ライフサイエンスコーパス: GPI-anchored protein

1 ocompatibility complex (MHC class I) Qa-2 (a GPI-anchored protein).

2 ow, conclusively, that human nyctalopin is a GPI anchored protein.

3 same rate as that seen for a DRM-associated GPI-anchored protein.

4 ecause it is a glycosylphosphatidylinositol (GPI)-anchored protein.

5 (PrP(C)) is a glycosylphosphatidylinositol (GPI)-anchored protein.

6 isfolding of a glycosylphosphatidylinositol (GPI)-anchored protein.

7 the plasma membrane by examining the flow of GPI-anchored proteins.

8 protein partially rescued the deficiency of GPI-anchored proteins.

9 ction at the omega+2 position in C. albicans GPI-anchored proteins.

10 s enzyme, leading to reduced accumulation of GPI-anchored proteins.

11 s found in aerolysin overlays used to detect GPI-anchored proteins.

12 r glycosylinositolphospholipids (GIPLs), and GPI-anchored proteins.

13 nt cells that are defective in production of GPI-anchored proteins.

14 normal levels of related glycoconjugates and GPI-anchored proteins.

15 the two toxins bind to different subsets of GPI-anchored proteins.

16 ls is an absence or marked deficiency of all GPI-anchored proteins.

17 lipid rafts and the membrane organization of GPI-anchored proteins.

18 or decreased cell surface expression of all GPI-anchored proteins.

19 ursors and restores C-terminal processing of GPI-anchored proteins.

20 to a physiologic role of naturally occurring GPI-anchored proteins.

21 ial effects on the uptake of transferrin and GPI-anchored proteins.

22 es have been implicated in the biogenesis of GPI-anchored proteins.

23 IGA-null cells showed partial restoration of GPI-anchored proteins.

24 osis that requires the direct cooperation of GPI-anchored proteins.

25 ane topology, but we find that they can form GPI-anchored proteins.

26 ure domain in the metabolism of misprocessed GPI-anchored proteins.

27 thus leading to greatly reduced activity on GPI-anchored proteins.

28 , which presumably increases its activity on GPI-anchored proteins.

29 s dominated by glycosylphosphatidylinositol (GPI)-anchored proteins.

30 e deficient in glycosylphosphatidylinositol (GPI)-anchored proteins.

31 icient in all glycosyl phosphatidylinositol (GPI)-anchored proteins.

32 rties of three glycosylphosphatidylinositol (GPI)-anchored proteins.

33 d GM1 but not glycosyl-phosphatidylinositol (GPI)-anchored proteins.

34 also endowed with glycophosphatidylinositol (GPI)-anchored proteins.

35 ak activity on glycosylphosphatidylinositol (GPI)-anchored proteins.

36 is of glycosylphosphatidylinisotol-anchored (GPI-anchored) proteins.

37 Null mutants of LORELEI-like-GPI-anchored protein 1 (LLG1), the closest relative of L

38 and acceptor-labeled antibodies against the GPI-anchored protein 5' nucleotidase (5' NT) at the apic

39 ncentrate much more in lipid rafts marked by GPI-anchored proteins (5' nucleotidase and folate recept

40 Glycophosphatidylinositol (GPI)-anchored proteins account for 26-35% of the Candida

41 by Triton X-100, had the same effect on the GPI-anchored protein alkaline phosphatase (PLAP) in SCRL

42 sistance was much higher than expected for a GPI-anchored protein alone and submicron domains of even

43 We show that diffusion of GPI-anchored proteins also becomes temperature dependent

44 kers, such as glycosyl phosphatidylinositol (GPI)-anchored proteins and glycosphingolipids, are incom

45 oteins such as glycosylphosphatidylinositol (GPI)-anchored proteins and nonreceptor tyrosine kinases

46 FRalpha is a GPI-anchored protein and a component of the caveolae fra

47 have now used FRET to study three different GPI-anchored proteins and a GSL endogenous to several di

48 take, including tubular membranes containing GPI-anchored proteins and dorsal membrane ruffles.

49 Analysis for the co-expression of specific GPI-anchored proteins and ecto-calreticulin in cells tha

50 the quality control pathways for unprocessed GPI-anchored proteins and identify transamidation of the

51 The results suggest a role for GPI-anchored proteins and lipid rafts in root-hair tip g

52 th lipid raft microdomains in the absence of GPI-anchored proteins and suggest that association of th

53 Thus cell surface diffusion of GPI-anchored proteins and transmembrane proteins that as

54 In an effort to identify GPI-anchored proteins and understand the possible role o

55 like GPI-anchored protein); At5g49270 (COBL9 GPI-anchored protein) and At5g65090 (inositol-1,4,5 trip

56 the putative GSL-enriched domains, Thy-1, a GPI-anchored protein, and GM1, a GSL, were followed with

57 gulation of the urokinase receptor (uPAR), a GPI-anchored protein, and in turn increased STAT-3 phosp

58 t seen after cross-linkage of Thy-1, another GPI-anchored protein, and were dependent on the GPI anch

59 rafts" enriched in glycosphingolipids (GSL), GPI-anchored proteins, and cholesterol have been propose

60 ated by lipid packing defects, possibly near GPI-anchored proteins, and the protein diffuses on the m

61 elated clinically, and glycophosphoinositol (GPI)-anchored protein (AP)-deficient cells can be found

62 crase isomaltase and alkaline phosphatase (a GPI-anchored protein) appeared partially depolarized in

63 -glycoside at 4 degrees C (representative of GPI-anchored proteins), appeared partially redistributed

64 Glycosylphosphatidylinositol (GPI)-anchored proteins are abundantly expressed in the i

65 Glycosylphosphatidylinositol (GPI)-anchored proteins are cell surface-localized protei

66 These glycosylphosphatidylinositol (GPI)-anchored proteins are expressed in distinct neurona

67 h cross-linked glycosylphosphatidylinositol (GPI)-anchored proteins are immobilized has been a myster

68 determine if glycosyl-phosphatidylinositol (GPI)-anchored proteins are involved in mammalian fertili

69 Glycosylphosphatidylinositol (GPI)-anchored proteins are nonmembrane spanning cell sur

70 Glycosylphosphatidylinositol (GPI)-anchored proteins are synthesized as precursor prot

71 Glycosylphosphatidylinositol (GPI)-anchored proteins are synthesized on membrane-bound

72 Glycosylphosphatidylinositol (GPI)-anchored proteins are ubiquitously expressed in the

73 Here we show that GPI-anchored proteins are associated with alpha subunits

74 We also showed that two additional GPI-anchored proteins are detergent-insoluble in SCRLs a

75 ortant for various biological processes, but GPI-anchored proteins are difficult to study.

76 e for endocytosis in T.brucei and hence that GPI-anchored proteins are endocytosed by clathrin-depend

77 We presented evidence that GPI-anchored proteins are insoluble because they associa

78 unction of HYAL2 is currently unknown, other GPI-anchored proteins are involved in signal transductio

79 immunochemical and functional criteria that GPI-anchored proteins are physically associated with G p

80 We first investigated whether GPI-anchored proteins are required for VacA toxicity by

81 GPI-anchored proteins are structurally and functionally

82 The mechanisms by which T. gondii GPI-anchored proteins are synthesized and transported th

83 tic changes in glycosylphosphatidylinositol (GPI)-anchored protein arrangement under varying perturba

84 re enriched in glycosylphosphatidylinositol (GPI)-anchored proteins, as well as proteins involved in

85 on channel protein in any tissue, and that a GPI-anchored protein associates with an HCN channel subu

86 ned as membrane domains containing clustered GPI-anchored proteins at the cell surface.

87 erophosphoryl diester phosphodiesterase-like GPI-anchored protein); At5g49270 (COBL9 GPI-anchored pro

88 f sphingolipids is specific for transport of GPI-anchored proteins because no effect on the rate of t

89 We propose that saponin solubilizes GPI-anchored proteins because the lipid composition of c

90 ng which time it may cleave approximately 10 GPI-anchored proteins before dissociating.

91 tors, including folate receptor (FR) beta, a GPI-anchored protein belonging to the folate receptor fa

92 Previous studies demonstrated that HJV is a GPI-anchored protein, binds the proteins neogenin and bo

93 PNT acutely inhibited the synthesis of GPI-anchored proteins, but the synthesis was rapidly res

94 toxin, or through removal of raft-associated GPI-anchored proteins by treatment with phosphatidylinos

95 cell membranes and allows solubilization of GPI-anchored proteins by Triton X-100, had the same effe

96 tabolic engineering of cell-surface GPIs and GPI-anchored proteins by using inositol derivatives carr

97 Cell-to-cell transfer of CD55 and CD59, 2 GPI-anchored proteins, by red cell microvesicles has bee

98 Glycosylphosphatidylinositol (GPI)-anchored proteins can be isolated from both cells a

99 DAF and other GPI-anchored proteins can be found in cholesterol-rich o

100 Among these advantages are that 1) GPI-anchored proteins can be painted onto cells that are

101 can be precisely controlled, and 4) multiple GPI-anchored proteins can be sequentially or concurrentl

102 Thus, cross-linked GPI-anchored proteins can diffuse through the membrane i

103 GPI-anchored proteins, candidate cargoes for alternate p

104 sis requires the interaction of CR3 with the GPI-anchored protein, CD14, independently of TLR/MyD88-i

105 There were significantly reduced levels of GPI-anchored proteins (CD55 and CD59) on the surface of

106 absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontro

107 whereas a small number are restricted to the GPI-anchored protein CD59 for initial membrane recogniti

108 When the GPI-anchored proteins CD59, CD48, and Thy-1 were immunop

109 n transfer is not limited to PrP(C), another GPI-anchored protein, CD90, also transfers from the dono

110 We examined whether GPI-anchored proteins could be transferred in vivo to de

111 intrinsic signaling abilities of the apical GPI-anchored protein DAF to open the tight junction barr

112 Many CVBs also interact with the GPI-anchored protein decay-accelerating factor (DAF).

113 ereus PI-PLC abolished its ability to cleave GPI-anchored proteins, decreased its inhibitory effects,

114 he X-chromosomal gene PIGA is known to cause GPI-anchored protein deficiency, 2 such hits are require

115 ll percentage of glycophosphatidyl inositol (GPI)-anchored protein-deficient neutrophils over extende

116 rectly measure the colony-forming ability of GPI-anchored protein-deficient CD34+ cells, we separated

117 The presence of GPI-anchored protein-deficient cells in myelodysplasia p

118 of 39 (23%) patients with myelodysplasia had GPI-anchored protein-deficient cells.

119 Early emergence of GPI-anchored protein-deficient hematopoiesis in a patien

120 he cleavage of glycosylphosphatidylinositol (GPI)-anchored proteins, disrupted plasma membrane locali

121 lthough the majority of characterized fungal GPI-anchored proteins do in fact localize to the cell wa

122 oan parasites, glycosylphosphatidylinositol (GPI)-anchored proteins dominate the surface of Toxoplasm

123 Recently, the glycosylphosphatidylinositol (GPI)-anchored protein DRAGON was identified as a co-rece

124 n-independent endocytic pathway known as the GPI-anchored protein-enriched early endosomal compartmen

125 In contrast, we find that GPI-anchored proteins exhibit temperature-independent di

126 CD177 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by a variable proportion

127 hich is a small glycosylphosphatidylinositol(GPI)-anchored protein expressed on lymphocytes and media

128 The relationship between GPI-anchored protein expression and bone marrow (BM) fai

129 No patient with normal GPI-anchored protein expression at presentation develope

130 n PNH BM, 27% of CD34+ cells showed abnormal GPI-anchored protein expression when assessed by CD59 ex

131 tation is sufficient to abolish cell surface GPI-anchored protein expression.

132 er targeting, transport, and function of all GPI-anchored protein family members.

133 signaling system, axon guidance pathway, and GPI-anchored proteins family.

134 so allow the production of other recombinant GPI-anchored proteins for laboratory and clinical invest

135 rom Clostridium septicum was used to capture GPI-anchored proteins from human breast cancer tissues,

136 ects fertilization by specifically releasing GPI-anchored proteins from the oolemma.

137 In spite of its importance for GPI-anchored protein functions, our current knowledge of

138 procedure for database analysis to identify GPI-anchored proteins (GAP) based on their possession of

139 plex GPI-anchored peptides/glycopeptides and GPI-anchored proteins/glycoproteins.

140 ") enriched in glycosylphosphatidylinositol (GPI)-anchored proteins, glycosphingolipids, and choleste

141 ted to a human glycosylphosphatidylinositol (GPI)-anchored protein, GML.

142 and virulence factors, lipophosphoglycan and GPI-anchored proteins, gp63, and its virulence was not a

143 This novel GPI-anchored protein (GPI-80) is highly homologous with

144 GPI-anchored proteins (GPI-APs) are essential for plant

145 teristics of fluorescent lipid analogues and GPI-anchored proteins (GPI-APs) in the live-cell plasma

146 re involved in biosynthesis and transport of GPI-anchored proteins (GPI-APs).

147 linositol-specific phospholipase C to remove GPI-anchored proteins greatly reduced HIV-1 sensitivity

148 lable individual samples showed that several GPI-anchored proteins had decreased cell-surface abundan

149 While several GPI-anchored proteins have been characterized, the biolo

150 While many GPI-anchored proteins have been characterized, the biolo

151 Here we show that different GPI-anchored proteins have different intracellular distr

152 bstituting 3'-mRNA end sequence of naturally GPI-anchored proteins (i.e., a sequence that contains th

153 (1) is defective in ER-to-Golgi transport of GPI-anchored proteins (i.e., Gas1p) while other proteins

154 proteins are GPI-anchored, and disruption of GPI-anchored proteins impairs cell wall integrity.

155 des a putative glycosylphosphatidylinositol (GPI)-anchored protein implicated in reception of the pol

156 cell biology of glycoinositol phospholipid (GPI)-anchored proteins in cultured cells, the in vivo fu

157 aft-associated glycosylphosphatidylinositol (GPI)-anchored proteins in the process by which Helicobac

158 To probe for microdomains enriched in GPI- anchored proteins in intact cell membranes, we used

159 allus suggest a differential requirement for GPI-anchored proteins in cell wall synthesis in these tw

160 demonstrated the efficacy of genes encoding GPI-anchored proteins in eliciting partially protective

161 sosomal GPIs are important for biogenesis of GPI-anchored proteins in L. major; (ii) sequestration of

162 utility analyzing antibodies against CD52, a GPI-anchored protein, in its native membrane environment

163 f transport of glycosylphosphatidylinositol (GPI)-anchored proteins, including Cwp2 and Gas1/Gpg1, fr

164 Alpha-toxin binds to several parasite GPI-anchored proteins, including surface antigen 3 (SAG3

165 ositol-specific phospholipase C that removed GPI-anchored proteins increased CD11b-specific binding o

166 activated exocytosis of vesicles containing GPI-anchored proteins, increasing membrane area and phag

167 lin in cells that were deficient in specific GPI-anchored proteins, indicated that ecto-calreticulin

168 cereus PI-PLC, which has strong activity on GPI-anchored proteins, inhibited bacterial escape from a

169 soluble protein requirements for packaging a GPI-anchored protein into ER-derived transport vesicles.

170 ells is known to incorporate Thy-1 and other GPI-anchored proteins into its membrane.

171 In order to identify the oolemmal GPI-anchored proteins involved in fertilization, egg sur

172 nstrate that a glycosylphosphatidylinositol (GPI)-anchored protein is also necessary because phosphat

173 pmentally regulated in schistosomes, and the GPI-anchored protein is localized to the outer tegument

174 s suggest that the intercellular transfer of GPI-anchored proteins is a regulated process, and may ha

175 to generate chemically defined analogues of GPI-anchored proteins is an important step toward elucid

176 The loss of certain GPI-anchored proteins is hypothesized to provide the mut

177 ammalian prion protein (PrP), a cell surface GPI-anchored protein, is a particularly noteworthy examp

178 Prion (PrP), a GPI-anchored protein, is infamous for being the only nor

179 Notch signalling through surface cleavage of GPI-anchored proteins, is targeted by Prdx4 oxidative ac

180 everal surface glycosylphosphatidylinositol (GPI)-anchored proteins, like the major surface antigen S

181 s (At4g26690 and At5g49270) encode predicted GPI-anchored proteins likely to be associated with lipid

182 n nature, many glycosylphosphatidylinositol (GPI)-anchored proteins localize in the lipid rafts.

183 luble membrane fractions have suggested that GPI-anchored proteins may be associated with glycosphing

184 t secretion and intracellular degradation of GPI-anchored proteins may occur in the same genetic back

185 ion of cholesterol-dependent nanoclusters of GPI-anchored proteins mediated by membrane-adjacent dyna

186 When RBC that were deficient (GPI)-anchored protein, obtained from five patients, with

187 a variety of glycosyl-phosphatidylinositol (GPI)-anchored proteins occur extracellularly, but the mo

188 Ly6G is a glycosylphosphatidylinositol (GPI)-anchored protein of unknown function that is common

189 ass spectrometry demonstrated that the major GPI-anchored proteins of T. brucei procyclic forms have

190 inds to phosphatidylcholine (PC) and cleaves GPI-anchored proteins off eukaryotic plasma membranes.

191 deficiency of glycosyl phosphatidylinositol (GPI)-anchored proteins on blood cells from patients with

192 We show that ART2.2 is expressed as a GPI-anchored protein on the surface of mature T cells.

193 Absence of GPI-anchored proteins on erythrocytes is responsible for

194 w cytometry was used to assess expression of GPI-anchored proteins on granulocytes.

195 ates of the GPI pathway but fails to display GPI-anchored proteins on its surface membrane.

196 To elucidate how BtPI-PLC searches for GPI-anchored proteins on the membrane surface, we measur

197 ature of other glycosylphosphatidylinositol (GPI)-anchored proteins or representative cell surface pr

198 ect displacement of the membrane anchor of a GPI-anchored protein or pro-protein causing release of t

199 Glycosylphosphatidylinositol (GPI)-anchored proteins participate in many cell surface

200 Glycosylphophatidylinositol (GPI)-anchored proteins play important roles in many biol

201 ngs provide strong evidence that one or more GPI-anchored proteins play an important role in beta-sec

202 GPI-anchored proteins play vital roles in signal transdu

203 obtained physical evidence for cross-linked GPI-anchored protein, Qa-2, binding to a transmembrane p

204 When aggregates of the GPI-anchored protein, Qa-2, were scanned across plasma m

205 pha-toxin, a pore-forming toxin that targets GPI-anchored protein receptors on the surface of mammali

206 e that alpha toxin, like aerolysin, binds to GPI-anchored protein receptors.

207 t, suggesting that it is bound to a separate GPI-anchored protein(s) at the surface of the cells.

208 The cell-surface GPI-anchored protein(s) involved in Abeta biogenesis may

209 A mutant CHO cell line (gpi85), which lacks GPI-anchored proteins, secreted lower levels of Abeta40,

210 analysis of maturing DCs, we identified the GPI-anchored protein semaphorin 7A (Sema7A) as being hig

211 Glycosylphosphatidylinositol (GPI)-anchored proteins serve as receptors for aerolysin;

212 toxin B-subunit and between antibody-labeled GPI-anchored proteins, showing these raft markers are in

213 sitol moieties present on both free GPIs and GPI-anchored proteins shows the presence of a diacylglyc

214 ngth influences the diffusion coefficient of GPI-anchored proteins: smaller proteins diffuse faster t

215 A diverse group of GPI-anchored protein structures are ubiquitously express

216 that binds to glycosyl phosphatidylinositol (GPI)-anchored proteins, such as Thy-1, on sensitive targ

217 own to bind to glycosylphosphatidylinositol (GPI)-anchored proteins, such as Thy-1.

218 ants showed strongly reduced accumulation of GPI-anchored proteins, suggesting that they all have def

219 ted it was a glycosyl phosphatidyl inositol (GPI)-anchored protein that had a cleavable COOH-terminal

220 D59) is a cell surface glycophosphoinositol (GPI)-anchored protein that prevents complement membrane

221 or (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, t

222 e-associated [glycosyl-phosphatidylinositol (GPI)-anchored] protein that we call DRAGON.

223 CD14, a GPI-anchored protein that associates with TLR4 in mediat

224 phila acetylcholinesterase (AChE) as a model GPI-anchored protein that can be manipulated in vivo wit

225 homologous with Vanin-1, a recently reported GPI-anchored protein that is expressed on perivascular t

226 These results suggest that cd59b encodes a GPI-anchored protein that is functionally active as a me

227 Thy-1 (CD90) is a small GPI-anchored protein that is particularly abundant on th

228 o aerolysin (a bacterial toxin that binds to GPI-anchored proteins), they were equally susceptible to

229 hich encodes a glycosylphosphatidylinositol (GPI)-anchored protein thought to be involved in ascospor

230 lease of transferase is specific, as another GPI-anchored protein, Thy-1 is not released.

231 romoter of the glycosylphosphatidylinositol (GPI)-anchored protein Thy1 have been widely used to exam

232 Cleavage of GP2, a GPI-anchored protein tightly associated with activation

233 es not express glycosylphosphatidylinositol (GPI)-anchored proteins to eliminate potential competitio

234 etic analysis of GPI anchor biosynthesis and GPI-anchored protein trafficking in T. gondii and other

235 ata suggest a potential therapeutic role for GPI-anchored protein transfer for severe PNH.

236 ses, which uniquely involve aggregation of a GPI-anchored protein, versus other protein misfolding di

237 Cell surface expression of major GPI-anchored proteins was diminished in GPI-deficient T.

238 iginating from a mutant cell line that lacks GPI-anchored proteins was not neutralized.

239 te of transport of carboxypeptidase Y, a non-GPI-anchored protein, was observed.

240 To examine the role of GPI-anchored proteins, we specifically removed these pro

241 ptor-like kinases and the SOS5 extracellular GPI-anchored protein were shown previously to act on a p

242 Several lymphocyte cell lines lacking GPI-anchored proteins were also shown to be less sensiti

243 As expected, GPI-anchored proteins were decreased on PB cells of PNH

244 The azide-labeled GPIs and GPI-anchored proteins were then tagged with biotin on li

245 as an axonal glycosyl-phosphatidyl-inositol (GPI)-anchored protein, whereas the MAG receptor has rema

246 major surface glycosyl phosphatidylinositol (GPI)-anchored protein which is rich in Glu-Pro repeats.

247 that ox-PAPC may initially bind to a 37-kDa GPI-anchored protein, which interacts with TLR4 to induc

248 ce predicted a glycosylphosphatidylinositol (GPI)-anchored protein with a signal peptide, a transmemb

249 sistent with the preferential association of GPI-anchored proteins with glycosphingolipid-enriched do

250 The strategy can be used to label GPI-anchored proteins with various tags for biological s