ライフサイエンスコーパス: GPI anchor

1 s a transmembrane (TM) domain instead of the GPI anchor.

2 of a Kunitz-3 domain, and (3) it contains a GPI anchor.

3 les to the cell surface via its TM motif and GPI anchor.

4 ct contain a second TM segment rather than a GPI anchor.

5 t compartment of the plasma membrane using a GPI anchor.

6 nd an extracellular domain with a C-terminal GPI anchor.

7 consistent with membrane association via its GPI anchor.

8 in reduced, but not absent, biosynthesis of GPI anchors.

9 membranes via a class of glycolipids called GPI anchors.

10 oding for arabinogalactans and proteins with GPI anchors.

11 tein (PfRipr) lack transmembrane domains and GPI anchors.

12 rane through a glycosylphosphatidylinositol (GPI) anchor.

13 ma membrane via a glycophosphatidylinositol (GPI) anchor.

14 membrane by a glycosylphosphatidylinositol (GPI) anchor.

15 osition of its glycosylphosphatidylinositol (GPI) anchor.

16 d a sialylated glycosylphosphatidylinositol (GPI) anchor.

17 f cells through a glycophosphatidylinositol (GPI) anchor.

18 membrane via a glycosylphosphatidylinositol (GPI)-anchor.

19 at is an essential and invariant part of all GPI-anchors.

20 GDPDs, cleaves glycosylphosphatidylinositol (GPI) anchors.

21 nd RAET1G, are glycosylphosphatidylinositol (GPI)-anchored.

22 enhanced non-amyloidogenic APP proteolysis, GPI-anchored ADAM10 was effectively targeted to rafts wh

23 ng LRE variants lacking domains critical for GPI anchor addition also rescued lre female gametophyte

24 Consistently, LRE-cYFP-TM, where GPI anchor addition domains were replaced with a single-

25 we provide evidence that increased levels of GPI anchor addition in malignant breast epithelial cells

26 which membrane localization is dependent on GPI anchor addition.

27 s the M8CM, but not the domains required for GPI anchor addition.

28 This modification is catalyzed by ART2.2, a GPI-anchored ADP-ribosyltransferase (ART) that is consti

29 ARTC2.2 is a toxin-related, GPI-anchored ADP-ribosyltransferase expressed by murine

30 s for longer than PrP(C) with a conventional GPI anchor and was not converted to PrP(Sc).

31 The results strongly suggest that GPI anchoring and the localization of PrP(C) to rafts ar

32 Furthermore, GPI anchors and transcriptional regulation are important

33 regions with a glycosylphosphatidylinositol (GPI) anchor and examined the associated effects on APP p

34 usually contain a glycophosphatidylinositol (GPI) anchor and large Asn-linked glycans, which can also

35 tivity depends on glycophosphatidylinositol (GPI) anchoring and the abundance of amyloid plaques and

36 Besides glycosylphosphatidylinositol (GPI) anchors and N-glycosylation, O-fucosylation has bee

37 In fungi, many cell wall proteins are GPI-anchored, and disruption of GPI-anchored proteins im

38 we show that products of both genes contain GPI-anchors, and unexpectedly, that GPI-anchored MMPs pr

39 dings should have important implications for GPI-anchored antibody-based therapy against HIV-1.

40 ndings should have important implications in GPI-anchored antibody-based therapy against HIV-1.

41 ng proteins involved in the synthesis of the GPI anchor are reported to cause a wide spectrum of inte

42 e-specific ADP ribosyltransferase (ART)-1, a GPI-anchored ART that transfers ADP-ribose from NAD to a

43 ses the clustering of sialic acid-containing GPI anchors at high densities, resulting in altered memb

44 tent with the hypothesis that the sialylated GPI anchor attached to PrP(C) acts as a synapse homing s

45 -anchored protein, and were dependent on the GPI anchor attached to PrP(C) containing two acyl chains

46 se that that the chemical composition of the GPI anchor attached to PrP(C) modified the local membran

47 he role of the glycosylphosphatidylinositol (GPI) anchor attached to PrP(C) in prion formation was ex

48 cleavage site 3 aa upstream of the predicted GPI anchor attachment site of ARTC2.2.

49 The data suggests that the GPI-anchor attachment and localization of LTPGs may be c

50 ovel gene products in protein glycosylation, GPI-anchor attachment, ER quality control, and retrieval

51 A GPI anchor bearing unsaturated fatty acid lipid chains (

52 ase (GPI-GnT), involved in the first step of GPI anchor biosynthesis in eukaryotes.

53 (PIGA), a gene involved in the first step of GPI anchor biosynthesis; however, alternative mutations

54 s required for glycosylphosphatidylinositol (GPI) anchor biosynthesis.

55 synthesis, and glycosylphosphatidylinositol (GPI)-anchor biosynthesis.

56 se genes associated with deficiencies of the GPI-anchor biosynthesis pathway and also serves to highl

57 rboxy-terminal glycosylphosphatidylinositol (GPI) anchor, BST2 represents a bona fide target of K5 th

58 -acylation (palmitoylation), prenylation and GPI anchors but until recently little was truly known ab

59 ttachment of a glycosylphosphatidylinositol (GPI) anchor, but whether TFPIbeta protein is actually ex

60 prions in vitro and suggest that the PrP(C) GPI anchor can modulate the propagation of synthetic TSE

61 To test whether GPI anchoring can modulate the propagation and spread of

62 To determine whether GPI anchoring can similarly modulate the assembly of oth

63 nal modifications, such as glycosylation and GPI anchoring, can affect the transmissibility of prions

64 ur results confirm a selective mechanism for GPI-anchored cargo loading into COPII vesicles and a rem

65 bSec24.1 pair selectively impairs ER exit of GPI-anchored cargo.

66 ric VLPs (cVLPs) containing influenza HA and GPI-anchored CCL28 as antigen and mucosal adjuvant, resp

67 We studied the adjuvanticity of GPI-anchored CCL28 co-incorporated with influenza HA-ant

68 Thus, GPI-anchored CCL28 in influenza VLPs act as a strong imm

69 Thus, the results suggest that the GPI-anchored CCL28 induces significantly higher mucosal

70 constitutively lipid raft-associated CD32a (GPI-anchored CD32a) exhibited increased capacity for IgG

71 IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neuri

72 e show that the folate-receptor 1 (FolR1), a GPI-anchored cell surface molecule, specifically marks m

73 ssed, glycosylphosphatidylinositol-anchored (GPI-anchored) cell surface glycoprotein.

74 s) by releasing it from the membrane through GPI-anchor cleavage.

75 An important physical property of GPI-anchored complement regulatory proteins such as DAF

76 g it is bound at cell surfaces to a separate GPI-anchored coreceptor.

77 interactions between PfRH5, PfRipr, and the GPI-anchored CyRPA clearly defines the components of the

78 the carboxyl-terminal GPI anchor, while the GPI anchor deletion mutant exhibits dominant negative ac

79 ) lacking the glycosylphosphatidyl inositol (GPI) anchor, denoted PrP(DeltaGPI).

80 nt of cells with Sup35NM fibrils induced the GPI anchor-dependent formation of self-propagating, dete

81 resemble PrPSc, raising the possibility that GPI anchor-dependent modulation of protein aggregation m

82 provide strong evidence that in cell culture GPI anchor-directed membrane association of PrP(C) is re

83 Glycosylphosphatidylinositol (GPI) anchor-directed membrane association appears to be

84 Together, these results showed that GPI anchoring directs the assembly of Sup35NM into non-f

85 y lipoprotein-binding protein 1 (GPIHBP1), a GPI-anchored endothelial cell protein, binds lipoprotein

86 These data suggest that female-derived GPI-anchored ENODLs play an essential role in male-femal

87 elevated serum alkaline phosphatase (ALP), a GPI-anchored enzyme, in all three affected children.

88 We report that glycosylphosphatidylinositol (GPI)-anchored ephrin-As function as "reverse" signaling

89 owever, the PrP was neither glycosylated nor GPI-anchored, existing as pro-PrP and retaining its GPI

90 We recently reported that GPI anchoring facilitated the induction of Sup35(GPI) pr

91 These data demonstrate GPI anchoring facilitates the propagation and spread of

92 Exchanging the GPI anchor for a nonraft transmembrane sequence redirect

93 ure N-linked glycans and did not require the GPI anchor for localization.

94 l cell lines were generated that expressed a GPI-anchored form of a model amyloidogenic protein, the

95 e required for glycosylphosphatidylinositol (GPI) anchor formation, as a strong candidate.

96 In contrast, PrP(C) containing a GPI anchor from which the sialic acid had been removed (

97 s and following the C-terminal addition of a GPI-anchor (from surface antigen EtSAG1) mCherry was exp

98 Ret also mediates GPI-anchored GFRalpha1 signaling in response to GDNF, a

99 Incorporation of GPI-anchored GIFT4 into VLPs as a molecular adjuvant rep

100 CD52 and CD24 antigens, which are naturally GPI-anchored glycopeptides/glycoproteins.

101 ication of the glycosylphosphatidylinositol (GPI)-anchored glycoprotein Juno as the egg plasma membra

102 By revisiting CD90, a GPI-anchored glycoprotein, we show that CD90 is expresse

103 at TbRFT1 plays a direct or indirect role in GPI anchor glycosylation in the Golgi apparatus.

104 ll surface via glycosylphosphatidylinositol (gpi) anchors have been proposed to regulate cell signali

105 and functional synaptogenesis, including the GPI-anchored heparan sulfate proteoglycan (HSPG) Wnt co-

106 ith Wnts, these glycosophosphotidylinositol (GPI)-anchored, heparan-sulfate proteoglycans bind ligand

107 Ly6e (Sca-2/Tsa1), Ly6g (Gr-1), and gpihbp1 (GPI-anchored high-density lipoprotein-binding protein 1)

108 vity on the apical membrane, confirming that GPI-anchored Hyal2 is expressed in NHBE cells and it rem

109 ignaling network and, furthermore, highlight GPI-anchor hydrolysis as a cell-intrinsic mechanism to a

110 of CD45, could functionally substitute for a GPI anchor in BST-2.

111 To clarify the role of the GPI anchor in TSE infection, cells expressing GPI-anchor

112 The role of the GPI-anchor in prion disease pathogenesis is still a chal

113 The type G nsLTPs (LTPGs) have a GPI-anchor in the C-terminal region which attaches the p

114 Thus, a form of RAET1G is GPI-anchored, in line with most other ULBP/RAET1 family

115 The GPI anchor is a complex structure comprising a phosphoet

116 The GPI anchor is attached to the protein in the endoplasmic

117 The glycosylphosphatidylinositol (GPI) anchor is a lipid and glycan modification added to

118 GPI-anchoring is a universal and critical post-translati

119 FLA4 is likely to be GPI-anchored, is highly N-glycosylated and carries two O

120 viruses internalized by cells expressing the GPI-anchored isoform (TVA800) were uniformly distributed

121 regulated post-translationally to produce a GPI-anchored isoform.

122 nsisting of the glycerophosphatidylinositol (GPI)-anchored, ligand binding receptor GDNF family recep

123 lum (ER), the glycosyl phosphatidylinositol (GPI)-anchor likely functions as a forward transport sign

124 ta1,6-glucans and that retain their original GPI anchor lipid.

125 had significantly reduced levels of the two GPI anchor markers, CD59 and a GPI-binding toxin, aeroly

126 GAP3, encoding a protein that is involved in GPI-anchor maturation.

127 P modifications, including glycosylation and GPI anchoring, may also influence cross-species infectiv

128 a host-encoded glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein, is necessary for pr

129 Reck, a GPI-anchored membrane protein, and Gpr124, an orphan GPC

130 ceptibility genes because their products are GPI-anchored membrane proteins expressed on lymphoid and

131 em are moderated by lynx proteins, which are GPI-anchored membrane proteins forming tight association

132 CD59 is a GPI-anchored membrane regulator of complement expressed

133 ed a novel parasite ligand, Plasmodium vivax GPI-anchored micronemal antigen (PvGAMA), that bound hum

134 ibility that pharmacological modification of GPI anchors might constitute a novel therapeutic approac

135 ch contains just two Mmps (secreted Mmp1 and GPI-anchored Mmp2) and one secreted Timp.

136 contain GPI-anchors, and unexpectedly, that GPI-anchored MMPs promote cell adhesion when they are re

137 In fact, attempts to demonstrate GPI anchor modification of human BST-2 by biochemical me

138 CD59, a broadly expressed GPI-anchored molecule, regulates formation of the membra

139 We replaced the GPI anchor motif in BST-2 with the TM regions of several

140 the functional importance of the C-terminal GPI anchor motif in BST-2.

141 lts demonstrate that the putative C-terminal GPI anchor motif in human BST-2 fulfills the requirement

142 ive C-terminal glycosylphosphatidylinositol (GPI) anchor motif.

143 nd a predicted glycosylphosphatidylinositol (GPI) anchor motif.

144 Signaling by the GPI anchor mutant also depended on Y6 of BST2.

145 turated acyl-chains are required for forming GPI-anchor nanoclusters.

146 it contains a GPI anchor, ruling out that a GPI anchor obstructs ERAD.

147 nterface and further suggest that preventing GPI anchoring of CaValpha2delta1 averts its cell-surface

148 propagation and selection can be affected by GPI anchoring of the host's PrP(C).

149 We examined the possibility of GPI anchoring of the protein in three ways: (i) Phosphat

150 Glycosylphosphatidylinositol (GPI) anchoring of proteins to the cell surface is import

151 Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrP(C)) influences

152 as a predicted glycosylphosphatidylinositol (GPI) anchor omega-site ((526)Asp), an N-glycosylation si

153 Thus, the lack of the GPI anchor on prions reduced the effect of the mouse-hum

154 These results demonstrate that the GPI anchor on PrP-sen is important for the persistent in

155 Thus, the lack of the GPI anchor on the PrPres from tg44 mice appeared to redu

156 this study, we tested the effect of lack of GPI anchoring on a species barrier model using mice expr

157 Previous in vivo studies on the effects of GPI anchoring on prion infectivity have not examined cro

158 expression of glycosylphosphatidylinositol (GPI) anchors on their cell surface, allowing quantificat

159 sociating with membrane microdomains via the GPI anchor or when we inhibited general protein transpor

160 sts as a pro-PrP as defined by retaining its GPI anchor peptide signal sequence (GPI-PSS).

161 hored, existing as pro-PrP and retaining its GPI anchor peptide signal sequence (GPI-PSS).

162 retaining its glycosylphosphatidyl-inositol (GPI) anchor peptide signal sequence (GPI-PSS).

163 A library encoding approximately 100 diverse GPI-anchored peptide toxins (t-toxins) derived from spid

164 e useful for the preparation of more complex GPI-anchored peptides, glycopeptides, proteins, and glyc

165 ion of SrtA to the synthesis of more complex GPI-anchored peptides/glycopeptides and GPI-anchored pro

166 The cell wall content of the GPI-anchored phospholipase B1 (Plb1) enzyme, which is re

167 itive to loss of lynx function, and that the GPI anchor plays a role in the normal function of the ly

168 GPI anchor protein deficiency is almost always due to so

169 Furthermore, sgRNA targeting GPI anchor protein pathway genes induced loss of functio

170 tic changes in glycosylphosphatidylinositol (GPI)-anchored protein arrangement under varying perturba

171 CD177 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by a variable proportion

172 des a putative glycosylphosphatidylinositol (GPI)-anchored protein implicated in reception of the pol

173 Ly6G is a glycosylphosphatidylinositol (GPI)-anchored protein of unknown function that is common

174 or (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, t

175 hich encodes a glycosylphosphatidylinositol (GPI)-anchored protein thought to be involved in ascospor

176 romoter of the glycosylphosphatidylinositol (GPI)-anchored protein Thy1 have been widely used to exam

177 isfolding of a glycosylphosphatidylinositol (GPI)-anchored protein.

178 k a transmembrane domain, myristoylation and GPI-anchor protein modifications.

179 Null mutants of LORELEI-like-GPI-anchored protein 1 (LLG1), the closest relative of L

180 FRalpha is a GPI-anchored protein and a component of the caveolae fra

181 on channel protein in any tissue, and that a GPI-anchored protein associates with an HCN channel subu

182 tors, including folate receptor (FR) beta, a GPI-anchored protein belonging to the folate receptor fa

183 whereas a small number are restricted to the GPI-anchored protein CD59 for initial membrane recogniti

184 he X-chromosomal gene PIGA is known to cause GPI-anchored protein deficiency, 2 such hits are require

185 In spite of its importance for GPI-anchored protein functions, our current knowledge of

186 analysis of maturing DCs, we identified the GPI-anchored protein semaphorin 7A (Sema7A) as being hig

187 ptor-like kinases and the SOS5 extracellular GPI-anchored protein were shown previously to act on a p

188 t seen after cross-linkage of Thy-1, another GPI-anchored protein, and were dependent on the GPI anch

189 sis requires the interaction of CR3 with the GPI-anchored protein, CD14, independently of TLR/MyD88-i

190 utility analyzing antibodies against CD52, a GPI-anchored protein, in its native membrane environment

191 ammalian prion protein (PrP), a cell surface GPI-anchored protein, is a particularly noteworthy examp

192 Prion (PrP), a GPI-anchored protein, is infamous for being the only nor

193 ses, which uniquely involve aggregation of a GPI-anchored protein, versus other protein misfolding di

194 n-independent endocytic pathway known as the GPI-anchored protein-enriched early endosomal compartmen

195 Glycosylphosphatidylinositol (GPI)-anchored proteins are ubiquitously expressed in the

196 n nature, many glycosylphosphatidylinositol (GPI)-anchored proteins localize in the lipid rafts.

197 ature of other glycosylphosphatidylinositol (GPI)-anchored proteins or representative cell surface pr

198 Glycosylphophatidylinositol (GPI)-anchored proteins play important roles in many biol

199 absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontro

200 he cleavage of glycosylphosphatidylinositol (GPI)-anchored proteins, disrupted plasma membrane locali

201 There were significantly reduced levels of GPI-anchored proteins (CD55 and CD59) on the surface of

202 GPI-anchored proteins (GPI-APs) are essential for plant

203 teristics of fluorescent lipid analogues and GPI-anchored proteins (GPI-APs) in the live-cell plasma

204 re involved in biosynthesis and transport of GPI-anchored proteins (GPI-APs).

205 We show that diffusion of GPI-anchored proteins also becomes temperature dependent

206 Thus cell surface diffusion of GPI-anchored proteins and transmembrane proteins that as

207 In an effort to identify GPI-anchored proteins and understand the possible role o

208 ortant for various biological processes, but GPI-anchored proteins are difficult to study.

209 ng which time it may cleave approximately 10 GPI-anchored proteins before dissociating.

210 tabolic engineering of cell-surface GPIs and GPI-anchored proteins by using inositol derivatives carr

211 In contrast, we find that GPI-anchored proteins exhibit temperature-independent di

212 rom Clostridium septicum was used to capture GPI-anchored proteins from human breast cancer tissues,

213 lable individual samples showed that several GPI-anchored proteins had decreased cell-surface abundan

214 proteins are GPI-anchored, and disruption of GPI-anchored proteins impairs cell wall integrity.

215 The loss of certain GPI-anchored proteins is hypothesized to provide the mut

216 ion of cholesterol-dependent nanoclusters of GPI-anchored proteins mediated by membrane-adjacent dyna

217 ass spectrometry demonstrated that the major GPI-anchored proteins of T. brucei procyclic forms have

218 inds to phosphatidylcholine (PC) and cleaves GPI-anchored proteins off eukaryotic plasma membranes.

219 To elucidate how BtPI-PLC searches for GPI-anchored proteins on the membrane surface, we measur

220 The azide-labeled GPIs and GPI-anchored proteins were then tagged with biotin on li

221 The strategy can be used to label GPI-anchored proteins with various tags for biological s

222 ated by lipid packing defects, possibly near GPI-anchored proteins, and the protein diffuses on the m

223 GPI-anchored proteins, candidate cargoes for alternate p

224 activated exocytosis of vesicles containing GPI-anchored proteins, increasing membrane area and phag

225 Notch signalling through surface cleavage of GPI-anchored proteins, is targeted by Prdx4 oxidative ac

226 ial effects on the uptake of transferrin and GPI-anchored proteins.

227 IGA-null cells showed partial restoration of GPI-anchored proteins.

228 osis that requires the direct cooperation of GPI-anchored proteins.

229 ane topology, but we find that they can form GPI-anchored proteins.

230 es have been implicated in the biogenesis of GPI-anchored proteins.

231 the plasma membrane by examining the flow of GPI-anchored proteins.

232 protein partially rescued the deficiency of GPI-anchored proteins.

233 s enzyme, leading to reduced accumulation of GPI-anchored proteins.

234 plex GPI-anchored peptides/glycopeptides and GPI-anchored proteins/glycoproteins.

235 ngth influences the diffusion coefficient of GPI-anchored proteins: smaller proteins diffuse faster t

236 is of glycosylphosphatidylinisotol-anchored (GPI-anchored) proteins.

237 overexpressing glycosylphosphatidylinositol (GPI)-anchored PrP(C).

238 rion infection where cells expressing either GPI-anchored PrP(C) or transmembrane-anchored PrP(C), wh

239 Only GPI-anchored PrP(C) supported persistent PrP(res) propag

240 ential influence of endogenous expression of GPI-anchored PrP(C) To further explore these questions,

241 he prion protein, PrP(res) We show that only GPI-anchored PrP(C) was able to convert to PrP(res) and

242 e to segregation of transmembrane PrP(C) and GPI-anchored PrP(res) in distinct membrane environments.

243 ion of PrP(C) gives rise to glycosylated and GPI-anchored PrP(Sc) The question of the sialylation sta

244 PI anchor in TSE infection, cells expressing GPI-anchored PrP-sen, anchorless PrP-sen, or both forms

245 hains from its glycosylphosphatidylinositol (GPI) anchor (PrP(C)-G-lyso-PI) bound readily to cells, i

246 rd the preparation of heparin disaccharides, GPI anchor pseudodisaccharides, and alpha-GluNAc/GalNAc.

247 ns interact with eosinophils through CD48, a GPI-anchored receptor important in allergy mainly as exp

248 We describe GlycoFRET for a GPI-anchored receptor, a G-protein-coupled receptor, and

249 izes soluble ICs through a mechanism used by GPI-anchored receptors and fluid-phase endocytosis.

250 either an acyl chain or sialic acid from the GPI anchor reduced the targeting of PrP(C) to synapses.

251 Thus, GPI anchor remodeling is independent of protein folding

252 results confirm the importance of the later GPI-anchor remodelling steps for normal neuronal develop

253 to disrupt residues predicted to facilitate GPI-anchoring, resulted in diminished surface expression

254 ERAD and provide evidence that it contains a GPI anchor, ruling out that a GPI anchor obstructs ERAD.

255 IFT4 was constructed by fusing a glycolipid (GPI)-anchoring sequence and incorporated into Env-enrich

256 inked with the glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin, which is a co-f

257 of T. brucei procyclic forms have truncated GPI anchor side chains in TbRFT1 null parasites when com

258 ation but also glycosylphosphatidylinositol (GPI) anchor side-chain modification.

259 chimeric protein, indicating that the BST-2 GPI anchor signal can function as a bona fide TM region.

260 placing the TM region of CD4 by the putative GPI anchor signal of human BST-2 resulted in proper memb

261 cts containing either a C-terminal wild-type GPI anchor signal sequence or a nonraft transmembrane se

262 BST2 with a glycosylphosphatidylinositol (GPI) anchor signal deletion, which is not expressed at t

263 nd appending a glycosylphosphatidylinositol (GPI) anchor signal sequence followed by GPI-phospholipas

264 r degradation, leading to predictions that a GPI anchor sterically obstructs ERAD.

265 The VSG glycosylphosphatidylinositol (GPI)-anchor strongly influences passage through the earl

266 hich do not attach EtN-P to mannose 1 of the GPI anchor, suggesting that Cdc1 removes the EtN-P added

267 ndent upon its glycosylphosphatidylinositol (GPI) anchor, suggesting that it is the increased density

268 However, GPI-anchored Sup35 aggregates were not stained with amyl

269 des a putative glycosylphosphatidylinositol (GPI)-anchored surface protein with a modified eight-cyst

270 alities in the synthesis and localization of GPI-anchored surface molecules.

271 PIGA is essential for GPI anchor synthesis, whereas PIGT is essential for atta

272 n genes of the glycosylphosphatidylinositol (GPI) anchor synthesis pathway.

273 t involves GDE2-mediated surface cleavage of GPI-anchored targets to inhibit Dll1-Notch signaling.

274 in and PAR-2 are co-expressed in HeLa cells, GPI-anchored testisin specifically releases the PAR-2 te

275 l surface by a glycosylphosphatidylinositol (GPI) anchor that multimerizes despite the absence of the

276 rn of RAET1G decreased in cells defective in GPI anchoring through mutant GPI-amidase.

277 nnose 2 of the glycosylphosphatidylinositol (GPI) anchor, thus permitting efficient endoplasmic retic

278 essential for attachment of the preassembled GPI anchor to proteins.

279 , a Cys protease that transfers an assembled GPI anchor to proteins.

280 s complex orchestrates the attachment of the GPI anchor to the C terminus of precursor proteins in th

281 ransamidase (GPIT), the enzyme that attaches GPI anchors to proteins as they enter the lumen of the e

282 addition of a glycosylphosphatidylinositol (GPI) anchor to its ectodomain has been reported to eleva

283 P linked via a glycosylphosphatidylinositol (GPI) anchor to the cell membrane (mGFP-GPI).

284 pe mice to determine the contribution of the GPI-anchor to the molecular mass and isoelectric point o

285 Ephrin-As are GPI-anchored to the membrane, requiring that they comple

286 In addition, GPI anchor-truncated tetherin exhibited a dominant-negat

287 the C-terminal glycosylphosphatidylinositol (GPI) anchor-truncated form, inhibited HBV virion egress

288 synthesized and attached to target proteins, GPI anchors undergo modification on lipid moieties.

289 We studied the effect of PrP GPI anchoring using a mouse-to-human species barrier mod

290 In the present study, we developed GPI-anchored variable regions (VHHs) of two heavy chain-

291 and rate of deposition of newly synthesized GPI-anchored variant surface glycoprotein on the cell su

292 pagation and spread of protein aggregates, a GPI-anchored version of the amyloidogenic yeast protein

293 re a family of glycosylphosphatidylinositol (GPI)-anchored VGCC-associated subunits that, in addition

294 we constructed glycosylphosphatidylinositol (GPI)-anchored VHH JM2 and JM4 along with an E4 control a

295 It has several glycosylphosphatidylinositol (GPI)-anchored virulence factors.

296 ich includes a glycosylphosphatidylinositol (GPI) anchor, was sufficient to restrict virus release wh

297 RAD is caused by canonical remodeling of its GPI anchor, which occurs in all GPI-APs and provides a p

298 Given the structural specificity of fungal GPI-anchors, which is different from humans, understandi

299 n of tetherin requires the carboxyl-terminal GPI anchor, while the GPI anchor deletion mutant exhibit

300 ) by enzymatically cleaving its cell-surface GPI anchor yielded similar effects.