ライフサイエンスコーパス: H chain

1 VJ whose products may not associate with the H chain.

2 layed a preference for binding to HLA-C free H chain.

3 the cell surface in association with the BCR H chain.

4 aGal that carry two copies of the knocked in H chain.

5 cript levels of CXCL13, IgG H chain, and IgM H chain.

6 d, and their modifications were localized to H chain.

7 e: All B cells start out with a 56R anti-DNA H chain.

8 nine by proline at position 48 of the HLA-A1 H chain.

9 d transgene, H76R that codes for an anti-DNA H chain.

10 cts residues in the alpha2 domain of one B27 H chain.

11 ery rare alpha helix in its third CDR of the H chain.

12 neutralizing or modifying DNA binding of the H chain.

13 in the intracellular tail of the HLA class I H chain.

14 t Ig miniloci encoding the nurse shark omega H chain.

15 or LILRB2 than HLA class I heterotrimers and H chains.

16 1 L chains could only do so with full-length H chains.

17 OVA into the C terminus of anti-receptor Ab H chains.

18 pha1, alpha2, and alpha3 domains of both B27 H chains.

19 nti-DNA binding when expressed with anti-DNA H chains.

20 patient, and thus ferritin consists only of H chains.

21 nd canine lens fiber cell L-chains and human H-chains.

22 nces far greater than the length of a single HS chain.

23 model, two FGFs and two FGFRs bind a single HS chain.

24 ructure and distribution of domains along an HS chain.

25 hat can be located at any position within an HS chain.

26 d on specific structural features within the HS chains.

27 factor/cytokine binding and signaling by its HS chains.

28 egree of sulfation that were internal to the HS chains.

29 pendent of the sulfation pattern of the bulk HS chains.

30 the highest binding affinity toward isolated HS chains.

31 of HSPG function by removing 6S from intact HS chains.

32 om glucosamine in highly sulfated regions of HS chains.

33 co-receptors require sulfated domains in the HS chains.

34 well as difficulties in separating isomeric HS chains.

35 n by binding IAPP via their heparan sulfate (HS) chains.

36 ctors and receptors through heparan sulfate (HS) chains.

37 CD98 H chain (4F2 Ag, Slc3a2) was discovered as a lymphocyte-

38 a, which is similar in size to L (60-69) and H chain (70-79) CRS.

39 igher proportion expresses the nontransgenic H chain allele.

40 Rearrangements on both H chain alleles exhibit junctional diversity consistent

41 t limit the contribution of B cells with Dmu H chain alleles to the repertoire.

42 B cells exhibit V(D)J rearrangements on both H chain alleles, yet allelic exclusion is tightly mainta

43 c reticulum by Ii binding to either the FcRn H chain alone or FcRn H chain-beta(2)-microglobulin comp

44 We then apply this method to Ab H chain amplicons to sequence the first, to our knowledg

45 AICDA- and POL eta-mediated mutations, 1470 H chain and 1313 kappa- and lambda-chain rearrangements

46 e alpha1/alpha2/alpha3 domains of the H2D(d) H chain and beta(2)-microglobulin (beta2m) and is the fu

47 role in the association between HLA class I H chain and beta(2)-microglobulin.

48 ress single copies of the unrearranged human H chain and L chain Ig gene loci.

49 ock-in mice carrying functionally rearranged H chain and L chain variable region genes isolated from

50 ridomas are clones that have inactivated the H chain and secrete only L chains.

51 election for productive rearrangements in Ig H chains and also by cultivation studies.

52 lum before exiting in association with MHC-I H chains and beta2-microglobulin as a trimolecular compl

53 chains could associate with both full-length H chains and Dmu, whereas secretion-incompetent lambda1

54 unction of B27 FHC dimers with other class I H chains and identified contact residues in KIR3DL2.

55 ritin from cataractous lenses contained more H-chain and bound 11-fold more iron than ferritin from n

56 Da) differed from the 21-kDa standard canine H-chain and from the 12-kDa modified H-chain present in

57 fferences in the characteristics of ferritin H-chain and its distribution in canine cataractous lense

58 FGF and one FGFR bind to the free end of the HS chain and dimerization require these ends to join, br

59 Finally, P. aeruginosa bound to HS chains and N-glycans coated on plastic surfaces, show

60 elated with transcript levels of CXCL13, IgG H chain, and IgM H chain.

61 a peptidic linker to the N terminus of mAb1 H chain, and paired mutations at the CH1-CL interface mA

62 eric antibodies and unique functional heavy (H)-chain antibodies (HCAbs).

63 Developmental processes leading to H chain antibody expression are unknown.

64 Human MHC class I H chains are encoded by the HLA-A, HLA-B, and HLA-C gene

65 Heparan sulfate (HS) chains are found in the extracellular matrix, covale

66 tion, or by enforced expression of the SMB19 H chain as a transgene, results in significant protectio

67 ing to either the FcRn H chain alone or FcRn H chain-beta(2)-microglobulin complex and appeared to be

68 facilitated an early step in the assembly of H chain-beta(2)m heterodimers, for which tapasin-ERp57 o

69 e symmetric FGF2-HS2-FGFR2 model, two acidic HS chains bind in a basic canyon located on the top face

70 of the unfolded protein response, including H chain binding protein (BiP; GRP78), C/Ebp homologous p

71 onitor IgG Abs, fluoresceinated IgG constant H chain-binding polyclonal F(ab')2 (IgHPolyFab) is used

72 0-kDa IgY comprised of two differently sized H chains bound to L chains and apparently often noncoval

73 njury factors through their heparan sulfate (HS) chains, but the importance of HSPGs in liver injury

74 sitates prior partial or complete removal of HS chains by endogenous heparanase.

75 tion, they exchange the gene encoding the Ig H chain C region by class switch recombination (CSR).

76 Using a transgene of the entire H chain C region locus, we demonstrate in this study tha

77 rAbs with a dockerin domain fused to the rAb H chain C terminus are efficiently secreted by mammalian

78 a H chain genes in a transgene of the entire H chain C-region locus.

79 H chain cDNA libraries were constructed from the RNA der

80 was achieved through mutations in the third H chain CDR (HCDR3) that conferred a markedly faster on-

81 H chain CDR sequences bore numerous replacement mutation

82 tic categorical selection of CDR-3 of the Ig H chain (CDR-H3) content in peritoneal cavity (PerC) B c

83 ition of the perinatal liver CDR-3 of the Ig H chain (CDR-H3) repertoire is marked by a paucity of N

84 naturally occurring somatic mutations in the H chain CDR2 region that conferred a markedly prolonged

85 lly activated B cell clones bear hydrophobic H chain CDR3s (HCDR3s) and are disseminated to most lymp

86 Nucleotide sequencing of H chain CDR3s of DEX-specific plasmablasts, sorted posti

87 hose activated by cytokines that regulate Ig H chain class switching to IgE.

88 The immunoglobulin heavy (H) chain class switch is mediated by a deletional recomb

89 elatively high arginine (Arg) content in the H chain complementarity determining region (H3), suggest

90 unit residues 46-53 of murine H-2L(d) MHC-I H chain, complexed with mAb 64-3-7, demonstrates solvent

91 ntigenic peptide, beta(2)-microglobulin, and H chain connected by flexible linkers.

92 onformational changes occur in a loop in the H chain constant domain.

93 regions, each of which is associated with a H chain constant region gene.

94 ation using a transgene of the entire murine H chain constant region locus.

95 sgenic lines, germline transcription of some H chain constant regions genes is severely impaired.

96 timulation with R-spondin and its binding to HS chains decorating syndecan-1 are indispensable for op

97 r HS polymerization, we demonstrate that the HS chains decorating syndecan-1 mediate aberrant Wnt pat

98 ed, and suggest the presence of intermediate H chain-deficient PLCs.

99 Disulfide-dependent B27 H chain dimers and multimers are stronger ligands for LI

100 hypothesis that additional levels of somatic H chain diversification may exist.

101 The truncated/V(H)-less mouse H chain Dmu forms precursor B cell receptors with the su

102 olecules (i.e., appropriate HLA alpha1alpha2 H chain domains fused with a mouse alpha3 domain and cov

103 However, the physiologic role of H chain editing (V(H) replacement and rearrangement on t

104 H chain editing is shown to involve VH replacement at th

105 In the process of immunoglobulin heavy (H) chain editing, these secondary rearrangements are med

106 two unmodified L chain subunits and a single H chain ending in glycine, but the second H chain termin

107 The human H chains expressed with these L chains also have relativ

108 ice, consistent with central deletion of 2F5 H chain-expressing B cells.

109 Because Igmu H chain expression was decreased in Emu-deficient pre-B

110 gene in a variant cell line lacking Emicro, H chain expression was lost, and interactions between V(

111 ior cavity of a genetically engineered human H-chain ferritin (HFn).

112 Overexpression of human H-chain ferritin (HuHF) is known to impart a degree of p

113 Three fluorescence variants of human H-chain ferritin were prepared in which Trp34 was introd

114 mposed of 24 subunits of two types, ferritin H chain (FHC) and ferritin L chain (FLC).

115 ly to HLA-B27 (B27) beta2-microglobulin free H chain (FHC) dimers than other HLA-class I molecules re

116 (beta2m) and peptide and (beta2m free) free H chain (FHC) forms including B27 dimers (termed B27(2))

117 reveals that L363 depends on both the L and H chains for binding to the glycolipid-mCD1d complex, al

118 The binding sites on HS chains form non-random, heterogeneous networks.

119 reB and lambda5 proteins, together with Igmu-H chains, form precursor BCRs (preBCRs).

120 a2-microglobulin-associated B27 and B27 free H chain forms (FHC), including disulfide-bonded H chain

121 I, whereas LILRB2 bound both folded and free H chain forms.

122 A mAb directed to TbKHC1, an orphan kinesin H chain from Trypanosoma brucei, inhibited T. musculi ex

123 this study, we generate KI models expressing H chains from two other HIV-1 Abs, 4E10 (another self-/p

124 The IgM H chain gene organization of cartilaginous fishes consis

125 s for a brief period following successful Ig H chain gene rearrangement.

126 Ig H chain gene transcripts isolated from the sections, reg

127 both truncated transgenes express the micro H chain gene well, they undergo very low or undetectable

128 lasma cells (AxJ) that express the identical H chain gene whose RNA is processed in different ways.

129 of its C-terminal domain (CTD) on the IgG2a H chain gene, comparing two mouse cell lines representin

130 ts works poorly in the context of the gamma1 H chain gene, resulting in expression of gamma1 H chains

131 used the VH3-09 (or closely related VH3-20) H chain gene, whereas no PF anti-matDsg1 used these gene

132 f the secreted form of the IgH mRNA from the H chain gene.

133 uction in class switch recombination for all H chain genes and the varied reduction in germline trans

134 ecial roles for some 3' enhancers; different H chain genes are affected by different 3' enhancer dele

135 reduction in germline transcription for some H chain genes could be caused by (i) insertion site effe

136 nd I exons for the murine gamma1 and gamma2a H chain genes in a transgene of the entire H chain C-reg

137 The chromosomal distribution of H chain genes in an Ig genotype can be inferred through

138 we name "initiator B cells." Analysis of BCR H chain genes isolated from these cells revealed evidenc

139 es; importantly, rearrangement of endogenous H chain genes was suppressed to a similar degree in STAT

140 ombination and germline transcription of all H chain genes.

141 sion, preventing rearrangement of endogenous H chain genes; importantly, rearrangement of endogenous

142 matosus, using the autoreactive germline D42 H chain (glD42H) site-directed transgenic NZB/W mouse.

143 In contrast, the conserved MHC class I H chain glycan played a minor role in CRT recruitment in

144 2 In addition, FGF22-FGFR1c2 can tolerate an HS chain having an N-acetylglucosamine residue at its no

145 ent and usage of the endogenous, nontargeted H chain (HC) allele.

146 surface expression was coincident with MHC-I H chain (HC) expression and was downregulated upon pertu

147 R signaling (BCR) because ablation of either H chain (HC) expression or BCR signaling causes B cells

148 bunit Igalpha or the VDJ segment of the IgH (H chain [HC]).

149 hain forms (FHC), including disulfide-bonded H chain homodimers (termed B27(2)).

150 The H-chain identified in cataractous fiber cells (29 kDa) d

151 xpressing the inherently autoreactive VH4-34 H chain (identified by the 9G4 mAb) and 9G4(+) plasma Ig

152 A series of control elements within the Ig H chain (Igh) locus has been implicated in regulating th

153 B cells produce Ig H chain (IgH) mRNA and protein, primarily of the membran

154 b repertoires, amplicons are created from Ab H chain (IgH) transcripts and sequenced on a high-throug

155 cell expression of CD32B or CD32C, and IgG1 H chain (IGHG1) and kappa-chain (IGKC) polymorphisms det

156 ance of arginines in CDR3 of the Ig variable H chain (IgVH).

157 saminoglycans, specifically heparan sulfate (HS) chains immobilized onto magnetic nanoparticles.

158 als, maturation of B cells expressing heavy (H) chain immunoglobulin (Ig) without light (L) chain is

159 ance triggered by self-reactivity of the 2F5 H chain impedes BnAb induction.

160 Deletion of CD98 H chain in B cells leads to complete failure of B cell p

161 Using a biomarker to track a self-reactive H chain in peripheral blood, we found evidence of simila

162 is prevented by chaperone association of the H chain in the endoplasmic reticulum.

163 The higher content of H-chain in assembled ferritin allows this molecule to se

164 The H-chain in both species was truncated, and its concentra

165 In addition, the accumulation of H-chain in deeper fiber layers of the lens may be part o

166 yndecan-4 acts as a receptor for TG2 via its HS chains in two ways: by increasing TG2-cell surface tr

167 ariations in the sulfation pattern along the HS chains influence their ability to interact with molec

168 he asymmetric FGF2-HS1-FGFR2 model, a single HS chain interacts with the FGF2-FGFR2 protein complex t

169 Sequence analysis of the third CDR of the H chain intervals obtained by PCR amplification of V(H)

170 nto the PLC, but impacted the recruitment of H chains into the PLC, and glycan-deficient H chains wer

171 The ferroxidase activity of the ferritin H chain is critical to store iron in its Fe3+ oxidation

172 The capacity to class switch the Ig H chain is critical to the effectiveness of humoral immu

173 The selection of Ab H chains is difficult to study because of the large dive

174 6-O-sulfation (6S) of glucosamine within HS chains is critical for many of these ligand interacti

175 IgG2a, with gamma2a H chains, is important for protection against viruses an

176 rinization and selection of a strain-matched H chain isotype are critical to generate ideal surrogate

177 TA-1-based surrogate Abs with a murine IgG2c H chain isotype were created.

178 zation of its classical Ig gene content (two H chain isotypes, mu and omega, and four L chain isotype

179 exploiting two targeted IgH transgenic mice (H chain knock-in [HKI]) that produce large numbers of fo

180 tional H chain rearrangements in an anti-DNA H chain knock-in mouse, B6.56R.

181 Induction of cGVH in anti-DNA H chain knockin (3H9KI) transgenic mice results in speci

182 rease in "double-producers," suggesting that H chain/L chain combinations with superior signaling pro

183 ther demonstrate that heparanase cleavage of HS chains leads to increased ability to support FGF2-dep

184 he potential randomization of cognate heavy (H) chain/light (L) chain pairing, which could occur to a

185 t attenuation of IL-7R signaling returns the H chain loci to an inaccessible state; this process has

186 ) B cells, demonstrating that IL-7 regulates H chain locus accessibility and V(D)J recombination via

187 usage of the endogenous (i.e., nontargeted) H chain locus and evidence of vigorous L chain editing;

188 ic model, we report here that editing at the H chain locus appears to occur exclusively in bone marro

189 ore how the underlying genetic makeup of the H chain locus influences the formation of particular DJ

190 the same recombinatorial machinery, but the H chain locus is accessible at the pro-B cell stage, whe

191 cated at the most distal 3' region of the Ig H chain locus, has multiple regulatory functions that co

192 hown to regulate the accessibility of the Ig H chain locus.

193 hat happen to successfully rearrange another H chain may be favored in the periphery.

194 Disruption of covalent bonds between both H chains may account in part for these effects.

195 lpha and gamma mRNAs made up the majority of H chain mRNAs in the adventitia.

196 The most highly sulfated regions of HS chains, N-sulfated (NS) domains, play prominent roles

197 w that altering specific Arg residues in the H chain of a human pathogenic beta2GPI-dependent aPL, IS

198 ansgenic mouse expresses a transgene-encoded H chain of an anti-DNA Ab.

199 BALB/c mice that express a transgene-encoded H chain of an anti-DNA Ab.

200 Therefore, Abs to the H chain of HLA-E may be responsible for some of the HLA-

201 The H chain of L363 features residue Trp-104, which mimics t

202 The H chain of these homodimeric antibodies consists of one

203 Heparanase promotes tumor growth by cleaving HS chains of proteoglycan and releasing HS-bound angioge

204 -glomerulus via binding to heparan sulphate (HS) chains of proteoglycans and co-associated with synde

205 The heparan sulfate (HS) chains of proteoglycans are a key regulatory compone

206 roglobulin reduced the expression of class I H chain on the cancer targets by >97%, but it did not re

207 lved in the biosynthesis of heparan sulfate (HS) chains, on the inflammatory response associated with

208 This variable domain of an H chain-only Ab (VHH or nanobody) significantly inhibite

209 ized H and L chains, with exceptions such as H chain-only Abs in camels or natural Ag receptors in sh

210 he formation of fully functional and diverse H chain-only antibodies in L(-/-) animals.

211 t the immature B cell stage, produce diverse H chain-only antibodies in serum.

212 with viral epitopes generates high affinity H chain-only antibodies, which, because of their smaller

213 bination, which facilitate the generation of H chain-only Ig-secreting plasma cells.

214 The generation of H chain-only IgG is caused by the loss of constant (C) g

215 acking clonotypes of anti-insulin B cells in H chain-only VH125Tg/NOD mice showed that BTK-dependent

216 eens were largely composed of the transgenic H chain paired with a spectrum of L chains, predominantl

217 xamined the molecular characteristics of the H chain portion of the Ag receptor.

218 canine H-chain and from the 12-kDa modified H-chain present in fiber cells of noncataractous lenses.

219 transcription factor Bright up-regulates Ig H chain production from select V region promoters and re

220 The accumulation of Ig gamma H chain protein was also diminished, but unexpectedly th

221 It is unclear if additional rounds of H chain rearrangement are driven by BCR specificity.

222 ese findings favor a single, early window of H chain rearrangement in B6.56R that precedes the expres

223 e manner in which B cells undergo additional H chain rearrangements in an anti-DNA H chain knock-in m

224 asin enhance beta(2)m and MHC class I heavy (H) chain recruitment to the PLC, with the ERp57 binding

225 Without combinatorial events, the shark IgM H chain repertoire is based on junctional diversity and,

226 This editing mechanism acts on the natural H chain repertoire; endogenous H chains with anti-DNA fe

227 They also have a simplified heavy (H) chain repertoire: All B cells start out with a 56R an

228 Light (L) chains that edit anti-DNA heavy (H) chains rescue B-cell development by suppressing DNA b

229 Remarkably, the H chain sequences isolated from individual lipogranuloma

230 how Sle2(z) impacts B cell tolerance, two Ig H chain site-directed transgenes, 3H9 and 56R, with spec

231 anscriptional level as opposed to effects on H chain stability.

232 The individual light (L) and heavy (H) chain subunits from the main and basic peaks were ana

233 ctivation-induced cytidine deaminase, clonal H chain switch, and an inverted lambda/kappa ratio of Ig

234 FHsiRNA decreased ferritin H-chain synthesis, but doubled ferritin L-chain synthesi

235 le H chain ending in glycine, but the second H chain terminated in lysine for one isoform and alpha-a

236 hain gene, resulting in expression of gamma1 H chains that is <1% the wild-type level.

237 in three prominent CR regions (CRR) on L and H chains that overlap but do not coincide with Ab CDR.

238 endogenous heparan sulfate proteoglycan with HS chains that is critical for junctional complex assemb

239 ertoire, which uses a short third CDR of the H chain, the anti-DEX response relies more intensely on

240 endent and correlate with positively charged H chain third CDR.

241 erential expansion of clones bearing certain H chain third complementary region (HCDR3) lengths.

242 sing most progenitor B cells expressing this H chain to be eliminated at the pre-B cell checkpoint.

243 erated mAb against Treml4 and engineered its H chain to express three different Ags (i.e., OVA, HIV G

244 disulfide-linked complexes and bring the mu H chain to the cell surface as part of the BCR but is in

245 g(H) transcription (Bright), up-regulates Ig H chain transcription 3- to 7-fold in activated B cells

246 elated with a reduction in mRNA encoding the H chain transcription factor, OBF-1/BOB-1/OCA-B.

247 Ig L and H chain transcription increased significantly, and heavy

248 The decrease in H chain transcripts correlated with a reduction in mRNA

249 rize the maturation of the repertoire of IgA H chain transcripts in circulating blood B cells during

250 CR, we amplified, cloned, and sequenced IgG4 H chain transcripts of PBMCs from 10 children with aller

251 of 60 wk, somatic mutation frequency of IgA H chain transcripts reached 25% of the adult values but

252 We found that IgA H chain transcripts were present in cord blood as early

253 Thus, naturally occurring H chain transcripts without C(H)1 (V(H)DJ(H)-hinge-C(H)2

254 , which, through alternative RNA splicing of H chain transcripts, begins to be coexpressed with IgM a

255 E, but also reduce IgE(+) B cell numbers and H chain transcripts.

256 mice bearing the autoreactive site-directed H chain transgene 3H9.

257 In C57BL/6 mice that express both the H chain transgene and the lupus susceptibility interval

258 as revealed in mice expressing a targeted Ig H chain transgene encoding BCRs with "multireactivity" f

259 BL/6 (B6) controls, each expressing the AM14 H chain transgene in the presence or absence of the IgG2

260 56R/56R mice that possessed the 56R anti-DNA H chain transgene inserted into both HC loci.

261 Introduction of an anti-insulin BCR H chain transgene restores diabetes in btk-deficient NOD

262 for Abs from B cells that expressed the 56R H chain transgene with "editor" L chains that did not co

263 ralizes or alters self-reactivity of the 56R H chain transgene.

264 of NOD mice was restricted using a fixed Ig H chain transgene.

265 We isolated two lines of mice in which the H chain transgenes were truncated at their 3' ends.

266 We addressed this question using a H chain transgenic (Tg) mouse model that lacks secreted

267 as hybridomas from the spleens of anti-dsDNA H chain transgenic mice also bind an additional, Golgi-a

268 Immunization of young TC.AM14 H chain transgenic mice with IgG2a(a) anti-chromatin imm

269 r of unselected mutations, we immunized B1-8 H chain transgenic mice with nitrophenyl to stimulate ni

270 iting frequencies of DNA Abs in the 3H9H/56R H chain transgenic mice, but the level of IgG2a anti-DNA

271 In site-directed anti-dsDNA H chain transgenic mice, loss of VprBP function in B cel

272 Using the anti-DNA H chain-transgenic mouse, 56R, we find that B cells with

273 the D-glucosamine residue in an immobilized HS chain using D-glucosaminyl 3-O-sulfotransferase.

274 somatic hypermutation (ac-Nglycs) within Ig H chain V region (IGHV) genes as alternative selective p

275 is optimally done by interrogation of paired H chain V region (VH) and L chain V region (VL) sequence

276 To study the selection of individual Ab H chain V region genes (V(H)), we performed CDR3 spectra

277 Analysis of the rearranged H chain V region genes of mAbs isolated from seven of th

278 ras, we demonstrate the dominant role of the H chain V region in TSHR recognition.

279 urally occurring somatic mutations in the Ab H chain V region of Fab19, a well-described neutralizing

280 time in blood, in the case of B-CLL with Ig H chain V region-unmutated BCR and <30% CD38(+) cells in

281 sis of B-1a, B-1b, and B-2 cell IgH V region H chain (V(H)) genes revealed increased usage of V(H)11

282 n the pathogenesis of OA, we analyzed the Ig H chain variable region (V(H)) genes of B cells recovere

283 The degradation of ferritin H-chain was blocked by both siRNAs, whereas only FHsiRNA

284 Histologic analysis revealed that the H-chain was distributed differently throughout cataracto

285 H chains into the PLC, and glycan-deficient H chains were impaired for tapasin-independent and tapas

286 In addition, HS chains were shown to contain significantly increased

287 This H chain, when combined with its original L chain, the la

288 residue capping the non-reducing end of the HS chain, where no further degradation can occur in the

289 me uptake was specifically inhibited by free HS chains, whereas closely related chondroitin sulfate h

290 on sugar residues along the heparan sulfate (HS) chain which results in a structural heterogeneity th

291 etory delta transcript resulted in two delta-H chains, which incorporated Cmu1 and variable domains.

292 oelectric-focusing analysis detected a HLA-A H chain with a unique isoelectric-focusing pattern, whic

293 del is made up of B cells expressing the 56R H chain with the lambdaX L chain.

294 n the natural H chain repertoire; endogenous H chains with anti-DNA features are expressed primarily

295 he human repertoire, and if so, do they edit H chains with anti-DNA signatures?

296 layed unique features in the third CDR of Ig H chains with minor alterations along the immunization c

297 light chains showed genetic instability of V(H) chains with only the hp-B6.1; the V(H) sequences from

298 osed primarily of NS domains internal to the HS chain with minor presence of non-reducing end (NRE) N

299 peeling reaction that specifically degrades HS chains with 3-O-sulfated glucosamine at the reducing-

300 antagonist surfen, and enzymatic removal of HS chains with heparinase III treatment as well as by si