1                Moreover, GFRP expression and GTPCHI activities have been found in the nucleus of both

2                              Striatal TH and GTPCHI staining was observed 3 weeks after rAAV transduc

3 e presence of numerous melanin-positive, but GTPCHI-ir immunonegative, neurons in the aged monkey and

4 aled that young monkeys and humans displayed GTPCHI-ir within melanin-containing and tyrosine-hydroxy

5 results identified indeed a functioning GFRP/GTPCHI axis in epidermal keratinocytes and melanocytes i

6 overflow, and animals in the non-hTH groups (GTPCHI and alkaline phosphatase) yielded minimal L-DOPA.

7 anosine triphosphate (GTP) cyclohydrolase I (GTPCHI) and its feedback regulatory protein (GFRP), wher

8     Guanosine triphosphate cyclohydrolase I (GTPCHI) is a critical enzyme in catecholamine function a

9 phosphate catalyzed by GTP cyclohydrolase I (GTPCHI).

10 oxylase (hTH) or human GTP-cyclohydrolase I [GTPCHI, the rate-limiting enzyme for tetrahydrobiopterin

11 ndicate that there is a dramatic decrease in GTPCHI-ir in nonhuman primates and humans as a function

12 CHI-ir neuronal number, a 63.5% reduction in GTPCHI-ir neuronal density, and a 37.6% reduction in neu

13 revealed that there was a 67.4% reduction in GTPCHI-ir neuronal number, a 63.5% reduction in GTPCHI-i

14 ls that received the mixture of MD-TH and MD-GTPCHI vector displayed BH4 independent in vivo L-DOPA p

15                               The density of GTPCHI-ir neurons within the nigra was similarly reduced

16 e present study assessed the distribution of GTPCHI immunoreactivity (-ir) within the monkey and huma

17 ecursor of pterins in archaea, homologues of GTPCHI have not been identified in most archaeal genomes

18 were significant reductions in the number of GTPCHI-ir nigral neurons in middle age (58.4%) and aged

19 s did not display shrinkage in the volume of GTPCHI-ir nigral neurons.

20  of reactions most similar to that seen with GTPCHI but unique in that the cyclic phosphate is the pr