ライフサイエンスコーパス: GPC

1 GPC protects inner medullary cells against the perturbin

2 GPC-B1 is a NAC transcription factor and has a paralogou

3 rating this secondary mutation into Candid#1 GPC, we hope to minimize the likelihood of reversion and

4 Portal vein infusion of 16:0/18:1-GPC induced PPARalpha-dependent gene expression and decr

5 Interaction of 16:0/18:1-GPC with the PPARalpha ligand-binding domain and coactiv

6 eoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC).

7 mouse model of lethal infection, rMACV/Cd#1-GPC was fully attenuated, more immunogenic than Candid#1

8 V with the Candid#1 glycoprotein (rMACV/Cd#1-GPC) exhibited growth properties similar to those of Can

9 Here, we generated rCl-13(GPC/VGKS) by introducing the corresponding revertant mut

10 e, and a detailed characterization of rCl-13(GPC/VGKS) can provide novel insights into the mechanisms

11 In addition, rCl-13(GPC/VGKS) grew to high titers in cultured cell lines and

12 Further analysis revealed that rCl-13(GPC/VGKS) infected fewer splenic plasmacytoid dendritic

13 within GP2 of rCl-13 and we show that rCl-13(GPC/VGKS) was unable to persist in mice.

14 ain of Cl-13 GP2 resulted in a virus, rCl-13(GPC/VGKS), that failed to persist in mice despite exhibi

15 entire alpha-fetoprotein (AFP), glypican-3 (GPC-3), melanoma-associated gene-A1 (MAGE-A1) and New Yo

16 ) of LASV (GPC spanning residues 441 to 449 [GPC(441-449)]), LCMV (GPC(447-455)), JUNV (GPC(429-437))

17 In contrast, a recombinant LCMV expressing a GPC whose processing into GP1 and GP2 was mediated by fu

18 Furthermore, a GPC shown recently to predict incident coronary heart di

19 o the wild-type virus, Junin virus lacking a GPC cleavage site replicated within successfully transfe

20 function of polymer molecular weight using a GPC with a UV detector; simultaneous RI detection allows

21 the K33A, F49A, and C57A mutations abolished GPC-mediated cell entry and therefore could not allow fo

22 extracts from yeast and plants could acylate GPC with acyl groups from acyl-CoA.

23 All enzymes utilize acyl-CoA to acylate GPC, forming lyso-PC, and they show broad acyl specifici

24 K465V and G467K mutations did not affect GPC processing, virus RNA replication, or gene expressio

25 d plants carrying knock-out mutations of all GPC-1 and GPC-2 genes exhibited delayed senescence but n

26 Trimethyl-amines (GPC and glycine-betaine) are characterized by strong har

27 arrying knock-out mutations of all GPC-1 and GPC-2 genes exhibited delayed senescence but normal anth

28 However, virus assembly and GPC incorporation into budded virions were unaffected.

29 nteen FUBC and 5 FUBC were drawn for GNB and GPC to yield 1 positive result.

30 To elucidate the importance of the GPB and GPC receptors relative to the well-described EBA-175/GPA

31 rved for polymer 2 over polymer 1 by NMR and GPC.

32 orter gene expression levels from the NP and GPC loci were confirmed with recombinant trisegmented LC

33 gment (rLCMV/TransS), where the viral NP and GPC open reading frames replaced one another.

34 roducts encoded by the S RNA segment (NP and GPC) were swapped to generate rLCMV/TransS.

35 of the cages after each synthetic step, and GPC verifies the presence of higher molecular weight SQ

36 S, (1)H and (13)C NMR spectroscopy, TGA, and GPC).

37 targets for JCV infection are astrocytes and GPCs and that infection is associated with progressive m

38 was noted primarily in human astrocytes and GPCs rather than oligodendrocytes, which instead express

39 r that was chimeric for human astrocytes and GPCs.

40 l entry into cells is mediated by arenavirus GPC that consists of an SSP, the receptor-binding GP1, a

41 ors of S1P-mediated processing of arenavirus GPC as a novel antiviral strategy.

42 efore, S1P-mediated processing of arenavirus GPC is a promising target for therapeutic intervention.

43 n the fundamental requirements of arenavirus GPC maturation and may serve as a strategy for the devel

44 iency and subcellular location of arenavirus GPC processing.

45 to characterize the processing of arenavirus GPC-derived target sequences by human SKI-1/S1P in a qua

46 nhibit S1P-mediated processing of arenavirus GPC.

47 arenaviruses bind to the membrane-associated GPC complex in accordance with their respective species

48 tibiotic therapy can be narrowly targeted at GPC in many acutely infected patients, but those at risk

49 e characterize a genetic interaction between GPC subunits that evolutionarily forces retention of the

50 ted in the internal segment of the bipartite GPC fusion peptide, which also contains four conserved c

51 recently been identified and shown to block GPC-mediated fusion of the viral and cellular endosomal

52 e Sobel test of mediation revealed that both GPCs mediated their respective relations between VF (as

53 tudy, we investigated the processing of BUNV GPC and found that both NSm and Gc proteins were cleaved

54 and grain yield was reduced by 1.0-1.6%, but GPC was increased by 0.50% for cv Yangmai16 and 0.80% fo

55 dispersities (M(w)/M(n) < 1.25) as judged by GPC.

56 This was further supported by GPC-matrix assisted laser desorption ionization time-of-

57 cometry and size average molecular weight by GPC.

58 nding protein that recognizes Glycophorin C (GPC) on the red blood cell (RBC) surface and that its bi

59 ptors glycophorin B (GPB) and glycophorin C (GPC).

60 r function during the glial progenitor cell (GPC) to astrocyte transition.

61 lls (NSCs), including glial precursor cells (GPCs), of Alzheimer's disease (AD) are unclear.

62 ed the properties of glial progenitor cells (GPCs) from the cortices of healthy control (HC) and AD s

63 by engrafting human glial progenitor cells (GPCs) into neonatal immunodeficient and myelin-deficient

64 , we engrafted human glial progenitor cells (GPCs) into neonatal immunodeficient mice.

65 chimeric mice using glial progenitor cells (GPCs) produced from induced pluripotent stem cells deriv

66 able to treatment by glial progenitor cells (GPCs), which give rise to astroglia and myelin-producing

67 these MAbs were unable to bind to a chimeric GPC composed of JUNV GP1 containing a small disulfide bo

68 To address this, MACV/JUNV chimeric GPCs were assessed for interaction with a group of alpha

69 racterized by gel permeation chromatography (GPC) and (1)H nuclear magnetic resonance (NMR) spectra.

70 sisted of (i) gel permeation chromatography (GPC) and adsorption chromatography using (ii) deactivate

71 s observed by gel permeation chromatography (GPC) and UV-vis spectroscopy, as well as labeling of the

72 and versatile gel permeation chromatography (GPC) methodology for molecular weight (MW) characterizat

73 Gel permeation chromatography (GPC), (1)H NMR spectroscopy, and matrix-assisted laser d

74 determined by gel permeation chromatography (GPC).

75 R spectra and gel permeation chromatography (GPC).

76 sing standard gel-permeation chromatography (GPC).

77 We used Gaussian Process Classifiers (GPC), a machine learning approach that assigns a predict

78 Proteoliposomes containing the cleaved GPC mediate pH-dependent membrane fusion, a characterist

79 Purified recombinant EDI3 protein cleaves GPC to form glycerol-3-phosphate and choline.

80 However, the critical enzyme cleaving GPC to produce choline, the initial step in the pathway

81 es of positive FUBC for gram-positive cocci (GPC) but not GNB.

82 ococci (CoNS) and other Gram-positive cocci (GPC) directly from VersaTREK blood culture bottles was e

83 tification of clustered Gram-positive cocci (GPC) in blood cultures and on appropriate antibiotic tre

84 microbial, with aerobic gram-positive cocci (GPC), and especially staphylococci, the most common caus

85 id was notable for many Gram-positive cocci (GPC), but cultures of BAL fluid and subcarinal lymph nod

86 omponent of the mature glycoprotein complex (GPC) and plays important roles not only in GPC expressio

87 in the viral envelope glycoprotein complex (GPC) is responsible for attenuation raise the prospect o

88 The glycoprotein complex (GPC) of arenaviruses, composed of stable signal peptide,

89 of the viral envelope glycoprotein complex (GPC), thereby raising concerns regarding the potential f

90 rain yield, and grain protein concentration (GPC) varied depending on cultivar and accumulated heat s

91 ve identified EDI3, a key enzyme controlling GPC and choline metabolism.

92 smic tail domains were essential for correct GPC maturation and production of infectious chimeric vir

93 lx/Cr, Glu/Cr, Gln/Cr, Asc/Cr, and decreased GPC/Cr and decreased left thalamic tNAA/Cr, NAA/Cr were

94 ferentiation phenotype in microRNA-deficient GPCs, overexpression of these targets in wild-type GPCs

95 Detailed GPC and NMR analyses demonstrate that branching density

96 The time evolution of the dual-detection GPC data, concentration of active catalyst, and monomer

97 -TOF mass spectrometry, and triple-detection GPC.

98 rs was obtained from solubility differences, GPC, and DOSY-NMR studies.

99 ly, we employed our sensor to show efficient GPC processing of a panel of pathogenic and nonpathogeni

100 transfected with plasmids expressing either GPC or both Gn and Gc revealed that Gn is posttranslatio

101 gate whether the regional extent of elevated GPC+PC were greater in BD-I patients with rapid cycling

102 We found significantly elevated GPC+PC levels in ACC, putamen and caudate of RC BD-I pat

103 ntrast, infectious Junin virus which encoded GPC cleaved by furin-like proteases was easily generated

104 ell fusion activity of ectopically expressed GPC to approximately 20% of wild-type levels.

105 rogates the ability of ectopically expressed GPC to mediate membrane fusion at endosomal pH.

106 e fusion activity of recombinantly expressed GPC.

107 nsmembrane domain of G2 may be important for GPC-mediated membrane fusion and its inhibition.

108 inpatients with blood cultures positive for GPC in the pre-PCR (15 January 2009 to 14 January 2010)

109 year after neonatal xenograft, the forebrain GPC populations of implanted mice were largely, and ofte

110 al polymerization, and the MWs obtained from GPC were further confirmed via nuclear magnetic resonanc

111 Glycerophosphocholine (GPC) is high in cells of the renal inner medulla where h

112 Glycerophosphocholine (GPC) metabolites modulate atherosclerosis and thus risk

113 ifically, a decreased glycerophosphocholine (GPC) to phosphocholine (PC) ratio was reported in breast

114 ivity coefficients of glycerophosphocholine (GPC), taurine, and myo-inositol.

115 erapy), increased PC, glycerophosphocholine (GPC) and tCho levels (p<0.04).

116 The mature arenavirus envelope glycoprotein GPC is a tripartite complex comprising a stable signal p

117 promoted by the virus envelope glycoprotein GPC.

118 mediated by the virus envelope glycoprotein GPC.

119 target the arenavirus envelope glycoprotein (GPC) have recently been identified and shown to block GP

120 The arenavirus envelope glycoprotein (GPC) initiates infection in the host cell through pH-ind

121 nization of the virus envelope glycoprotein (GPC) on the cell surface by using immunogold electron mi

122 The arenavirus envelope glycoprotein (GPC) retains a stable signal peptide (SSP) as an essenti

123 act on the tripartite envelope glycoprotein (GPC) through its unusual stable signal peptide subunit t

124 act on the arenavirus envelope glycoprotein (GPC) to prevent membrane fusion.

125 ecombinant LCMV containing the glycoprotein (GPC) gene of LASV within the backbone of the immunosuppr

126 chimeric viruses (via envelope glycoprotein [GPC] exchange).

127 mediated by the viral envelope glycoprotein, GPC.

128 The glycoprotein, GPC, is the sole antigen expressed on the viral surface

129 Unlike other viral envelope glycoproteins, GPC contains a myristoylated stable signal peptide (SSP)

130 ycosylphosphatidylinositol-linked glypicans (GPCs), the basement membrane proteoglycan perlecan (HSPG

131 V (GPC(429-437)), MACV (GPC(444-452)), GTOV (GPC(427-435)), and WWAV (GPC(428-436)) that displayed hi

132 For example, heterotypic GPC complexes are unable to support virion entry.

133 Human GPCs and astrocytes were infected more readily than olig

134 w methods for generating and isolating human GPCs, the myelin disorders may now be compelling targets

135 efficient engraftment and expansion of human GPCs in murine hosts has led to the development of human

136 Engraftment of human GPCs in normally myelinated and immunodeficient mice res

137 this report, we demonstrate that the hybrid GPC complexes are properly assembled, proteolytically cl

138 The iC-GPC assay (iCubate, Huntsville, AL) provides a molecular

139 A preliminary evaluation of the iC-GPC assay using 203 clinical or seeded specimens demonst

140 strong than those with the newly identified GPCs.

141 hown previously that SSP is a key element in GPC-mediated membrane fusion, and that GPC sensitivity t

142 n yield, as well as the observed increase in GPC due to heat stress.

143 unique pH-sensing intersubunit interface in GPC, but atomic-level structural information is unavaila

144 (GPC) and plays important roles not only in GPC expression and processing but also in the membrane f

145 ceeds through a structural reorganization in GPC in which the ectodomain of the transmembrane fusion

146 udies have suggested that SSP is retained in GPC through interaction with a zinc-binding domain (ZBD)

147 cible deletion of all canonical microRNAs in GPCs in vitro led to a block in the differentiation to a

148 naling proteins similar to those observed in GPCs from AD patients.

149 Similar results were observed in GPCs isolated from AD transgenic mice.

150 compared beta-catenin signaling proteins in GPCs from AD versus HC subjects and studied the effect o

151 comparable with concentrations that inhibit GPC-mediated membrane fusion.

152 Interestingly, GPCs from AD patients exhibited elevated levels of glyco

153 ymatic activity, increased the intracellular GPC/PC ratio, and decreased downstream lipid metabolites

154 to normal titers, and the processing of its GPC critically depended on cellular furin, but not S1P.

155 d for interaction with a group of alpha-JUNV GPC monoclonal antibodies (MAbs) and mouse antisera agai

156 s loop causing interference, mouse anti-JUNV GPC antisera that solely neutralized pseudovirions beari

157 rgeted GP1, with those that neutralized JUNV GPC-pseudovirions competing with each other for RBS bind

158 [GPC(441-449)]), LCMV (GPC(447-455)), JUNV (GPC(429-437)), MACV (GPC(444-452)), GTOV (GPC(427-435)),

159 We find that Junin virus (JUNV) GPC clusters into discrete microdomains of 120 to 160 nm

160 ions to rescue the fusion deficiency in K33Q GPC.

161 combinant Candid#1 (rCan) virus bearing K33S GPC is viable and retains its attenuated genotype under

162 increase fitness in rCan, reversion in K33S-GPC rCan is likely to be lethal.

163 rts, alpha-HB was a positive correlate and L-GPC a negative correlate of insulin sensitivity, with al

164 alpha-HB and L-GPC are independent predictors of worsening glucose tole

165 To test the predictivity of alpha-HB and L-GPC for incident dysglycemia, alpha-HB and L-GPC measure

166 GPC for incident dysglycemia, alpha-HB and L-GPC measurements were obtained in two observational coho

167 ivity was examined, alpha-HB inhibited and L-GPC stimulated glucose-induced insulin release in INS-1e

168 each standard deviation of predictor), and L-GPC was a negative predictor (0.64 [0.48-0.85] and 0.67

169 in accuracy when substituting alpha-HB and L-GPC with 2-h OGTT glucose concentrations.

170 a-HB) and linoleoyl-glycerophosphocholine (L-GPC) as joint markers of insulin resistance (IR) and glu

171 ngeneic target cells pulsed with either LASV GPC(441-449) or LCMV GPC(447-455) in vivo and provided s

172 -A*0201 mice with the Old World peptide LASV GPC(441-449) or LCMV GPC(447-455) induced high-avidity C

173 of the glycoprotein precursor (GPC) of LASV (GPC spanning residues 441 to 449 [GPC(441-449)]), LCMV (

174 subunits in a native-like Lassa virus (LASV) GPC trimer expressed in insect cells.

175 /LASV-GPC were shown to increase rCl-13/LASV-GPC infectivity in mice.

176 cells, but in contrast to Cl-13, rCl-13/LASV-GPC was unable to establish persistence in immunocompete

177 e GP2 cytoplasmic domain (CD) of rCl-13/LASV-GPC were shown to increase rCl-13/LASV-GPC infectivity i

178 of the Armstrong strain of LCMV (rCl-13/LASV-GPC) exhibited Cl-13-like growth properties in cultured

179 w door to widespread application of VSV-LASV-GPC as a safe and efficacious oncolytic chimeric virus w

180 had two brain tumors, intratumoral VSV-LASV-GPC injection in one tumor (glioma or melanoma) led to c

181 n contrast, a novel chimeric virus (VSV-LASV-GPC) containing genes from both the Lassa virus glycopro

182 pulsed with either LASV GPC(441-449) or LCMV GPC(447-455) in vivo and provided significant protection

183 Old World peptide LASV GPC(441-449) or LCMV GPC(447-455) induced high-avidity CD8(+) T-cell response

184 g residues 441 to 449 [GPC(441-449)]), LCMV (GPC(447-455)), JUNV (GPC(429-437)), MACV (GPC(444-452)),

185 GP1 provided enhanced neutralization of MACV GPC when this loop was removed.

186 Abs) and mouse antisera against JUNV or MACV GPC.

187 sulfide bonded loop (loop 10) unique to MACV GPC, suggesting that this loop may block MAbs interactio

188 V (GPC(447-455)), JUNV (GPC(429-437)), MACV (GPC(444-452)), GTOV (GPC(427-435)), and WWAV (GPC(428-43

189 s I viral envelope glycoproteins, the mature GPC complex contains a cleaved stable signal peptide (SS

190 the number and relative proportion of mouse GPCs fell as a function of time, concomitant with the mi

191 mately replaced the host population of mouse GPCs, ultimately generating mice with a humanized glial

192 Mice allografted with murine GPCs showed no enhancement of either LTP or learning.

193 ution at this position stabilizes the native GPC complex and thereby prevents the induction of pH-dep

194 nd G2 that is involved in priming the native GPC complex for pH-induced membrane fusion.

195 ing polymer (1) was characterized by 1H NMR, GPC, FT-IR, and UV-vis and had a number average molecula

196 With respect to the obtained (1)H NMR, GPC, and contact angle results, the possibility for furt

197 aracterized using a variety of methods (NMR, GPC, IR, DLS, etc.).

198 We find that nonmyristoylated GPC mutants of the Candid #1 strain of Junin virus displ

199 We identified novel GPCs strongly associated with multiple CVD risk factors

200 We identified several novel GPCs that were associated with multiple CVD risk factors

201 date a new molecular mechanism of adult NSCs/GPCs on neurogenesis and demonstrate a regulatory role f

202 Shh itself was elevated in hippocampal NSCs/GPCs.

203 deficits of Ptc1-Gli1 signaling induced NSCs/GPCs into asymmetric division, which results in an incre

204 anolamine as acyl donors in the acylation of GPC.

205 iral agents that target this novel aspect of GPC membrane fusion may be useful in the treatment of ar

206 Degradation of GPC is catalyzed by the glycerophosphocholine phosphodie

207 f 4.1R to bind to the cytoplasmic domains of GPC, Duffy, and XK.

208 00G5 be present concomitant with exposure of GPC to acidic pH.

209 5 identifies an on-path intermediate form of GPC.

210 s to high NaCl- and urea-induced increase of GPC.

211 indings identify the pH-sensing interface of GPC as a highly vulnerable target for antiviral interven

212 hat its binding correlates with the level of GPC on the RBC surface.

213 Increased levels of GPC+PC suggest alterations in the membrane phospholipids

214 9242 efficiently prevented the processing of GPC from the prototypic arenavirus lymphocytic choriomen

215 160 nm in diameter and that this property of GPC is independent of its myristoylation and of coexpres

216 The in vitro reconstitution of GPC-mediated membrane-fusion activity offers unprecedent

217 ortant insights into the biological roles of GPC SSP and implicates it as a good target for the devel

218 n the stable signal peptide (SSP) subunit of GPC, and we demonstrate the utility of this interaction

219 that Abeta treatment impaired the ability of GPCs from HC subjects to generate new neurons and caused

220 ling deregulation resulting abnormal loss of GPCs may contribute to a cognition decline in AD brains.

221 serum lipidomics to identify a new panel of GPCs, and tested whether any of these GPCs are associate

222 inhibitors share a common binding pocket on GPC.

223 ptide (Abeta, a hallmark of AD pathology) on GPCs.

224 ystem to decrease expression of GPA, GPB, or GPC via lentiviral short hairpin RNA transduction of ery

225 lso inhibited by SNV GPC and by either NP or GPC of ANDV.

226 The cleavage mechanism of orthobunyavirus GPCs and the host proteases involved have not been clari

227 erentiation of S. aureus from CoNS and other GPC within 30 min from the time of blood culture positiv

228 virus (JUNV), have nearly identical overall GPC architecture and share a host receptor, transferrin

229 pport a critical role for PAF-R agonistic Ox-GPCs in the pathophysiology of XPA photosensitivity.

230 aled increased levels of sn-2 short-chain Ox-GPCs along with native PAF.

231 To date, oxidized glycerophosphocholines (Ox-GPCs) with platelet-activating factor (PAF) activity pro

232 Here we provide evidence that these Ox-GPCs play a pivotal role in the photosensitivity associa

233 ied out included sugar estimation, SDS-PAGE, GPC, color, FT-IR, DSC, thermal stability, solubility, e

234 Glycero-3-phosphocholine (GPC), the product of the complete deacylation of phospha

235 , glycerophosphocholine plus phosphocholine (GPC+PC)) in bipolar disorder using in vivo proton magnet

236 The arenavirus glycoprotein (GP) precursor GPC is processed by the cellular site 1 protease (S1P) t

237 sid protein (NP) and glycoprotein precursor (GPC) and is robustly inhibited by SNV GPC alone.

238 both the Lassa virus glycoprotein precursor (GPC) and VSV showed no adverse actions within or outside

239 f the viral envelope glycoprotein precursor (GPC) by the cellular subtilisin kexin isozyme 1 (SKI-1)/

240 Hantavirus glycoprotein precursor (GPC) is posttranslationally cleaved into two glycoprotei

241 cleoprotein (NP) and glycoprotein precursor (GPC) loci within the S segment of the prototypic arenavi

242 e same region of the glycoprotein precursor (GPC) of LASV (GPC spanning residues 441 to 449 [GPC(441-

243 us genus-encodes the glycoprotein precursor (GPC) that is proteolytically cleaved to yield two viral

244 inding but that OCEV glycoprotein precursor (GPC)-pseudotyped retroviruses poorly entered 53 human ca

245 tions present in Can glycoprotein precursor (GPC).

246 protein (NP) and the glycoprotein precursor (GPC).

247 ety is cryptically disposed in the prefusion GPC complex and may function late in the fusion process

248 With semi-preparative GPC the LMWDF (DP3) fractions in the wheat grain based f

249 by different chemometrics for grain protein (GPC) and amylose content (AC) of BR and proximate compos

250 s the 4.1R-associated transmembrane proteins GPC, Duffy, XK, and Kell readily extractable by nonionic

251 Unlike other class I viral fusion proteins, GPC retains its stable signal peptide (SSP) as an essent

252 tial resolution and absolute quantification, GPC+PC levels from the anterior cingulate cortex (ACC),

253 In this report we show that the recombinant GPC precursor can be produced as a discrete native-like

254 the MWD of the "bulk" (all polymers, from RI-GPC analysis) provides important mechanistic information

255 ant proteins and a panel of alanine-scanning GPC mutants revealed that F100G5 binding is dependent on

256 ion into myelin-deficient shiverer mice, SCZ GPCs showed premature migration into the cortex, leading

257 the siRNA-mediated knockdown of other SDCs, GPCs, HSPG2, and agrin had no effect on HCV attachment.

258 on-mass spectrometry, we identified 69 serum GPCs within the 450 to 680 m/z range.

259 ursor (GPC) and is robustly inhibited by SNV GPC alone.

260 Jak/STAT signaling is also inhibited by SNV GPC and by either NP or GPC of ANDV.

261 The solubilized GPC is antigenically indistinguishable from the native p

262 ionization time-of-flight mass spectroscopy (GPC-MALDI ToF MS), which revealed the exclusive formatio

263 nt in GPC-mediated membrane fusion, and that GPC sensitivity to acidic pH is modulated in part throug

264 We also find that GPC containing the uncleaved GP1-GP2 precursor is not su

265 hagic fever arenaviruses, we have shown that GPC is unique among class I viral fusion proteins in tha

266 ions with other arenaviruses suggesting that GPC cleavage is essential for arenavirus infectivity.

267 enic New World arenaviruses, suggesting that GPC cleavage represents no barrier for zoonotic transmis

268 initial step in the pathway controlling the GPC/PC ratio, remained unknown.

269 use inhibition of EDI3 activity corrects the GPC/PC ratio and decreases the migration capacity of tum

270 d to higher levels from the NP than from the GPC locus.

271 a mechanism whereby SSP is positioned in the GPC complex to modulate pH-dependent membrane fusion.

272 introduce a furin recognition site into the GPC of LCMV.

273 critical for intracellular transport of the GPC complex to the cell surface and for its membrane-fus

274 Through our studies of the GPC envelope glycoprotein of the hemorrhagic fever arena

275 rrectly predicts efficient processing of the GPC of the newly emergent pathogenic Lujo virus by human

276 receptors are of greater importance than the GPC receptor, supporting a hierarchy of erythrocyte rece

277 vo Taken together, our data suggest that the GPC SSP plays an essential role in mediating viral entry

278 It was found that while the GPC extravirion domains were readily exchangeable, homol

279 of putative cleavage sites derived from the GPCs of newly discovered arenavirus by the SKI-1/S1P of

280 UNV, and in purified Candid#1 virions, these GPC microdomains are soluble in cold Triton X-100 deterg

281 These GPCs may be sensitive indicators of obesity-related risk

282 nel of GPCs, and tested whether any of these GPCs are associated, in adolescence, with classical risk

283 also observed in cultured cells, where this GPC increased the binding of Hh to Patched 1 (Ptc1).

284 orkup procedure, as determined by MALDI-TOF, GPC, and (1)H and 2D NMR.

285 characterization of the intact transmembrane GPC complex of Junin arenavirus and its interaction with

286 ns, affected Ptc1-Gli1 signaling, we treated GPCs with Abeta peptides, we found that high dose of Abe

287 In the tripartite GPC complex, pH-dependent membrane fusion is triggered t

288 overexpression of these targets in wild-type GPCs blocked differentiation.

289 Using GPC, activity to neutral faces presented during the happ

290 stribution (MWD) of Hf-bound polymers via UV-GPC analysis.

291 EBOV GP-dependent, but not Lassa fever virus GPC-dependent, entry into a variety of cell lines in a d

292 ng at this critical interface in Lassa virus GPC.

293 -13 persistence and also revealed that virus GPC-host interactions yet to be elucidated critically co

294 Wheat GPC genes showed the opposite transcription profile (hig

295 The closest rice homolog to both wheat GPC genes is Os07g37920 which is located on rice chromos

296 The wheat GPC-B1 gene located on chromosome 6B is an early regulat

297 a paralogous copy on chromosome 2B in wheat, GPC-B2.

298 positive patient blood culture bottles with GPC seen in clusters with Gram staining were tested usin

299 ed on rice chromosome 7 and is colinear with GPC-B2.

300 PC(444-452)), GTOV (GPC(427-435)), and WWAV (GPC(428-436)) that displayed high-affinity binding to HL