ライフサイエンスコーパス: GPi

1 GPi DBS also resulted in a significant (P < 0.01) declin

2 GPi DBS improved UPDRS motor ratings (36%, P < 0.001) an

3 GPi DBS substantially reduced the AER, restoring lost hi

4 GPi DBS was associated with lower mean performance on on

5 GPi increases and their suppressive effects, perhaps on

6 GPi neurons that project to the pre-SMA are located in a

7 GPi stimulation led to a significant improvement in tic

8 Forty-five subjects (23 GPi, 22 STN) completed the protocol.

9 a total sample size of 502 PD patients (254 GPi DBS, 248 STN DBS), were included in this meta-analys

10 cts of posterior internal pallidal ablation (GPi pallidotomy) on parkinsonian signs and symptoms were

11 or improvement, measured by UPDRS-III, after GPi DBS, compared to STN DBS (17.5 +/- 13.0 vs 14.6 +/-

12 im was to compare the effects of STN DBS and GPi DBS on the AER.

13 y activates GABA(B) receptors in the GPe and GPi and contributes significantly to the control of the

14 increased the spontaneous firing of GPe and GPi neurons, suggesting that GABA released from the axon

15 types are functionally homologous to GPe and GPi neurons, we recorded from neurons in area X of singi

16 , 4.5-5.5, and 7.0-9.0 msec for both GPe and GPi neurons.

17 emporal firing pattern of neurons in GPe and GPi underlie the beneficial effect of HFS in the STN in

18 d internal segments of the pallidum (GPe and GPi) receive heavy GABAergic innervations from the neost

19 oimmunoradiography) was increased in GPe and GPi, likely reflecting increased striatal input and incr

20 nal segments of the globus pallidus (GPe and GPi, respectively).

21 tagonist)-sensitive responses in the GPe and GPi.

22 GABAergic innervation to the GPe itself and GPi.

23 study revealed no difference between STN and GPi DBS in the change of co-primary mood and cognitive o

24 improvement were observed with both STN and GPi DBS.

25 easures (mood and cognition) between STN and GPi in the optimal DBS state.

26 In contrast, STN and GPi phase led cortex in the 70-85 Hz band.

27 The difference between the effect of STN and GPi stimulation on movement-related activity was mainly

28 *, phase, or SW images (P < .05) for STN and GPi visualization.

29 ntrast-to-noise ratios (CNRs) of the STN and GPi were also measured.

30 D diagnosed with ICD, neurons in the STN and GPi would be more responsive to reward-related stimuli a

31 s resulted in increased discharge in STN and GPi, comparable with the changes seen after MPTP but did

32 uch as altered discharge patterns in STN and GPi, may play an important role in the generation of par

33 te decreased in GPe but increased in STN and GPi.

34 tionally defined regions of the striatum and GPi/SNr to determine the relationships between thalamost

35 nd significant positive correlations between GPi firing rates and thalamic glucose metabolism in both

36 Both GPi and GPe firing frequencies differed significantly wi

37 results suggest that responsiveness to both GPi and STN DBS is similar among different PD motor subt

38 njected into localized regions of the caudal GPi in squirrel monkeys.

39 hemes to target fibers ventral to the caudal GPi or at the rostral pole of GPi appear to be misguided

40 The fiber bundle ventral to the caudal GPi was mainly devoid of labeling.

41 en, and the ventrolateral part of the caudal GPi; 2) a "limbic" circuit involves the rostral one-thir

42 In contrast, decreasing GPi volumes were associated with decreasing levels of ir

43 ge was observed in any of these areas during GPi stimulation.

44 owed a higher proportion of regularly firing GPi cells compared with the other groups (p<0.001).

45 Enrolled patients received surgery for GPi DBS and then were randomly assigned in a 1:1 ratio (

46 t inhibition in the GPe, whereas the STN-GPe-GPi inhibitory response dominates over the STN-GPi excit

47 on and Wisconsin Card Sorting (STN improved, GPi worse with stimulation).

48 The difference in GPi activity between "on" and "on with dyskinesias" sugg

49 xcitation followed by a strong inhibition in GPi neurons.

50 voked a predominantly inhibitory response in GPi neurons.

51 t to identify the optimal targeting sites in GPi and STN for reversal of parkinsonian signs through a

52 tion to motor and associative territories in GPi was confirmed by examining the corresponding regions

53 dial extent of the sensorimotor territory in GPi and the lateral portion of the sensorimotor territor

54 profitable response is identified, increased GPi activity suppresses alternative responses, sharpenin

55 trode data from the globus pallidus interna (GPi) and globus pallidus externa (GPe) in children under

56 ucleus (STN) versus globus pallidus interna (GPi) DBS surgery.

57 c nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.

58 als from MEs in the globus pallidus interna (GPi) in two of the cases.

59 ted that DBS of the globus pallidus interna (GPi) might.

60 and/or ipsilateral globus pallidus interna (GPi) or scalp EEG during voluntary movements of a hand-h

61 leus (STN, n=84) or globus pallidus interna (GPi, n=80), using standardised neuropsychological tests.

62 or part of the globus pallidus pars interna (GPi) contralateral to the moving hand, which was paralle

63 to the primate external (GPe) and internal (GPi) pallidal segments.

64 imulation (DBS) of globus pallidus internus (GPi DBS) and subthalamic nucleus (STN DBS) are effective

65 icacy of bilateral globus pallidus internus (GPi) DBS in patient's with severe Tourette's syndrome.

66 c nucleus (STN) or globus pallidus internus (GPi) deep brain stimulation (DBS), found that stimulatio

67 nucleus (STN) and globus pallidus internus (GPi) in reward and punishment processing, and deep brain

68 ures targeting the globus pallidus internus (GPi) to treat medically intractable hypokinetic and hype

69 gle neurons in the globus pallidus internus (GPi), the primary BG output nucleus, in nonhuman primate

70 ion of the BG, the globus pallidus internus (GPi).

71 best stimulation target for a PD patient is GPi or STN.

72 lated interaction between DA release in left GPi and pre-SMA, a mechanism that may also apply to othe

73 In contrast, HF-2 neurons, like GPi neurons, discharged continuously without bursts or l

74 Dyskinesias result from an imbalanced low GPi discharge, a circumstance that may be susceptible to

75 The median GPi firing frequency was higher in the primary group tha

76 30% of the volume of the dentate and <15% of GPi.

77 A subset (29%) of GPi neurons showed learning-related effects, decreasing

78 thophysiology and the mechanism of action of GPi DBS.

79 led along the medial and inferior borders of GPi at centrorostral levels were traceable to the medial

80 es than on T2w images for differentiation of GPi from the internal capsule and external globus pallid

81 The overall effect of GPi DBS on UPDRS III was not significantly different fro

82 The effect of GPi DBS was similar to STN DBS except for depression, ho

83 ationship between the depth of modulation of GPi neurons and forearm rotation amplitude, direction, o

84 ted no differences in the firing patterns of GPi neurons from DYT1 and DYT6 patients.

85 to the caudal GPi or at the rostral pole of GPi appear to be misguided.

86 ntral striatum, and the rostromedial pole of GPi; and 3) an "associative"circuit exists between the c

87 terior ventrolateral sensorimotor portion of GPi and to less selectively target STN, centrally, the i

88 bers originating from the caudal portions of GPi, including the motor territory, do not course ventro

89 ating from motor and associative portions of GPi, small quantities of the anterograde/ retrograde tra

90 ignificant in comparison with stimulation of GPi.

91 involves the caudate-receiving territory of GPi (dorsal one-third), the dorsolateral Pf (Pfdl), and

92 discrete regions in the central territory of GPi and the lateral portion of STN are sufficient to ame

93 , in particular, from the motor territory of GPi has important clinical relevancy.

94 onal cerebral glucose utilization on and off GPi stimulation.

95 9 patients were randomised to STN (n=147) or GPi (n=152) DBS surgery.

96 ubjects were randomized to unilateral STN or GPi DBS.

97 facilitatory decreases in internal pallidal (GPi) activity are primarily greater under sensory-trigge

98 procedures targeting the internal pallidum (GPi) and the subthalamic nucleus (STN) have led to major

99 trical stimulation of the internal pallidum (GPi) or the subthalamic nucleus (STN) improves clinical

100 and external segment of the globus pallidus (GPi and GPe, respectively) in two rhesus monkeys rendere

101 nucleus (STN) and internal globus pallidus (GPi) (P < 0.001), as well as in the dorsal pons and prim

102 the internal segment of the globus pallidus (GPi) and in the substantia nigra (SN) of cynomolgus monk

103 the internal segment of the globus pallidus (GPi) and the cerebellar nuclei (Cb) to the thalamus in t

104 ic ablation of the internal globus pallidus (GPi) for Parkinson's disease causes resting metabolic ch

105 the internal segment of the globus pallidus (GPi) from an awake Parkinson's disease patient undergoin

106 the internal segment of the globus pallidus (GPi) improves Parkinson's disease and increases frontal

107 the internal segment of the globus pallidus (GPi) recorded during this procedure were significantly l

108 c nucleus (STN) or internal globus pallidus (GPi) reduces dyskinesias remain largely unknown.

109 the internal segment of the globus pallidus (GPi) was recorded intraoperatively in the same patients

110 scores of STN and internal globus pallidus (GPi) were recorded by two neuroradiologists on all image

111 tivity through the internal globus pallidus (GPi), external globus pallidus, motor cortex, thalamus,

112 the internal segment of the globus pallidus (GPi).

113 nervation from the internal globus pallidus (GPi).

114 the internal segment of the globus pallidus (GPi).

115 ation (DBS) at the internal globus pallidus (GPi).

116 the internal segment of the globus pallidus (GPi).

117 the internal segment of the globus pallidus (GPi).

118 that exhibit activity similar to the primate GPi, and non-thalamus-projecting neurons that exhibit ac

119 A higher proportion of regular GPi cells was also seen in patients with fixed/tonic dys

120 charges of globus pallidus internal segment (GPi) neurons in monkeys performing a visually driven for

121 tus of the globus pallidus internal segment (GPi) plays a key role in mediating the effects of antipa

122 nglia, the globus pallidus internal segment (GPi) projects to the thalamus and brainstem nuclei there

123 he external segment (GPe), internal segment (GPi), and ventral pallidum (VP)-in 8 HD cases compared w

124 eus (STN) and the internal pallidal segment (GPi) and in the development of parkinsonian motor signs.

125 culata (SNpr) and internal pallidal segment (GPi).

126 The inhibition of the SNpr/GPi should, in turn, disinhibit the thalamus to facilita

127 We observed that some GPi neural pairs oscillated synchronously at the tremor

128 i inhibitory response dominates over the STN-GPi excitatory response in the GPi.

129 al activity led or lagged behind that in STN/GPi were similar, around 20 ms, regardless of the overal

130 ative signals within the striatum, thalamus, GPi, and STN were all associated with increases and decr

131 Additionally, we found that GPi tremor-related activity at a given site could fluctu

132 These results suggest that GPi may initiate reward-related signals through its effe

133 The GPi firing frequency showed a positive correlation with

134 ation involving the ventral thalamus and the GPi (statistical parametric map: P < 0.05, corrected).

135 he STN and coherence between the STN and the GPi was dominated by activity at 70-85 Hz, which increas

136 TN and the coherence between the STN and the GPi were dominated by activity with a frequency of <30 H

137 allidal relay nucleus of the thalamus by the GPi.

138 In contrast, the GPi was less affected, with a 38% reduction in overall v

139 eral nucleus pars oralis (VLo) following the GPi injections or in the central portion of the ventral

140 reotactic MRI determined coordinates for the GPi target.

141 GPe ( approximately 400 ms long) and in the GPi (60 ms long).

142 ed to Parkinson's tremor first arises in the GPi and is then propagated to the cerebello-thalamo-cort

143 ests that patterned neuronal activity in the GPi is important in the mechanism of hyperkinetic disord

144 Increased (18)F-dopa uptake in the GPi is seen in early PD which then is lost in advanced P

145 We recorded single cells in the GPi of parkinsonian monkeys continuously through the "of

146 In the GPi, labeling was most pronounced along the ventral, lat

147 neurons (p<0.05) in the STN, but not in the GPi.

148 ectrodes implanted in the STN and six in the GPi.

149 over the STN-GPi excitatory response in the GPi.

150 tion was significant for the STN but not the GPi group.

151 nly in the dorsal and ventral borders of the GPi and that their activity was strongly modulated by ex

152 ular nucleus (EPN, the rodent homolog of the GPi).

153 ted with deep brain stimulation (DBS) of the GPi.

154 as recorded in either the STN (n=100) or the GPi (n=100).

155 A less well known fact is that the GPi also projects to the lateral habenula (LHb) which is

156 ollectively, these findings suggest that the GPi neurons that we studied were not significantly invol

157 activity) drove network activity through the GPi, which effectively influenced the cerebello-thalamo-

158 ve the nigropallidal dopamine pathway to the GPi but not to the external segment of the globus pallid

159 d function of the dopamine projection to the GPi serves, we propose, to maintain a more normal patter

160 motor subtype may have a greater response to GPi DBS with respect to gait.

161 patients appear to respond less robustly to GPi-DBS than their DYT1 counterparts, most likely reflec

162 ither medical therapy (N = 18) or unilateral GPi pallidotomy (N = 18).

163 imilar for patients randomised to STN versus GPi DBS (1.5% vs 0.7%; Fisher's exact p=0.61), but sever

164 PD motor subtypes and by DBS target (STN vs GPi).

165 sociative" territory of the nucleus, whereas GPi neurons that project to the SMA are located in a mor

166 n (DBS) for dystonia and investigate whether GPi and GPe firing rates differ between dystonia types.

167 parkinsonian patients, 6 with STN and 6 with GPi stimulators, we used H2(15)O positron emission tomog

168 The reduced AER with GPi DBS could be explained by retrograde stimulation of

169 Clinical improvement with GPi DBS is associated with reduced expression of an abno

170 significantly less frequent in patients with GPi DBS than STN DBS with homogeneous studies (pooled RR

171 atients with DYT1 dystonia also treated with GPi-DBS by the same team.

172 Within GPi, neurons labeled from leg M1 were located in dorsal

173 finding, some paired recording sites within GPi showed periods of transient synchronization.