ライフサイエンスコーパス: H-atom abstraction

1 se ions react like typical diradicals (e.g., H atom abstractions).

2 idate radicals, allowing their first use for H atom abstraction.

3 action with H atom donors proceed via direct H atom abstraction.

4 th the aliphatic C-H bonds of amino acids by H atom abstraction.

5 ilic substrate PPh3 but is not activated for H-atom abstraction.

6 iminyl radical was too slow to compete with H-atom abstraction.

7 ither retro-Bergman ring opening or external H-atom abstraction.

8 rmodynamically and kinetically competent for H-atom abstraction.

9 s 6 and 7 that also come from intermolecular H-atom abstraction.

10 C-C bond constructions, dehalogenations, and H-atom abstractions.

11 After the H-atom abstraction, a reasonable pathway for substrate h

12 zed in the presence of this cluster both via H-atom abstraction and oxygenation with approximately 50

13 uted alpha-ketoamides proceed by competitive H-atom abstraction and sequential SET-desilylation pathw

14 0, which were all formed from intramolecular H-atom abstraction and trapping of the corresponding bir

15 tetradecane) are evaluated in hydrogen atom (H-atom) abstraction and oxo-transfer reactions.

16 330 nm, and tau = 50 ns) via intramolecular H-atom abstraction as the main photoreactivity of 3.

17 in k(cat) (approximately 3000-fold) support H-atom abstraction as the relevant substrate-activation

18 I, an Fe(IV)-Fe(IV) complex, followed by the H-atom abstraction at the transition state III leading t

19 approximately 7) and strongly suggests that H atom abstraction by the peroxyl radical occurs with su

20 rimental and theoretical evidence for direct H-atom abstraction by ABLM and proposes an attractive me

21 fined by the NRVS data, show that the direct H-atom abstraction by ABLM is thermodynamically favored

22 Direct H-atom abstraction by ABLM would generate a reactive Fe(

23 proposed mechanism for LO catalysis involves H-atom abstraction by an FeIII-OH- site, best described

24 This result suggests that H-atom abstraction by benzophenone is rapid and that the

25 -TOH) enables tuning their reactivity toward H-atom abstraction by peroxyl radicals.

26 mechanisms of reaction initiated by toluene H-atom abstraction chemistry are detailed.

27 f 4-methyl-N-hydroxyphthalimide (4-Me-NHPI), H-atom abstraction competes with self-decomposition in t

28 spectra of isoleucine and leucine show that H-atom abstraction distal to the alpha-carbon occurs pre

29 step of all these processes, intramolecular H-atom abstraction efficiently intercepts the p-benzyne

30 ial and proton affinity contributions to the H-atom abstraction energy.

31 The pi-trajectory for H atom abstraction (Fe(IV) horizontal lineO oriented per

32 nol led to formation of 5 via intermolecular H-atom abstraction followed by lactonization.

33 Fe(III)-OOH is found to be more effective in H-atom abstraction for strong C-H bonds, while the highe

34 ion that Fe(III)-O2(-) species can carry out H atom abstraction from a C-H bond to initiate the 4-ele

35 by a direct reversal mechanism initiated by H atom abstraction from C-6 of the thymine dimer.

36 comitantly, supposedly capable of the second H atom abstraction from C9.

37 mu-oxo)dicupric core is highly activated for H atom abstraction from CH(4).

38 H atom abstraction from CH2 sites, followed by a fission

39 resulting Cu(II)-O2(*-) is activated toward H atom abstraction from cysteine.

40 rs in addition to the intrinsic rate of C-4' H atom abstraction from DNA sugars.

41 single spectrum permits the relative rate of H atom abstraction from each position to be determined.

42 vity consistent with a minor contribution of H atom abstraction from the -OCH3 group to the overall r

43 ructural basis for direct and stereospecific H atom abstraction from the buried G(734) of pyruvate fo

44 n-and that homolysis of SAM concomitant with H atom abstraction from the substrate is readily reversi

45 rrous intermediate, formed by O(2)-activated H atom abstraction from the substrate, can exploit diffe

46 iperidin-1-yloxidanyl) resulted in immediate H- atom abstraction from the benzylic position of the ch

47 s significantly stronger than the C7-H bond, H-atom abstraction from C4 is facilitated by H-bond form

48 In contrast, H-atom abstraction from substrate by the side-on Cu(II)(

49 dition to the aminoxyl moiety of 4-O-TPO and H-atom abstraction from the 2- or 6-methyl groups or fro

50 osphoglycolate termini that are derived from H-atom abstraction from the 4'-position of the deoxyribo

51 rrect orientation and distal O character for H-atom abstraction from the ACV substrate.

52 generate a reactive Cu(II)/O(2) species for H-atom abstraction from the C-H bond of substrates.

53 3 is also formed via H-atom abstraction from the corresponding mu-1,1-hydrope

54 roxyl radical to the double bond followed by H-atom abstraction from the intermediate by another equi

55 orts the conclusion that cleavage occurs via H-atom abstraction from the sugar moieties, consistent w

56 The rate constants for H-atom abstraction from these substrates correlate well

57 Intramolecular hydrogen atom (H-atom) abstraction from the o-OCH3 group effectively in

58 ctive oxygen-centered radical 2b undergoes a H-atom abstraction (HAA) reaction with 1,4-cyclohexadien

59 N]Ni horizontal lineNAd (1), which undergoes H-atom abstraction (HAA) reactions with benzylic substra

60 In this work we probed the specific role of H atom abstraction in HydG-catalyzed carbon monoxide and

61 tigate possible reactive Cu/O(2) species for H-atom abstraction in peptidylglycine alpha-hydroxylatin

62 substrates, whereas the transition state of H atom abstraction is destabilized, presumably due to a

63 H-atom abstraction is favored by a high E(o) of the FeII

64 nsity in terms of relative rate constants of H-atom abstraction (k(inh)) from the various tocopherol

65 ring opening, k(-1), and the intermolecular H-atom abstraction, k2, were determined from the depende

66 strate that TsrM does not catalyse substrate H-atom abstraction like most radical SAM enzymes.

67 dants, capable of activating C-H bonds by an H-atom abstraction mechanism.

68 ions revealed that the reaction barriers for H-atom abstraction of cyclohexane by the ground state of

69 a reaction mechanism involving dibenzylamine H-atom abstraction or electron-transfer oxidation by the

70 c radical clock substrate support a stepwise H-atom abstraction/radical rebound pathway.

71 The substrate H-atom abstraction reaction by the Cu(II)(M)-OOH interme

72 a significant effect on the energetics of a H-atom abstraction reaction by the Cu(II)(M)-OOH interme

73 e putative Cu(II)(M)-OOH intermediate in the H-atom abstraction reaction of PHM.

74 The radical 12 undergoes a H-atom abstraction reaction with 1,4-cyclohexadiene to y

75 s, which would be a product of Cu(II)(M)-OOH H-atom abstraction reaction.

76 frontier molecular orbitals involved in the H-atom abstraction reaction.

77 I)-OOH complexes are found to perform direct H-atom abstraction reactions but with very different rea

78 isms of O-O bond homolysis and electrophilic H-atom abstraction reactions.

79 ar orbitals (FMOs) and their contribution to H atom abstraction reactivity.

80 trast to the behavior of LS Fe(III)-OOH, the H-atom abstraction reactivity of HS Fe(III)-OOH is found

81 Conversely, H-atom abstraction reactivity on an S = 2 surface allows

82 In addition to the expected H-atom abstraction, several unprecedented reaction pathw

83 rizontal lineO unit is much more reactive at H-atom abstraction than its S = 1 counterpart and sugges

84 , with a phenolic substrate, involving a net H-atom abstraction to cleave the bridging peroxo O-O bon

85 ted state decays by efficient intramolecular H-atom abstraction to form a 1,4-biradical, 8, that has

86 sitizer moiety, undergoes intramolecular 1,4-H-atom abstraction to form biradical 6, which was identi

87 bond into an alkyl chain by double hydrogen (H) atom abstraction using molecular O2.

88 e substrate can undergo different reactions (H-atom abstraction vs. electrophilic aromatic attack) wi

89 mpetition experiments, the rate constant for H atom abstraction was determined and found to be about

90 suggested by Aoyama, involves excited-state H-atom abstraction while the other, put forth by Whitten