ライフサイエンスコーパス: Gran

1 sion or single-subject/session maps from the grand (5-session) maps.

2 a single Cd(II) binding site, GrandL12AL16C [Grand = AcG-(LKALEEK)(5)-GNH(2)], GrandL26AL30C, and Gra

3 ecific populations, the genetic basis of the grand adaptive sweep of selective evolutionary change, m

4 sponsible for Mendelian disorders provides a grand and unprecedented opportunity for geneticists.

5 e classified into a Murre virus species; and Grand Arbaud virus, Precarious Point virus, and Manawa v

6 d to cover a wide range of hydrophobicities (grand average hydropathy (GRAVY) scores of -0.6 to 1.9).

7 The grand average of all the significantly correlated subtha

8 s most clearly in the difference between the grand-average ERPs for attending to vs. ignoring the con

9 The grand-averaged difference in root mean squared voltage b

10 , 53 cousin, 7 grandparent-grandchild, and 9 grand-avuncular pairs.

11 ca and the Bahamas (Abaco, Eleuthera, Exuma, Grand Bahama, Long Island and New Providence).

12 anging from 79.1% to 100% in Long Island and Grand Bahama, respectively, illustrating the capacity of

13 ranged from 0.989 in Long Island to 1.000 in Grand Bahama, with limited haplotype sharing observed am

14 A case study was conducted on the Grand Banks of Newfoundland, Canada.

15 oints to a few specific locations around the Grand Banks where LSW is most often injected into the in

16 ty stratigraphy for Casamayoran age fauna at Gran Barranca (Chubut, Argentina) indicate that the Barr

17 indicate that Barrancan faunal levels at the Gran Barranca date to within the magnetochronologic inte

18 ally dated magnetic polarity stratigraphy at Gran Barranca with the Cenozoic geomagnetic polarity tim

19 logical Guanche individuals originating from Gran Canaria and Tenerife.

20 exposed to the outfall of the Las Palmas de Gran Canaria wastewater treatment plant.

21 rs, here represented by two individuals from Gran Canaria.

22 bsent in the most recently colonized island, Gran Canaria.

23 Equilibrium BD simulations in the grand canonical ensemble indicate that the channel is ve

24 The grand canonical ensemble lies at the core of quantum and

25 We then perform grand canonical ensemble simulations that enable us to s

26 d at an atomistic resolution within the semi-grand canonical ensemble using mutation moves to rapidly

27 iversal features of disordered bosons in the grand canonical ensemble.

28 nt to that of a lattice gas of bosons in the grand canonical ensemble; bromine doping introduces diso

29 A grand canonical formalism is developed to combine discre

30 ed physiological concentration, although the grand canonical free energy profiles are uphill for HTT

31 et was allowed to fluctuate via the use of a Grand Canonical Monte Carlo (GCMC) methodology.

32 Grand canonical Monte Carlo (GCMC) simulation provides m

33 d vapor adsorption experiments together with Grand Canonical Monte Carlo (GCMC) simulations, and coul

34 uantum mechanics (QM)-based force fields and grand canonical Monte Carlo (GCMC) simulations.

35 ntal observations are consistent with ReaxFF grand canonical Monte Carlo (ReaxFF-GCMC) calculations,

36 ns based on molecular dynamics combined with grand canonical Monte Carlo and free energy simulations

37 Grand canonical Monte Carlo Brownian dynamics (GCMC/BD)

38 Enabled by a new grand canonical Monte Carlo method for membrane simulati

39 Grand canonical Monte Carlo simulation reveals that not

40 of 26.7 kJ/mol, which was validated through grand canonical Monte Carlo simulation studies of CH4 ad

41 tical and methodological developments to the grand canonical Monte Carlo simulation technique.

42 Grand canonical Monte Carlo simulations and single compo

43 CO(2)/H(2)O gas mixtures were determined by grand canonical Monte Carlo simulations at temperature/p

44 hotoelectron spectroscopy, and complementary grand canonical Monte Carlo simulations coupled to a tig

45 Extensive grand canonical Monte Carlo simulations in combination w

46 Grand canonical Monte Carlo simulations of defective can

47 The study starts with grand canonical Monte Carlo simulations on a suite of 10

48 e filling of one site compared to the other: grand canonical Monte Carlo simulations support these ex

49 Grand canonical Monte Carlo simulations were also perfor

50 f Cs migration in partially saturated clays, Grand Canonical Monte Carlo simulations were applied to

51 Grand canonical Monte Carlo simulations were carried out

52 In this work, grand canonical Monte Carlo simulations were used to pre

53 n these structures was studied by performing grand canonical Monte Carlo simulations with appropriate

54 diffraction, density functional theory, and grand canonical Monte Carlo simulations, we show that in

55 terpenetrated structure has been modelled by grand canonical Monte Carlo simulations.

56 We performed grand canonical Monte Carlo/Brownian dynamics (GCMC/BD)

57 rameworks (COFs) from first-principles-based grand canonical Monte-Carlo simulations.

58 In this article we make use of a grand canonical screening approach recently proposed to

59 The grand canonical simulation method accounts for the acid/

60 osition pathways of LiBH4 nanoclusters using grand-canonical free-energy minimization based on total

61 nic structure methods and characterized with Grand-canonical Monte Carlo simulations for methane upta

62 By calculating the grand-canonical partition function term by term, we show

63 w paleocanyon that was carved in the eastern Grand Canyon 25 to 15 million years ago (Ma), negating t

64 consistent with a 5 to 6 Ma age for western Grand Canyon and Marble Canyon.

65 (4)He/(3)He spectra for eastern Grand Canyon apatites of differing He date, radiation da

66 (4)He/(3)He thermochronometry data from the Grand Canyon basement that tightly constrain the near-su

67 al. reported that development of the western Grand Canyon began about 17 million years ago.

68 that geological observations do not require Grand Canyon carving coeval with Colorado River integrat

69 and inferred incision data indicate that the Grand Canyon evolved via headward erosion from west to e

70 The age and evolution of the Grand Canyon have been subjects of great interest and de

71 leading to their inference that the western Grand Canyon incised much earlier than previously though

72 Using Grand Canyon incision rates and Pliocene basaltic volcan

73 Flowers and Farley propose that the Grand Canyon is 70 million years old.

74 The Grand Canyon is one of the most dramatic features on Ear

75 nium-lead dating evidence for an old western Grand Canyon on the assumption that groundwater table de

76 Similar data for the western Grand Canyon provide evidence that it was excavated to w

77 ast 17 million years, in contrast to eastern Grand Canyon samples that yielded much faster rates (166

78 nterior-basin deposits near the mouth of the Grand Canyon show that no paleocanyon existed in that ar

79 ndicator speleothems) from nine sites in the Grand Canyon showed uranium-lead dating evidence for an

80 hronometry to propose that the western paleo-Grand Canyon was nearly as deep 70 million years ago (Ma

81 Samples in the western Grand Canyon yielded apparent water table decline rates

82 tarkly contrasting models for the age of the Grand Canyon-70 versus 6 million years-can be reconciled

83 er-term rates derived from sites outside the Grand Canyon.

84 congenital ataxia restricted to one area of Grand Cayman Island.

85 at affect this process identified two genes, GRAND CENTRAL (GCT)and CENTER CITY (CCT).

86 by CENTER CITY (CCT; Arabidopsis MED12) and GRAND CENTRAL (GCT; Arabidopsis MED13) are required for

87 t decisions by agricultural companies in the Gran Chaco and Chiquitano, a region that has become the

88 ced this locus in a wild population from the Gran Chaco.

89 single- or few-layered nanosheets remains a grand challenge and becomes the bottleneck to essential

90 The grand challenge before us is to sustainably meet humanit

91 eously produce viable tools for a biological grand challenge domain with no extant solutions.

92 tanding of human intelligence is perhaps the grand challenge for 21st-century science, with broad imp

93 atalyzing any desired chemical reaction is a grand challenge for computational protein design.

94 neered and industrial environments remains a grand challenge for geomicrobiology.

95 cules that target allosteric sites remains a grand challenge for ligand discovery.

96 the neural correlates of consciousness is a grand challenge for neuroscience.

97 emical and thermal properties is viewed as a grand challenge for scientists and engineers.

98 There is a grand challenge for the detection of target molecules at

99 rochemical window in solid electrolytes is a grand challenge for the synthesis of battery materials.

100 ing the combination of these properties is a grand challenge for the synthesis of sulfide-based solid

101 This grand challenge has mostly proved ineffective because of

102 er in response to environmental stimuli is a grand challenge in active materials, structures, and rob

103 reserving 3D context, represents an enduring grand challenge in biology.

104 enome of an organism into its phenotype is a grand challenge in biology.

105 characterization of supported catalysts is a grand challenge in catalytic science.

106 proteins from first principles represents a grand challenge in chemistry and structural biology.

107 pologies at the molecular level represents a grand challenge in chemistry.

108 dioxide to multicarbon products remains as a grand challenge in electrochemical CO2 reduction.

109 A grand challenge in material science is to understand the

110 anostructures and identical composition is a grand challenge in materials chemistry.

111 A grand challenge in materials research is to understand c

112 has been developed to address the number one grand challenge in metabolomics, which is the large-scal

113 d particularly protein folding, is a classic grand challenge in molecular biophysics.

114 and materials at the level of electrons is a grand challenge in science, relevant to our understandin

115 tionship to solid-state phase formation is a grand challenge in synthesis science.

116 A grand challenge in synthetic biology is to use our curre

117 n from large-scale functional data sets is a grand challenge in systems biology.

118 A grand challenge is assembling and positioning the nanopa

119 A grand challenge is to develop a general cancer screening

120 ction and provision of human sustenance, the grand challenge is to intervene before more tipping poin

121 Modern chemistry's grand challenge is to significantly improve catalysts fo

122 It is currently a grand challenge of chemistry, materials science, and eng

123 starting purely from a protein sequence is a grand challenge of computational biology.

124 tein structure from amino acid sequence is a grand challenge of computational molecular biology.

125 ell as climate atmosphere ocean science is a grand challenge of contemporary science with important s

126 us providing instrumental technology for the grand challenge of engineering N2-fixing cereals.

127 n as a complementary solution to address the Grand Challenge of global food security and environmenta

128 ution in deep tissue is often considered the grand challenge of optical imaging.

129 stly arising from feed production, is thus a grand challenge of sustainability science.

130 A grand challenge of systems biology is to predict the kin

131 ow-entropy states is an essential step and a grand challenge of the whole emulation enterprise.

132 liquids, and offering the potential to solve grand challenge problems.

133 A grand challenge that crosses synthetic chemistry and bio

134 veloped a new microgel array to address this grand challenge through robotic printing of complex stem

135 It is a grand challenge to develop a truly effective medication

136 However, it has been a grand challenge to maintain the viability, functionality

137 It remains a grand challenge to replace platinum group metal (PGM) ca

138 Control of these complex systems is a grand challenge, for example, in mitigating the effects

139 Once regarded as a grand challenge, protein folding has seen great progress

140 Princeton University Health Grand Challenge, US National Institutes of Health (NIH),

141 ever, in silico vaccine prediction remains a grand challenge.

142 choose, an aspiration of the Dial-a-Molecule Grand Challenge.

143 and fabricate biological machines remains a grand challenge.

144 films at submicrometer resolution presents a grand challenge.

145 t unite all lineages (the tree of life) is a grand challenge.

146 and their ecological determinants remains a grand challenge.

147 uld accelerate progress toward meeting this "grand challenge."

148 Special attention will be paid to the grand-challenge related to detection, quantification and

149 Grand Challenges Canada (Government of Canada), Saving B

150 Bill & Melinda Gates Foundation, Grand Challenges Canada, and the UK Medical Research Cou

151 Grand Challenges Canada, Bill & Melinda Gates Foundation

152 Grand Challenges Canada, the Bill & Melinda Gates Founda

153 Bill & Melinda Gates Foundation, Grand Challenges Canada, UK Medical Research Council.

154 Bill & Melinda Gates Foundation, Grand Challenges Canada, UK Medical Research Council.

155 National Institutes of Health, Grand Challenges Canada.

156 ment to define this conversion as one of the Grand Challenges for Biology in the 21st Century.

157 One of the grand challenges in chemistry has been to directly obser

158 Grand challenges in global change research and environme

159 Health (as part of the Bill & Melinda Gates Grand Challenges in Global Health Initiative).

160 n international panel announces a list of 14 Grand Challenges in Global Health, and scientists throug

161 reservoir of enzymes that could help address grand challenges in human health, energy, and sustainabi

162 tocatalyts for water splitting is one of the grand challenges in solar energy conversion.

163 and Nervous System Disorders established a "Grand Challenges Initiative." The goal is to help frame

164 One of the grand challenges of human genetics to systematically map

165 cular profile datasets represents one of the grand challenges of Systems Biology.

166 US National Institutes of Health, Princeton Grand Challenges Program.

167 Future directions and grand challenges to realize these goals are highlighted

168 We then examine several environmental "grand challenges" and discuss how urban land teleconnect

169 r conclusions, we present our choice of the "grand challenges" for the preservation and sharing of ch

170 One of the remaining "grand challenges" in chemistry is the development of a n

171 e social dynamics prevent the formation of a grand coalition and therefore full cooperation.

172 As part of the "Grand Convergence: Aligning Technologies and Realities i

173 These grand cycle variations are probed by alpha - Omega dynam

174 leads to beating effects responsible for the grand cycles (350-400 years) superimposed on a standard

175 kward for 800 years reveals the two 350-year grand cycles superimposed on 22 year-cycles with the fea

176 r the next millennium predicts further three grand cycles with the closest grand minimum occurring in

177 asymmetric cell divisions, only one in four 'grand-daughter' cells undergoes a 'mating-type switch',

178 aternal grandmother smoking in pregnancy and grand daughters having adverse scores in Social Communic

179 affect fertility of resulting daughters and grand-daughters.

180 o now subsume all of the other shuttles as a grand description of the role(s) of lactate in numerous

181 up in longevity gains, and avoid a so-called grand divergence in health and longevity.

182 Gran Dolina is a cavity infilled by at least 25 m of Ple

183 n the teeth of the Sima del Elefante-TE9 and Gran Dolina-TD6 Atapuerca hominins (1.2-0.8 million year

184 e but refute the anthropocentric view that a grand enhancement in Darwinian selection underlies human

185 experiment, the first multi-thousand-member grand ensemble of simulations using a general circulatio

186 hed that uses the many ongoing projects as a grand experiment.

187 Islands provide the venue of one of nature's grand experiments in evolution.

188 trolled by nuclear control factors, and in a grand feedback the cell adhesion and signaling systems d

189 The oleoresin secreted by grand fir (Abies grandis) is composed of resin acids der

190 e initial step of resin acid biosynthesis in grand fir (Abies grandis).

191 abietadiene synthase has been isolated from grand fir and the heterologously expressed bifunctional

192 atalyzed by the sesquiterpene synthases from grand fir are among the most complex of any terpenoid cy

193 Abietadiene synthase from grand fir catalyzes two sequential, mechanistically dist

194 es and/or inhibitors for recombinant AS from grand fir.

195 ction of all of the resin acid precursors of grand fir.

196 tric cardiology site), and the Altru Clinic, Grand Forks, North Dakota (primary care site), which is

197 a childhood in Germany and being a youth in Grand Forks, North Dakota, I went to Harvard University,

198 dering at the mesoscopic scale are among the grand fundamental science challenges.

199 oil washing ashore in Plaquemines Parish and Grand Isle, Louisiana, and Pensacola, Florida, in May 20

200 across HRRs from 0.58 chronic conditions in Grand Junction, Colorado, to 1.23 in Miami, Florida (mea

201 he dissolved phases, were collected from the Grand, Kalamazoo, Saint Joseph, and Lower Fox rivers and

202 les from five Lake Michigan tributaries [the Grand, Kalamazoo, St. Joseph, and Lower Fox Rivers, and

203 )(5) M for Baby L12C to 2.5 x 10(-)(9) M for Grand L9C for binding of the third thiolate to a linear

204 The binding of Hg(II) to the peptide Grand L9C is similar in energetics for metal binding in

205 Approximately, 11 kcal/mol of the Hg(II)(Grand L9C)(3)(-) stability is due to peptide interaction

206 ilies, JME was most common (40%) followed by grand mal (GM) only (35%).

207 Families with either pure grand mal epilepsy or absence epilepsy contributed equal

208 Epilepsy with grand mal on awakening (EGMA) is a well-defined subtype

209 Transgenic mice also had a grand mal seizure disorder accompanied by a correspondin

210 rring either randomly during the day (random grand mal) or on awakening (awakening grand mal), and ju

211 random grand mal) or on awakening (awakening grand mal), and juvenile absence epilepsy (JAE).

212 N2O, and NH3 from a 2006 model year Mercury Grand Marquis flexible fuel vehicle (FFV) operating on E

213 Exposure to low-protein grand-maternal diet leads to decreased ovarian reserve a

214 CP without protein or leucine ingestion, the grand mean +/- SEM plasma 3-HIB concentration decreased

215 This effect compared with a grand mean effect of g = -0.98 and was significantly lar

216 Nevertheless, the grand mean firing rate of the whole pyramidal cell popul

217 We calculated a grand mean for individual seafood items, based on report

218 Farmed fish generally had lower grand mean Hg concentrations than their wild counterpart

219 rom 35 +/- 2 to 14 +/- 1 micromol/L) and the grand median [quartiles] FGF21 concentration increased (

220 ting total solar irradiance estimates during grand minima.

221 further three grand cycles with the closest grand minimum occurring in the forthcoming cycles 26-27

222 The most recent "grand minimum" of solar activity, the Maunder minimum (M

223 in the cerebral cortex, cerebellum, parotid grand, myocardium, and bowel mostly reflected the (18)F-

224 two dessert bananas of commercial interest (Grand Nain and Gros Michel), alongside a newly created h

225 Cavendish', 'Giant Cavendish', 'Dwarf Red', 'Grand Nain', 'Eilon', 'Gruesa', 'Silver', 'Ricasa', 'Wil

226 Our findings indicate ways in which the Grand National could be made safer for horses and illust

227 By analysing data from the past 15 Grand National races (consisting of 560 starts by horses

228 As in other competitive sports, the famous Grand National steeplechase, which is held at Aintree in

229 "This grand natural scene was a physical correlate of Francis'

230 his study the presence of aroma compounds in Gran Negro (Vitis vinifera L.) grapes was investigated i

231 These results from Gran Negro were compared with those of Brancellao and Mo

232 witchable fluorescent proteins (PS-FPs) open grand new opportunities in biological imaging.

233 males switching to invest in their existing (grand)offspring, thereby increasing their inclusive fitn

234 cts from the National Heart, Lung, and Blood Grand Opportunity Exome Sequencing Project.

235 ed by the 1000 Genomes Project and the NHLBI Grand Opportunity Exome Sequencing Project.

236 rameters on million-year time scales induce "grand orbital cycles," but the behavior and the paleoenv

237 Immunomedics, Amgen, Canceropole Grand Ouest, the GOELAMS/LYSA group and the French Natio

238 ," was held on November 10-12, 2009 at Hotel Grand Palace, Tokyo, Japan.

239 and transsexuals by way of retention of the grand parental epigenotype on the X chromosome.

240 ansfer of information, such as the effect of grand parental smoking or exposure to other toxic compou

241 to convey a sense that one need not have a "grand plan" to have a successful life in science.

242 f tissue engineering has not full-filled its grand potential of engineering such combinatorial scaffo

243 The $10 million grand prize will be awarded to the first team to meet al

244 If there is no grand prize winner, lesser awards will be made for singl

245 Cultivars Iceberg and Grand Rapids that were released in the 18th and 19th cen

246 the Michigan Thumper (Michigan Instruments, Grand Rapids, MI), as an industrial standard, and the mi

247 stance at this locus originate from cultivar Grand Rapids.

248 loyed in wastewater-dominated reaches of the Grand River (Kitchener, ON) to verify their feasibility

249 h across an urban environment in the central Grand River watershed (Ontario, Canada).

250 ature, land use and surficial geology in the Grand River, Canada, a seventh-order river in an agricul

251 have been reported for several years in the Grand River, in southern Ontario, Canada, in close proxi

252 uscaloosa, Weyburn-Midale, Bass Islands, and Grand Ronde carbon sequestration geologic formations.

253 In this Grand Round we describe a 2-year-old child from the USA

254 In this Grand Round, we present the case of an otherwise healthy

255 In this Grand Round, we review the clinical features of hypervir

256 In this Grand Round, we review the clinical features, epidemiolo

257 In this Grand Round, we review the clinical features, epidemiolo

258 the man in his world." We hope this unusual Grand Rounds case intrigues you as it reminds you of Cus

259 In celebration of this milestone, a unique Grand Rounds case is presented.

260 linical practice guidelines was ensured by a grand rounds lecture and by posting guideline reminders

261 This Grand Rounds review describes the evaluation and evidenc

262 The Oncology Grand Rounds series is designed to place original report

263 The Oncology Grand Rounds series is designed to place original report

264 The Oncology Grand Rounds series is designed to place original report

265 The Oncology Grand Rounds series is designed to place original report

266 f local physician and nurse opinion leaders; grand rounds site visits; and premeasurement and postmea

267 This Grand Rounds summarizes the factors to consider when cou

268 In this Grand Rounds, 2 prominent clinicians debate whether to i

269 In this Grand Rounds, 2 prominent endocrinologists debate the is

270 coordinator at each facility, consisting of grand rounds, a chart reminder system, group discussion

271 studies, included a presentation at medical grand rounds, a publication in the staff newsletter, mee

272 t physicians and nurses include use of joint grand rounds, patient care seminars, and interprofession

273 In this Grand Rounds, the case of a 30-year-old man with a 12-ye

274 In this Grand Rounds, the guideline is reviewed and an expert di

275 In this grand rounds, we focus on development, validation, and a

276 In this Grand Rounds, we summarize the results of the clinical t

277 Residents of Bocozel or Grand Saline who were eligible for the vaccination campa

278 ation and subsequent protein sequencing on a grand scale to identify individual components.

279 humans have ever created, presents a unique grand-scale natural experiment that allows ecologists to

280 +/- 0.51 D vs 2.03 +/- 1.03 D, P < .001) and Grand Seiko (0.46 +/- 0.45 D vs 0.99 +/- 1.0 D, P < .001

281 Measurements were taken with the Grand Seiko autorefractor (RyuSyo Industrial Co., Ltd.,

282 er manufactured) or a Grand Seiko WR 5100-K (Grand Seiko Co., Hiroshima, Japan) autorefractor.

283 ke Success, NY; no longer manufactured) or a Grand Seiko WR 5100-K (Grand Seiko Co., Hiroshima, Japan

284 s, NY [no longer manufactured] or WR 5100-K; Grand Seiko, Hiroshima, Japan).

285 ations in the hypothalamus-pituitary-adrenal grand stress.

286 ortality displacement, which is the ratio of grand sum deficit to grand sum excess mortality, decreas

287 , which is the ratio of grand sum deficit to grand sum excess mortality, decreased as a function of e

288 nanotechnology and nanosciences) to the very grand (sustainable development, global change and ecosys

289 Ultimately, this grand synthesis should improve predictive capability of

290 s within both the classical scenario and the Grand Tack scenario of terrestrial planet formation, and

291 ermine how cognitive systems change over the grand time scale of an entire life, as few cognitive sys

292 tive method, the best estimate of the global grand total is roughly 200 extinctions.

293 ome at physiological pH, this resulting in a grand total of 1151 gene products identified after the c

294 ll plates analyzed in 1 day is considered a "grand tray", and the method is cross-validated with stan

295 rse and would constrain new physics from the grand unification scale to the Planck scale.

296 A grand unified model (GUM) is developed to achieve fundam

297 onopoles resulting from symmetry breaking in grand unified theories.

298 Clark argues that predictive coding offers a Grand Unified Theory (GUT) of brain function.

299 oach to evolutionary biology, in lieu of any grand unified theory updated to include microbial genomi

300 cal control agents, these results expand the grand view of the diversity of mycoviruses and provide p