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1 Mutagenesis of Asp413 to Thr resulted in a GTF which expressed only about 12% of the wild-type acti
7 aluminum hydroxide (alum) with buffer, alum-GTF, or alum-GTF together with either Escherichia coli D
8 s also observed after administration of alum-GTF with the P. gingivalis DNA either together or separa
9 roxide (alum) with buffer, alum-GTF, or alum-GTF together with either Escherichia coli DNA, Fusobacte
10 trary to expectation, animals receiving alum-GTF plus bacterial DNA (P. gingivalis in particular) dem
12 gg, increased the amount of GTF activity and GTF antibody-reactive protein ca. fivefold but did not c
13 hanced the immunological response to CAT and GTF epitopes, but also extended the protective effect of
14 nct domains, also found in GTF180-DeltaN and GTF-SI glucansucrases of glycoside hydrolase family 70.
15 SOCS]), the effects of P. gingivalis DNA and GTF exposure on rat splenocyte production of SOCS family
16 mooth-surface molar caries in the GBP59- and GTF-immunized S. mutans-infected groups were each signif
18 weeks after the second injection, GBP59- and GTF-injected rats contained significant levels of saliva
19 ct to induce antibody reactive with GbpB and GTF native proteins, rats were injected subcutaneously w
20 yte proliferative responses to CAT, GLU, and GTF were observed after coimmunization with CAT-GLU comp
21 load increased both GOP and SBR, and GOP and GTF were correlated (P < 0.001), suggesting that the two
25 e synthesis of the glucans to which GbpA and GTFs can bind and which promote S. mutans attachment to
26 ator, histone acetyltransferases (HATs), and GTFs onto immobilized chromatin and naked DNA templates
28 pression of several genomic islands, such as GTF-B/C, TnSmu, CRISPR1-Cas and CRISPR2-Cas, was found t
30 gnition of S. mutans cell surface-associated GTF by specific antibodies but had no effect on antibodi
32 ental caries can be induced to peptide-based GTF vaccines after mucosal administration if combined wi
34 r-insoluble glucan synthesis from sucrose by GTF was noted at a concentration as low as 7.8 microgram
35 p in our understanding of gene regulation by GTFs for all three domains of life and provides an examp
37 The levels of immunoglobulin A (IgA) anti-C-GTF activity in the nasal wash from both groups after im
40 a, and vaginal immunoglobulin A (IgA) anti-C-GTF responses and higher levels of plasma IgG anti-C-GTF
42 en and MPL-AF had higher salivary IgA anti-C-GTF responses than mice immunized with antigen plus MPL-
45 n preparation rich in glucosyltransferase (C-GTF) from Streptococcus mutans, alone or in liposomes.
46 tococcus mutans crude glucosyltransferase (C-GTF) with or without MPL-AF added to the vaccine or inco
49 tion resulted in an anamnestic response to C-GTF resulting in 10- and 100-fold increases in saliva an
51 ng protein-coimmunoprecipitation, ChIP-Chip, GTF perturbation and knockout, and measurement of transc
55 glucosyltransferase-enriched preparation (E-GTF) administered by nasal or tonsillar topical spray.
56 can-synthesizing glucosyltransferase enzyme (GTF-I) from Streptococcus mutans and thioredoxin from Es
57 s streptococcal glucosyltransferase enzymes (GTF) can provide immunity to dental caries infection.
58 (Taspase1) cleaves a ubiquitously expressed GTF (TFIIA) to enable tissue-specific (testis) transcrip
59 4RPE all had similar levels of extracellular GTF activity, strain CH107 had less than 15% of the pare
62 se II (pol II)-general transcription factor (GTF) complexes are unstable, an assembly of pol II with
63 polymerase II general transcription factor (GTF) that has also been implicated in the mechanism of a
68 (Pol II), and general transcription factors (GTFs) initially occurred at the inducible PPARgamma2 pro
71 f a number of general transcription factors (GTFs), all of which have been either cloned or purified
72 of HSFs with general transcription factors (GTFs), as has been described for numerous other transcri
73 ghly purified general transcription factors (GTFs), for differential core promoter-dependent transcri
74 h contain the general transcription factors (GTFs), RNA polymerase II (Pol II), and coactivators.
75 including the General Transcription Factors (GTFs), RNA polymerase II (RNA pol II), co-activators, co
76 ssue-specific general transcription factors (GTFs), such as testis-specific TBP-related factor 2 (TRF
79 erence sequence(s), a Gene Transfer Format (.GTF) file with CDS information and a SNP report(s) in an
80 intermediate in assembly, consisting of four GTFs and promoter DNA, could be isolated and supplemente
84 0 to -80 Torr, while transfer function gain (GTF) was calculated to assess the linear dynamic relatio
87 ain (GLU) of the enzyme glucosyltransferase (GTF), which is an important virulence factor of Streptoc
88 nd vicinity with GBP59, glucosyltransferase (GTF), or phosphate-buffered saline (sham injection), eac
91 inding (GLU) domains of glucosyltransferase (GTF) of mutans streptococci has resulted in enhanced lev
92 ed strong inhibition of glucosyltransferase (GTF), in vitro adherence and glucan-induced agglutinatio
93 Streptococcus sobrinus glucosyltransferase (GTF), an enzyme involved in dental caries pathogenesis,
94 Glucans produced by the glucosyltransferase (GTF) of Streptococcus gordonii confer a hard, cohesive p
95 aliva that inhibits the glucosyltransferase (GTF) of Streptococcus mutans, a virulence enzyme involve
96 f Streptococcus mutans glucosyltransferases (GTF) have been shown to induce protective immunity in Sp
98 Mutans streptococcal glucosyltransferases (GTF) have been demonstrated to be effective components o
100 acid sequences of the glucosyltransferases (GTFs) of mutans streptococci with those from the alpha-a
101 l-terminal domain with glucosyltransferases (GTFs), the enzymes responsible for catalyzing the synthe
106 ylase complex which is capable of inhibiting GTF and may contribute to control of S. mutans colonizat
107 munization as a simple alternative to intact GTF to enhance protective immunity against cariogenic mi
109 inding of C/EBP activators, Pol II, and most GTFs preceded the interaction of SWI/SNF enzymes with th
110 owever, cross-reacting antibody to S. mutans GTF or GBP59 was not induced by the respective antigen.
116 hat calculated for the GBDs of two S. mutans GTFs, one of which catalyzes the synthesis of water-solu
117 T-cell proliferation) was observed to native GTF following MAP 11 (amino acids 847 to 866; VVINNDKFVS
118 y that elicited immunoreactivity with native GTF and demonstrated protection against dental caries in
122 adsorbed to HA was reduced by adsorption of GTF to the same surface and was almost completely abolis
123 ry determinant, rgg, increased the amount of GTF activity and GTF antibody-reactive protein ca. fivef
125 her Gly or Ala resulted in enzymes devoid of GTF activity, indicating the essential nature of these t
128 insoluble and recombinantly expressed GLU of GTF and that this construct was especially effective in
130 had previously selected peptide subunits of GTF for vaccine development based on putative functional
134 ) and salivary IgA antibody levels to CAT or GTF than rats immunized with either construct alone.
135 otective immunity induced by either GBP59 or GTF appears to result from antibodies to independent epi
136 t sufficient, in the context of all purified GTFs and RNA polymerase II, to mediate transcription syn
137 R analyses indicated that partially purified GTFs from the Spp+ strains CH1, CH2RPE, and CH4RPE all p
139 are unstable, an assembly of pol II with six GTFs and promoter DNA could be isolated in abundant homo
141 m the communized group inhibited S. sobrinus GTF-mediated insoluble glucan synthesis in vitro above t
142 ized as above or with Streptococcus sobrinus GTF and then infected with S. sobrinus to explore the ef
145 ants, also bound intact mutans streptococcal GTF in an enzyme-linked immunosorbent assay and inhibite
146 inciting antigen, with mutans streptococcal GTFs, and with a 21-mer peptide (CAT) containing an aspa
148 imated central BP with greater accuracy than GTFs in the low PP amplification group (e.g., central sy
149 Temperature-activity profiles indicated that GTF adsorbed to surfaces had a lower temperature optimum
150 ave also expanded in number, indicating that GTF diversification and expansion is a general phenomeno
153 constructs from the CAT or GLU region of the GTF of mutans streptococci or coimmunized with a combina
155 to induce mucosal antibody in the rat to the GTF peptide vaccines HDS and HDS-GLU after intranasal ad
156 ition of the GbpB-derived SYI peptide to the GTF-derived CAT peptide construct not only enhanced the
157 site-directed mutagenesis approach with the GTF-I enzyme of Streptococcus mutans GS-5, we identified
161 present in the glucan-binding domain of the GTFs had little overall effect on enzymatic activity, al
163 Promoter DNA was associated only with the GTFs, suspended above the pol II cleft and not in contac
164 support the functional significance of these GTF domains in dental caries pathogenesis and present co
165 among the activator proteins and these three GTFs were not detected with other transcription factors,
168 of serum immunoglobulin G (IgG) antibody to GTF or CAT in the CAT-GLU group were significantly great
171 ry IgA antibody, and T-cell proliferation to GTF compared to animals immunized with alum-GTF alone.
172 arly in this study, the enhanced response to GTF after immunization with the CAT-GLU construct result
173 d in serum IgG and salivary IgA responses to GTF and CAT which were greater than after coimmunization
174 domains of Fos and Jun abolished binding to GTFs, although the presence of DNA was not required for
179 induce immune responses which interfere with GTF-mediated glucan synthesis in vitro, and can protect
181 nvolved in protein-protein interactions with GTFs: one is the repressor domain (RD) located in the N-
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