ライフサイエンスコーパス: Gq protein

1 MCH with high affinity, and signals through Gq protein.

2 tors are also coupled to phospholipase C via Gq proteins.

3 o receptors to couple to the Gs, Gi, Go, and Gq proteins.

4 ly of G proteins; some forms can also act on Gq proteins.

5 In contrast, sustained Gq-protein activation impaired the functionality of dire

6 Acute Gq-protein activation in direct-pathway or indirect-path

7 orresponding to the C-terminal domain of the Gq protein alpha subunit (Galphaq-Ct peptide) and charac

8 f severe cardiomyopathy, which overexpresses Gq protein and hematopoietic progenitor kinase-/germinal

9 nic M3 receptors, which couple to endogenous Gq protein and mediate a stimulatory effect of carbachol

10 le response in rat aorta by coupling to both Gq protein and the PTX-sensitive G(o) protein.

11 ogenous agonists, which causes activation of Gq proteins and phospholipase C, and generation of inosi

12 meabilized cells, contraction was blocked by Gq-protein antibodies, but not by other G-protein antibo

13 were used to determine the specific role of Gq-protein-binding by GRK2.

14 tion, alpha1B-adrenergic receptors couple to Gq proteins, calcium signaling and protein kinase C acti

15 Hormonal stimulation of Gq-protein coupled receptors triggers Ca2+ mobilization

16 The mechanism by which the Gq protein-coupled CCK receptor activates Ras, however,

17 ndent mechanism may provide the link between Gq protein-coupled CCK receptor stimulation and Ras acti

18 ypothesis that estrogen acts through a novel Gq protein-coupled membrane estrogen receptor (ER).

19 FAP-hM3Dq mice) that expresses an engineered Gq protein-coupled receptor (Gq-GPCR) known as hM3Dq DRE

20 We have previously shown that Gq protein-coupled receptor (GqPCR) agonists stimulate e

21 P2Y4 is a Gq protein-coupled receptor activated by uridine-5'-trip

22 The Gq protein-coupled receptor agonists phenylephrine (PE)

23 Gq protein-coupled receptor pathways become activated an

24 Activation of Gq protein-coupled receptors (GqPCRs) might induce diver

25 lular mechanisms that require the following: Gq-protein-coupled 5-HT2 receptor activation, new BDNF s

26 ooth muscle cell (VSMC) growth by activating Gq-protein-coupled AT1 receptors, which leads to elevati

27 Here we investigated how Gq-protein-coupled metabotropic glutamate receptor 5 (mG

28 Gq-protein-coupled receptors (GqPCRs) are widely distrib

29 ansmitters, autacoids, or hormones acting on Gq-protein-coupled receptors may serve as physiological

30 aq on the interaction of GRK2 with activated Gq-protein-coupled receptors.

31 In contrast, Gq protein coupling to NTS1 in various lipid nanodiscs w

32 onformational states of the CCK2R activating Gq-protein-dependent pathway (CCK2R(G)) or recruiting be

33 Both Gq-protein-dependent signaling and protein kinase C acti

34 yze this effect anatomically, we manipulated Gq-protein-dependent signaling selectively in neurons be

35 e precise impact and underlying mechanism of Gq-protein-dependent signals remain poorly understood.

36 e precise impact and underlying mechanism of Gq-protein-dependent signals remain unclear.

37 ecular mechanism and functional relevance of Gq-protein-driven signals in striatal circuits under nor

38 ecular mechanism and functional relevance of Gq-protein-driven signals in striatal circuits under nor

39 fluoxetine can stimulate egg laying via the Gq protein EGL-30, independent of SER-1, SER-4, or 5HT.

40 lly, we find that the presence of noncognate Gq protein enhances cAMP stimulated by two Gs-coupled re

41 Expression of a constitutively active Gq protein in mice reduces UCP1 expression in BAT, whole

42 use FR to investigate whether inhibition of Gq proteins is an effective post-receptor strategy to ta

43 Whereas activation of the Gq/protein kinase C pathway in HEK293 cells causes susta

44 d protein compared with cells treated with a Gq protein lacking the TAT sequence.

45 ng in the NTS depresses the baroreflex via a Gq protein-mediated activation of phospholipase C, which

46 minergic neurons and generate 2-AG through a Gq-protein-phospholipase C-DAGL cascade.

47 ology, we found that sustained activation of Gq-protein signaling impairs the functionality of striat

48 Specifically, sustained Gq-protein signaling inactivates striatal neurons by an

49 triatal circuits can be "turned on" by acute Gq-protein signaling or "turned off" by sustained Gq-pro

50 otein signaling or "turned off" by sustained Gq-protein signaling.

51 r (hM1) with respect to receptor binding and Gq-protein signaling.

52 ing ligand binding, indicating activation of Gq-protein signaling.

53 IL3), bound NKB but impaired dissociation of Gq-protein subunits from the receptor compared with WT N

54 3-acetylcholine (M3-ACh) receptor as well as Gq-protein subunits with high spatiotemporal resolution

55 he receptor predominantly interacts with the Gq protein, thereby activating phospholipase C and incre

56 f full-length receptors, whereas coupling of Gq protein was abolished in the T310 truncated mutant de

57 ino acid residues, respectively, couple with Gq protein with an efficiency similar to that of full-le