ライフサイエンスコーパス: GPT

1 GPT (10 U/ml) decreased neuronal death caused by exposur

2 GPT and changes of JTH scores at onset of PN were signif

3 GPT has also been predicted to act on the cytosolic face

4 GPT is an effective neuroprotectant against glutamate ex

5 GPT was again neuroprotective, decreasing neuronal death

6 In subgroup analyses, GPT was associated with improved survival for the 2107 h

7 GPT2 and GPT differ in mRNA expression in that GPT2 is highly exp

8 NFTs, such as JTH and GPT, may have utility for predicting PN, but further tes

9 ctural models supported associations between GPT and improved survival in the overall cohort (adjuste

10 The BIPM GPT facility uses state-of-the-art flow measurement, che

11 ously released glutamate, neuroprotection by GPT is not dependent on added pyruvate.

12 large load of glutamate, neuroprotection by GPT was enhanced by adding pyruvate to the medium.

13 t the protein level to the previously cloned GPT.

14 The cloned GPT gene and associated polymorphisms will be useful for

15 xist, but only one ALT gene has been cloned, GPT.

16 In contrast, GPT was superior to CM for all visits in the Clinical Gl

17 and synthesis of the DPAGT1 encoded enzyme, GPT, in determining the abundance of cytoplasmic beta-ca

18 enzymatically inactive (but properly folded) GPT mutants.

19 20.6 improved to adjusted means of 17.6 for GPT and 16.5 for CM, with no significant difference betw

20 Plasma GOT, GPT, and hepatic MMP-9 activity increased 2.5-fold, and

21 wed for a median of 3.3 years; 915 (34%) had GPT.

22 Patients who had GPT had lower mortality rates than those who did not (2.

23 hs per 100 person-years for patients who had GPT vs. those who did not have GPT; adjusted HR, 0.60 [C

24 The sequence of hamster GPT predicted multiple transmembrane segments.

25 Thus, hamster GPT must cross the ER membrane at least three times, con

26 ients who had GPT vs. those who did not have GPT; adjusted HR, 0.60 [CI, 0.43 to 0.82]; P = 0.002) an

27 We have definitively mapped human GPT to the terminus of 8q using several methods.

28 reviously reported protein sequence of human GPT-1.

29 n, we mapped the cosmid containing the human GPT gene to chromosome band 8q24.3.

30 The human GPT genomic sequence spans 2,7 kb and consists of 11 exo

31 Finally, PCR primers specific to human GPT amplify sequences contained within a "half-YAC" from

32 or a histidine in GPT-1 and an asparagine in GPT-2, which causes a gain or loss of an NlaIII restrict

33 Changes in GPT and JTH scores over the first two cycles were often

34 ution in codon 14, coding for a histidine in GPT-1 and an asparagine in GPT-2, which causes a gain or

35 spans is the largest hydrophilic segment in GPT and, as judged by site-directed mutagenesis, has a n

36 GPT sequences or epitope tags inserted into GPT, after selective permeabilization of the plasma memb

37 egulated; transcription of the mouse mammary GPT gene is stimulated by the lactogenic hormones, insul

38 Mixing experiments indicated that mature GPT was competent for oligomerization.

39 In standard Cox models, GPT was associated with improved survival (adjusted HR,

40 ts in regulating the expression of the mouse GPT (mGPT) gene was investigated by transient transfecti

41 croscopy with antibodies specific for native GPT sequences or epitope tags inserted into GPT, after s

42 This study examined the ability of GPT to protect neurons of the hippocampal slice preparat

43 her than promote, nonspecific aggregation of GPT.

44 and characterized cDNA and genomic clones of GPT.

45 on, GPT2 seems to be the predominant form of GPT at the mRNA level in these tissues.

46 ll as activating a nonfunctional fraction of GPT.

47 In this study, we cloned a homolog of GPT and named it GPT2, and the corresponding protein ALT

48 s were detected by chemical cross-linking of GPT and by a dominant-negative effect caused by co-expre

49 Overexpression of GPT was unable to reverse the effects of translation arr

50 Thus, transcriptional up-regulation of GPT/GOT1 genes is a major mechanism, in response to ER s

51 Sessions of GPT and CM were held weekly for the first 12 weeks and m

52 th and 10th predicted transmembrane spans of GPT were found to be cytosolic.

53 leavage sites; (iii) in vitro translation of GPT; and (iv) site-directed mutagenesis.

54 Use of GPT was independently associated with improved survival

55 and the SLO system showed that overexpressed GPT was not functional in vivo, although it was highly a

56 The two polymorphic GPT isozymes are the results of a nucleotide substitutio

57 at these motifs functions in vivo to repress GPT gene expression.

58 ) of liver injury, as measured by both serum GPT levels and percent hepatocellular necrosis, was dram

59 injury and inflammation as measured by serum GPT levels and neutrophil infiltration.

60 unction (JTH) and the Grooved Pegboard Test (GPT), were performed at baseline and during subsequent c

61 typic and phenotypic susceptibility testing (GPT) optimizes antiretroviral selection, but its effect

62 The more abundant expression of GPT2 than GPT, especially in muscle and fat, suggests a unique and

63 From these results, we conclude that GPT is one of a very small number of multitransmembrane

64 In this report, we demonstrate that GPT forms functional oligomers, probably dimers.

65 These results demonstrate that GPT subunits can physically interact and influence each

66 The GPT mutants had no effect on two other dolichol-P-depend

67 ability depending on the type of cereal, the GPT and the antibody used.

68 First, two cosmids shown to contain the GPT sequence were derived from a chromosome 8-specific l

69 In addition, a cosmid containing the GPT sequence also contains a previously unmapped, polymo

70 determination of the molecular basis of the GPT isozyme variants will permit PCR-based detection of

71 decades, although chromosomal mapping of the GPT locus in the 1980s produced conflicting results.

72 A series of 5'-deletions of the GPT promoter identified a distal negative regulatory reg

73 TP inhibition increased transcription of the GPT/GOT1 genes through up-regulation of the IRE1alpha/cJ

74 his wavelength based on gas phase titration (GPT) measurements.

75 superior to placebo in patients assigned to GPT (difference, -1.7; 95% CI, -3.2 to -0.1; P = .04) or

76 Glutamate pyruvate transaminase (GPT) is a highly active glutamate degrading enzyme that

77 ase (GOT) and glutamic pyruvic transaminase (GPT) levels were determined by enzymatic method, and the

78 and 4) serum glutamic pyruvic transaminase (GPT) levels.

79 r damage as measured by serum transaminases (GPT) demonstrate similar acute (3-6 h) post-I/R response

80 DP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) is an endoplasmic reticulum (ER) enzyme responsible

81 th LLO initiation by GlcNAc-1-P transferase (GPT), mannose-P-dolichol synthase, glucose-P-dolichol sy

82 DP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT), which initiates N-linked glycosylation by catalyzi

83 N-acetylglucosamine-1-phosphate transferase (GPT), the enzyme that initiates the pathway for the bios

84 variants of glutamate pyruvate transminase (GPT) (E.C.2.6.1.2) have been used as genetic markers in

85 bodies to well-defined gluten protein types (GPT) isolated from wheat, rye and barley flours.

86 igated by transient transfections of various GPT promoter/luciferase (Luc) constructs into primary mo

87 xpressed in muscle, fat, and kidney, whereas GPT is mainly expressed in kidney, liver, and heart.

88 These results revealed which GPT each antibody is most sensitive to and provided nove