ライフサイエンスコーパス: GTPase

1 GTPase activity was essential only for turnover of FtsZ2

2 GTPase-activating proteins (GAPs) and guanine exchange f

3 d Ras-related C3 botulinum toxin substrate 1 GTPase activity and actin polymerization.

4 anine nucleotide exchange factor (GEF) and a GTPase activating protein (GAP) is an efficient method f

5 al homologue, LRRK2 was proposed to act as a GTPase activated by dimerization (GAD), while recent rep

6 sensitivity to mutation when regulated by a GTPase activating protein and a nucleotide exchange fact

7 utations within a gene predicted to encode a GTPase activating protein (GAP) for Ras.

8 rol of the fungal ras2 gene, which encodes a GTPase central to fungal reproductive development.

9 response to amino acids, including GATOR1, a GTPase activating protein for RAGA, and GATOR2, a positi

10 Dynamin is a GTPase that plays a vital role in clathrin-dependent end

11 We show that ELMOD1 is a GTPase-activating protein in hair cells for the small GT

12 anine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs).

13 tion-based nucleotide binding, intrinsic and GTPase-activating protein-stimulated GTPase, and ARL3 gu

14 od pathways, involving ubiquitin ligases and GTPase exchange factors/GTPase-activating proteins (GEF/

15 growth phenotype in absence of RsgA, another GTPase, well known to act in 30S subunit assembly.

16 e peripheral sites of the PH domain, the Arf GTPase and, unexpectedly, the Sec7 domain.

17 The Arf-GEFs activate Arf GTPases and are therefore the key molecular decision-mak

18 ynthetic sorting center of the cell, the Arf GTPases are responsible for coordinating vesicle formati

19 E3 ligase and ADP-ribosylation factor (ARF) GTPase activity.

20 we focused on ADP ribosylation factor (Arf) GTPases, which orchestrate a variety of regulatory funct

21 the role of ADP-ribosylation factor 1 (ARF1)-GTPase and its effector ARF-guanine-exchange factors (GE

22 Unlike the ubiquitously expressed human Arf6 GTPase, PSD3 localization is restricted to the brain, pa

23 ard the vesicular trafficking regulator Arf6 GTPase is required for matrix degradation.

24 ospholipase Dalpha1 (PLDalpha1), both act as GTPase-activity accelerating proteins (GAPs) for the Gal

25 PLC-beta isoforms also function as GTPase-activating proteins, potentiating Gq deactivation

26 ediated by a family of Dynamin-like Atlastin GTPase proteins.

27 culum membranes is catalyzed by the atlastin GTPase.

28 echanism involves trans-dimerization between GTPase heads and a favorable crossover conformational sh

29 conformation that functions as a GTP-binding GTPase and is required for cancer stem cell survival.

30 , as the closed conformation has GTP binding/GTPase activity, and the open conformation transamidase

31 on to disorganize/inactivate the GTP binding/GTPase site.

32 experiments were accompanied by biochemical GTPase activity assays and transendothelial resistance m

33 ntifiers are phosphoinositides and GTP-bound GTPases, which provide well-defined but mutable labels.

34 l cell-cell communication, all controlled by GTPases of the RHO family.

35 ions were comparable to those of a canonical GTPase with an effector.

36 Rga1, a Cdc42 GTPase-activating protein, prevents budding within the d

37 ator of cell polarity, the activity of CDC42 GTPase is tightly controlled in maintaining normal hemat

38 eta-Arrestin1 binds and suppresses the Cdc42 GTPase-activating protein ARHGAP21, we hypothesize that

39 ucleotide exchange factors for Rac and Cdc42 GTPases.

40 d increased activation of both Rac and Cdc42 GTPases.

41 rotein 1 (IQGAP1), an effector of Rac1/CDC42 GTPases, in the regulation of actin cytoskeleton dynamic

42 ins that belong to the subgroup of centaurin GTPase family, encoded by CENTG1 located in CDK4 amplico

43 Dynamins are mechano-chemical GTPases involved in the remodeling of cellular membranes

44 ARL13B is a ciliary GTPase with at least three missense mutations identified

45 tion following the selective loss of ciliary GTPase Arl13b in interneurons impairs interneuronal morp

46 Here, we identify a universally conserved GTPase (HflX) as a bona fide dissociation factor of the

47 affold proteins, such as IQ motif containing GTPase activating protein 1 (IQGAP1), are promising targ

48 an ERK scaffold protein, IQ motif containing GTPase activating protein 1 (IQGAP1).

49 egion mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2 (proteinase-activ

50 that LGR5 interacts with IQ motif-containing GTPase-activating protein 1 (IQGAP1), an effector of Rac

51 OK2 directly phosphorylates the cytoskeletal GTPase Septin7, at an evolutionary conserved residue.

52 ribosome, confirming the ribosome-dependent GTPase activity of the Obg family.

53 rectly binds preproteins through its dimeric GTPase domain.

54 ing through Rag GTPases, and GATOR1 displays GTPase activating protein (GAP) activity for RAGA and RA

55 hosphorylation of the mitochondrial division GTPase dynamin-related protein 1 promoted mitochondrial

56 affold as well as an ADP-ribosylation factor-GTPase-activating protein.

57 biquitin ligases and GTPase exchange factors/GTPase-activating proteins (GEF/GAP).

58 Rheb is a Ras family GTPase, which binds to and activates mammalian target of

59 SGK1 promotes expression of the Rho family GTPase Cdc42, a positive regulator of actin assembly, ce

60 ling through sequestration of Rac/Rho family GTPases and by using monomeric actin as bait to recruit

61 Rho family GTPases are critical regulators of cellular functions th

62 Rho family GTPases regulate diverse cellular events, such as cell m

63 ts, Gbetagamma subunits, and some Rho family GTPases, phospholipase C-beta (PLC-beta) isoforms hydrol

64 Rho family GTPases, the prototypical members of which are Cdc42, Ra

65 The total cellular content of Rho-family GTPases was higher in anti-inflammatory cells, but this

66 e latter may signal through other RHO-family GTPases.

67 cific isoform of the large, membrane fission GTPase, can be activated in nonneuronal cells downstream

68 and mitochondrial recruitment of the fission GTPase dynamin-related protein 1 (DRP1).

69 ubcellular distribution that is required for GTPase signaling.

70 ted PLC-beta3 activation and for the Galphaq GTPase-activating protein activity of PLC-beta.

71 e nucleotide dissociation inhibitors (GDIs), GTPase-activating proteins (GAPs), or the chaperone/GEF

72 osyltransferase domain that inactivates host GTPases.

73 cluster other proteins directly involved in GTPase signaling mechanisms.

74 e we demonstrate that the interferon-induced GTPase family of guanylate-binding proteins (GBPs) coats

75 nce protein 1 (MX1) is an interferon-induced GTPase that plays an important role in the defense of ma

76 ich led to formation of interferon-inducible GTPase-containing aggregates and hampered recruitment of

77 tion of autophagy proteins and IFN-inducible GTPases to inhibit replication of positive-sense RNA vir

78 LC3 conjugation system and the IFN-inducible GTPases were necessary to inhibit MNV replication in mic

79 proteins and the induction of IFN-inducible GTPases, which are known to destroy the membrane of vacu

80 hampered recruitment of interferon-inducible GTPases to vacuolar pathogens.

81 tosolic distribution of interferon-inducible GTPases.

82 rms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream s

83 equence of hypotheses for how intracellular (GTPase) and ECM signaling jointly regulate lamellipodial

84 4 of Dyn2 to alanine (Dyn2K44A) disrupts its GTPase activity.

85 and promoting vascular relaxation due to its GTPase accelerating protein activity toward Galphaq.

86 mplex signaling network composed of kinases, GTPases, and lipids, such as phosphoinositides, helps to

87 Dynamin is a large GTPase that forms a helical collar at the neck of endocy

88 OPA1, a gene encoding a mitochondrial large GTPase involved in cristae structure and mitochondrial n

89 The large GTPase dynamin mediates membrane fission during clathrin

90 at PI(4)P is needed to anchor Arl8 (Arf-like GTPase 8) and its effector homotypic fusion/vacuole prot

91 e mitochondrial fission protein dynamin-like GTPase Drp1.

92 ted the protein ADP-ribosylation factor-like GTPase 13b (ARL13b) as a model palmitoylated ciliary pro

93 erial division, polymers of the tubulin-like GTPase FtsZ assemble at midcell to form the cytokinetic

94 (ER) is mediated by a class of dynamin-like GTPases known as atlastin (ATL).

95 that interacts with members of the Rho-like GTPases from Plants (ROP) small GTPase family.

96 nfluences their ability to control localized GTPase activity in the context of migration and invasion

97 orosarcina pasteurii UreG (SpUreG), a P-loop GTPase and the first discovered native ID enzyme, involv

98 ue GTP-specific antibody fragment to monitor GTPase cycling in the presence of a guanine nucleotide e

99 n this work, we show that RabA2, a monomeric GTPase from common bean, is required for the progression

100 Dynamins are a family of large, multidomain GTPases involved in key cellular processes in eukaryotes

101 model whereby RAPGEF5 activates the nuclear GTPases, Rap1a/b, to facilitate the nuclear transport of

102 However, the ObgE GTPase activity was stimulated upon binding to the ribos

103 Disruption of GTPase domain dimerization abolishes the fusogenic activ

104 n mechanism that regulates the Ras family of GTPases and provides an important mechanism by which SIR

105 s critical actions of the atlastin family of GTPases in maintaining the morphology of the endoplasmic

106 tivated downstream of the Ras superfamily of GTPases, and Ras-PI3K interaction plays a key role in pr

107 ad only modest effects on GTP binding and on GTPase activity and did not perturb stability of the MCM

108 ith CDR formation, whereas the role of other GTPases in this process is either lacking or inconclusiv

109 n XLRP.Mutations in the Retinitis Pigmentosa GTPase Regulator (RPGR) cause retinal dystrophy, but how

110 Mutations in the Retinitis Pigmentosa GTPase Regulator (RPGR) cause X-linked RP (XLRP), an unt

111 sa (RP) associated with retinitis pigmentosa GTPase regulator gene (RPGR) mutations.

112 FtsZ comprises a polymerizing GTPase domain, an intrinsically disordered C-terminal li

113 ng induces conformational changes to promote GTPase domain dimerization in the transition state.

114 through its affinities for the membrane Rab GTPase Ypt7.

115 g LRRK2 kinase phosphorylates a group of Rab GTPase proteins including Rab29, within the effector-bin

116 Overexpression of a specific subset of Rab GTPase-activating proteins (RabGAPs) inhibited histamine

117 understanding of the molecular basis of Rab GTPase-regulated membrane trafficking in eukaryotic cell

118 The Rab GTPase effector, Rab-coupling protein (RCP) is known to

119 ers of functional diversification in the Rab GTPase gene family in three Paramecium aurelia species.

120 Here, the authors identify the Rab GTPase Rab35 as an essential component of this contracti

121 ptotic cells, through recruitment of the Rab GTPase UNC108.

122 tein particle (TRAPP) complexes activate Rab GTPases by catalyzing GDP/GTP nucleotide exchange.

123 Ypt1 and Sec4 are essential Rab GTPases that control the early and late stages of the ye

124 Activation and inactivation of Rab GTPases by GEFs and GAPs promotes or terminates vesicle

125 ost-translational geranylgeranylation of Rab GTPases represents one way to control the activity of th

126 s the post-translational modification of RAB GTPases that contain C-terminal CXC motifs.

127 cts of C-terminal carboxylmethylation on RAB GTPases and provide a rationale for targeting ICMT in th

128 ncrease in the activated levels of small Rab GTPases such as Rab5 and Rab7, both key regulators of en

129 teine residues of CaaX proteins and some RAB GTPases.

130 s, presumably by inactivating the target Rab GTPases.

131 Zerial was the first to discover that Rab GTPases represent identity markers for different membran

132 e of the established players include the Rab GTPases, the SNARE complex proteins, and others, which f

133 Rab-GTPase binding effector protein 2 (RABEP2) was identifie

134 pH-sensitive machinery downstream of the Rab-GTPase Ypt7 needed for SNARE-mediated lipid bilayer merg

135 e-nucleotide exchange factor activating Rab5 GTPases, is required for both pre- and postinvasive immu

136 GTP-bound Rab5 GTPases accumulate in the encasement, but not the papill

137 e molecular level, RIN1 signals through Rab5 GTPases that control endocytosis of cell-surface recepto

138 in and demonstrate that FLCN acts as a Rab7A GTPase-activating protein.

139 P19, we identify CEP350, FOP, and the RABL2B GTPase as proteins organizing the first known mechanism

140 ar superoxide scavenger) or NSC 23766 (a Rac GTPase inhibitor) completely inhibited Siglec-8-mediated

141 at are associated with the activation of Rac GTPase and its cytoskeletal targets.

142 he unexpected pro-oncogenic functions of Rac GTPase-activating proteins also challenged the dogma tha

143 o to stimulate the signaling activity of Rac GTPase: Abl gates the activity of the spectrin repeats o

144 anonical Crk-p130Cas complex to activate Rac GTPases in numerous contexts.

145 ed mechanism for coordination of Rho and Rac GTPases.

146 , ROS production, and stimulation of the Rac GTPases, which control chemotaxis and ROS.

147 e study was to characterize the role of Rac1 GTPase for the mineralocorticoid receptor (MR)-mediated

148 tive effects of PGA2 by activating Rap1/Rac1 GTPase and protein kinase A targets at cell adhesions an

149 We demonstrate that Rac3 GTPase is critical for integrating the adhesion of invad

150 , which are transduced to mTORC1 via the Rag GTPases and the Ragulator complex.

151 Multiple protein complexes regulate the Rag GTPases in response to amino acids, including GATOR1, a

152 nput to this system, and act through the Rag GTPases to promote the translocation of mTORC1 to the ly

153 through a pathway that converges on the Rag GTPases, an obligate heterodimer of two related GTPases.

154 ction of GATOR1 with its substrates, the Rag GTPases, and with GATOR2.

155 quires intersubunit communication by the Rag GTPases, providing a rationale for why they exist as a d

156 plex regulates mTORC1 signalling through Rag GTPases, and GATOR1 displays GTPase activating protein (

157 cilitates mTORC1 activation by inducing RagA GTPase recruitment of mTORC1 to the lysosomal outer surf

158 n for TRPM8 that unexpectedly acts as a Rap1 GTPase inhibitor, thereby inhibiting endothelial cell mo

159 Unlabelled RAP1 GTPase and HIV integrase proteins were selectively detec

160 key regulator of this cascade is the Nf1 Ras GTPase activating protein (RasGAP), which attenuates Ras

161 A subset of Ras GTPase genes linked to membrane remodeling were upregula

162 f-assembly of plasma membrane-associated Ras GTPases has major implications to the regulation of cell

163 ond system is driven by interferon-regulated GTPases that promote rupture of pathogen-containing vacu

164 of the small GTPase Arl3 and its regulatory GTPase activating protein (GAP) Retinitis Pigmentosa 2 (

165 ADP ribosylation factor family of regulatory GTPases, but is atypical in having a non-homologous, C-t

166 The dynamin-related GTPase atlastin (ATL) catalyzes membrane fusion of the e

167 The mouse immunity-related GTPase (IRGM1) was overexpressed in embryonic fibroblast

168 Mitofusins are dynamin-related GTPases that are essential for mitochondrial fusion.

169 ases, an obligate heterodimer of two related GTPases.

170 Rho GTPase activity needs to be precisely tuned at distinct

171 Apical constriction depends on a Rho GTPase signaling pathway (T48/Fog) that is deployed by t

172 iation of intronic variants in ARHGAP15 (Rho GTPase-activating protein 15; rs4662344-T: P=1.9 x 10(-1

173 and have elucidated the role of atypical Rho GTPase RhoBTB in Drosophila neurological function and po

174 imaging including the use of FRET-based Rho GTPase biosensors.

175 (MMP12)/MMP13, catenin alpha3 (CTNNA3), rho GTPase-activating protein 24 (ARHGAP24), angiopoietin 4

176 kemia-associated RhoGEF (LARG)-dependent Rho GTPase activation.

177 The downstream Rho GTPase effectors mediating actin polymerization through

178 chondrial membrane protein mitochondrial Rho GTPase 1 (Miro1) is a master regulator of mitochondrial

179 90RhoGAP-A and -B, are key regulators of Rho GTPase signaling and are essential for actin cytoskeleta

180 cations in the design and application of Rho GTPase targeting strategies in future cancer therapies.

181 lmonella effector SopE, we recapitulated Rho GTPase-driven actin polymerization at model phospholipid

182 tegrating guidance signals with the ROP1 Rho GTPase signaling and coordinating intracellular signalin

183 cient mice, we define the poorly studied Rho GTPase TC10 as an immunomodulatory molecule playing a ro

184 cular targets in PCa cells including the Rho GTPase family members (for example, CDC42, CDC42EP3, RAC

185 Rho GTPases are the major players that guide cells through s

186 ondrial ROS (mtROS) levels and activates Rho GTPases, which then induces F-actin formation.

187 r pathways downstream of Cdc42, Rac, and Rho GTPases are well documented, but we know surprisingly li

188 idely acknowledged, the role of atypical Rho GTPases (such as RHOBTB2) in neurodevelopment has barely

189 erturbations in four signaling pathways, Rho GTPases, actin, microtubule, and kinases-related pathway

190 titioning of charged polarity-regulating Rho GTPases like Rho1 or Cdc42 in a protein charge-dependent

191 in caused the translocation of the small Rho GTPases RhoA, Cdc42, and Rac1/2/3 from cell membranes to

192 Although the role of typical Rho GTPases and other Rho-linked proteins in synaptic plasti

193 Differences in PtdIns3K and Rho-GTPase activity were attributable to the activity of cal

194 The highly conserved Rho-GTPase Cdc42p promotes yeast fusion through interaction

195 ed cells deficient for the mitochondrial Rho-GTPase 1 (Miro1), an essential mediator of microtubule-b

196 mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fetal l

197 evealed a smoke-induced up-regulation of Rho-GTPase-dependent actin cytoskeletal signaling that can l

198 r mechanism by which cell spreading and RhoA GTPase activity control FA formation through YAP to stab

199 Significantly, both RhoA GTPase gain- and loss-of-function mutations have been di

200 sin RLC phosphorylation is regulated by RhoA GTPase during ACh stimulation, and NM RLC phosphorylatio

201 Toll-like receptors and suppression of RhoA GTPase signaling.

202 -mefloquine enantiomer bound to the ribosome GTPase-associated centre.

203 Here we identify Rab7A, a small GTPase important for endocytic trafficking, as a novel F

204 Arf-like protein 13b (ARL13b) is a small GTPase that functions as a guanosine nucleotide exchange

205 a guanine exchange factor for Rab26, a small GTPase that specifically directs synaptic vesicles to pr

206 pression of 131 genes including Ral, a small GTPase.

207 Here we show that another small GTPase, Rab2, is also required for autophagosome and end

208 an endosomal budding, upstream of ARF6 small GTPase and its effector phospholipase D2, directly phosp

209 cytoskeleton regulation by controlling small GTPase translation in neutrophils at wound sites.

210 showed that the ubiquitously expressed small GTPase Arf6 is required for normal ethanol-induced sedat

211 ic oncogenic phenotypes.The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogenic func

212 s important to know which specific GEF-small GTPase dyad functions in a given cellular process.

213 The conserved ARF-like small GTPase ARL-8 is localized to SVPs and directly activates

214 nipulation, permeability measurements, small GTPase activity, luciferase assays, chromatin immunoprec

215 uced the activity of the pro-migratory small GTPase regulator Rac1.

216 ormation on the new functional role of small GTPase, NOG1, in guard cell signaling and early plant de

217 e signaling events linking JAKs to rho small GTPase activation by chemokines is still incompletely de

218 y increased the activation of the RhoA small GTPase.

219 the Rho-like GTPases from Plants (ROP) small GTPase family.

220 nanoscopy, we explore the role of the small GTPase ARF1 in mediating transport steps at the Golgi.

221 OPI coated vesicle is initiated by the small GTPase Arf1 that recruits the coatomer complex to the me

222 ycling between both sites requires the small GTPase Arf6 but neither caveolin1 (Cav1) nor Cavin1.

223 terestingly, a known ACAP2 target, the small GTPase Arf6, supported histamine-evoked WPB exocytosis,

224 s and showed that it tightly binds the small GTPase ARL2 but appears to be inactive.

225 7 as novel interaction partners of the small GTPase Arl3 and its regulatory GTPase activating protein

226 some dispersal through coupling to the small GTPase Arl8 and the kinesins KIF1B and KIF5B.

227 sitively regulated the activity of the small GTPase CDC42, deletion of which caused severe defects in

228 ciate with decreased expression of the small GTPase Rab11 and the Rab7 effector RILP.

229 grin-dependent local activation of the small GTPase RAC1 at the plasma membrane to control the activi

230 s well as signaling via ERK1/2 and the small GTPase Rac1); however, CXCL14 bound to CXCR4 with high a

231 ymerization by directly activating the small GTPase Rac1.

232 ytoskeleton by local activation of the small GTPase Rac1.

233 s been linked to the activation of the small GTPase Ras homolog family member A (RhoA) by the Galpha1

234 The activation of Raf kinases by the small GTPase Ras requires two major sets of phosphorylations.

235 naling to integrins is mediated by the small GTPase Ras-proximate-1 (Rap1).

236 mTORC1 is activated by the small GTPase RHEB (Ras homologue enriched in brain) and inhibi

237 ivator-inhibitor network, in which the small GTPase Rho amplifies its activity by recruiting its acti

238 and ROCK2) function downstream of the small GTPase RhoA to drive actomyosin cytoskeletal remodeling.

239 al adhesion assembly by activating the small GTPase RhoA.

240 of the actin cytoskeleton through the small GTPase RhoA.

241 The roles of protein kinase C and the small GTPase, Rab9, in alpha1B-AR vesicular traffic were inves

242 atory principles and functions of this small GTPase.

243 ed that NUMB and NUMBL interacted with small GTPase Rab7 to transition ERBB2 from early to late endos

244 H-Ras, K-Ras, and N-Ras are small GTPases that are important in the control of cell prolif

245 expressing DiRas1 or DiRas2, which are small GTPases that bind SmgGDS and act as tumor suppressors.

246 Cellular movement is controlled by small GTPases, such as RhoA.

247 and that this process is regulated by small GTPases.

248 ous GEFs and also a host of Ras family small GTPases, it is important to know which specific GEF-smal

249 ed activation of downstream Ras family small GTPases, which ultimately lead to ERK, JNK, and p38 phos

250 ring that is controlled by Rho-family small GTPases.

251 by several paralog families, including small GTPases, coiled-bundle proteins, and proteins with beta-

252 The Rab family of small GTPases functions in multiple aspects of cellular membra

253 the post-translational prenylation of small GTPases that perform a plethora of cellular functions.

254 , can reliably dissect the response of small GTPases to site-specific modifications.

255 al roles in regulating the activity of small GTPases.

256 tion, and interactions with a suite of small GTPases.

257 e the signaling between RABs and other small GTPases, some of which have a crucial role in the traffi

258 d the membrane localization of several small GTPases and this was potentiated by zoledronic acid.

259 es, which act as effectors for several small GTPases, and has been specifically identified to functio

260 e trans-Golgi and was regulated by the small GTPases Arl1 and Arl8, suggesting a role in trans-Golgi

261 Here, we show that the small GTPases Cdc42 and RhoA act as a regulatory circuit downs

262 The small GTPases of the Rho family (RhoA, Rac1, and Cdc42) play a

263 regulation, and that expression of the small GTPases was markedly increased in miR-142(-/-) neutrophi

264 Emc10 signaled through small GTPases, p21-activated kinase, and the p38 mitogen-activ

265 sic and GTPase-activating protein-stimulated GTPase, and ARL3 guanine nucleotide exchange factor acti

266 on assays and light microscopy, we find that GTPase activation and trans-SNARE complex zippering have

267 The GTPase dynamin-related protein 1 (Drp1) is essential for

268 se flipping that we suggest may activate the GTPase activity of Lsg1.

269 This process requires COPII proteins and the GTPase activity of the COPII subunit SAR1.

270 oth the WASP homology 1 (WH1) domain and the GTPase binding domain (GBD) of N-WASP and no binding to

271 phosphatidylinositol-3,4-biphosphate and the GTPase Rab5 then appear and remain as the uncoating vesi

272 ation of both protein kinase A (PKA) and the GTPase Ras, and is induced upon the activation of beta-a

273 Because the GTPase activity of each of these proteins depends on int

274 ich lipid droplets (LDs) in the liver by the GTPase ARF1, which is a key activator of lipolysis.

275 we cloned, expressed, and characterized the GTPase LdSar1 and other COPII components like LdSec23, L

276 ures of engineered human MFN1 containing the GTPase domain and a helical domain during different stag

277 ation stabilizes the dimer and decreases the GTPase activity.

278 tudied for its role in membrane fission, the GTPase dynamin also regulates early stages of CME.

279 ct activator of mTOR, and its inhibitor, the GTPase-activating protein tuberin (TSC2), may play a rol

280 Moreover, the GTPase-activating function of GIT1 toward the vesicular

281 Here, the authors identify inhibitors of the GTPase activating function of LRS, not affecting its cat

282 e analyses reveal enhanced expression of the GTPase RAC1 and cholesterol-biosynthesis-associated gene

283 the lipidated minimal membrane anchor of the GTPase, N-Ras (tN-Ras).

284 DB and BICD2's membrane vesicle partner, the GTPase Rab6a.

285 Herein, we demonstrate that the GTPase activity of IcmF powers the ejection of the inact

286 Furthermore, we found that the GTPase activity of OPA1 is critical for maintaining cris

287 Indeed, we observed that the GTPase activity of the mutated proteins was impaired.

288 mains are 50 degrees rotated relative to the GTPase domain.

289 tion can rescue cytokinesis failure when the GTPase-activating protein (GAP) CYK-4 is disrupted, Rac

290 fect highly conserved amino acids within the GTPase domain of the protein that are critical for GTP a

291 key mechanistic question, then, is how these GTPase arrays are formed.

292 ave the way to further studies into how this GTPase regulates bacterial physiology, including persist

293 the preprotein-binding regions on the Toc159 GTPase domain (Toc159G) of pea (Pisum sativum) using cle

294 LRRK2 has guanosine triphosphatase (GTPase) and kinase activities, and mutations in LRRK2 ar

295 e recycling small guanosine triphosphatases (GTPases) Rab4 or Rab11 was sufficient to maintain GJs up

296 s involving small guanosine triphosphatases (GTPases) regulate cell polarization.

297 ignal via the Rag guanosine triphosphatases (GTPases) to promote the localization of mTORC1 to the ly

298 Rho family small guanosine triphosphatases (GTPases), which are regulated by the opposing actions of

299 composed primarily of genes associated with GTPase signaling, calcium signaling and cell death.

300 s granule responses and co-localisation with GTPase Activating Protein (SH3 domain) Binding Proteins