti

20 w is that Rabs are soluble in their inactive GDP-bound form, and only upon activation and conversion

21 es in the low-frequency modes of the GTP and GDP-bound forms appear to play a role in ligand binding.

22 Rabs in their GDP-bound form are kept soluble in the cytoplasm by the

23 of the Galpha subdomain, whereas the apo and GDP-bound forms are considerably more open and dynamic.

24 AGS3 stabilizes Galpha(i3) in its GDP-bound form, as it inhibits the increase in tryptopha

25 On the other hand, the inhibition of the GDP-bound form decreased Vmax, but did not alter the Ca2

26 tely 20-kDa GTPases that are inactive in the GDP-bound form, depends on guanine nucleotide-exchange p

27 eam activator Concertina, in its GTP but not GDP bound form, dissociates DRhoGEF2 from microtubule ti

28 ine nucleotide binding state of Rad with the GDP-bound form exhibiting 5-fold better binding to CaM t

29 , a protein that extracts Rab GTPases in the GDP-bound form from membranes, potently inhibits fusion.

30 Comparison with the structure of EF-Tu in GDP-bound form from Thermus aquaticus shows that althoug

31 We propose that conversion of ARF6 into the GDP-bound form in the apical domain of hair cells is ess

32 s is determined by the ratio of GTP-bound to GDP-bound forms in the cell.

33 th regions also stabilize G alpha(i1) in its GDP-bound form, inhibiting the increase in intrinsic try

34 Conversion from the GTP- to the GDP-bound form is achieved by a weak endogenous GTPase a

35 sults suggest that conversion of ARF6 to its GDP-bound form is necessary for final stabilization of t

36 of a Rho family member, whereas the inactive GDP-bound form is sequestered primarily in the cytoplasm

37 ir ability to cycle between the GTP- and the GDP-bound forms is thought to be crucial for their funct

38 ncreased rate of cycling between the GTP and GDP-bound forms leading to cell transformation.

39 However, unlike the wild-type protein, the GDP-bound form of alpha(T)E203A was constitutively activ

40 re particularly important in stabilizing the GDP-bound form of ARD1.

41 iates preferentially with Cdc24, whereas the GDP-bound form of Bud1 associates with Bem1.

42 we found that AGS3 binds exclusively to the GDP-bound form of Galpha(i3).

43 o, and this interaction is stronger with the GDP-bound form of Galphao.

44 8 bound exclusively to the GTP-, but not the GDP-bound form of Ha-Ras.

45 somewhat different mechanism, given that the GDP-bound form of many G protein alpha subunits does not

46 hat REP forms a stable complex only with the GDP-bound form of Rab but not the GTP-bound form, sugges

47 o show that, although FIPs interact with the GDP-bound form of Rab11 in vitro, the binding affinity (

48 GTP-bound RAB7, but not a dominant-negative GDP-bound form of RAB7, promoting rapid transfer and lys

49 show that RPGR primarily associates with the GDP-bound form of RAB8A and stimulates GDP/GTP nucleotid

50 ug-like molecules that bind to a site on the GDP-bound form of Ral.

51 s have shown that NTF2 binds directly to the GDP-bound form of Ran/TC4 and to proteins of the nuclear

52 port pathway and that the association of the GDP-bound form of Ran/TC4 with NTF2 helps define vectori

53 sociation inhibitor (GDI) complexes with the GDP-bound form of Rho and inhibits its activation.

54 fect of product inhibition by binding to the GDP-bound form of RhoA with a Kd of 6 microM in comparis

55 The GDP-bound form of the GTGs exhibits greater ABA binding

56 e-depleted form of Cdc42Hs and weakly to the GDP-bound form of the GTP-binding protein but does not b

57 o the structures for the signaling-inactive, GDP-bound form of the protein, contrary to what has been

58 or the selective interaction of REP with the GDP-bound form of the Rab substrate.

59 A resolution X-ray crystal structure of the GDP-bound form of the RanQ69L mutant that is used extens

60 n inhibitors (GDIs), form a complex with the GDP-bound form of the Rho family of monomeric G proteins

61 AlF4--induced complex formation between the GDP-bound form of the Rho subfamily G-protein Cdc42Hs an

62 between eIF-5A and TGase is specific for the GDP-bound form of the TGase and is not detected when the

63 switch regions of the GTP-bound but not the GDP-bound form of this mutant adopt an "open conformatio

64 Moreover, unlike the GDP-bound forms of alphaT*, alphaT*(R238A) and alphaT*(R

65 rast, mu4 binds equally well to the GTP- and GDP-bound forms of ARF1 and is less dependent on switch

66 ecially surprising was that the GMP-PCP- and GDP-bound forms of Cdc42 did not show detectable differe

67 YopT cleaves GTP- and GDP-bound forms of RhoA equally, suggesting that the cle

68 e RopGAP CRIB domain interacts with GTP- and GDP-bound forms of Rop, as well as the transitional stat

69 The distribution between the GTP- and GDP-bound forms of the protein is regulated by evolution

70 ll GTPases may be regulated by both GTP- and GDP-bound forms of the protein.

71 The structures of the GDP-bound forms of the wild-type and mutant proteins are

72 latively low affinity for the GTPgammaS- and GDP-bound forms of these proteins.

73 fectors can distinguish between the GTP- and GDP-bound forms of this G-protein and ensure that the ne

74 on that is intermediate between the GTP- and GDP-bound forms of wild-type Ras and that is similar to

75 es for both active (GTP-bound) and inactive (GDP-bound) forms of Galpha subunits.

76 ild-type Galpha(t) and three of its mutants (GDP-bound form only): F332A, A322S, and Q326A that are k

77 lled by the interconversion between GTP- and GDP-bound forms partly regulated by the binding of the g

78 subunits are thought to lock G alpha in the GDP-bound form, prevent it from activating its effector,

79 bound form promoted by GEFs and its inactive GDP-bound form promoted by GAPs to affect the control of

80 that cycles between a guanosine diphosphate (GDP)-bound form (RanGDP) and a guanosine triphosphate (G

81 h p97 and NTF2 are specific for the GTP- and GDP-bound forms, respectively.

82 ild-type RhoA is predominantly in the [(32)P]GDP-bound form, RhoA(Val-14) is predominantly in the [(3

83 other guanine nucleotide binding proteins in GDP-bound forms show that the Mg2+ co-ordination pattern

84 ycle between GTP- and guanosine diphosphate (GDP)-bound forms, suggesting that regulation of RhoH exp

85 he transition state (TDalphaGDP*AMF) and the GDP-bound form (TDalphaGDP) with RGS-r and PDE, respecti

86 on the mutants that show that even in their GDP-bound forms, the A322S and F332A mutants acquire an

87 s trigger conversion of Ras from an inactive GDP-bound form to an active GTP-bound form.

88 s), which convert them from their "inactive" GDP-bound form to the "active" GTP-bound form.

89 synthesis initiation factor 2 (eIF2) from a GDP-bound form to the active eIF2-GTP complex.

90 We fused the Rho family GTPase Cdc42 in its GDP-bound form to the photosensory domain of phytochrome

91 Pgamma complexed with Talpha (both GTP- and GDP-bound forms) was not ADP-ribosylated; however, agmat