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1 /m(2) bolus followed by 2400 mg/m(2) over 46 h).
2 g(II)-DOM-sulfide equilibration times (4-142 h).
3 magnitude of the magnetostriction anomaly at H*.
4 ameters, mice were sleep deprived (SD) for 6 h.
5 es, including a predicted half-life of 16-19 h.
6 en the circadian period by approximately 2.5 h.
7 nd purification can be achieved within 12-24 h.
8 ce, extending the life cycle from 24 h to 40 h.
9 r 15-20 min, but diminish by tenfold after 4 h.
10 between a dysbiotic cutaneous microbiome and HS.
12 , t1/2, for PHE-exposed cells were 0.16-0.51 h(-1) and 1.4-4.3 h, respectively, and the 1-octyne cont
16 vestigate whether changes of (13)C/(12)C, (2)H/(1)H, and (15)N/(14)N ratios of NDMA give rise to isot
17 e characterized by both one-dimensional ((1) H, (13) C, (31) P) and two-dimensional (COSY, NOESY, DOS
20 e delta1 methyl groups, which facilitated (1)H/(13)C methyl TROSY NMR measurements with opposing liga
21 PCR (A2AR) that are deuterated apart from (1)H/(13)C NMR probes at isoleucine delta1 methyl groups, w
24 l analysis of a prototypical Vbeta8.1(+) TCR-H-2D(b)-GAP5040-48 ternary complex revealed that germlin
25 s of CD8(+) T cells revealed the presence of H-2L(d)/AH1-specific T cells and an expansion of sequenc
26 (6) obtained from 4,4',5,5'-tetranitro-2H,2'H-3,3'-bipyrazole (4) by N-amination and N-azo coupling
28 t of the width of a peak (Wh), at any height h (a fixed height, not a fixed fraction of the peak maxi
29 s been exploited to achieve meta-selective C-H activation by using a covalently attached, U-shaped te
30 en to be effective for accelerating C(sp(3))-H activation directed by weakly coordinating auxiliaries
31 es the advancements in Pd-catalyzed C(sp(3))-H activation via various redox manifolds, including Pd(0
32 flow protocol has been developed for bond C-H activation which promotes the alpha-cyanation of secon
33 that the absence of Topoisomerase and RNase H activity in Escherichia coli or Saccharomyces cerevisi
35 in DNA methylation were observed between 24-h aerobically and anaerobically germinating embryos, whe
37 nd autoradiographic studies were performed 1 h after injection of (125)I-pentixafor (7.5 MBq/kg).
38 ptide preferentially accumulates in tumor (2 h after injection) and is rapidly cleared from all other
39 ts were quantitatively similar at 72 and 144 h after injection, but tumor-to-blood-pool SUV ratios in
40 ate cancer (PCa) is routinely performed at 1 h after injection, later scans may be beneficial because
42 were missing key data, death sooner than 24 h after the index date, therapy with an active antibioti
45 xperimental and theoretical studies of the C-H amination reaction mediated by the iron dipyrrinato co
46 3,4-tetrahydroqui noline is reported, the (1)H and (13)C NMR data of which are in excellent agreement
47 tial scanning calorimetry, and sequential (2)H and (31)P solid-state nuclear magnetic resonance spect
48 increased by 22 +/- 4 and 23 +/- 4% after 48 h and 14 days, respectively (P < 0.01); the plasma C-pep
49 regulated after endothelial denudation at 24 h and 21 d compared with contralateral untreated, nonden
51 onbulk(H)/epsilonbulk(C), where Deltadelta(2)H and Deltadelta(13)C are changes in isotope ratios duri
53 cellular spheroids can be achieved within 24 h and further boosted by incorporating collagen fibrils
54 re, we demonstrate the use of bench-stable N-H and N-alkyl oxaziridines derived from readily availabl
55 The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p
57 with KCN, transport is much faster (ca. 100 h) and higher K2MX4 equilibrium ratios are obtained (>/=
58 short lived protein (t(1/2) approximately 1 h) and is specifically degraded by the mitochondrial pro
59 ) and linked to Hospital Episode Statistics (HES) and Office for National Statistics (ONS) mortality
60 er in IBS patients than in healthy subjects (HS), and IBS patients on a 4-week LFM diet had improved
61 gate whether changes of (13)C/(12)C, (2)H/(1)H, and (15)N/(14)N ratios of NDMA give rise to isotope f
62 nosa was isolated, the TTD was typically <26 h, and no differences between Bactec and BacT/Alert bott
63 port a silver-free Pd(II)-catalyzed C(sp(3))-H arylation of saturated bicyclic and tricyclic amine sc
64 to 48-70 h led to successive gamma-C(sp(3))-H arylation/intramolecular amidation and the constructio
65 l group of CH fruits were pre-conditioned 48 h at 20 degrees C prior to low-temperature exposure (pre
67 sorption of water via the electron-deficient H atom and the subsequent dissociation of the electron-r
69 tains, at the same time, no less than twenty H-atoms available for either alpha- or beta-hydride elim
70 omplex 2, while 3 itself is able to abstract H-atoms from weaker X-H bonds such as TEMPO-H to re-form
71 ls (ICs) express the proton pumping vacuolar H(+)-ATPase (V-ATPase) and are extensively involved in a
72 elongation growth and play a key role in PM H(+)-ATPase activation by inhibiting PP2C.D family prote
73 turally similar to more potent vacuolar-type H(+)-ATPase inhibitors, which all inhibited LGR5 interna
74 and land use variables to estimate daily 24 h averaged ground-level PM2.5 concentrations over the co
75 ng the treatment response, quantification of HEs becomes crucial and hence clinicians now seek to mea
77 bulk CeO2, and identifies surface features, H(+) binding sites, Ce(3+) locations, and O vacancies on
78 he nitrite reductase gene (aniA), the factor H-binding protein gene (fHbp), and the capsule biosynthe
82 eaction with fluorobenzene afforded the CAr -H bond activation product [1-F-2-IMe -C6 H4 ](+) I(-) (3
83 t dioxazolone amidating agents via C(sp(3) )-H bond activation to generate the desired amidated produ
85 itionally, many transition-metal-catalyzed C-H bond additions to polarized pi bonds occur within casc
86 ve been engineered to catalyze abiological C-H bond amination reactions, but the yields of these reac
87 provide a "bottom-up" fundamental insight, C-H bond cleavage in methane over Ni-based catalysts was i
88 Cp*RhCl to accelerate the cleavage of the C-H bond of N-pentafluorophenylbenzamides, providing a new
89 sequent dissociation of the electron-rich HO-H bond via H transfer to N on the nickel surface, benefi
91 r34 maintains solvent exclusion and the core H-bond network in the active site by relocating to repla
92 (2) AChRs respond strongly to ACh because an H-bond positions the QA to interact optimally with the r
93 rings, and weakly to Cho because a different H-bond tethers the ligand to misalign the QA and form we
95 tudied in view of its ability to form triply H-bonded complexes with a suitably complementary 2,6-dia
96 ted fucosylation mechanism facilitated by an H-bonded network, which is corroborated by mutagenesis e
97 erning formation of aggregates (1604cm(-1)), H-bonded parallel- and antiparallel-beta-sheets (1690cm(
100 ionships between the functional groups and C-H bonds of a substrate has been exploited to achieve met
101 low chemoselectivity for the amination of C-H bonds over competing reduction of the azide substrate
102 ty for insertion of the nitrene units into C-H bonds over reduction of the azides to the sulfonamides
104 rtho-specific nitration of aromatic C(sp(2))-H bonds using chelation-assisted removable vicinal diami
109 unprecedented intermolecular aliphatic C-F...H-C interaction was observed in the X-ray crystal struct
111 tic variants in inhibitory complement factor H (CFH) are also features of both ARMD and TMA, we hypot
112 is optimally done by interrogation of paired H chain V region (VH) and L chain V region (VL) sequence
114 h the redox state, hence suggesting that the H channel could play a more general role as a dielectric
117 sity (Ht), gene diversity within population (Hs), coefficient of gene differentiation (Gst) and level
118 n + H2 S (150 muM NaSH) during prolonged (24-h) cold (4 degrees C) storage exhibited significantly (p
119 cocaine and methamphetamine greatly increase HS content and sulfation levels in the lateral hypothala
120 levels in the lateral hypothalamus and that HS contributes to the regulation of cocaine seeking and
121 described to do this at an adequate rate is H(+)-coupled lactate efflux on monocarboxylate transport
126 ule-out strategies: limit of detection (LOD, hs-cTnI<2 ng/L), single cutoff (hs-cTnI<5 ng/L), 1-hour
127 e cutoff (hs-cTnI<5 ng/L), 1-hour algorithm (hs-cTnI<5 ng/L and 1-hour change<2 ng/L), and the 0/1-ho
128 ection (LOD, hs-cTnI<2 ng/L), single cutoff (hs-cTnI<5 ng/L), 1-hour algorithm (hs-cTnI<5 ng/L and 1-
132 blinded central analyses of baseline and 24 h CTs, with dIVH defined as new intraventricular haemorr
137 We used English Hospital Episode Statistics (HES) data collected between April 2009 and March 2014 to
139 e dual-element C-H isotope approach (LambdaC-H = Deltadelta(2)H/Deltadelta(13)C approximately epsilon
140 H isotope approach (LambdaC-H = Deltadelta(2)H/Deltadelta(13)C approximately epsilonbulk(H)/epsilonbu
141 , the radical 2 has a half-life, tau1/2 = 49 h (DeltaH(double dagger) = 17.9 +/- 0.8 kcal mol(-1)), w
142 w that values of Tajima's D and Fay and Wu's H depend in a direct way on a peculiar measure of tree b
146 )H/Deltadelta(13)C approximately epsilonbulk(H)/epsilonbulk(C), where Deltadelta(2)H and Deltadelta(1
149 acrolein (28 mug m(-3)) exceeded the acute 1-h exposure REL for the highest emitting vaporizer/voltag
151 tients who underwent MRI at baseline then 24 h following intravenous infusion of ketamine (0.5 mg/kg)
152 enem (by 30-min intravenous infusion every 8 h) for 7-14 days; regimens were adjusted for renal funct
153 ent evidence that susceptibility of trees to H. fraxineus is associated with their iridoid glycoside
154 lorectal cancer locally assessed as dMMR/MSI-H from 31 sites (academic centres and hospitals) in eigh
156 onstruct triaryl(heteroaryl)methanes via a C-H functionalization in good to excellent yield, and repr
157 ropargylamines, such as A(3) couplings and C-H functionalization of alkynes, have been described and
159 tes show a specific capacity of about 130 mA h g(-1) at 35 C (fully charged within 100 s) and susta
161 24 hours, 185 of 385 infants (48.1%) in the HS group were admitted compared with 202 of 387 infants
163 nteraction on the water nanodroplet (SO2)O...H(H2O) may incur effects on the SO2 chemistry in atmosph
164 adical approaches, such as a facile remote C-H HAT step, with that of transition-metal-catalyzed chem
166 xpressed as Wh = p(ln h)(q), where h is hmax/h, hmax being the peak amplitude, and p and q being cons
168 es H2 under mild conditions, and catalyses C-H hydride abstraction plus H2 generation from a model su
174 ) of the hydroalane adducts as well as DIBAL-H in its aggregation states support this experimental fi
176 rapid dose-dependent clearance (t(1/2) 10-60 h) in contrast to 1F11, which presented a dose-proportio
178 fect also included the late disease phase (8 h), indicating an important effect of extra-acinar CTSD
183 Here we confirm PRC1-Br140 and PRC1-Fs(1)h interactions and identify their genomic binding sites.
184 gma-bond metathesis mechanism in which an Fe-H intermediate is postulated to be a key reactive specie
185 00 mg ceftazidime and 500 mg avibactam (by 2 h intravenous infusion every 8 h) or 1000 mg meropenem (
187 n can be expressed as Wh = p(ln h)(q), where h is hmax/h, hmax being the peak amplitude, and p and q
191 yme known to catalyse the oxidation of NAD(P)H, is upregulated when p16 is inactivated by looking at
193 more subtypes, including subtypes A1, F, G, H, J, and K and unclassified fragments, including one su
194 LSSE), magnetocrystalline anisotropy field (H K) and surface perpendicular magnetic anisotropy field
195 ontact (SC) ion-selective electrodes (ISEs) (H(+), K(+), and Na(+)) have outstanding performance char
197 nation it is shown that ions arising from (2)H-labeled tracers are completely differentiated from tho
200 Prolonging the reaction period to 48-70 h led to successive gamma-C(sp(3))-H arylation/intramole
201 transits into a magnetically distinguishable HS-LS phase with monoclinic P21 symmetry before returnin
202 ion between a LS ground state and an ordered HS-LS phase with symmetry breaking from monoclinic P21/n
203 andard addition of water is combined with (1)H magic angle spinning (MAS) NMR detection, absolute qua
204 obiome was characterized in 30 patients with HS (mean [SD] age, 46.9 [14.0] years; 19 [63% female]) a
205 lism and further affecting motor behavior in HD mice, thus constituting a promising agent for HD neur
206 tion-time curve further increased to 6045 ng h/ml (P=0.03), and trough levels increased to 218 ng/ml
207 This will be of potential use for monitoring HD mouse model disease progression and evaluating precli
208 ned and at a 2-propanol flow rate of 160 muL/h, MPA demonstrated the greatest shift in mobility (1.58
212 been confirmed independently by dating three H. naledi teeth with combined U-series and electron spin
213 ntiated into DARPP32-positive neurons, these HD neurons were more susceptible to death than WT neuron
216 chemical marker has been identified, the (1)H NMR chemometrics approach may contribute in the choice
217 s, we carried out metabolomic analysis by (1)H NMR spectroscopy of media from astrocyte-spinal neuron
221 o measure these interactions through both (1)H nuclear Overhauser enhancement (NOE) and paramagnetic
223 d CF2H groups and the important roles of CF2-H...O hydrogen bonds in influencing intermolecular inter
227 nes, whose flux had a decline of 8% after 24 h of operation in biofouling experiments, while that of
229 ilability in 15 healthy male adults after 52 h of sleep deprivation and following 14 h of recovery sl
231 e, although the MS-AFST assay performed at 3 h of the in vitro antifungal exposure failed to detect C
235 ibactam (by 2 h intravenous infusion every 8 h) or 1000 mg meropenem (by 30-min intravenous infusion
240 1 and mutant HTT aggregates in the brains of HD patients as well as in a murine model that recapitula
244 of steric selection and the presence of a P-H...pi interaction between the ligand and a conserved ar
245 heory indicate that differential pi-pi and C-H...pi interactions within a scaffold organized by multi
247 67% relative to baseline at greater than 24 h post-infusion, the most robust reduction observed to d
248 significantly less extracellular HSV-1 by 24 h postinfection (hpi), suggesting a unique neuronal resp
249 HS (26.2% men and 73.8% women), the overall HS prevalence in the US population sample was 0.10%, or
251 with 6 mg/kg 6c either simultaneously or 18 h prior to systemic AMPH administration reduced both AMP
254 r cation channel SlTPC1 and the two vacuolar H(+)-pumps, SlAVP1 and SlVHA-A1, which in turn are revea
256 and infection of a mouse model, we show that H. pylori deregulates mitochondria by two novel mechanis
258 lial cells with wild-type and VacA-deficient H. pylori strains, treatment of cells with purified VacA
259 unveil two novel mitochondrial effectors in H. pylori-host interaction with links on gastric pathoge
260 lized equation can be expressed as Wh = p(ln h)(q), where h is hmax/h, hmax being the peak amplitude,
261 reviewed for demographics, Hanifin & Rajka (H&R) and United Kingdom Working Party (UKWP) criteria.
265 tes were collected 6 h (inflammatory) and 24 h (resolving) following carrageenan-induced pleurisy in
266 posed cells were 0.16-0.51 h(-1) and 1.4-4.3 h, respectively, and the 1-octyne controls ranged from 0
270 , hyperglycaemia significantly enhanced [(3) H]ryanodine binding and Ca(2+) /calmodulin-dependent pro
271 We identified a centrin-binding site within H. sapiens Prp40 homolog A (HsPrp40A), which contains a
275 ltidimensional single- and double-quantum (1)H solid-state NMR spectroscopy with density functional t
277 erein, we discovered a mild and metal-free C-H sulfenylation/intramolecular rearrangement cascade rea
285 sociation of the electron-rich HO-H bond via H transfer to N on the nickel surface, beneficial to the
287 of their "post burn-in" efficiency over 3400 h under full sun illumination in ambient conditions.
288 ation in the presence of all metals within 1 h under hyperthermia conditions, Cu(II) activation produ
289 ation) resulted in clearly different LambdaC-H values: 28 +/- 4 (oxidation), 0.7 +/- 0.1 and 0.9 +/-
290 ents, we measured hydrogen isotope (delta(2) H) values of metabolically inert feathers and metabolica
291 The selenate uptake rate for S. pinnata (1 h) was three- to four-fold higher than for nonhyperaccum
292 recognize known major antigenic sites in MeV-H, we identified a D4 genotype variant that escapes neut
295 , markers of severity were reduced only at 1 h, whereas in the complete KO, this effect also included
296 3 orders of magnitude longer than that for 1-H, which decays via 1,5-HAT (tau1/2 = 48 s, DeltaH(doubl
297 cross-flow shear for a prolonged period (120 h) while maintaining NaCl rejection near 85% and 96% for
299 Eda, which caused a milder form of X-linked HED (XLHED), contained low levels of EDA capable of bind
300 morphology and position are pre-patterned by HD-ZIPIII and KAN gene expression in the shoot, leading
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