ライフサイエンスコーパス: GTP cyclohydrolase

1 ic amino acid dopa decarboxylase (AADC), and GTP cyclohydrolase 1 (CH1) in a single transcription uni

2 Endothelium-targeted overexpression of GTP cyclohydrolase 1 (GCH), the rate limiting enzyme in

3 GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobi

4 Here we report that reduction of cardiac GTP cyclohydrolase 1 (GCH1) degradation by genetic and p

5 GTP cyclohydrolase 1 (GCH1) is rate limiting in the prov

6 The rate limiting step for BH4 production is GTP Cyclohydrolase 1 (GCH1).

7 no-associated viruses expressing human TH or GTP cyclohydrolase 1 (GTPCH1) were injected into the str

8 g adeno-associated viruses expressing TH and GTP cyclohydrolase 1 (GTPCH1).

9 terin (a BH4 precursor) or overexpression of GTP cyclohydrolase 1 (the rate-limiting enzyme for BH4 b

10 studies have revealed an association between GTP cyclohydrolase 1 polymorphisms, which decrease tetra

11 GTP cyclohydrolase 1, encoded by the GCH1 gene, is an es

12 BH4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 bi

13 tent of this biopterin increases with age in GTP cyclohydrolase 1-deficient hyperphenylalaninemia-1 (

14 We have studied the GTP-cyclohydrolase 1 (GCH-1) gene in 30 patients with th

15 GTP-cyclohydrolase 1 (GTP-CH1) catalyzes the first step

16 BH4, oxidised biopterins, GTP-cyclohydrolase 1 (GTPCH-1, the rate-limiting enzyme

17 nterference RNA (siRNA)-mediated "knockdown" GTP cyclohydrolase-1 (GTPCH1), the rate-limiting enzyme

18 t the expression of an unregulated bacterial GTP cyclohydrolase-1 in plants would increase pterin bio

19 The expression of bacterial GTP cyclohydrolase-1 in transgenic Arabidopsis resulted

20 The folE gene encoding GTP cyclohydrolase-1 was cloned from Escherichia coli an

21 We postulated that GTP cyclohydrolase-1, which catalyzes the first committe

22 duced elevations in tyrosine hydroxylase and GTP cyclohydrolase activities.

23 We previously reported that deficits in GTP cyclohydrolase activity in Drosophila heterozygous f

24 es of the interaction include an increase in GTP cyclohydrolase activity, with concomitant protection

25 mes that regulate biopterin bioavailability, GTP cyclohydrolase and dihydrofolate reductase exhibited

26 te analogues and inhibitors suggest that the GTP cyclohydrolase and pyrophosphate phosphohydrolase ac

27 s suggest that both tyrosine hydroxylase and GTP cyclohydrolase are induced in a coordinate and trans

28 ueF exhibits sequence homology to the type I GTP cyclohydrolases characterized by FolE, but contrary

29 exhibits significant homology to the type I GTP cyclohydrolases characterized by FolE.

30 Dominantly inherited guanosine triphosphate (GTP)-cyclohydrolase deficiency, otherwise known as Segaw

31 ize biogenic amine and BH4 metabolism in the GTP cyclohydrolase deficient hph-1 mouse.

32 Instead, it uses a new type of thermostable GTP cyclohydrolase enzyme that produces 2-amino-5-formyl

33 no recognizable homologues of the canonical GTP cyclohydrolase enzymes that are required for ribofla

34 which is much faster than those of canonical GTP cyclohydrolase enzymes.

35 s end-product BH(4) via interaction with the GTP cyclohydrolase feedback regulatory protein (GFRP).

36 y for the rate-limiting BH4 synthetic enzyme GTP cyclohydrolase (GCH) became undetectable in the swea

37 Endothelium-targeted overexpression of GTP cyclohydrolase (GCH) I increased levels of the endot

38 GTP cyclohydrolase (GCH) III from Methanocaldococcus jan

39 We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for

40 GTP-cyclohydrolase (gch1), the first enzyme in this path

41 transduction with nitric oxide synthase with GTP cyclohydrolase genes.

42 BH4 synthesis is controlled enzymatically by GTP cyclohydrolase (GTPCH), we used GTPCH-depleted mice

43 creases H4B levels and enzymatic activity of GTP cyclohydrolase (GTPCH)-1, the first step of H4B bios

44 t whether AMPK suppresses the degradation of GTP-cyclohydrolase (GTPCH I), a key event in vascular en

45 of pain sensitivity and chronicity, and the GTP cyclohydrolase haplotype is a marker for these trait

46 Similarly, a GTP cyclohydrolase I (fol2) mutant of yeast (Saccharomyc

47 d a similar situation in Escherichia coli: a GTP cyclohydrolase I (folE) mutant, deficient in pterin

48 matic l-amino acid decarboxylase (AADC), and GTP cyclohydrolase I (GCH1) transcription; increases str

49 Overexpression of GTP cyclohydrolase I (GCH1), the rate-limiting enzyme fo

50 GTP cyclohydrolase I (GCHI) mediates the first and commi

51 GTP cyclohydrolase I (GCYH-I) is an essential Zn(2+)-dep

52 GTP cyclohydrolase I (GCYH-I) is the first enzyme of the

53 that the first enzyme of the folate pathway, GTP cyclohydrolase I (GCYH-I), encoded in Escherichia co

54 GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzy

55 BH4 levels, in part through the induction of GTP cyclohydrolase I (GTPCH I), the rate-limiting enzyme

56 5812 base pairs of rat GTP cyclohydrolase I (GTPCH) 5'-flanking region were clo

57 Recently the GTP cyclohydrolase I (GTPCH) gene was isolated as the fi

58 Inhibition of GTP cyclohydrolase I (GTPCH) has been used as a selectiv

59 GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme

60 enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I (GTPCH), rate-limiting enzyme in bi

61 e a selective and direct-acting inhibitor of GTP cyclohydrolase I (GTPCH), the first and rate-limitin

62 s factor alpha (TNF-alpha) without affecting GTP cyclohydrolase I (GTPCH), the rate-limiting enzyme i

63 Expression of both iNOS and GTP cyclohydrolase I (GTPCH), the rate-limiting enzyme i

64 (BH4), secondary to decreased expression of GTP cyclohydrolase I (GTPCH).

65 ihydro-d-neopterin triphosphate catalyzed by GTP cyclohydrolase I (GTPCHI).

66 Furthermore, expression of GTP cyclohydrolase I (the rate-limiting enzyme in de nov

67 otein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin and

68 nase, arginine decarboxylase gene activator, GTP cyclohydrolase I and a repressor of purine biosynthe

69 del for the quaternary structure of GFRP and GTP cyclohydrolase I complexes.

70 Conversely, both switching off GTP cyclohydrolase I expression as well as inhibiting it

71 GTP cyclohydrolase I feedback regulatory protein (GFRP)

72 phenylalanine through complex formation with GTP cyclohydrolase I feedback regulatory protein (GFRP).

73 one and those additionally modified with the GTP cyclohydrolase I gene indicate that BH4 is critical

74 ted with fibro-blasts possessing both TH and GTP cyclohydrolase I genes displayed biochemical restora

75 To examine further the importance of GTP cyclohydrolase I in gene therapy for PD, in vivo mic

76 y a single enzyme, as is known to occur with GTP cyclohydrolase I in the Eucarya and Bacteria, but ra

77 The activity of GTP cyclohydrolase I is inhibited by (6R)-L-erythro-5,6,

78 al restoration in a rat model of PD and that GTP cyclohydrolase I is sufficient for production of BH4

79 cells with Tet-regulated expression of human GTP cyclohydrolase I to regulate intracellular BH4 avail

80 Because GFRP is a pentamer and GTP cyclohydrolase I was shown here by cross-linking exp

81 hasone prevented the coordinate induction of GTP cyclohydrolase I with NOS2 after exposure to interle

82 We used a synthetic gene based on mammalian GTP cyclohydrolase I, because this enzyme is predicted t

83 diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, decreased endothelium-dependent va

84 st enzyme in the cofactor synthesis pathway, GTP cyclohydrolase I, is activated by phosphorylation an

85 omato fruit up to 140-fold by overexpressing GTP cyclohydrolase I, the first enzyme of pteridine synt

86 decline by fruit-specific overexpression of GTP cyclohydrolase I, the first enzyme of pteridine synt

87 vitro data demonstrate that NAMDA inhibited GTP cyclohydrolase I, the rate-limiting enzyme for BH4 b

88 h tetracycline-regulated expression of human GTP cyclohydrolase I, the rate-limiting enzyme in BH4 sy

89 nd stimulatory complexes is equal to that of GTP cyclohydrolase I.

90 h of the two outer faces of the torus-shaped GTP cyclohydrolase I.

91 y MptA (MJ0775 gene product), a new class of GTP cyclohydrolase I.

92 he first enzyme in its biosynthetic pathway, GTP cyclohydrolase I.

93 ntameric GFRP associate with one molecule of GTP cyclohydrolase I.

94 transfer of human guanosine 5'-triphosphate (GTP) cyclohydrolase I (GTPCH I), the first and rate-limi

95 sis is controlled by guanosine triphosphate (GTP) cyclohydrolase I (GTPCHI) and its feedback regulato

96 um, by targeted transgenic overexpression of GTP-cyclohydrolase I (GCH), prevented hypoxia-induced pu

97 AKR1B1), carbonyl reductase (CBR1 and CBR3), GTP-cyclohydrolase I (GCH1), and 6-pyruvoyltetrahydrobio

98 he key enzyme involved in BH(4) synthesis is GTP-cyclohydrolase I (GTPCH-I), which is stimulated by e

99 ng human tyrosine hydroxylase (hTH) or human GTP-cyclohydrolase I [GTPCHI, the rate-limiting enzyme f

100 r in HPS, where activities of the key enzyme GTP-cyclohydrolase I are in the normal range, but total

101 tly increased de novo synthesis for 6BH4 via GTP-cyclohydrolase I concomitant with high levels of 6BH

102 involved in 6BH4 biosynthesis/recycling and GTP-cyclohydrolase I feedback regulatory protein were ex

103 drobiopterin bioavailability by upregulating GTP-cyclohydrolase I gene expression and activity, resul

104 ype (X haplotype) in the GCH1 gene, encoding GTP-cyclohydrolase I, the rate-limiting enzyme in biopte

105 th significant (>40%) amino acid identity to GTP cyclohydrolase II (GCH II), which catalyzes the comm

106 Three GTP cyclohydrolase II homologues in the Streptomyces coe

107 This enzyme is different than the bacterial GTP cyclohydrolase II which catalyzes both reactions.

108 he gene encoding a putative dual-functioning GTP cyclohydrolase II-3,4-dihydroxy-2-butanone-4-phospha

109 and FLU encoding the dual-functional protein GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phospha

110 n of this enzyme confirms the involvement of GTP cyclohydrolase III (ArfA) in archaeal riboflavin and

111 This activity has been reported for a GTP cyclohydrolase III protein from Methanocaldococcus j

112 proposed to begin with an archaeal-specific GTP cyclohydrolase III that hydrolyzes the imidazole rin

113 ct, but not the NGF effect, NGF also induced GTP cyclohydrolase in a cAMP-dependent manner, while the

114 Sphingosine induced GTP cyclohydrolase in a protein kinase C-independent man

115 to acetylcholine, which was inhibited by the GTP-cyclohydrolase inhibitor 2,4-diamino-6-hydroxypyrimi

116 GTP cyclohydrolase is composed of a highly conserved hom

117 re the induction of tyrosine hydroxylase and GTP cyclohydrolase is not coordinately regulated.

118 Mammalian GTP cyclohydrolase is subject to end-product inhibition

119 were additionally modified with the gene for GTP cyclohydrolase l; an enzyme critical for BH4 synthes

120 Whereas canonical GTP cyclohydrolases produce this formylamino-pyrimidine

121 Here we report the identification of a new GTP cyclohydrolase that converts GTP to 7,8-dihydro-d-ne

122 MptA is the archetype of a new class of GTP cyclohydrolases that catalyzes a series of reactions

123 Induction of GTP cyclohydrolase (the rate-limiting enzyme for the pro

124 d the activities of tyrosine hydroxylase and GTP cyclohydrolase, the rate-limiting enzymes in catecho

125 mine release, and we found that the gene for GTP cyclohydrolase, which effectively regulates TH throu

126 Expression of GTP cyclohydrolase, which produces tetrahydrobiopterin (