ライフサイエンスコーパス: Gly residue

1 ment of a C14:0 fatty acid to the N-terminal Gly residue.

2 other proteins via the conserved C-terminal Gly residue.

3 MLLT sequence was replaced with one to nine Gly residues.

4 tubulin is polyglycylated with one to three Gly residues.

5 ects, however, can be in part compensated by Gly residues.

6 as found for CDR3alpha that contained Pro or Gly residues.

7 experiments enhanced sensitivity for Pro and Gly residues; [2-(13)C]glycerol labeling clarified Val,

8 )N and NH chemical shifts including those of Gly residues 48, 51, 53, and 54 causing their loss of di

9 s, formed from the primary sequence -Gln-Tyr-Gly- (residues 66-68), are arranged in a approximately 2

10 Although the insertion of a Gly residue (absent in arrestins but present in the puta

11 nd electrostatic interaction and the lack of Gly residues adjacent to the Asp ligand explain the rema

12 Our results suggest that the unique Gly residues allow the PDE6 metal binding site to adopt

13 h contains the propeptide and the C-terminal Gly residue, and omega-MVIIA-Gly, which differs from the

14 red in FXIa when Gly193 is replaced by a non-Gly residue, and residues with side chains that branch a

15 The Gly residues are adjacent to the highly conserved metal

16 ence dependency of the motif determined that Gly residues are required at specific positions where on

17 Furthermore, the conserved C-terminal Gly-Gly residues are required for sentrinization to occur.

18 ptides in which the ubiquitin C-terminal Gly-Gly residues are retained on the modified lysine residue

19 The peptide with a highly conserved Gly residue at P3 position was 3-fold more active as a s

20 l structures of several oxidoreductases, the Gly residue at the end of a beta-strand facilitates a sh

21 3.2 and 2.0, respectively, are observed for Gly residues at high magnetic field strengths, but even

22 In contrast, Gly residues at loop positions 2, 4, 6, and 7, none of w

23 Helices IV and V contain five Gly residues at positions 115, 121, 141, 147, and 150, a

24 Mutations of two Gly residues at positions 776 and 778 in this loop drama

25 4)-Gly(23)), with six of the seven conserved Gly residues at the interhelical interface.

26 e RetGC1 binding site, insertion of an extra Gly residue between Ser-173 and Leu-174 as well as delet

27 In contrast, peptide 4, containing two Gly residues but no Pro in the turn, formed only a small

28 Replacement of Gly residues C-terminal to GFPGER did not affect integri

29 , Delta(Delta G degrees )(X) for the Ala and Gly residues decrease with increasing peptide length.

30 Mutation of the conserved PDV1 C-terminal Gly residue did not block PDV1 insertion into the outer

31 led that the +57-Da forms have an additional Gly residue directly N-terminal of the expected Asp(84),

32 ns within an absolutely conserved, cytosolic Gly residue (e.g., betaG37S) had significantly less acti

33 -73 and Asp-74 for the corresponding Ser and Gly residues (ED/SG mutation) of RGS9 diminished the DEP

34 This difference is due to an extra Gly residue found in the FMN binding loop in NOS compare

35 Gly residues (Gly58, 61 and 62) in the beta-turn and pos

36 ptides were synthesized, also containing two Gly residues, GWGIK and LWGIG, and did not have the abil

37 in the C6Rv spontaneous revertant the mutant Gly residue has been changed to Ser at this position.

38 The seventh conserved Gly residue in position 13 adopts a positive angle, enab

39 ion of losing the contribution of the native Gly residue in terminating beta-strand propagation and t

40 n the collagen triple helix that replace one Gly residue in the (Gly-X-Y)(n) repeating pattern by a l

41 The conservation of this Gly residue in the high-abundance chemoreceptors of E. c

42 The presence of conserved Gly residue in the linker region suggests that flexibili

43 microbial peptide [Gly(6)]ccTP 1a with eight Gly residues in an 18-residue sequence.

44 Mutagenesis of any of these Gly residues in GR1 and GR2 reduced catalytic activity t

45 In our model, Gly residues in GXXXG motifs pack against small Ala or V

46 riple-helix that replace one of the required Gly residues in the (Gly-Xaa-Yaa)(n)() repeating sequenc

47 Gly to Ser mutations within the two Gly residues in the essential GFPGER sequence prevented

48 ffect of a substitution of either of the two Gly residues in the glycophorin A GxxxG-motif by Ala or

49 Thus, Gly residues in the TM domain of other viral fusion prot

50 Helical instability induced by gly residues in the transmembrane domain (TMD) of G prot

51 ecificity for this loss of function, the two Gly residues in TM20 were replaced with either Ala or Le

52 a) chemical shielding parameters for central Gly residues in tripeptides adopting alpha-helix, beta-s

53 weakly active (15%) but reintroduction of a Gly residue into TM14 by a single Ile --> Gly substituti

54 ructural studies indicate that the invariant Gly residue is located in an atypical, classic-type beta

55 n the TraF X-ray structure the corresponding Gly residue is positioned near an alpha-helical domain t

56 fere with triple-helix formation, and when a Gly residue is replaced by Ser to model an osteogenesis

57 Thus, at least one TM Gly residue is required for a late step in fusion mediat

58 ompetent hCG subunits and that the invariant Gly residue is required for efficient cystine knot forma

59 sitive bond of the peptides (between the Tyr-Gly residues) is located centrally between the donor and

60 Non-Gly residues located near the left-handed alpha-helical

61 rystallographic data reveal that a conserved Gly residue (located at the juncture between the linker

62 Kinetic measurements show that some of these Gly residues measurably alter the rates of metal ion ass

63 t modification of PML requires the conserved Gly residue near the C termini of sentrin proteins.

64 Because sentrin possesses the conserved Gly-Gly residues near the C terminus, it is likely that thes

65 bond vector and the diffusion tensor of the Gly residues needed to be readjusted.

66 state from myristoyl-CoA to the NH2-terminal Gly residue of cellular proteins.

67 e (Nmt) attaches myristate to the N-terminal Gly residue of proteins involved in a variety of signal

68 nt attachment of myristate to the N-terminal Gly residue of proteins with diverse functions.

69 arlier has been identified as the N-terminal Gly residue of the gamma-chain, which is replaced by Val

70 ond and ligates protein-LPXT to the terminal Gly residue of the nascent cross-bridge of peptidoglycan

71 pied by the much smaller and hydrogen-bonded Gly residue of the repeating (Gly-X-Y)(n) sequence.

72 proteinases (MMPs) cleave collagen after the Gly residue of the triplet sequence Gly approximately [I

73 -interactive role for the hydrophobic and/or Gly residues of both spike 1 and spike 3.

74 When the conserved Gly-Gly residues of sentrin were changed to Gly-Ala, only se

75 the ubiquitin domain and the C-terminal Gly-Gly residues of sentrin.

76 nd S. typhimurium showed that the N-terminal Gly residue or the length of the cryptdin-4 N terminus a

77 which the MLLT sequence was replaced by four Gly residues performed good aspartate chemotaxis.

78 Mutation of the native Gly residue preceding the intein blocked splicing and cl

79 hemistry of the product hydroperoxide, and a Gly residue promotes oxygenation at the proximal end of

80 We postulate that this conserved Gly residue provides a flexible hinge within the Top1p c

81 Simple modifications centered on the Arg and Gly residues quickly led to a modified peptide (1) with

82 A linker encompassing six extra Gly residues relative to wild-type EmrE failed to give r

83 three indispensable disulfide bonds and one Gly residue required structurally for an atypical beta-b

84 ed by Gln, Leu, or Ala, the alpha-subunit 69(Gly) residue substituted by Ser, and the alpha-subunit 1

85 horter with Cys substitutions for obligatory Gly residues than with Cys substitutions in the Y positi

86 The analogues also contained a C-terminal Gly residue that is believed to be present when the pept

87 precursors are synthesized with a C-terminal Gly residue that is posttranslationally converted to a t

88 containing Cys substitutions for obligatory Gly residues, the Cys substitution at alpha1-519 did not

89 mutations in type I collagen that change one Gly residue to a larger residue and that break the typic

90 in the C terminus of HDAC10 which changes a Gly residue to Cys, suggesting that HDAC10 molecules con

91 First, one to four Gly residues were inserted between Thr-218 and Pro-219.

92 Gly residues were significantly (2.6-fold; P = 0.004) mo

93 highly glycosylated sites have a penultimate Gly residue, whereas those that are less highly glycosyl

94 oxygenase these residues are replaced by two Gly residues which do not provide sufficient steric hind

95 mic dissociation by loss of ammonia from the Gly residue, which occurs from the ground ( X ) electron

96 Peptides carrying multiple Pro and Gly (residues with lowest helical propensity) retain str

97 were obtained by replacement of the original Gly residue with N alpha-substituted Gly (NSG) "peptoid"

98 ons resulting in replacement of one obligate Gly residue within the repeating (Gly-Xaa-Yaa)(n) triple

99 nfluenza virus having a single semiconserved Gly residue within the transmembrane domain mutated to L

100 The SR domain and the Gly residues within the Gly-rich domain of RBP1 were fou

101 transfection assay, we demonstrate that the Gly residues within the Gly-rich domain, the ribonucleop

102 Overall, Gly residues yield surprisingly small effects at loop po