ライフサイエンスコーパス: H-bond

1 on conditions by in situ activation of the C-H bond.

2 e to a nitrosoarene and activate the sp(2) C-H bond.

3 ts the reactive metal center to a specific C-H bond.

4 ophilic insertion of the nitride into the Si-H bond.

5 aker bond strength of Ni-H relative to the C-H bond.

6 adiative deactivation of excited states by N-H bonds.

7 alkylation of allylic and benzylic C(sp(3))-H bonds.

8 d enantioselective borylations of aromatic C-H bonds.

9 lyzed, enantioselective silylation of aryl C-H bonds.

10 silylations of unactivated, primary C(sp(3))-H bonds.

11 genative coupling is not limited to C(sp(2))-H bonds.

12 cted functionalization of the gamma-C(sp(3))-H bonds.

13 d functionalization of unactivated C(sp(3) )-H bonds.

14 oxidative addition of Rh(I) into the beta-C-H bonds.

15 iates are implicated that feature reactive N-H bonds.

16 tramolecular amidation of the gamma-C(sp(3))-H bonds.

17 ct derivative containing multiple types of C-H bonds.

18 e most organic compounds have many similar C-H bonds.

19 mI2(H2O)n should be able to form very weak C-H bonds.

20 ecies (O(MeAN)-LA) able to oxidize C-H and O-H bonds.

21 loped to catalytic O-transfer from N2O to Si-H bonds.

22 electivity at the most accessible tertiary C-H bonds.

23 the catalyst, and the other cleaves remote C-H bonds.

24 n/intramolecular amidation of gamma-C(sp(3))-H bonds.

25 olar solvent for formation of intramolecular H-bonds.

26 our strategy, a highly robust supramolecular H-bonded 1D ensemble was used to order the appended crow

27 eal that the receptor, owing to the enhanced H-bonding ability of thiourea groups, initially encapsul

28 three catalytic cycles to achieve hydridic C-H bond abstraction (enabled by polarity matching), alkyl

29 tivity of RSSH eclipses that of alpha-TOH in H-bond-accepting media because of their low H-bond acidi

30 ties compared to similar complexes lacking a H-bond acceptor.

31 mation of H-bonded complexes between anionic H-bond acceptors (HBAs) and neutral H-bond donors (HBDs)

32 ipating ligands at Pd(II) in aerobic sp(3)-C-H bond acetoxylation processes and are involved in redox

33 es, sulfenic acids), which tend to have high H-bond acidities.

34 H-bond-accepting media because of their low H-bond acidity (alpha2(H) approximately 0.1).

35 Recent developments in C-H bond activation and functionalization by Pt complexes

36 ant in an intermetal oxygen atom transfer, C-H bond activation and olefin epoxidation reactions.

37 es that the key step of alkane metathesis (C-H bond activation followed by beta-H elimination) occurs

38 lective monoarylation of aromatic rings by C-H bond activation is developed.

39 Exploiting C-H bond activation is difficult, although some success ha

40 C-H bond activation is predicted to be reversible, consist

41 ligands replaced with MeCN indicates that C-H bond activation is sensitive to those ligands and vari

42 ence of pyridine or DMAP, reversible sp(2) C-H bond activation occurred, forming orthometalated compl

43 On Ni clusters, C-H bond activation occurs via an oxidative addition step

44 atter mediates frustrated Lewis pair type Si-H bond activation of the silane substrates.

45 The B-H bond activation process produces P-hydrido-1,3,2-diaza

46 eaction with fluorobenzene afforded the CAr -H bond activation product [1-F-2-IMe -C6 H4 ](+) I(-) (3

47 n invoked as intermediates in Mn-catalyzed C-H bond activation reactions.

48 The initial C-H bond activation remains as the sole kinetically releva

49 t dioxazolone amidating agents via C(sp(3) )-H bond activation to generate the desired amidated produ

50 on of 25 with HCCTol gives irreversible sp C-H bond activation under kinetic control, and with MeCCPh

51 tho-aryl-N-methoxyamides via N-H, C-N, and C-H bond activation, and (4) isocoumarin synthesis using R

52 the eta(2)-coordinated ligand followed by N-H bond activation, bis(imino)pyridine modification, and

53 Thus, hydrogenation, C-H bond activation, C-C, C-N, C-O bond formation, hydroly

54 a eta(2)-H,H sigma-complex showing little Ga-H bond activation, through species of intermediate geome

55 sulfur in THF affords 4(*) via unexpected C-H bond activation, which represents the first anionic di

56 e reactivity of compound I with respect to C-H bond activation.

57 ymes has inspired new synthetic methods in C-H bond activation.

58 sed catalysis proceeds through five steps: C-H bond activation; C-C coupling via a concerted 1,2-aryl

59 rent positions resulting in regioselective C-H bond activation; paradoxically, the strongest C-H bond

60 itionally, many transition-metal-catalyzed C-H bond additions to polarized pi bonds occur within casc

61 ing both gamma-C(sp(2))-H and gamma-C(sp(3))-H bonds afforded moderate yields of the gamma-C(sp(2))-H

62 ve coupling of beta-vinyl and ortho-methyl C-H bonds affords dimethylindene, demonstrating that the d

63 alyzed three-component coupling of C(sp(2) )-H bonds, alkynes, and halogenating agents to give alkeny

64 sis of an acid-induced deactivation of the C-H bonds alpha to nitrogen toward HAT to PINO as evidence

65 rization in C6 D6 find aromaticity-modulated H-bonding (AMHB) energy effects of approximately +/-30 %

66 as a cocatalyst in a Cp*Rh(III)-catalyzed C-H bond amidation proceeding by an intramolecular amide t

67 The chemoselectivity for C-H bond amination is greater than 20:1 in all cases.

68 e catalyze enantioselective intramolecular C-H bond amination reactions of sulfonyl azides.

69 ve been engineered to catalyze abiological C-H bond amination reactions, but the yields of these reac

70 rtho fluorine substituents adjacent to the C-H bond and 1,2,3,4-tetrafluorobenzene.

71 e, during which a Ni-atom inserts into the C-H bond and donates its electron density into the C-H bon

72 ective coupling between ketone beta-C(sp(3))-H bonds and aliphatic alkynes using an in situ-installed

73 ated C-H bonds over 3 degrees alkyl C(sp(3))-H bonds and apply these insights to reaction optimizatio

74 ity profiles of species featuring reactive N-H bonds and estimate their homolytic N-H bond enthalpies

75 es approaching the surface, activating the O-H bonds and inducing deprotonation.

76 ctions e.g. hydroxylation of non-activated C-H Bonds and stereoselective synthesis.

77 se pairs to drug-receptor binding, hydrogen (H-)bonding and aromaticity are common features of hetero

78 and propofol bind to this pocket by forming H-bond and halogen-bond interactions with Ser-876, Met-9

79 rophobic burial include shorter and stronger H-bonds, and increased entropy in the folded state.

80 in reactivity toward tertiary and benzylic C-H bonds are observed.

81 or C-H alkylation reactions, wherein sp(3) C-H bonds are replaced with sp(3) C-alkyl groups.

82 C-H bonds are ubiquitous structural units of organic molec

83 interactions are removed when intramolecular H-bonds are formed and therefore provide an increased dr

84 lladium-catalyzed, pyrazole-directed sp(3) C-H bond arylation by aryl iodides.

85 These forces may include H-bonding as indicated by sorption enthalpy determined b

86 the formation of intramolecular phenol-amide H-bonds as a function of solvent composition.

87 resence of fluorine differentiates between C-H bonds at different positions resulting in regioselecti

88 Aryl and benzylic C-H bonds at other locations remain intact during this dir

89 hen surveyed in terms of the nature of the C-H bond being activated (C(sp(2))-H or C(sp(3))-H), the n

90 a an E1 mechanism with the cleavage of Cbeta-H bond being rate determining.

91 ions predicted to allow formation of a fully H-bonded beta-hairpin at the fibril edge while interferi

92 nd antiparallel-beta-sheets (1690cm(-1)) and H-bonded beta-turns (1664cm(-1)).

93 a via neutral His413, regardless of a labile H bond between Ser382 and the hydroxyethylfarnesyl group

94 31 in R411A-alpha2 is dynamic, reforming the H-bond between Y731 and Y730 to allow RT to propagate to

95 hanced (a) when the bond asymmetry between C-H bond breaking and O-H bond formation in the transition

96 Intriguingly, C-H bond breaking does not occur prior to the addition of

97 ion of 21-d3-progesterone, indicating that C-H bond breaking is a rate-limiting step over a 10(4)-fol

98 species are stable in the absence of weak C-H bonds, but decay via N-O bond homolysis to ferrous or

99 adjacent, energetically favored secondary C-H bonds, but the mechanism explaining this intriguing pr

100 w mechanism that involves activation of an O-H bond by the ferryl complex is proposed.

101 Activation of O-H bonds by inorganic metal-oxo complexes has been docume

102 not next to a functional group) secondary C-H bonds by means of rhodium-carbene-induced C-H insertio

103 has been developed via the merger of NHC and H-bonding catalysis.

104 The borylation of C-H bonds catalyzed by transition metals has been investig

105 short-range cooperative effects may occur in H-bond chains.

106 vage step is not rate-determining, but the C-H bond cleavage and C-Si bond-forming steps together inf

107 Examples of using TAML activators for C-H bond cleavage applied to fine organic synthesis conclu

108 action of the adsorbed complexes underwent C-H bond cleavage at temperatures as low as 150 kelvin (K)

109 This suggested that, in contrast to direct C-H bond cleavage catalyzed by a high-valent iron intermed

110 position by C(sp(3) )-(sp(3) ) and C(sp(3) )-H bond cleavage gives access to distal carbon radicals t

111 Furthermore, the first C-H bond cleavage in methane is favored as the local oxida

112 provide a "bottom-up" fundamental insight, C-H bond cleavage in methane over Ni-based catalysts was i

113 eneral agreement with expected mechanisms (C-H bond cleavage in oxidation by persulfate, C-Cl bond cl

114 ate that the activation energy for methane C-H bond cleavage is 9.5 kilojoule per mole (kJ/mol) lower

115 f I2 and TBHP as the green oxidant via the C-H bond cleavage of the benzylic carbon under mild reacti

116 Methane undergoes highly facile C-H bond cleavage on the stoichiometric IrO2(110) surface.

117 Kinetic isotope effects indicated that the C-H bond cleavage step is not rate-determining, but the C-

118 different engineered reactions: oxidative C-H bond cleavage using heat-activated persulfate, transfo

119 livering/accepting a proton (H(+)) via its N-H bond cleavage/formation.

120 nothricin, uncovered an example of such an O-H-bond-cleavage event.

121 is 4-fold accelerated upon formation of the H-bonded complex.

122 ve been used to investigate the formation of H-bonded complexes between anionic H-bond acceptors (HBA

123 Nevertheless, their ability to form H-bonded complexes has been only marginally touched.

124 tudied in view of its ability to form triply H-bonded complexes with a suitably complementary 2,6-dia

125 interplay between inter- and intramolecular H-bonded conformer topologies for the same peptide templ

126 theses, the activation of carbon-hydrogen (C-H) bonds converts them directly into carbon-carbon or ca

127 toxidations in the presence of a very strong H-bonding cosolvent (DMSO), which slowed the observed ra

128 Heterolysis of the Si-H bond, deprotonation of the heteroarene, addition of th

129 ied dentin matrix, which was not affected by H-bond destabilization by urea.

130 rocarbons characterized by relatively high C-H bond dissociation energies.

131 The O-H bond dissociation energy of the Fe(II)-OH2 complex was

132 Very low N-H bond dissociation enthalpies, ranging from 65 (Fe-C id

133 A ladder of H-bond donating residues creates a 'polar track' demarki

134 Oligomers that have a H-bond donor and acceptor on the ends of the chain can f

135 ally driven by the presence of an endocyclic H-bond donor.

136 or organic crystal engineering, where double-H-bonding donor boronic acids could act as suitable orga

137 anionic H-bond acceptors (HBAs) and neutral H-bond donors (HBDs) in organic solvents.

138 onto polypeptide side-chains, serve as both H-bond donors and acceptors at neutral pH and disrupt th

139 Mismatched duplexes that have an excess of H-bond donors are stabilized by the interaction of two p

140 es, addition of polar functional groups with H-bond donors increased metabolic stability but decrease

141 lectron donors such as trimethylamine and to H-bond donors such as methanol.

142 f magnitude larger than expected from simple H-bond dynamics.

143 perimentally revealed by comparing homodimer H-bond energies of aromatic heterocycles with analogs th

144 In toluene, the trend of H-bond enhancement is observed with a smaller magnitude

145 ive N-H bonds and estimate their homolytic N-H bond enthalpies (BDEN-H) via redox and acidity titrati

146 The mutant R411A(alpha) disrupts the H-bonding environment and conformation of Y731, ostensib

147 lyzed method for oxidative imidoylation of C-H bonds exhibits unique features that have important imp

148 ) mass spectrometry (MS) reports on backbone H-bond fluctuations.

149 nd asymmetry between C-H bond breaking and O-H bond formation in the transition state is minimized, a

150 with X-ray photoelectron spectroscopy, and O-H bond formation of H interstitial defects is predicted

151 thermochemical analysis indicates that the C-H bond formed in the rate-determining step has a bond di

152 This intermolecular C-H bond functionalization does not requires any exogenous

153 This formal C-H bond functionalization is a direct and efficient means

154 lves dual photocatalysis ensuing two sp(3) C-H bond functionalization of N,N-dimethylanilines.

155 oselective catalytic cross-dehydrogenative C-H bond functionalization protocol for the construction o

156 bundant potassium cation as a catalyst for C-H bond functionalization seems to be without precedent,

157 Co(III)- and Cp*Rh(III)-catalyzed directed C-H bond functionalizations with diazo-compound substrates

158 m-catalyzed enantioselective borylation of C-H bonds has been reported.

159 The proximal C-gamma(sp(3))-H bonds have been oxidized by palladium-catalyzed acetox

160 classes of enantioselective silylations of C-H bonds have been reported recently, but little mechanis

161 studies here by introducing single-backbone H-bond impairing modifications (alpha)N-methyl Gln or l-

162 A single specific C-H bond in a substrate can be activated by using a 'direc

163 that cleavage by oxidative addition of an O-H bond in H2O is the rate-determining step in this react

164 severely curtailed by the distance of the C-H bond in question from the directing group, and by the

165 Significantly, the weakened N-H bonds in ((iPr)PDI)Mo(NH3)2(eta(2)-C2H4) enabled hydro

166 stem in which the geometry and the number of H bonds in a chain were systematically controlled.

167 Recently, it was reported that C-H bonds in aromatic heterocycles were converted to C-Si

168 vironments for the hydroxylation of strong C-H bonds in enzymatic reactions.

169 ort the rapid room-temperature cleavage of C-H bonds in pyridine, 4-tert-butylpyridine, and 2-phenylp

170 d C-H carbonylation reactions of methylene C-H bonds in secondary aliphatic amines lead to the format

171 This species reacts with weak O-H bonds in TEMPO-H and 4-dimethylaminophenol ((NMe2)PhOH

172 bimetallic species are capable of cleaving C-H bonds in the supporting ligands, and kinetic studies s

173 of the chain can fold to form intramolecular H-bonds in the free state.

174 These interactions stabilize H-bonds in the vicinity of the active site, thereby mask

175 The importance of the H-bonding interaction as a prerequisite for reductive cl

176 H-bonding interactions between the sugar and the protein

177 nd pyridine N-oxide groups form duplexes via H-bonding interactions between these recognition units.

178 metric complex that is stabilized via strong H-bonding interactions.

179 ent powerful and direct methods to convert C-H bonds into amine groups that are prevalent in many com

180 he rates are more dependent on the type of X-H bond involved than the associated DeltaG degrees .

181 This is the first use of N-iodoamide for C-H bond iodination.

182 Surprisingly, in P4H, a strong aliphatic C-H bond is activated, while thermodynamically much weaker

183 Cleavage of the H-H bond is followed by hydride transfer to the enzyme's o

184 threefold C-F bond activations, where each C-H bond is transformed to a C-Fe bond whereas each C-F bo

185 a- and gamma-alkynylation of amide C(sp(3) )-H bonds is enabled by pyridine-based ligands.

186 he direct functionalization of unactivated C-H bonds is ushering in a paradigm shift in the field of

187 The functionalization of carbon-hydrogen (C-H) bonds is one of the most attractive strategies for mo

188 ating the recognition sites), intramolecular H-bonding is favored, and the folded state is highly pop

189 Pervasive H-bonding is found at all interdomain interfaces, which

190 mploying unprotected indazoles with a free N-H bond, isomerization is averted because the heterocycle

191 We additionally show that the O-H bond length in these catalysts can be measured with su

192 been reported in the activation of alkane C-H bonds, many C(sp(3))-H activation/C-C and C-heteroatom

193 heterocycles with analogs that have the same H-bonding moieties but lack cyclic pi-conjugation.

194 one-dimensional network of intermolecularly H-bonded molecules stacked in an antiparallel sheet alig

195 the selenolate-ligated compound I cleaves C-H bonds more rapidly than the wild-type intermediate.

196 e Fe/Co heterobimetallic species activates C-H bonds much more rapidly than the Co/Co homobimetallic

197 easing temperature, indicative of a changing H-bond network at the surface of the protein.

198 r34 maintains solvent exclusion and the core H-bond network in the active site by relocating to repla

199 for the proper positioning of G40 through a H-bond network that involves G42 as a bridging unit betw

200 ted fucosylation mechanism facilitated by an H-bonded network, which is corroborated by mutagenesis e

201 The H-bonding networks within the nanoclusters resemble the

202 ct, consistent with the calculations for the H-bonded O-O homolysis mechanism.

203 rated by homolytic cleavage of a weakened Si-H bond of a hypercoordinated silicon species as detected

204 ; this intermediate then adds a beta-vinyl C-H bond of a second styrene molecule before reductively e

205 litates the functionalization of the sp(3) C-H bond of acetophenones.

206 e electrophilic aromatic substitution of a C-H bond of benzene is one of the archetypal transformatio

207 ontrolling the heterolytic cleavage of the H-H bond of dihydrogen is critically important in catalyti

208 , (t) BuNC, and even into a benzylic sp(3) C-H bond of ethylbenzene.

209 s active sites that are able to cleave the C-H bond of methane at temperatures </=200 degrees C, enab

210 Cp*RhCl to accelerate the cleavage of the C-H bond of N-pentafluorophenylbenzamides, providing a new

211 rous triamide 1 results in cleavage of the B-H bond of pinacolborane through addition across the elec

212 zontal lineO oriented perpendicular to the C-H bond of substrate) was found to lead to the S = 2 five

213 on of two indole C(sp(2))-H and one C(sp(3))-H bond of the active methylene residue.

214 by abstracting the hydrogen atom from the C-H bond of the alcohol (R(1) CH(OH)R(2) ).

215 f the "Si(I)2" unit of 2 into the olefinic C-H bond of the imidazole ring of 1 and four-membered cycl

216 ent of elemental selenium, the B-B and C(1) -H bonds of 8 were cleaved to give the cyclic 1,9-diboryl

217 ionships between the functional groups and C-H bonds of a substrate has been exploited to achieve met

218 ive bromination of gamma-methylene C(sp(3) )-H bonds of aliphatic amides and delta-methylene C(sp(3)

219 actions of sulfoxonium ylides with C(sp(2) )-H bonds of arenes and heteroarenes in the presence of a

220 n and functionalization of the beta-C(sp(3))-H bonds of carboxylic acids are well documented, but onl

221 tive transformation of sp(2) C-F and sp(2) C-H bonds of fluoroarenes and heteroarenes to sp(2) C-Al b

222 terium incorporation (up to 49%) in acidic C-H bonds of ketone and alkyne substrates (pKa from 18.7 t

223 ls that selectively cleave one of the four C-H bonds of methane and thus make it amenable for further

224 iphatic amides and delta-methylene C(sp(3) )-H bonds of nosyl-protected alkyl amines are developed us

225 ps via palladium insertion into the C(sp(3))-H bonds of one of the prochiral methyl groups.

226 n break the strong (105-111 kcal mol(-1) ) C-H bonds of pyridine substrates are unknown.

227 mol(-1), which is among the weakest known X-H bonds of stable reagents.

228 thods to functionalize the alpha-methylene C-H bonds of these systems enantioselectively is of great

229 The beta-methylene C(sp(3) )-H bonds of various carbocyclic rings were also successfu

230 ide, 2) net hydrogen-atom transfer to form N-H bonds, or 3) C-H amination of the alkyl linker of the

231 mine) prefers to activate alpha-conjugated C-H bonds over 3 degrees alkyl C(sp(3))-H bonds and apply

232 roxylases preferentially oxygenate primary C-H bonds over adjacent, energetically favored secondary C

233 low chemoselectivity for the amination of C-H bonds over competing reduction of the azide substrate

234 ty for insertion of the nitrene units into C-H bonds over reduction of the azides to the sulfonamides

235 Site-selective aliphatic C(sp(3))-H bond oxidation reactions serve as the cornerstone of t

236 onalization of the less activated benzylic C-H bonds para to the CH2N(CH3)2 group in the aerobic oxid

237 erning formation of aggregates (1604cm(-1)), H-bonded parallel- and antiparallel-beta-sheets (1690cm(

238 e results demonstrate the transferability of H-bond parameters for anions between different solvents

239 Diverse C-H bond partners also exhibit good reactivity for a range

240 es for a solvent-directed switch of both the H-bonding pattern and the handedness of foldamer helices

241 motifs, all with maximally Grotthus-ordered H-bond patterns that successfully prevent recombination

242 first time the formation of a supramolecular H-bonded polymeric ribbon.

243 H-bonds position ACh and choline differently in the arom

244 (2) AChRs respond strongly to ACh because an H-bond positions the QA to interact optimally with the r

245 ble to carry out reactions directly on the C-H bonds, previously considered to be unreactive.

246 There is no correlation between the H-bonding properties of the anions and the pKa values of

247 for the diborylation of secondary benzylic C-H bonds, providing direct access to polyboron building b

248 es, relying on eight-, six- or five-membered H-bonded pseudocycles (C8, C6 or C5), depending on the s

249 d activation; paradoxically, the strongest C-H bond reacts preferentially.

250 nt C-H bonds, the position of the reacting C-H bonds relative to the directing group, and stereochemi

251 ytic enantioselective functionalization of C-H bonds represents a highly atom- and step-economic appr

252 The intermolecular amination of C-H bonds represents a particularly desirable and challeng

253 Intramolecular H-bonding represents a useful strategy to limit internal

254 d middle regions have adequate hydration and H-bonding residues to form potential proton-conducting c

255 and donates its electron density into the C-H bond's antibonding orbital.

256 ecules typically contain multiple types of C-H bonds, selective C-H functionalization is a major ongo

257 Catalytic C-H bond silylation is facile with partially fluorinated a

258 Singly H-bonded species are dominant at 10 mol %, due to strong

259 llent opportunity for obtaining meaningful N-H bond strength data.

260 H-bond strength modulation due to enhancement or disrupt

261 ectroscopic/analytic study to estimate the N-H bond strengths of several species of interest.

262 Thermodynamic knowledge of the N-H bond strengths of such species is scant, and is especi

263 lf is able to abstract H-atoms from weaker X-H bonds such as TEMPO-H to re-form 2.

264 containing primary and secondary benzylic C-H bonds, such as toluene or ethylbenzene.

265 rings, and weakly to Cho because a different H-bond tethers the ligand to misalign the QA and form we

266 the iridium center to activate a different C-H bond than in the cases of directing donor coordination

267 Instead of the secondary C-H bond, the new catalyst is capable of precise site-sele

268 gy, the scope, the reactivity of different C-H bonds, the position of the reacting C-H bonds relative

269 The method also works well for benzylic C-H bonds, thereby constituting the missing version of the

270 upernucleophile Co(I), converting an initial H bond to a full electron transfer as start of the reduc

271 hich the enzyme scaffold causes a specific C-H bond to be functionalized by placing it close to the i

272 tive azo directed 1,4-addition of an ortho C-H bond to maleimides has been developed using Co(III) ca

273 cavity that limits access of the secondary C-H bond to the reactive intermediate.

274 tive cross-coupling between C(sp(2))-H and N-H bonds to produce dihydroimidazobenzimidazoles.

275 mplexes capable of forming an intramolecular H-bond to the coordinated water ligand, and these comple

276 adduct with 4-NO2-phenol, which includes an H-bond to the peroxo O-atom distal to Fe (resonance Rama

277 XB hemispheres, geometrically rigidified by H-bonding to eight MeOH molecules and encapsulation of t

278 This binding mode requires H-bonding to Ser119 and a dramatic conformational switch

279 in at the fibril edge while interfering with H-bonding to the next incoming monomer exhibit poor amyl

280 lves O-O homolysis, where the phenol remains H-bonding to the peroxo OCu in the transition state (TS)

281 unctionalized N-azoles via direct covalent N-H bond transformations onto N-C bonds.

282 lculations show that the formation of triple H-bonds triggers a significant elongation of the N horiz

283 actone through the oxidation of a tertiary C-H bond under conditions that minimize epoxidation of an

284 e. starting from strong directional multiple H bonds up to weaker nondirectional bonds taking into ac

285 as capable of oxidizing ferrocene and weak O-H bonds upon activation with proton donors.

286 ese MMOs harnesses O2 to functionalize the C-H bond using different chemistry.

287 rtho-specific nitration of aromatic C(sp(2))-H bonds using chelation-assisted removable vicinal diami

288 oxidative cleavage of benzylic and allylic C-H bonds using DDQ can be coupled with an intra- or inter

289 molecular cross-coupling of C(sp(2))-H and N-H bonds using N-iodosuccinimide (NIS) has been demonstra

290 a metal-oxygen site-pair that cleaves the C-H bond via a sigma bond metathesis reaction, during whic

291 sequent dissociation of the electron-rich HO-H bond via H transfer to N on the nickel surface, benefi

292 ted hydrocarbons and unactivated aliphatic C-H bonds via a metal-hydride pathway.

293 pha-diazo carbonyl compounds into Si-H and S-H bonds was developed.

294 triles in the presence of activated C(sp(3))-H bond, which results in good yields of the halogenated

295 tion, during which the Co inserts into the C-H bond while the oxygen abstracts the leaving H-atom in

296 ted the formation of a stable intramolecular H-bond, while alternative hypotheses that could explain

297 between multiple, relatively strong sp(3) C-H bonds whose chemical behavior often differ only subtly

298 selective oxidative arylation of benzylic C-H bonds with arylboronic esters.

299 ionalize secondary, tertiary, and benzylic C-H bonds with good yields and functional group compatibil

300 syn-syn conformer through a pair of frontal H-bonds with the relevant AA partner.