ライフサイエンスコーパス: GTPase-activating protein

1 igh levels of RAS-GTP had loss of NF1, a RAS GTPase activating protein.

2 affold as well as an ADP-ribosylation factor-GTPase-activating protein.

3 kinesin-6 motor, and CYK-4/MgcRacGAP, a Rho GTPase-activating protein.

4 NF1 gene, which encodes neurofibromin, a RAS GTPase-activating protein.

5 in and demonstrate that FLCN acts as a Rab7A GTPase-activating protein.

6 k loop, and this inhibition depends on Cdc42 GTPase-activating proteins.

7 ere, we demonstrate that IQ motif containing GTPase activating protein 1 (IQGAP1) binds to TGF-beta r

8 IQ motif-containing GTPase activating protein 1 (IQGAP1) plays a central rol

9 affold proteins, such as IQ motif containing GTPase activating protein 1 (IQGAP1), are promising targ

10 MAPK scaffolds, such as IQ motif-containing GTPase activating protein 1 (IQGAP1), assemble pathway k

11 an ERK scaffold protein, IQ motif containing GTPase activating protein 1 (IQGAP1).

12 naling and decrease Ile Gln motif containing GTPase Activating Protein 1 phosphorylation.

13 ng adenosine diphosphate-ribosylation factor GTPase activating protein 1 revealed high reactivity fre

14 ng with HvMAGAP1 (Microtubule Associated ROP-GTPase Activating Protein 1).

15 beta-arrestin 2 and Ile Gln motif containing GTPase Activating Protein 1, a regulator of mammalian ta

16 We demonstrate that AnkB binds to Rab GTPase Activating Protein 1-Like (RabGAP1L) and recruits

17 ellular scaffold protein IQ motif containing GTPase-activating protein 1 (IQGAP1) as an LGR4-interact

18 IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a cytoskeleton-i

19 that LGR5 interacts with IQ motif-containing GTPase-activating protein 1 (IQGAP1), an effector of Rac

20 5C (Chk1, Chk2, and H2AX), as well as on Ran GTPase-activating protein 1 conjugated to small ubiquiti

21 n (CREB) phosphorylation via RASA1 (p120 Ras GTPase-activating protein 1) down-regulation, whereas mi

22 In this study, IQGAP1 (IQ motif-containing GTPase-activating protein 1), a new Nrf2 interaction par

23 iation of intronic variants in ARHGAP15 (Rho GTPase-activating protein 15; rs4662344-T: P=1.9 x 10(-1

24 egion mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2 (proteinase-activ

25 the cortical development gene Slit-Robo Rho GTPase-activating protein 2 (SRGAP2) duplicated three ti

26 osteosarcoma metastasis, including Slit-Robo GTPase-Activating Protein 2 (Srgap2).

27 AP220, the PKA holoenzyme, and the IQ domain GTPase-activating protein 2 isoform (IQGAP2) that is enr

28 ontrol protein 42) and Srgap2 (SLIT-ROBO Rho GTPase-activating protein 2).

29 (MMP12)/MMP13, catenin alpha3 (CTNNA3), rho GTPase-activating protein 24 (ARHGAP24), angiopoietin 4

30 preading through its interaction partner Rho GTPase-activating protein 29 (ArhGAP29), a GTPase activa

31 In the present study, we show that the Arf-GTPase activating protein-3 (ArfGAP3), a well characteri

32 ted within intron 1 of the gene encoding Rho GTPase activating protein 6 (ARHGAP6).

33 nly C. elegans homolog of the mammalian Arf6 GTPase-activating proteins ACAP1 and ACAP2.

34 sequence that was capable of enhancing RGS7 GTPase-activating protein activity in solution by an all

35 ted PLC-beta3 activation and for the Galphaq GTPase-activating protein activity of PLC-beta.

36 The RGS domain of RGS6, known only for its GTPase-activating protein activity toward Galpha subunit

37 Overexpression of SNX26 resulted in a GTPase-activating protein activity-dependent decrease in

38 which encodes a protein with strong RhoGAP (GTPase activating protein) activity and weak Cdc42GAP ac

39 nstrate that BLOC-1 is an endosomal Rab-GAP (GTPase-activating protein) adapter complex in yeast.

40 s for control of the cytoskeleton by the Arf GTPase-activating protein AGAP1 has not been characteriz

41 Here, we demonstrate that the Rho-GTPase-activating protein alpha2-chimaerin is specifical

42 he unexpected pro-oncogenic functions of Rac GTPase-activating proteins also challenged the dogma tha

43 sensitivity to mutation when regulated by a GTPase activating protein and a nucleotide exchange fact

44 TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate

45 DLC1 encodes a RhoA GTPase-activating protein and tumor suppressor lost in c

46 r Raf and concomitantly increases binding to GTPase-activating proteins and the rate of GTP hydrolysi

47 SYNGAP1, a synaptic Ras GTPase activating protein, and SHANK3, a synaptic scaffo

48 tment of Aurora B kinase, male germ cell Rac GTPase-activating protein, and RhoA to the cortex was im

49 he NF1 gene encodes for neurofibromin, a RAS GTPase-activating protein, and thus negatively regulates

50 NEDD9 directly binds to Arf6-GTPase-activating protein, ARAP3 and Arf6-effector GGA3,

51 These Rac-GTPase activating proteins are regulated by the lipid se

52 1 adenosine diphosphate ribosylation factor-gtpase-activating protein (ARF-GAP).

53 Here, we show that the Arf GTPase-activating protein (ArfGAP) Gcs1 is a Drs2 effect

54 Together with GTPase-activating proteins (ArfGAPs) and guanine exchang

55 prising the Cdc42-interactor IQGAP1, the Rho GTPase-activating protein ARHGAP10, and the integrin int

56 ivator, whereas actin polymerization and the GTPase-activating protein ArhGAP15 are essential for pro

57 d in the identification of the Rac1-specific GTPase-activating protein ARHGAP17 and the guanine nucle

58 pheroids of human cells, we identify the Rho GTPase activating protein ARHGAP18 as an effector of YAP

59 eta-Arrestin1 binds and suppresses the Cdc42 GTPase-activating protein ARHGAP21, we hypothesize that

60 strated that selective expression of the Rho GTPase-activating protein ARHGAP42 in smooth muscle cell

61 A proteomics analysis identified the Rab43 GTPase-activating protein as a downstream target of Akt.

62 here that Rab10 is a bona fide target of the GTPase-activating protein AS160, which is inhibited afte

63 during interphase by the essential bipartite GTPase-activating protein Byr4-Cdc16.

64 kinesin-6 forms a complex with a Rho-family GTPase-activating protein called MgcRacGAP to signal to

65 through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory an

66 ate of GTP hydrolysis via both intrinsic and GTPase-activating protein-catalyzed mechanisms, resultin

67 onstrate that Ajuba interacts with the Cdc42 GTPase activating protein CdGAP, a GAP for Rac1 and Cdc4

68 Cdc42 GTPase-activating protein (CdGAP) is a phosphoprotein sh

69 -3-3 does not alter in vitro activity of the GTPase-activating protein complex.

70 differential regulation of the Ras-homology-GTPase-activating protein [corrected] (Rho-GAP) activity

71 They show that the GTPase-activating protein, CYK4, suppresses equatorial c

72 Finally, we showed that Carabin Ras-GTPase-activating protein domain and calcineurin-interac

73 its calcineurin-interacting site and Ras/Rab GTPase-activating protein domain, functions as an endoge

74 Homeostatic sleep control requires the Rho-GTPase-activating protein encoded by the crossveinless-c

75 Elimination of Ras GTPase-activating protein enhanced E-CD4 but decreased T

76 GTPase-activating protein enhances these changes in GTP

77 RhoA activity and its regulated GTPase-activating protein FilGAP are elevated during ear

78 ly inactivated in cancer, encodes a Rho-GAP (GTPase activating protein) focal adhesion protein whose

79 equires the distal-pole tag Bud8 and Rga1, a GTPase activating protein for Cdc42, which inhibits budd

80 Thus, TBC1D16 is a GTPase activating protein for Rab4A that regulates trans

81 response to amino acids, including GATOR1, a GTPase activating protein for RAGA, and GATOR2, a positi

82 ARAP3, a GTPase activating protein for Rho and Arf family GTPases

83 o GTPase-activating protein 29 (ArhGAP29), a GTPase activating protein for Rho proteins.

84 Chimaerins, a family of GTPase activating proteins for the small G-protein Rac,

85 In this paper, we identify SH3BP1, a GTPase-activating protein for Cdc42 and Rac, as a regula

86 es of cultured hippocampal neurons, and as a GTPase-activating protein for Cdc42, it decreased the F-

87 gulator of G protein signaling 2 (RGS2) is a GTPase-activating protein for G(q/11)alpha and G(i/o)alp

88 Conversely, ARHGAP25, a GTPase-activating protein for Rac, was up-regulated in A

89 which occurs in the absence of the predicted GTPase-activating protein for Ras, leads to reduction in

90 nd tuberin form the TSC complex that acts as GTPase-activating protein for Rheb and negatively regula

91 independent of its best known function as a GTPase-activating protein for Rho small GTPases.

92 lator of G-protein signaling 18 (RGS18) is a GTPase-activating protein for the G-alpha-q and G-alpha-

93 strates that the loss of DAB2IP, a novel Ras-GTPase activating protein frequently found in many cance

94 ing through Rag GTPases, and GATOR1 displays GTPase activating protein (GAP) activity for RAGA and RA

95 neurofibromin functioning as a Ras-specific GTPase activating protein (GAP) and Spred1 acting on hit

96 A key role in this process belongs to the GTPase Activating Protein (GAP) complex that catalyzes G

97 lexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifical

98 y, we demonstrate that Pex11p functions as a GTPase activating protein (GAP) for Dnm1p in vitro.

99 C1 signaling by interacting with GATOR1, the GTPase activating protein (GAP) for RagA/B.

100 GATOR1 is a GTPase activating protein (GAP) for RagB whereas GATOR2

101 utations within a gene predicted to encode a GTPase activating protein (GAP) for Ras.

102 eIF5 is the GTPase activating protein (GAP) for the eIF2 . GTP . Met

103 linked retinitis pigmentosa protein RP2 is a GTPase activating protein (GAP) for the small GTPase Arl

104 The mammalian Tsc1-Tsc2 GTPase activating protein (GAP) heterodimer is a critica

105 anine nucleotide exchange factor (GEF) and a GTPase activating protein (GAP) is an efficient method f

106 of the small GTPase Arl3 and its regulatory GTPase activating protein (GAP) Retinitis Pigmentosa 2 (

107 lexes regulate the Rags, including GATOR1, a GTPase activating protein (GAP), and GATOR2, a positive

108 Bud2 is a GTPase activating protein (GAP), and the only known subs

109 Rapid GTPase activating protein (GAP)-mediated inactivation (R

110 Arf6 and the Arf6 GTPase-activating protein (GAP) ACAP1 are established re

111 GATOR1 has GTPase-activating protein (GAP) activity for RagA and Ra

112 localizes to membrane protrusions, where its GTPase-activating protein (GAP) activity is required for

113 Through its GTPase-activating protein (GAP) activity toward Rheb, th

114 The YopE C-terminal domain has GTPase-activating protein (GAP) activity.

115 e NF1-encoded protein neurofibromin is a Ras GTPase-activating protein (GAP) and can directly limit R

116 fector Raf while promoting the engagement of GTPase-activating protein (GAP) and GTP hydrolysis.

117 RAB10 and its GTPase-activating protein (GAP) AS160 comprise the princ

118 ncovered a novel role for the Cdc42-directed GTPase-activating protein (GAP) Bem2 in Cdc42 polarizati

119 ition of the small G protein Rac1 by the Rac GTPase-activating protein (GAP) beta2-Chimaerin (beta2Ch

120 We identify the Rac-specific GTPase-activating protein (GAP) breakpoint cluster regio

121 shuttles heterodimeric, G(i/o)alpha-specific GTPase-activating protein (GAP) complexes composed of Gb

122 tion can rescue cytokinesis failure when the GTPase-activating protein (GAP) CYK-4 is disrupted, Rac

123 ExoT possesses an N-terminal GTPase-activating protein (GAP) domain and a C-terminal

124 cell division axis by signaling through its GTPase-activating protein (GAP) domain and Cdc42.

125 on interactions with CYK-4/MgcRacGAP, a Rho GTPase-activating protein (GAP) domain containing protei

126 show that, contrary to expectations, the Rho GTPase-activating protein (GAP) domain of CYK-4 promotes

127 eir effects via an intracellular R-Ras/M-Ras GTPase-activating protein (GAP) domain or by activation

128 ing synaptic F-actin through its cytoplasmic GTPase-activating protein (GAP) domain.

129 1), but not guanine exchange factor (GEF) or GTPase-activating protein (GAP) enzymes, and is exclusiv

130 interacting protein) is a member of the Ras GTPase-activating protein (GAP) family that has been pre

131 is a multifunctional protein that acts as a GTPase-activating protein (GAP) for Arf GTPases, as well

132 igmentosa 2 polypeptide (RP2) functions as a GTPase-activating protein (GAP) for ARL3 (Arf-like prote

133 Bud2p, which functions as a GTPase-activating protein (GAP) for Bud1p/Rsr1p, is requ

134 s established the mouse TBC1D20 protein as a GTPase-activating protein (GAP) for RAB1 and RAB2, and b

135 Here we demonstrate that TBC1d5, a GTPase-activating protein (GAP) for Rab7, is a high-affi

136 TBCK is a putative GTPase-activating protein (GAP) for small GTPases of the

137 ent systematic approaches identified Rga2, a GTPase-activating protein (GAP) for the Cdc42 Rho-type G

138 synGAP is a neuron-specific Ras and Rap GTPase-activating protein (GAP) found in high concentrat

139 o show that the Saccharomyces cerevisiae Arf GTPase-activating protein (GAP) homolog Gcs1p uses a rel

140 he yeast Rab5 Vps21, which also recruits the GTPase-activating protein (GAP) Msb3.

141 eracts with the PDZ binding motif of the Rho GTPase-activating protein (GAP) Myosin-9A.

142 We identified CNT-2, an Arf GTPase-activating protein (GAP) of the AGAP family, as a

143 The Ras GTPase-activating protein (GAP) p120RasGAP inhibits Ras

144 We found that the GTPase-activating protein (GAP) p190RhoGAP-A was selecti

145 ide exchange factor (GEF) Scd1 and the Cdc42 GTPase-activating protein (GAP) Rga4.

146 b3 and Rab27 has been reported; however, the GTPase-activating protein (GAP) specific for Rab27B has

147 Neurofibromatosis type I (Nf1) is a GTPase-activating protein (GAP) that inactivates the onc

148 SynGAP is a Ras/Rap GTPase-activating protein (GAP) that is a major constitu

149 Deleted in Liver Cancer 1 (DLC1) is a RHO GTPase-activating protein (GAP) that negatively regulate

150 several GTPases (Arf4, Rab6, Rab11) and the GTPase-activating protein (GAP), ArfGAP with SH3 domain,

151 the signaling gene RGS2, which encodes for a GTPase-activating protein (GAP), is a key regulatory hub

152 ith alanine impaired both intrinsic and TSC2 GTPase-activating protein (GAP)-mediated GTP hydrolysis

153 that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is

154 The GTPase-activating protein (GAP)-related domain is requir

155 re we identify Msb3/Gyp3 as a specific Vps21 GTPase-activating protein (GAP).

156 One effector, YopE, functions as a Rho GTPase-activating protein (GAP).

157 the Src homology 3 (SH3) domain of p115 Rho GTPase-activating protein (GAP).

158 ide exchange factor [GEF]) and RhoGAPp190 (a GTPase activating protein [GAP]), that show robust inter

159 The activity of GTPases is regulated by GTPase activating proteins (GAPs) and GTP exchange facto

160 Plexins are Ras/Rap family GTPase activating proteins (GAPs) and we find that the P

161 They achieve this by acting as GTPase activating proteins (GAPs) for Galpha subunits an

162 of Hh signaling via their ability to act as GTPase activating proteins (GAPs) for GTP-bound Galphai,

163 GTPase activating proteins (GAPs) from pathogenic bacter

164 GTPase-activating proteins (GAPs) accelerate hydrolysis

165 complex, protecting it from inactivation by GTPase-activating proteins (GAPs) and from nucleotide ex

166 GTPase-activating proteins (GAPs) and guanine exchange f

167 change factors, but essential roles for Arf1 GTPase-activating proteins (GAPs) are less clear.

168 The substrates for most Rab GTPase-activating proteins (GAPs) are unknown.

169 GTPase-activating proteins (GAPs) decrease the amount of

170 e describe the first screen for putative Rab-GTPase-activating proteins (GAPs) during collective cell

171 ly identified members of the ELMOD family as GTPase-activating proteins (GAPs) for ARL2 that displaye

172 and Tre2/Bub2/Cdc16 (TBC) domain containing GTPase-activating proteins (GAPs) for defects in DCV rel

173 Regulators of G protein signaling (RGS) are GTPase-activating proteins (GAPs) for G(i) and G(q) alph

174 nd ELMOD2 recently were shown to function as GTPase-activating proteins (GAPs) for the Arf family of

175 leotide exchange factors (GEFs) activate and GTPase-activating proteins (GAPs) inhibit RhoA activity.

176 eam guanine nucleotide exchange factors, and GTPase-activating proteins (GAPs) is differentially dysr

177 ss of function of two distinct RhoA-specific GTPase-activating proteins (GAPs) leads to opposite neur

178 t Galphao's ability to become deactivated by GTPase-activating proteins (GAPs) or by its intrinsic GT

179 erging class of coat components has been the GTPase-activating proteins (GAPs) that act on the ADP-ri

180 AGAPs are a subtype of Arf GTPase-activating proteins (GAPs) with 11 members in hum

181 guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and also post-transla

182 Rab activity is modulated in part by GTPase-activating proteins (GAPs), and many RabGAPs shar

183 At least six ADP-ribosylation factor (Arf) GTPase-activating proteins (GAPs), including ARAP2 (an A

184 e nucleotide dissociation inhibitors (GDIs), GTPase-activating proteins (GAPs), or the chaperone/GEF

185 This GTPase is negatively regulated by the GTPase-activating proteins (GAPs), which are important f

186 activities of Rho GTPases are stimulated by GTPase-activating proteins (GAPs), which contain a RhoGA

187 anine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which partner with on

188 e factors (GEFs) and negatively regulated by GTPase-activating proteins (GAPs).

189 anine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs).

190 lled guanine nucleotide exchange factors and GTPase-activating proteins (GAPs).

191 Ras GTPase activity and confer resistance to GTPase-activating proteins (GAPs).

192 uanine nucleotide exchange factors [GEFs] or GTPase-activating proteins [GAPs]) are involved in coord

193 factors; GEFs) and Rho GTPase inactivators (GTPase-activating proteins; GAPs), we find that Abr, a p

194 biquitin ligases and GTPase exchange factors/GTPase-activating proteins (GEF/GAP).

195 a proteomic approach, we identified the RhoA-GTPase-activating protein Gem-interacting protein (GMIP)

196 SynGAP is a Ras-GTPase activating protein highly enriched at excitatory

197 We show that ELMOD1 is a GTPase-activating protein in hair cells for the small GT

198 r, a dual guanine nucleotide exchange factor-GTPase-activating protein, in this process.

199 creased steady state levels of Tbc1d1, a RAB-GTPase activating protein involved in Glucose 4 transpor

200 AT]; a scaffold protein, IQ motif containing GTPase activating protein (IQGAP); and three NFAT kinase

201 ysin/Rvs (F-BAR) Cdc15p, IQ motif containing GTPase-activating protein (IQGAP) Rng2p, and formin Cdc1

202 IQ motif-containing GTPase-activating protein (IQGAP) scaffolding proteins r

203 We found that the IQ-motif-containing GTPase-activating protein IQGAP1 interacts directly with

204 Here we show that ArhGAP30, a Rho GTPase-activating protein, is a pivotal regulator for p5

205 protein signaling 2 (RGS2), a G(q)-specific GTPase-activating protein, is strongly implicated in car

206 lified by select IQGAPs (IQ motif containing GTPase-activating proteins) known to coordinate cellular

207 L. pneumophila GTPase-activating protein LepB inactivates Rab1 before i

208 of MeaB is incomplete in the absence of the GTPase-activating protein MCM and therefore unable to st

209 ng caused by depletion of male germ cell Rac GTPase-activating protein (MgcRacGAP), a component of th

210 exception of the Crossveinless-c (Cv-c) Rho GTPase-activating protein, most effectors exert little m

211 efect of macrophages lacking the RhoGAP (Rho GTPase-activating protein) myosin IXb (Myo9b).

212 tions in the NF1 gene, which encodes the RAS GTPase-activating protein neurofibromin.

213 lex containing the spine regulator Rac1, its GTPase-activating protein neuron-associated developmenta

214 4, which encodes the ADP ribosylation factor GTPase-activating protein nevershed/AGD5.

215 1743-1757) shows that a Cdc42-specific GTPase-activating protein (NOMA-GAP) regulates the branc

216 MglB, the GTPase-activating protein of MglA, regulates motor rever

217 In this paper, we report that RasGAP (GTPase-activating protein of Ras) prevented indirect act

218 m involves p120 catenin interaction with Rho GTPase activating protein (p190RhoGAP), leading to p190R

219 known target of miRNA-132 is the Rho family GTPase-activating protein, p250GAP.

220 PLC-beta isoforms also function as GTPase-activating proteins, potentiating Gq deactivation

221 Rga1, a Cdc42 GTPase-activating protein, prevents budding within the d

222 Added GTPase-activating protein promotes GTP hydrolysis by Ypt

223 ine nucleotide exchange factors) and RhoGAP (GTPase activating proteins), proteins that control the a

224 emonstrate that TBC1D15, a mitochondrial Rab GTPase-activating protein (Rab-GAP), governs autophagoso

225 Expression of the Rab3 GTPase activating protein, Rab3Gap1, was restored in Ppp

226 Overexpression of a specific subset of Rab GTPase-activating proteins (RabGAPs) inhibited histamine

227 olyze GTP very slowly unless assisted by Rab GTPase-activating proteins (RabGAPs).

228 docytes, we identified a RhoA-activated Rac1 GTPase-activating protein (Rac1-GAP), Arhgap24, that was

229 esides on chromatin, and the cytoplasmic Ran GTPase activating protein RanGAP.

230 The Ran GTPase activating protein (RanGAP) is important to Ran s

231 Its localization is tightly regulated by the GTPase-activating protein RanGAP1 and the nuclear guanos

232 en characterized as a coactivator of the Ran GTPase-activating protein RanGAP1.

233 ce of the widespread down-regulation of Rap1 GTPase-activating protein (Rap1GAP), a negative regulato

234 Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is tho

235 y reduced by silencing expression of the Ras-GTPase activating protein (Ras-GAP) neurofibromin, a 5-H

236 demonstrate that RASAL2, which encodes a RAS-GTPase-activating protein (RAS-GAP), is a functional tar

237 nclude functional alteration of GTPases, Ras GTPase-activating proteins, Ras guanine exchange factors

238 Yeast 2-hybrid analyses identified the Ras GTPase-activating protein Rasa1, a known regulator of ly

239 ect found in our previous studies of the Ras GTPase activating protein (RasGAP) and the elongation fa

240 125V) in the scat Rasa3 gene, encoding a Ras GTPase activating protein (RasGAP), and elucidate the me

241 key regulator of this cascade is the Nf1 Ras GTPase activating protein (RasGAP), which attenuates Ras

242 NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss drives c

243 r Grb2-associated binder-1 (GAB1) on its RAS GTPase-activating protein (RASGAP) binding sites and is

244 ide derived from the N2 fragment of p120 Ras GTPase-activating protein (RasGAP), sensitizes tumor cel

245 Ras GTPase-activating proteins (RasGAPs) inhibit signal tran

246 asal, belonging to the GAP1 subfamily of Ras GTPase-activating proteins (RasGAPs) with dual RasGAP/Ra

247 cleotide exchange factors and the Arf family GTPase-activating proteins, respectively.

248 , a tumor suppressor gene that encodes a Ras-GTPase-activating protein, results in hyperactivity of R

249 (XLRP) resulting from mutations in the ARL3 GTPase activating protein, retinitis pigmentosa 2 (RP2).

250 Loss of the Cdc42 GTPase activating proteins, Rga2 and Bem3, also abolishe

251 p curvature, countering the effects of Cdc42 GTPase-activating protein Rga4.

252 tinas, immunostaining for Gbeta3 and for the GTPase activating proteins RGS7, RGS11, R9AP and Gbeta5

253 on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and its ab

254 rons require Crossveinless-c, a specific Rho-GTPase-activating protein (Rho-Gap), to alter their memb

255 a member of the Slit-Robo sub-family of Rho GTPase-activating proteins (Rho GAPs), controls actin an

256 DLC1 tumor suppressor gene, which encodes a GTPase activating protein (RhoGAP) for the RhoA and RhoC

257 , which might install platforms allowing Rho-GTPase-activating protein (RhoGAP) activity to be focuse

258 nd S567) in the DLC1 tumor suppressor, a Rho GTPase-activating protein (RhoGAP) associated with focal

259 Centralspindlin, composed of the Rho family GTPase-activating protein (RhoGAP) MgcRacGAP/CYK-4 and t

260 The DLC1 gene encodes a Rho GTPase-activating protein (RhoGAP) that functions as a t

261 BPGAP1 is a Rho GTPase-activating protein (RhoGAP) that regulates cell m

262 se proteins are inactivated by Rho-selective GTPase-activating proteins (RhoGAP), which have generall

263 RHO GTPase-activating proteins (RHOGAPs) are one of the majo

264 er cancer genes (DLC1-3) encode Rho-specific GTPase-activating proteins (RhoGAPs).

265 a different ribosomal protein sequence or by GTPase-activating protein sequence resulted in a partial

266 Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (

267 s granule responses and co-localisation with GTPase Activating Protein (SH3 domain) Binding Proteins

268 e factor (Gartenzwerg) or overexpressing its GTPAse-activating protein showed that ARF1-GTP is essent

269 vitro and in vivo, whereas mutations in rho-GTPase-activating protein showed the same phenotype as P

270 lks) and degradation of spine-associated Rap GTPase-activating protein (SPAR) to reduce synaptic exci

271 FilGAP is an FLNA-binding GTPase-activating protein specific for RAC, which in viv

272 Whereas ARAP1 encodes a GTPase activating protein, STARD10 is a member of the st

273 tion-based nucleotide binding, intrinsic and GTPase-activating protein-stimulated GTPase, and ARL3 gu

274 by Rab6A', even in the presence of cellular GTPase-activating proteins, suggesting that the function

275 we demonstrate that the function of Synaptic GTPase-Activating Protein (SynGAP), a key synaptic prote

276 in (FMRP) and haploinsufficiency of synaptic GTPase-activating protein (SynGAP), two prevalent monoge

277 2-Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs).

278 The Rab-GTPase-activating proteins TBC1D1 and TBC1D4 (AS160) wer

279 reactivates a cryptic transcript of the Rab GTPase activating protein TBC1D16 (TBC1D16-47 kDa; refer

280 Insulin-elicited phosphorylation of the GTPase-activating protein TBC1D4 (AS160) suppresses its

281 eurofibromatosis type 1 (Nf1) gene encodes a GTPase activating protein that negatively regulates smal

282 enes, including Arhgap1, which encodes a RHO GTPase activating protein that was required for tumor ce

283 SEC23 is a GTPase-activating protein that activates the SAR1 GTPase

284 RASA1 is a GTPase-activating protein that acts as a negative regula

285 gulator of G protein signaling (RGS) Sst2, a GTPase-activating protein that dampens pheromone recepto

286 RASA1 (also known as p120 RasGAP) is a Ras GTPase-activating protein that functions as a regulator

287 y controls the expression of p190RhoGAP-A, a GTPase-activating protein that inhibits small GTPase Rho

288 ARHGAP25 is a Rac-specific GTPase-activating protein that is expressed primarily in

289 spine development are regulated by ASAP1, a GTPase-activating protein that modulates Arf4 GTPase act

290 QGAP1 binds to both RhoA and p190A-RhoGAP, a GTPase-activating protein that normally inhibits RhoA ac

291 ng to Akt substrate of 160 kD (AS160), a Rab GTPase-activating protein that regulates the trafficking

292 ion of regulator of G-protein signaling 2, a GTPase-activating protein that restricts Gaq and Gas sig

293 issociation inhibitor [GDI]) or Gyp1p/Gyp7p (GTPase-activating protein)-this kinase phosphorylates HO

294 dria during infection and acts as a specific GTPase-activating protein to interfere with the function

295 calcium-promoted Ras inactivator (CAPRI), a GTPase-activating protein, to the plasma membrane downst

296 RC1) by the increased minichromosome loss 1/ GTPase-activating proteins toward Rags 1 (Iml1/GATOR1) c

297 ct activator of mTOR, and its inhibitor, the GTPase-activating protein tuberin (TSC2), may play a rol

298 s of a kinesin-6 motor (Pav/kinesin-6) and a GTPase-activating protein (Tum/RacGAP).

299 ed GTP hydrolysis in water, Ras, and Ras.Ras-GTPase-activating protein using quantum mechanics/molecu

300 We discovered that DAB2IP, a novel Ras-GTPase-activating protein, was frequently epigenetically