ライフサイエンスコーパス: GDP

1 GDP and GTP accelerate and decelerate Drp1/actin binding

2 GDP polyribonucleotidyltransferase (PRNTase) is an uncon

3 Adaptive VL achieved an ICER <1x GDP if second-line ART and VL costs simultaneously decre

4 is estimated to be equivalent to 17% of 2010 GDP, or $14.5 trillion in the 175 countries assessed wit

5 latory (GPR) motif binds inactive Galphai1/3-GDP.

6 Product mass suggests formation of a GDP(S) adduct along with a second thiophosphorylation, i

7 il displays preference for a GTP-type over a GDP-type microtubule lattice and contributes to the inte

8 tive mutant of Rab1), and GFP-LdRab1:S22N (a GDP-locked dominant negative mutant of Rab1).

9 imilar to Streptomyces hygroscopicus VldE, a GDP-valienol-dependent pseudoglycosyltransferase enzyme.

10 glutinin I (UEA-I) was completely abrogated, GDP-Fuc was still detected in the mutant.

11 nerate GDP-Arap, while synthesizing abundant GDP-fucose.

12 Allowing GDP-to-GTP exchange on terminal subunits in simulations

13 lopmental syndrome, likely caused by altered GDP/GTP binding that inactivate the protein and induce G

14 ystal structures of apo form and GTP analog, GDP, and guanosine-3',5'-bisdiphosphate (ppGpp)-bound Bi

15 p = 0.003; women: r = -0.369, p < 0.001) and GDP per capita (men: r = -0.164, p = 0.036; women: r = -

16 s dGTP and TTP select for substrates ADP and GDP, respectively.

17 a transition-state analogue with AlF4(-) and GDP complexed to G1alpha, a small G protein, heralded a

18 of the Galpha subdomain, whereas the apo and GDP-bound forms are considerably more open and dynamic.

19 gross domestic product [GDP] per capita, and GDP per capita per disability-adjusted life-year [DALY])

20 oups, geographic regions, age, education and GDP levels, and increasing trend was observed over the 5

21 is mainly dimeric in the nucleotide-free and GDP-bound states, while it forms monomers upon GTP bindi

22 A competition assay between GDP and GDP analogues in the GpppA formation and pRNA transfer a

23 ay enzymes GDP-mannose dehydratase (GMD) and GDP-fucose synthetase (GMER) were expressed ectopically;

24 ion of GDP-mannose 4,6-dehydratase (GMD) and GDP-L-fucose synthase (FS), is conserved in the parasite

25 ed by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxymannose 3,5-epimerase-4-reductase (FX

26 ed by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxymannose 3,5-epimerase-4-reductase (FX

27 ts quite different structures in its GTP and GDP forms.

28 [koff = 0.093 and 0.148 min(-1) for GTP and GDP, respectively).

29 lled by the interconversion between GTP- and GDP-bound forms partly regulated by the binding of the g

30 s the energy difference between the GTP- and GDP-tubulin thermodynamic states.

31 actose 1-phosphate, glucose 1-phosphate, and GDP-glucose when grown on galactose.

32 sed as a proportion of potential GDP, annual GDP losses were greatest in low-income and middle-income

33 ll-length BipA from Escherichia coli in apo, GDP-, and ppGpp-bound forms.

34 Upon arl2 RNA intereference, Arl2-GDP expression, or arl2 deletions, microtubule abnormali

35 ne nucleotide exchange factor (GEF) for ARL3-GDP.

36 capable of generating GDP-glucose as well as GDP-mannose.

37 This is the first report of a bacterial GDP-regulated thioesterase and of covalent linkage of th

38 A competition assay between GDP and GDP analogues in the GpppA formation and pRNA tr

39 The cycling between GDP- and GTP- bound forms of the Ras protein is partly r

40 hich likely regulates RHEB shuttling between GDP-bound and GTP-bound forms.

41 bit subtle differences in their GTP-binding, GDP/GTP-exchange, and GTP-hydrolysis activities, but the

42 e presence of ML297 or the G-protein blocker GDP-beta-S, DA induced a further decrease in spike firin

43 fs) by accelerating the replacement of bound GDP with GTP.

44 s, requires sequential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deox

45 s, requires sequential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deox

46 generated, we characterized three candidate GDP-glucose pyrophosphorylases.

47 relative to Cote d'Ivoire's 2013 per capita GDP ($1500).

48 to be 0.043 per 1000 to cost 0.5 per capita GDP per DALY.

49 per 1000 in Nigeria, to cost 0.5 per capita GDP per DALY.

50 tural dimensions, controlling for per capita GDP, the 1990 baseline level of coverage, percent urban

51 complexes activate Rab GTPases by catalyzing GDP/GTP nucleotide exchange.

52 Agonist-receptor binding causes GDP-to-GTP exchange and dissociation of the Galpha subun

53 attice twist from that of the also compacted GDP-MT.

54 h DCX specifically recognizes this compacted GDP-like MT lattice.

55 rneurons in both generating and coordinating GDPs across the hippocampus.

56 However, distributing current GDP growth more equally across income groups as in the 1

57 r-pairs bound (CDP/dATP, UDP/dATP, ADP/dGTP, GDP/TTP) that reveal the conformational rearrangements r

58 identification of guanosine 5'-diphosphate (GDP) as a promising hepcidin-binding agent.

59 e G12X mutants and guanosine 5'-diphosphate (GDP) or GDPnP (a stable GTP analogue) were transferred t

60 tion, farnesylated guanosine 5'-diphosphate (GDP)-bound K-Ras4B is predominantly autoinhibited by its

61 De novo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans, requires se

62 De novo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans, requires se

63 s in neonatal rat CA3 pyramidal cells during GDPs.

64 3 pyramidal cells dynamically changes during GDPs from excitatory at the GDPs' onset to inhibitory at

65 ribosome, as observed in the presence of EF4-GDP and P site tRNA.

66 eIF2 GDP/GTP status is regulated by eIF5 (GAP and GDI functio

67 ereby altering the off-rate of GDP from eIF2*GDP/eIF5 complexes.

68 Following GTP hydrolysis, eIF2-GDP is recycled back to TC by its guanine nucleotide exc

69 he complex of eIF2B with its substrate, eIF2-GDP, reaction intermediates, apo-eIF2 and eIF2-GTP, and

70 IF5, thought to primarily function with eIF2-GDP and TC respectively.

71 The unconventional mRNA capping enzyme (GDP polyribonucleotidyltransferase, PRNTase; block V) do

72 rst, the trypanosome de novo pathway enzymes GDP-mannose dehydratase (GMD) and GDP-fucose synthetase

73 for microtubule dynamics do not account for GDP-to-GTP exchange on the growing microtubule end, so o

74 ng of $9.86 (95% CI 3.92-15.8), adjusted for GDP per capita.

75 After adjusting for GDP per capita, length of highways, female illiteracy, t

76 ture that has similar binding affinities for GDP, GTP and other guanine nucleotides.

77 ion being close to its apparent affinity for GDP-bound FtsZ.

78 TP is 10-fold lower than that calculated for GDP.

79 , we showed that the Michaelis constants for GDP and pppAACAG (VSV mRNA-start sequence) are 0.03 and

80 were observed upon substitution of GDPnP for GDP as well as for the G12X mutants relative to wild-typ

81 g CGE-derived interneurons are important for GDP generation; however, their contribution relative to

82 tomyces venezuelae has such a preference for GDP-glucose and can utilize ADP-glucose to some extent t

83 These results establish a requirement for GDP-fucose for L. major viability and predict the existe

84 pha1, and beta2-beta3 are not only vital for GDP release during G protein activation, but they are al

85 erm global decoupling of freight demand from GDP.

86 (FucT) catalyzes the transfer of fucose from GDP-fucose to asparagine-linked GlcNAc of the N-glycan c

87 e FUT1 catalyzes the transfer of fucose from GDP-fucose to terminal galactosyl residues on xyloglucan

88 ments and miniring structures formed by FtsZ-GDP.

89 en the composition of oligomers of free FtsZ-GDP and free FtsZ-GTP formed in solution.

90 d to measure the equilibrium binding of FtsZ-GDP and FtsZ-GTP to ZipA immobilized at controlled densi

91 FtsA* had a similar stabilization of FtsZ-GDP minirings.

92 In the case of FtsZ-GDP, equilibrium binding does not appear to be saturable

93 analyses showed the presence of GDP-fucose (GDP-Fuc), the precursor for all fucosylation reactions,

94 s involved in alpha-1,6 linked fucosylation, GDP-mannose 4, 6-dehydratase (Gmds) and to a lesser exte

95 head domain within the elongation factor G (GDP)-bound ribosome complex.

96 Here, we show that while EF-G*GDP does not stably bind to the ribosome and induce tran

97 the ribosome and induce translocation, EF-G*GDP in complex with phosphate group analogs BeF3(-) and

98 sition in K-Ras4B-GTP; in K-Ras4B(G12C/G12D)-GDP they expose the bound nucleotide which facilitates t

99 ch residues are high (0.78-0.88) in Galphai1*GDP and lower (0.67-0.75) in Galphai1*GTPgammaS, althoug

100 The dynamics at Ax180 is slower in Galphai1*GDP than in Galphai1*GTPgammaS.

101 lF4(-)-insensitive mutant (G42R) of Galphai1-GDP, as observed by size exclusion chromatography and di

102 Finally, a preformed RGS14.Galphai1-GDP complex exhibits full capacity to stimulate the GTPa

103 ) group based on the structure of a RhoA/GAP-GDP-MgF3(-) TSA complex.

104 MD-GMER line lacked the capacity to generate GDP-Arap, while synthesizing abundant GDP-fucose.

105 t not for the GTPase activity that generates GDP (pRNA acceptor).

106 ophosphorylase that is capable of generating GDP-glucose as well as GDP-mannose.

107 erneurons play a dominant role in generating GDPs compared with their CGE counterparts.

108 urden to US $1.390 billion (0.002% of global GDP).

109 inducing pathology due to loss of the Golgi GDP mannose transporter.

110 Even though all impair GAP-assisted GTP --> GDP hydrolysis, the mutation frequencies of K-Ras4B in h

111 of GTP and a non-hydrolyzable analog of GTP, GDP*BeF3(-) are similar.

112 ity and how rapid kinase/phosphatase and GTP/GDP cycles increase responsiveness and allow kinetic pro

113 e proposed GAP role for ELMOD1, the ARF6 GTP/GDP ratio was significantly elevated in rda/rda utricles

114 r-dimer association to solution changes (GTP/GDP, urea, and trimethylamine oxide).

115 and the mutants (K-Ras4B(G12C/G12D/G12V)-GTP/GDP, K-Ras4B(G13D)-GTP/GDP, K-Ras4B(Q61H)-GTP/GDP) and t

116 B(G12C/G12D/G12V)-GTP/GDP, K-Ras4B(G13D)-GTP/GDP, K-Ras4B(Q61H)-GTP/GDP) and their complexes with GAP

117 mutations that affect GTP hydrolysis or GTP/GDP exchange modified this localization.

118 DP, K-Ras4B(G13D)-GTP/GDP, K-Ras4B(Q61H)-GTP/GDP) and their complexes with GAP.

119 ifferent complexes, bound either to Ran (GTP/GDP) or tRNA or both.

120 Rho proteins are small GTP/GDP-binding proteins primarily involved in cytoskeleton

121 e predicted that both variants alter the GTP/GDP binding pocket and show that they both have localiza

122 Their GTP/GDP cycle is often tightly connected to a membrane/cytos

123 ns on the wild-type K-Ras4B (K-Ras4B(WT)-GTP/GDP) catalytic domain, the K-Ras4B(WT)-GTP-GAP complex,

124 Decreasing the cytosolic GTP:GDP ratio increases the incorporation of Shs1 vs Cdc11,

125 ansferase Cps2L and the guanidylyltansferase GDP-ManPP with these analogues showed that all were acce

126 sidues involved in stabilization of hepcidin-GDP complex.

127 Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleoti

128 me paracentesis was significantly reduced in GDP group, compared with controls (P < .05).

129 ular switches", alternating between inactive GDP-bound and active GTP-bound conformation.

130 s of signaling by switching between inactive GDP-bound and active GTP-bound forms.

131 effects of both variants with known inactive GDP- and active GTP-bound RAB11B mutants, we modeled the

132 w is that Rabs are soluble in their inactive GDP-bound form, and only upon activation and conversion

133 between active (GMPPNP-bound) and inactive (GDP-bound) proteins revealed differences between the fam

134 preferentially phosphorylates the inactive (GDP-bound) state of Rab1.

135 to GTP binding, whereas it did not influence GDP binding or GTP hydrolysis.

136 The G-protein inhibitor GDP-beta-S, anti-Galphaq antibodies, the PLC inhibitor U

137 This effect is prevented by internal GDP-beta-S or inhibiting OX1Rs, CB1Rs, phospholipase C o

138 disrupting the conversion of GTP-Rab3a into GDP-Rab3a and that overexpressing Rab3a can rescue this

139 disrupting the conversion of GTP-Rab3a into GDP-Rab3a and thus impairing the docking of BDNF vesicle

140 que small GTPase with unusual high intrinsic GDP release but low intrinsic GTP binding rate.

141 To address the question of why Tau is GDP-tubulin-biased, we tested whether Tau might affect M

142 motif, stabilizing the Galpha subunit in its GDP-bound conformation.

143 sults suggest that conversion of ARF6 to its GDP-bound form is necessary for final stabilization of t

144 ective at inhibiting the exchange of labeled GDP in both mutant (G12C and G12V) and wild type Ras.

145 h community are accessible across all legume GDPs, through similar interfaces and using common APIs.

146 la project encompassing LIS and other legume GDPs.

147 inding motif upon replacement of the ligand (GDP versus GDPnP).

148 of an alternative mechanism for maintaining GDP-Fuc in the parasite.

149 we report here that SmgGDS does not mediate GDP/GTP exchange on DiRas1.

150 the G-protein RhoA complexed with MgF3(-) , GDP, and RhoGAP, which has the mutation Arg85'Ala.

151 ssociation upon the completion of the native GDP --> GTP exchange reaction, but also explains measura

152 ly active (GTP bound), or dominant-negative (GDP bound) rab17.

153 ing on particular species, and also numerous GDPs for these species.

154 and lost significance when more than 11% of GDP was spent.

155 e USA than in Europe ($340 billion [2.33% of GDP] vs $217 billion [1.28%]).

156 e novo pathway, which requires the action of GDP-mannose 4,6-dehydratase (GMD) and GDP-L-fucose synth

157 Interestingly, the co-administration of GDP and ferrous sulphate (FeSO4) ameliorated the turpent

158 In contrast, the kinetic analysis of GDP-ManPP was only possible with three out of eight anal

159 vide both allosteric and direct catalysis of GDP unbinding and release and GTP binding.

160 w that active ARF6 increases the exchange of GDP for GTP on Rab3A, a prerequisite for secretion.

161 (Rac1) GTPase, facilitating the exchange of GDP for GTP on Rac1.

162 Rho*) is the GPCR catalyzing the exchange of GDP for GTP on the heterotrimeric G protein transducin (

163 Membrane-cytoplasm exchange of GDP-Cdc42 was faster than that of GTP-Cdc42, and computa

164 more, either the 2'- or 3'-hydroxyl group of GDP was found to be required for efficient pRNA transfer

165 analogues and identified chemical groups of GDP as essential for the substrate activity.

166 r nucleotide sugar transporter for import of GDP-L-fucose into the Golgi and is required for proper p

167 e effect of Ca(2+)/CaM on the interaction of GDP- and GTP-loaded K-Ras4B with heterogeneous model bio

168 KO of two isoforms of GDP-D-mannose epimerase (OsGME) reduced the foliar AsA l

169 ed the foliar AsA level by 20-30%, and KO of GDP-L-galactose phosphorylase (OsGGP) by 80%, while KO o

170 a lack of fucosylation consequent to loss of GDP-fucose synthesis contributes to colon carcinogenesis

171 oxo group, N-1-hydrogen, or N-7-nitrogen, of GDP for the cap formation.

172 verage, the economic burden as percentage of GDP was larger in middle-income countries than in high-i

173 on produce the same biochemical phenotype of GDP-fucose deficiency.

174 Previous analyses showed the presence of GDP-fucose (GDP-Fuc), the precursor for all fucosylation

175 ng to eIF2, thereby altering the off-rate of GDP from eIF2*GDP/eIF5 complexes.

176 the alpha-helical domain and the release of GDP during G-protein activation.

177 rt with eIF5 to prevent premature release of GDP from eIF2gamma and thereby ensure tight control of p

178 and 12/13 classes, catalyzing the release of GDP from Galpha and subsequent binding of GTP.

179 ed via the posttranscriptional repression of GDP-l-galactose phosphorylase (GGP), a major control enz

180 Increasing the share of GDP spent on health is not sufficient to reduce catastro

181 itively with GDP per person and the share of GDP spent on health, and incidence correlated negatively

182 stinct from recently described structures of GDP- or GTP-bound RhoA.

183 re also necessary for proper GTP binding (or GDP rebinding).

184 to 0.016 min(-1)], without affecting GTP or GDP dissociation kinetics [koff = 0.093 and 0.148 min(-1

185 depolymerization by the presence of a GTP or GDP/Pi cap.

186 When expressed as a proportion of potential GDP, annual GDP losses were greatest in low-income and m

187 would result in losses of 1.25% of potential GDP, or $20.7 trillion (2010 US$, purchasing power parit

188 d in vitro as giant depolarizing potentials (GDPs) during the first postnatal week.

189 eferred to as giant depolarizing potentials (GDPs) in the hippocampus.

190 In addition, we found that Tau prefers GDP-like tubulin conformations, which implies that Tau b

191 Increasing Gross Domestic Product (GDP) growth rates alone cannot restore absolute mobility

192 to 0.4-13% of global gross domestic product (GDP) in 2050.

193 3 times the current gross domestic product (GDP) per capita.

194 partner violence and gross domestic product (GDP) per person (-0.055, p=0.0009) becomes non-significa

195 trophic spending and gross domestic product (GDP) per person, the Gini coefficient for income inequal

196 rcentage of national gross domestic product (GDP) spent on social protection programmes (excluding he

197 economic output, or gross domestic product (GDP).

198 6% of their combined gross domestic product (GDP).

199 I 1.8-1.9) of global gross domestic product (GDP).

200 ed costs (>1% of the gross domestic product [GDP] in the European Union).

201 enchmarks ($100, 0.5 gross domestic product [GDP] per capita, and GDP per capita per disability-adjus

202 with high per capita gross domestic product [GDP] that collectively concentrate most global wealth) w

203 ment Index [HDI] and Gross Domestic Product [GDP]) using linear regression analysis.

204 trajectories of the Global Drifter Program (GDP) data set, it was found that oceanic eddies are asym

205 ffinity to regulatory proteins including Rab GDP dissociation inhibitors (GDIs).

206 (TORC1), by its direct association with Rab GDP dissociation inhibitor beta, which likely regulates

207 tide exchange factor (GEF, Mon1-Ccz1), a Rab-GDP dissociation inhibitor (GDI) complex (prenylated Ypt

208 Finally, Rab9-GDP expression did not affect adrenergic-mediated calciu

209 d when a dominant-negative Rab9 mutant (Rab9-GDP) was employed.

210 e assembly of the full-length RagA(GTP):RagC(GDP) dimer bound to Ragulator at 16 A resolution, reveal

211 K27 binds preferentially to the inactive Ras GDP form with a Kd of 4 nM and structural studies suppor

212 Ras.GDP weakly binds to the catalytic but not to the alloste

213 c site of activated Sos more weakly than Ras.GDP, suggesting that Sos should actively promote unidire

214 This confirms that Ras.GDP cannot properly activate Sos at the allosteric site.

215 K-Ras/GDPnP complexes relative to the K-Ras/GDP complexes, whereas a decrease in fragmentation effic

216 that measure different aspects of the RasGTP/GDP cycle, we established that overexpression of RasGRP1

217 -driven increased in flux through the RasGTP/GDP cycle, which is mechanistically very different from

218 calization and phosphorylation status of Rho GDP dissociation inhibitor 1 (RhoGDI1).

219 We propose that Tau's GDP preference allows the cell to independently regulate

220 Our structural analysis revealed that six GDP nucleotides bound the enzyme in close proximity to a

221 gumes, and to better accommodate specialized GDPs that serve particular legume species.

222 To better accommodate other specialized GDPs, LIS uses open-source GMOD components where possibl

223 complex by keeping it in the resting state (GDP-bound).

224 nhibiting MGE interneurons in CA1 suppressed GDPs in CA3 and vice versa; conversely, they could also

225 growing microtubules often exposed terminal GDP-bound subunits without undergoing catastrophe.

226 e results gave a preliminary indication that GDP may possibly inhibit the hepcidin-FPN interactions.

227 The in vitro studies revealed that GDP caused FPN stabilization (FPN-GFP cell lines) and in

228 the nucleotide interaction and revealed that GDP is required for activity.

229 These results suggest that GDP a promising natural small-molecule inhibitor that ta

230 measures (-0.015, p=0.472), suggesting that GDP per person is a marker for social transformations th

231 The GDP polyribonucleotidyltransferase (PRNTase) domain of t

232 The GDP-Fuc de novo pathway, which requires the action of GD

233 the function of this metabolic route and the GDP-Fuc pool that is generated during this stage may be

234 e the bound nucleotide which facilitates the GDP-to-GTP exchange.

235 lusion renders RagC incapable of gaining the GDP-bound state necessary to stimulate mTORC1.

236 To determine how the GDP-glucose is generated, we characterized three candida

237 A higher proportion of patients in the GDP group than controls survived until 12 months (68.6%

238 h Alexa 488 (C5) fluorescent dye (Ax) in the GDP, GTPgammaS (collectively, GXP), and Ric-8A-bound sta

239 nown to adopt different conformations in the GDP- and GTP-bound states of Galpha, undergo structural

240 tructure of ObgE at 1.85-A resolution in the GDP-bound state, showing the characteristic N-terminal d

241 ore accessible in the GTP-to-GDP than in the GDP-to-GTP exchange.

242 We propose that conversion of ARF6 into the GDP-bound form in the apical domain of hair cells is ess

243 present the crystal structure of an NST, the GDP-mannose transporter Vrg4, in both the substrate-free

244 h annual costs taking up more than 2% of the GDP.

245 -4/Myrlysin, a subunit of BORC, promotes the GDP-to-GTP exchange of ARL-8 in vitro and recruits ARL-8

246 rowth and invasion rates, revealing that the GDP-Fuc de novo metabolic pathway is not essential for t

247 Thus, we propose that the GDP/GTP exchange may not be sufficient for activation; i

248 ation; instead, our results suggest that the GDP/GTP exchange, HVR sequestration, farnesyl insertion,

249 eraction is almost 100-fold tighter with the GDP-bound than the GTP-bound protein.

250 re-guided mutagenesis of residues within the GDP-binding pocket identified Arg(93) as playing a key r

251 y changes during GDPs from excitatory at the GDPs' onset to inhibitory at the GDPs' peak.

252 glutamatergic currents act in synergy at the GDPs' onset.

253 tory at the GDPs' onset to inhibitory at the GDPs' peak.

254 at are investing a small proportion of their GDP in this area.

255 For a country spending 0% of their GDP on social protection, moving to spending 1% of their

256 l protection, moving to spending 1% of their GDP was associated with a change of -18.33 per 100,000 p

257 E strongly and preferentially contributed to GDP generation.

258 ave historically grown with a correlation to GDP, and there is limited evidence of near-term global d

259 o pay threshold of Intl$16,060-equivalent to GDP per capita in Goa-per quality-adjusted life year gai

260 th proteins were able to salvage l-fucose to GDP-fucose.

261 nteraction prevents the conversion of GMP to GDP, resulting in GMP accumulation upon amino acid downs

262 oA/GAP catalysis of the hydrolysis of GTP to GDP are poorly understood.

263 conserved motifs that promote hydrolysis to GDP.

264 NA (pRNA) from 5'-triphospho-RNA (pppRNA) to GDP via a covalent enzyme-pRNA intermediate to generate

265 ica was the most affected region relative to GDP and also the largest contributor to global absolute

266 nce of GTP or GTP analogs, and subsequent to GDP release, Galpha forms a stable nucleotide-free compl

267 Interneurons importantly contribute to GDPs, due to the depolarizing actions of GABA early in d

268 transition is more accessible in the GTP-to-GDP than in the GDP-to-GTP exchange.

269 tivities, and that introducing a bias toward GDP tubulin has little impact on the observed MT stabili

270 blockade of the GABA(A) receptors transforms GDPs to epileptiform discharges suggesting dual, both ex

271 Transient GDP exposure on the growing plus end slowed elongation b

272 cleotide sugar transporter that translocates GDP-L-fucose into the Golgi lumen.

273 , we show that GFT preferentially transports GDP-L-fucose over other nucleotide sugars in vitro, whil

274 tivate heterotrimeric G proteins and trigger GDP release.

275 e versa; conversely, they could also trigger GDPs in CA1 that propagated to CA3 and vice versa.

276 own the rearrangements in the ribosome-EF-Tu-GDP-Pi-Lys-tRNA(Lys) complex following GTP hydrolysis by

277 irst, aa-tRNAs in ternary complex with EF-Tu.GDP are selected in a step where the accuracy increases

278 thways correspond to either reversible EF-Tu.GDP dissociation from the ribosome prior to the major co

279 Then, following dissociation of EF-Tu.GDP from the ribosome, the accuracy is further increased

280 change when EF-Tu.GTP is converted to EF-Tu.GDP, forms part of an aminoacyl(aa)-tRNA.EF-Tu.GTP terna

281 t Sos should actively promote unidirectional GDP --> GTP exchange on Ras in preference of passive hom

282 Conformational changes upon GDP/GTP exchange were directly observed in solution, on

283 om streptomycetes is unusual in that it uses GDP-glucose as the donor substrate rather than the more

284 pppA formation and pRNA transfer assay using GDP analogues as pRNA acceptors indicated that the PRNTa

285 ished how S. venezuelae can make and utilize GDP-glucose in the biosynthesis of trehalose 6-phosphate

286 tor specificity of VSV PRNTase using various GDP analogues and identified chemical groups of GDP as e

287 ompartments and the plasma membrane, whereas GDP-locked Rab8 forms large cytoplasmic aggregates.

288 To test whether GDP-fucose itself was essential for Leishmania viability

289 ct TM6 motions to regulate the rate at which GDP-bound beta2AR-Gs complexes are formed and the effici

290 om the fungal pathogen Candida albicans with GDP and Mg2+ in the active site.

291 ered that B56 preferentially associated with GDP forms of RasC and RasD, but not with RasG in vitro,

292 to 0.5 degrees x 0.5 degrees grid cells with GDP and population as surrogate indexes.

293 in its apoform and in a ternary complex with GDP and a xylo-oligosaccharide acceptor (named XLLG).

294 he structure of Myo9b-RhoGAP in complex with GDP-bound RhoA and magnesium fluoride.

295 horylation of Rab1 disrupts interaction with GDP dissociation inhibitor 1 (GDI1), but not guanine exc

296 Binding of various forms of Ras (loaded with GDP and mimics of GTP or nucleotide-free) at the alloste

297 phic payments was correlated positively with GDP per person and the share of GDP spent on health, and

298 e HVR-autoinhibited K-Ras4B-GTP states, with GDP-bound-like orientations of the helices.

299 er, then the ICER would be less than the 1 x GDP per capita threshold and thus very cost effective.

300 Whereas only AFKP80 yielded GDP-d-Arap from exogenous d-Arap, both proteins were abl