ライフサイエンスコーパス: H. somnus

1 H. somnus induced endothelial cell apoptosis in as littl

2 H. somnus strain 2336 LOS was found to contain some sial

3 The number of adherent H. somnus was significantly increased by prior activatio

4 significantly reduced the number of adherent H. somnus.

5 egies and vaccines to protect cattle against H. somnus disease.

6 nisms are A. pleuropneumoniae ATCC 27090 and H. somnus ATCC 700025.

7 oeae, and Haemophilus influenzae, as well as H. somnus, reacted with some phase-variable epitopes in

8 Future comparisons between H. somnus 129Pt and virulent strains will aid in the dev

9 that some LOS epitopes are conserved between H. somnus and other Haemophilus and Neisseria species, t

10 Heparin was also shown to bind H. somnus in a 4 degrees C binding assay.

11 -weight heparin-binding protein expressed by H. somnus.

12 The mechanisms used by H. somnus to migrate from the bloodstream into the centr

13 either heat-killed H. somnus, formalin-fixed H. somnus, nor purified lipooligosaccharide altered mono

14 ntigenic variation and stability in LOS from H. somnus strains and phase variants.

15 tion period, whereas conditioned medium from H. somnus-treated BBEC caused a modest reduction in TEER

16 The goal of this study was to determine if H. somnus alters brain endothelial cell monolayer integr

17 However, LOS antigenic diversity in H. somnus has not been adequately investigated.

18 reacted with some phase-variable epitopes in H. somnus LOS.

19 We found unique genes in H. somnus 129Pt involved in lipooligosaccharide biosynth

20 ue to 5'-CAAT-3' tandem sequences present in H. somnus genes.

21 wing electroporation of pCAATDeltalob2A into H. somnus 738, several allelic exchange mutants were iso

22 Neither heat-killed H. somnus, formalin-fixed H. somnus, nor purified lipool

23 surface, thus contributing to the ability of H. somnus to infect the bovine CNS.

24 sulfated glycosaminoglycans in adherence of H. somnus to BBEC.

25 Our comparative analyses of H. somnus 129Pt, H. influenzae Rd, and H. ducreyi 35000H

26 lts of a genome-wide comparative analysis of H. somnus 129Pt, Haemophilus influenzae Rd, and Haemophi

27 results indicate that outer core epitopes of H. somnus LOS exhibit a high degree of random, phase-var

28 Heat inactivation of H. somnus culture filtrates partially reduced the apopto

29 Clinical isolates of H. somnus exhibited intrastrain, as well as interstrain,

30 ow report that growth of disease isolates of H. somnus with CMP-N-acetylneuraminic acid (CMP-NeuAc) o

31 In addition, the LOS of H. somnus shares conserved epitopes with LOS from Neisse

32 lation of the LOS enhanced the resistance of H. somnus to the bactericidal action of antiserum to LOS

33 We report the genome sequence of H. somnus 129Pt, a nonpathogenic commensal preputial iso

34 The sialyltransferase of H. somnus strain 738 was confirmed to preferentially sia

35 Pathogenic strains of H. somnus are a significant cause of systemic disease in

36 may occur at a high rate in some strains of H. somnus, and that phase variation may, in part, be due

37 ata suggest that heparin-binding proteins on H. somnus could serve as initial adhesins to sulfated pr

38 an important virulence mechanism to protect H. somnus against the host immune system.

39 ous glycosaminoglycans significantly reduced H. somnus adherence to resting and TNF-alpha-activated B

40 LOS components of about 4.3 kDa in the same H. somnus isolates, including a non-phase-varying strain

41 k but that two IgBP-negative serum-sensitive H. somnus strains from asymptomatic preputial carriers d

42 tis is commonly seen as a result of systemic H. somnus infections, the pathogenesis of vascular damag

43 In this study, we demonstrate that H. somnus adheres to, but does not invade, bovine brain

44 These data demonstrate that H. somnus and its LOS induce endothelial cell apoptosis,

45 In this study, we demonstrated that H. somnus (pathogenic isolates 649, 2336, and 8025 and a

46 We found that H. somnus LOS, which is heat stable, induced endothelial

47 Our laboratory has previously reported that H. somnus has the ability to adhere to, but not invade,

48 Therefore, this study shows that H. somnus has two IgBPs, including a peripheral membrane

49 ation and that LOS structure is important to H. somnus virulence.

50 Viable H. somnus organisms induced greater endothelial cell apo

51 of endothelial cell apoptosis, as did viable H. somnus organisms.

52 Since viable H. somnus cells release membrane fibrils and blebs, whic

53 his study support the hypothesis that viable H. somnus alters integrity of the blood-brain barrier by

54 When H. somnus 129Pt was electrotransformed with shuttle vect

55 BBEC incubated with H. somnus underwent rapid cytoskeletal rearrangement, si