ライフサイエンスコーパス: Glanzmann

1 Glanzmann thrombasthenia (GT), an autosomal recessive bl

2 Glanzmann thrombasthenia is an inherited bleeding disord

3 Glanzmann thrombasthenia is an inherited bleeding disord

4 Glanzmann thrombasthenia is an inherited bleeding disord

5 Glanzmann thrombasthenia, an inherited bleeding disorder

6 Glanzmann's thrombasthenia is a qualitative platelet dis

7 In contrast, a Glanzmann mutation at the -1 position of the first Ca(2+

8 was not observed in platelets derived from a Glanzmann's patient, who lacked functional integrin alph

9 with LAD-III show symptoms of both LAD-I and Glanzmann's thrombasthenia.

10 ult in a serious bleeding disorder, known as Glanzmann thrombasthenia.

11 ovel flow cytometry-based aggregation assay, Glanzmann platelets were still capable of forming small

12 nique patient with clinical features of both Glanzmann thrombasthenia and leukocyte adhesion deficien

13 n 3 ethnically distinct families affected by Glanzmann thrombasthenia.

14 90 years ago with a clinical description by Glanzmann of a bleeding disorder associated with a defec

15 ing of new mechanisms of mutagenesis causing Glanzmann thrombasthenia, and our findings will be valua

16 ents with severe combined immune deficiency, Glanzmann's thrombasthenia, Hermansky-Pudlak syndrome, M

17 The human bleeding disorder Glanzmann thrombasthenia (GT) can result from defects in

18 beta(3) integrin cause the bleeding disorder Glanzmann thrombasthenia.

19 erizes a form of the human bleeding disorder Glanzmann's thrombasthenia, fails to rescue beta 3(-/-)

20 752Pro) responsible for the genetic disorder Glanzmann thrombasthenia Paris I did not inhibit cell ad

21 his is exemplified by the bleeding disorder, Glanzmann thrombasthenia (GT), where abnormalities of th

22 One rare example of a platelet disorder, Glanzmann thrombasthenia (GT), is characterized by life-

23 in forms of the inherited platelet disorder, Glanzmann thrombasthenia (GT), mutant alpha(IIb)beta(3)

24 aturally occurring mutations responsible for Glanzmann thrombasthenia and to point mutations that aff

25 resistant membrane (DRM) rafts but that from Glanzmann's thrombasthenic platelets failed.

26 5-year-old white man was diagnosed as having Glanzmann thrombasthenia.

27 's Republic of China was diagnosed as having Glanzmann's thrombasthenia based on (1) nearly a lifelon

28 ment option in a noncompliant patient having Glanzmann's thrombasthenia and briefly discusses other h

29 chain or SLP-76 and in patients with type I Glanzmann thrombasthenia.

30 l, with basic insights resulting in improved Glanzmann thrombasthenia carrier detection and prenatal

31 alphaIIbbeta3 expression and/or function in Glanzmann's thrombasthenia patients, platelet dysfunctio

32 yndrome and kindlin-3 deficiency, but not in Glanzmann thrombasthenia lacking the platelet pool of fi

33 the natural alphaIIb mutations occurring in Glanzmann's thrombasthenic patients.

34 vated platelets was also markedly reduced in Glanzmann platelets (deficient in GP IIb/IIIa).

35 The bleeding seen in Glanzmann's thrombasthenia usually includes bruising, ep

36 ch presents with bleeding similar to that in Glanzmann thrombasthenia and platelet dysfunction in add

37 During studies of the molecular basis of Glanzmann thrombasthenia in a child of mixed Caucasian b

38 We report a case of Glanzmann thrombasthenia in a Pakistani child whose plat

39 demonstrate ex vivo phenotypic correction of Glanzmann thrombasthenia and support the potential use o

40 telets from a patient with a variant form of Glanzmann thrombasthenia that expressed normal levels of

41 A 39-year-old female with a history of Glanzmann's thrombasthenia presented for periodontal the

42 fibrinogen uptake and the pathophysiology of Glanzmann's thrombasthenia.

43 tients, classic aggregometry or perfusion of Glanzmann or LAD-III platelets over collagen-coated slid

44 To develop methods for gene therapy of Glanzmann thrombasthenia, a murine leukemia virus (MuLV)

45 roline mutation, known to cause a variant of Glanzmann's thrombasthenia, inhibits the ability of the

46 and genestein], and with Bernard-Soulier or Glanzmann's platelets, we demonstrated that TR1-41-induc

47 the deficiency was not as severe as in other Glanzmann's thrombasthenia patients.

48 3 complexes on the platelet surface produces Glanzmann thrombasthenia.

49 integrin cause the bleeding disorder termed Glanzmann's thrombasthenia.

50 nonexpression and a bleeding tendency termed Glanzmann thrombasthenia.

51 sruption of the ligand binding domain by the Glanzmann thrombasthenia mutation beta3-D119Y constituti

52 Insertion of the Glanzmann mutation beta3-S752P into the cytoplasmic doma

53 he Leu214Pro mutation appears to produce the Glanzmann thrombasthenia phenotype by both qualitative a

54 rction and other thrombotic diseases whereas Glanzmann thrombasthenia, in which platelet aggregation

55 previously reported as being associated with Glanzmann thrombasthenia (GT), 20 associated with alloim

56 Similar results were obtained with Glanzmann thrombasthenia platelets.

57 so observed on platelets from a patient with Glanzmann thrombasthenia, indicating that alphaII(b)beta

58 defective alphaIIbbeta3 from a patient with Glanzmann thrombasthenia.

59 ribes the dental treatment of a patient with Glanzmann's thrombasthenia.

60 ated in iPSCs derived from two patients with Glanzmann thrombasthenia (GT), an inherited platelet dis

61 Patients with Glanzmann thrombasthenia or Leukocyte Adhesion Deficienc

62 The platelets from three patients with Glanzmann thrombasthenia, who lacked GPIIb/IIIa receptor

63 nding domains of alphaIIb in 2 patients with Glanzmann thrombasthenia.

64 nt IgG-adherent platelets from patients with Glanzmann's thrombasthenia.