ライフサイエンスコーパス: Goodpasture

1 Goodpasture (GP) autoimmune disease is caused by autoant

2 Goodpasture (GP) disease is an autoimmune disorder in wh

3 Goodpasture antibodies only breach the quaternary struct

4 Goodpasture autoantibodies bind two conformational epito

5 Goodpasture autoantibodies, which bound to murine alpha3

6 Goodpasture autoantigen [collagen alpha3(IV)NC1; approxi

7 Goodpasture disease is an autoimmune kidney disease medi

8 Goodpasture epitopes in the native autoantigen are crypt

9 Goodpasture syndrome is an autoimmune disease of the kid

10 Goodpasture syndrome is an autoimmune vascular disease a

11 Goodpasture's (GP) disease is caused by autoantibodies t

12 ents with anti-basement membrane disease and Goodpasture syndrome.

13 S posttransplantation anti-GBM nephritis and Goodpasture disease.

14 ing type I diabetes, multiple sclerosis, and Goodpasture disease, is associated with particular human

15 erlying the pathogenesis of human autoimmune Goodpasture disease.

16 la melanogaster, and Danio rerio do not bind Goodpasture autoantibodies, while Xenopus laevis, chicke

17 tive Danio rerio alpha3(IV)NC1 does not bind Goodpasture autoantibodies.

18 nforced M-alpha3alpha4alpha5(IV) hexamers by Goodpasture antibodies is a novel mechanism whereby path

19 to ROS specifically enhanced recognition by Goodpasture antibodies in a sequential and time-dependen

20 itions, like bronchiectasis, coagulopathies, Goodpasture's syndrome, and acute bronchopulmonary infec

21 ds, which comprehensively locked the cryptic Goodpasture autoepitopes in the mouse GBM.

22 cells infiltrate the kidney and mice develop Goodpasture disease.

23 In contrast, alpha3NC1 monomers elicited Goodpasture-like murine antibodies, targeting the E(A) a

24 to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for

25 stration to rodents was sufficient to expose Goodpasture epitope in vivo and initiate autoantibody pr

26 y of reactive oxygen species (ROS) to expose Goodpasture epitopes buried within NC1 hexamers obtained

27 n probably contains one recognition site for Goodpasture autoantibodies, and an algorithm analysis of

28 Human Goodpasture antigen-binding protein (GPBP) is an atypica

29 In contrast, human Goodpasture autoantibodies recognized the separate E(A)

30 ) NC1 antibodies that cross-react with human Goodpasture [anti-GBM/anti-alpha3(IV) NC1] autoantibodie

31 The immunodominant Goodpasture autoepitope, located within the E(A) region,

32 In Goodpasture's (anti-glomerular basement membrane) diseas

33 In Goodpasture's disease, circulating autoantibodies bind t

34 The reasons for autoimmunity in Goodpasture syndrome may lie in an age-dependent deterio

35 reditary leiomyomatosis, and autoimmunity in Goodpasture syndrome; however, the transcriptional and d

36 he conformations of the antibody epitopes in Goodpasture's disease and Alport's post-transplantation

37 Rapidly progressive glomerulonephritis in Goodpasture disease is mediated by autoantibodies bindin

38 ith several autoimmune conditions, including Goodpasture syndrome.

39 inst these two putative regions co-inhibited Goodpasture autoantibodies binding to denatured human al

40 contributes to the emergence of the 2 major Goodpasture epitopes on the human alpha3(IV)NC1 domain,

41 phritis, diabetes mellitus, IgA nephropathy, Goodpasture's syndrome, and Alport syndrome renal epithe

42 The development of Goodpasture's disease may be considered an autoimmune "c

43 cture may be a key factor in the etiology of Goodpasture disease.

44 erdin reductase (hBVR) and the expression of Goodpasture antigen-binding protein (GPBP), a nonconvent

45 re we investigate the molecular mechanism of Goodpasture disease, an HLA-linked autoimmune renal diso

46 glomerulonephritis (EAG), an animal model of Goodpasture's disease, can be induced in Wistar Kyoto (W

47 glomerulonephritis (EAG), an animal model of Goodpasture's disease, can be induced in Wistar Kyoto (W

48 glomerulonephritis (EAG), an animal model of Goodpasture's disease, can be induced in Wistar Kyoto (W

49 glomerulonephritis (EAG), an animal model of Goodpasture's disease, can be induced in Wistar Kyoto (W

50 nephritis (EAG), which is an animal model of Goodpasture's disease, can be induced in Wistar Kyoto ra

51 oimmune glomerulonephritis (EAG), a model of Goodpasture's disease, Wistar Kyoto (WKY) rats immunized

52 mmunity in the pathogenesis of this model of Goodpasture's disease.

53 on event in the etiology and pathogenesis of Goodpasture autoimmune disease.

54 bunits were identified as a native target of Goodpasture autoantibodies in the GBM of squirrel monkey

55 rular basement membrane (GBM) are targets of Goodpasture autoantibodies or Alport posttransplant neph

56 antation nephritis was compared with that of Goodpasture autoantibodies from patients with autoimmune

57 lomerular basement membrane (GBM) disease or Goodpasture's syndrome is among the earliest recognized

58 ot from healthy controls or col(IV)-reactive Goodpasture's syndrome patients after renal transplant,

59 NC1 hexamers than the partially sequestered Goodpasture autoepitopes.

60 The Goodpasture (GP) autoantigen has been identified as the

61 (GN) resulting from autoimmunity against the Goodpasture antigen alpha3(IV)NC1.

62 ssociation, a property that is shared by the Goodpasture autoantibodies.

63 kelihood of two immunologic epitopes for the Goodpasture antigen.

64 e's disease are specific for epitopes in the Goodpasture antigen (the NC1 domain of the alpha3 chain

65 by 30-50%, respectively, thereby keeping the Goodpasture epitopes largely concealed when compared wit

66 For some hexameric epitopes, like the Goodpasture epitopes, exposure to ROS specifically enhan

67 ain of type IV collagen (alpha3(IV)NC1), the Goodpasture autoantigen.

68 is for the crypticity of the epitopes of the Goodpasture autoantigen, the alpha3alpha4alpha5 noncolla

69 pical protein kinase that phosphorylates the Goodpasture auto-antigen, the alpha3 chain of collagen I

70 y demonstrates, for the first time, that the Goodpasture antigen-binding protein (GPBP) binds to huma

71 pends on both Ab and T cell responses to the Goodpasture Ag noncollagenous domain 1 of the alpha3-cha

72 f squirrel monkeys, a species susceptible to Goodpasture autoantibody-mediated nephritis.

73 In summary, our findings characterize two Goodpasture epitopes confined to each end of the alpha3

74 ephritis and lung hemorrhage associated with Goodpasture syndrome.

75 145-specific T cells expand in patients with Goodpasture disease and, in alpha3135-145-immunized HLA-

76 Moreover, patients with Goodpasture disease display a clonally expanded alpha313

77 autoreactive T cells found in patients with Goodpasture disease.

78 antibodies were analyzed in 14 patients with Goodpasture's disease and 2 patients with Alport's post-

79 new therapeutic strategies for patients with Goodpasture's disease and other autoimmune disorders.

80 Autoreactive T cells in patients with Goodpasture's disease are specific for epitopes in the G

81 undant autoreactive T cells in patients with Goodpasture's disease are specific for peptides in the a

82 antibodies were analyzed in 57 patients with Goodpasture's disease, and kidney-bound antibodies were

83 In patients with Goodpasture's disease, both autoantibodies to the alpha3

84 Patients and rodents with Goodpasture's syndrome (GPS) develop severe autoimmune c